Jon Marles-Wright
@jmarlesw.bsky.social
Scientist, husband to @lislowe, father. Views my own. He/him.
Reposted by Jon Marles-Wright
Proud and excited to see my first, first-author paper out on @pnas.org! Huge thank you to Jon @jmarlesw.bsky.social, Luning and my colleagues for their amazing guidance throughout.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
November 14, 2025 at 1:22 PM
Proud and excited to see my first, first-author paper out on @pnas.org! Huge thank you to Jon @jmarlesw.bsky.social, Luning and my colleagues for their amazing guidance throughout.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Jon Marles-Wright
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 13, 2025 at 8:14 PM
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
November 13, 2025 at 9:57 AM
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
Reposted by Jon Marles-Wright
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
Structural insights into cobalamin loading and reactivation of human methionine synthase
Human methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in...
www.biorxiv.org
November 11, 2025 at 12:48 PM
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
Reposted by Jon Marles-Wright
Afternoon starts with former #Salgadolab student @adamcrawshaw.bsky.social getting the audience engaged on #microcrystals and @diamondlightsource.bsky.social VMXm beamline.
November 6, 2025 at 1:52 PM
Afternoon starts with former #Salgadolab student @adamcrawshaw.bsky.social getting the audience engaged on #microcrystals and @diamondlightsource.bsky.social VMXm beamline.
Reposted by Jon Marles-Wright
Another exciting day in Newcastle for structural biology! The CCP4 Structural Biology Meeting 2025 is here!
November 6, 2025 at 10:27 AM
Another exciting day in Newcastle for structural biology! The CCP4 Structural Biology Meeting 2025 is here!
Reposted by Jon Marles-Wright
A great overview of #cryoEM in Newcastle from @jmarlesw.bsky.social at #NorthernEye opening @nusbf.bsky.social
November 5, 2025 at 10:31 AM
A great overview of #cryoEM in Newcastle from @jmarlesw.bsky.social at #NorthernEye opening @nusbf.bsky.social
Reposted by Jon Marles-Wright
Woo. The big day is finally here. @jmarlesw.bsky.social kicking off the Northern Eye Opening Symposium
November 5, 2025 at 10:28 AM
Woo. The big day is finally here. @jmarlesw.bsky.social kicking off the Northern Eye Opening Symposium
Reposted by Jon Marles-Wright
Please join us in the North East on the 5th of November as we celebrate with a one day symposium for the launch of our BBSRC funded 100 keV Tundra TEM aka the Northern Eye:
nusbf.ncl.ac.uk/ccpem-tfs-ne...
The symposium has been kindly sponsored by
@thermofishersci.bsky.social & @ccpem.bsky.social
nusbf.ncl.ac.uk/ccpem-tfs-ne...
The symposium has been kindly sponsored by
@thermofishersci.bsky.social & @ccpem.bsky.social
Grand Opening of the Northern eye, a cryo-TEM in Newcastle
Grand Opening of the Northern Eye in Newcastle, a100 kV Tundra cryo-TEM in Newcastle University on Wednesday 5th November 2025
nusbf.ncl.ac.uk
October 21, 2025 at 9:31 AM
Please join us in the North East on the 5th of November as we celebrate with a one day symposium for the launch of our BBSRC funded 100 keV Tundra TEM aka the Northern Eye:
nusbf.ncl.ac.uk/ccpem-tfs-ne...
The symposium has been kindly sponsored by
@thermofishersci.bsky.social & @ccpem.bsky.social
nusbf.ncl.ac.uk/ccpem-tfs-ne...
The symposium has been kindly sponsored by
@thermofishersci.bsky.social & @ccpem.bsky.social
Interested in alpha-oxoamine synthases and their use in biotech? Here's a nice methods paper on the production and characterisation of an engineered T. maritima variant from colleagues in the @campopianogroup.bsky.social: www.sciencedirect.com/science/arti...
