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jorgelandgrave1.bsky.social
@jorgelandgrave1.bsky.social
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wyomingwormboy.bsky.social
Greetings! I decided to make a YouTube video of my AlphaFold workshop that I've given a few times in the past year. Caveats aside, people seem to find this useful for thinking about how to model protein interactions and how to interpret various AF outputs 1/2

www.youtube.com/watch?v=u63o...
David's AlphaFold WorkShop 2026
YouTube video by David Fay
www.youtube.com
January 2, 2026 at 11:03 PM
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elife.bsky.social
Aged mice and human samples show patterned loss of Purkinje cells in the cerebellum, revealing a spatial signature of ageing that may help explain why motor coordination and behaviour decline over time.
Cerebellar Purkinje cell stripe patterns reveal a differential vulnerability and resistance to cell loss during normal aging in mice
Purkinje cell subpopulations have varying vulnerability to age-related neurodegeneration, creating a striped pattern of cell loss that reflects the developmental, anatomical, and functional…
buff.ly
December 11, 2025 at 11:28 PM
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elife.bsky.social
The pattern of cell death in the cerebellum differs between disease and normal ageing.
Degenerative brain patterns
The pattern of cell death in the cerebellum differs between disease and normal aging.
buff.ly
December 5, 2025 at 9:02 PM
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natmetabolism.nature.com
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease
Nature Metabolism, Published online: 21 November 2025; doi:10.1038/s42255-025-01409-4This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
bit.ly
November 28, 2025 at 11:06 PM
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natmetabolism.nature.com
Cholesterol fuels microglia in chronic stroke
Nature Metabolism, Published online: 23 September 2025; doi:10.1038/s42255-025-01362-2Cholesterol accumulation in microglia drives persistent inflammation after stroke. In this issue of Nature Metabolism, Zhao et al. suggest that enhancing microglial cholesterol catabolism may offer a promising strategy to reduce brain damage and improve recovery.
bit.ly
September 30, 2025 at 2:45 PM
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lucas.farnunglab.com
New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com
Protein Domain Designer tool for the generation of publication-ready protein domain diagrams
September 29, 2025 at 3:01 PM
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natmetabolism.nature.com
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
Nature Metabolism, Published online: 22 September 2025; doi:10.1038/s42255-025-01365-zThe authors introduce the Neurolipid Atlas, a dynamic resource for the community to gain insight into lipid alterations in neurodegenerative disease, and they leverage the platform to show how cholesterol alterations in astrocytes can dysregulate neuroinflammatory pathways in Alzheimer disease.
bit.ly
September 22, 2025 at 2:32 PM
Reposted
natmetabolism.nature.com
Cholesterol fuels microglia in chronic stroke
Nature Metabolism, Published online: 23 September 2025; doi:10.1038/s42255-025-01362-2Cholesterol accumulation in microglia drives persistent inflammation after stroke. In this issue of Nature Metabolism, Zhao et al. suggest that enhancing microglial cholesterol catabolism may offer a promising strategy to reduce brain damage and improve recovery.
bit.ly
September 23, 2025 at 2:44 PM