Characterisation and engineering of thermostable PLP-dependent alpha-oxoamine synthases (AOSs); versatile C-C bond forming biocatalysts
The toolbox of C-C bond forming biocatalysts is forever expanding as demand increases for new and sustainable routes to organic molecules. One class o…
www.sciencedirect.com
September 29, 2025 at 8:54 AM
Interested in alpha-oxoamine synthases and their use in biotech? Here's a nice methods paper on the production and characterisation of an engineered T. maritima variant from colleagues in the @campopianogroup.bsky.social: www.sciencedirect.com/science/arti...
Reposted by Jon Marles-Wright
The Quinn group are interested in stress-sensing and signalling mechanisms in human pathogenic fungi and their importance in virulence. They are also interested anti-fungal mechanisms mediated by the bacterial type-vi secretion system.
👉 @nclfungalgroup.bsky.social
www.ncl.ac.uk/medical-scie...
👉 @nclfungalgroup.bsky.social
www.ncl.ac.uk/medical-scie...
September 22, 2025 at 11:39 AM
The Quinn group are interested in stress-sensing and signalling mechanisms in human pathogenic fungi and their importance in virulence. They are also interested anti-fungal mechanisms mediated by the bacterial type-vi secretion system.
👉 @nclfungalgroup.bsky.social
www.ncl.ac.uk/medical-scie...
👉 @nclfungalgroup.bsky.social
www.ncl.ac.uk/medical-scie...
Reposted by Jon Marles-Wright
The Palmer group are interested in the mechanisms bacteria use to compete with one another during colonisation. Her group are focused on the type vii secretion system and the toxins it exports.
Follow @proftracypalmer.bsky.social for more insights.
www.ncl.ac.uk/medical-scie...
Follow @proftracypalmer.bsky.social for more insights.
www.ncl.ac.uk/medical-scie...
September 22, 2025 at 11:38 AM
The Palmer group are interested in the mechanisms bacteria use to compete with one another during colonisation. Her group are focused on the type vii secretion system and the toxins it exports.
Follow @proftracypalmer.bsky.social for more insights.
www.ncl.ac.uk/medical-scie...
Follow @proftracypalmer.bsky.social for more insights.
www.ncl.ac.uk/medical-scie...
Reposted by Jon Marles-Wright
Next up, @nickj-dent-res.bsky.social
His group is interested in all aspects of oral biofilms and how they contribute to oral health and disease. They look at adhesion and colonisation of surfaces, intermicrobial interactions and the role of the biofilm matrix.
blogs.ncl.ac.uk/nickjakubovi...
His group is interested in all aspects of oral biofilms and how they contribute to oral health and disease. They look at adhesion and colonisation of surfaces, intermicrobial interactions and the role of the biofilm matrix.
blogs.ncl.ac.uk/nickjakubovi...
September 22, 2025 at 11:52 AM
Next up, @nickj-dent-res.bsky.social
His group is interested in all aspects of oral biofilms and how they contribute to oral health and disease. They look at adhesion and colonisation of surfaces, intermicrobial interactions and the role of the biofilm matrix.
blogs.ncl.ac.uk/nickjakubovi...
His group is interested in all aspects of oral biofilms and how they contribute to oral health and disease. They look at adhesion and colonisation of surfaces, intermicrobial interactions and the role of the biofilm matrix.
blogs.ncl.ac.uk/nickjakubovi...
Reposted by Jon Marles-Wright
Next introducing Dr Alessandra Dantas.
The Dantas group is interested in stress responses, antifungal resistance and in understanding the molecular mechanisms driving fungal adaptation to environmental stressors.
@alesdantas.bsky.social
www.ncl.ac.uk/dental/about...
The Dantas group is interested in stress responses, antifungal resistance and in understanding the molecular mechanisms driving fungal adaptation to environmental stressors.
@alesdantas.bsky.social
www.ncl.ac.uk/dental/about...
September 22, 2025 at 12:32 PM
Next introducing Dr Alessandra Dantas.
The Dantas group is interested in stress responses, antifungal resistance and in understanding the molecular mechanisms driving fungal adaptation to environmental stressors.
@alesdantas.bsky.social
www.ncl.ac.uk/dental/about...
The Dantas group is interested in stress responses, antifungal resistance and in understanding the molecular mechanisms driving fungal adaptation to environmental stressors.
@alesdantas.bsky.social
www.ncl.ac.uk/dental/about...
Reposted by Jon Marles-Wright
Last introduction for the today..
Dr Kesha Josts @kjosts.bsky.social
The Josts lab are working on the mechanisms of iron transport in bacterial pathogens, with a focus on Pseudomonas aeruginosa.
www.ncl.ac.uk/cbcb/staff/p...
Dr Kesha Josts @kjosts.bsky.social
The Josts lab are working on the mechanisms of iron transport in bacterial pathogens, with a focus on Pseudomonas aeruginosa.
www.ncl.ac.uk/cbcb/staff/p...
September 22, 2025 at 12:46 PM
Last introduction for the today..
Dr Kesha Josts @kjosts.bsky.social
The Josts lab are working on the mechanisms of iron transport in bacterial pathogens, with a focus on Pseudomonas aeruginosa.
www.ncl.ac.uk/cbcb/staff/p...
Dr Kesha Josts @kjosts.bsky.social
The Josts lab are working on the mechanisms of iron transport in bacterial pathogens, with a focus on Pseudomonas aeruginosa.
www.ncl.ac.uk/cbcb/staff/p...
Reposted by Jon Marles-Wright
@jmarlesw.bsky.social is a structural biochemist. His group are interested in how bacteria sense and respond to their environment. Jon is Academic Lead for our Electron Microscopy Facility and is excited for our new Tundra microscope to be up and running.
www.marles-wright-lab.org
www.marles-wright-lab.org
September 22, 2025 at 12:10 PM
@jmarlesw.bsky.social is a structural biochemist. His group are interested in how bacteria sense and respond to their environment. Jon is Academic Lead for our Electron Microscopy Facility and is excited for our new Tundra microscope to be up and running.
www.marles-wright-lab.org
www.marles-wright-lab.org
Welcome week at the university again. Number 28 for me. Looking forward to welcoming our 7th MRes Biotech and Biodesign cohort this morning.
September 15, 2025 at 8:39 AM
Welcome week at the university again. Number 28 for me. Looking forward to welcoming our 7th MRes Biotech and Biodesign cohort this morning.
Reposted by Jon Marles-Wright
Finally, we're recruiting!
If you'd like to do a PhD using NMR structures to study the dynamics of a metalloenzyme, then you're in luck! Come to Warsaw for this project, in collaboration with Simone Ciofi-Baffoni's group at CERM, Florence: ibb.edu.pl/app/uploads/...
If you'd like to do a PhD using NMR structures to study the dynamics of a metalloenzyme, then you're in luck! Come to Warsaw for this project, in collaboration with Simone Ciofi-Baffoni's group at CERM, Florence: ibb.edu.pl/app/uploads/...
May 12, 2025 at 4:40 PM
Finally, we're recruiting!
If you'd like to do a PhD using NMR structures to study the dynamics of a metalloenzyme, then you're in luck! Come to Warsaw for this project, in collaboration with Simone Ciofi-Baffoni's group at CERM, Florence: ibb.edu.pl/app/uploads/...
If you'd like to do a PhD using NMR structures to study the dynamics of a metalloenzyme, then you're in luck! Come to Warsaw for this project, in collaboration with Simone Ciofi-Baffoni's group at CERM, Florence: ibb.edu.pl/app/uploads/...
York Uni campus looking splendid today. Visiting Biology for a viva.
May 12, 2025 at 10:10 AM
York Uni campus looking splendid today. Visiting Biology for a viva.
Happy April 25th to all who observe the perfect date.
a man and a woman are talking into microphones and the woman is wearing a sash that says rhode island on it
ALT: a man and a woman are talking into microphones and the woman is wearing a sash that says rhode island on it
media.tenor.com
April 25, 2025 at 12:53 PM
Happy April 25th to all who observe the perfect date.
Interested in Engineering Biology and spending a few days in the best city in the world? Designer Biology 2025 is coming to Newcastle: 29-31st July. Abstracts and registration is open: www.efbiotechnology.org/designerbiol...
April 8, 2025 at 8:50 AM
Interested in Engineering Biology and spending a few days in the best city in the world? Designer Biology 2025 is coming to Newcastle: 29-31st July. Abstracts and registration is open: www.efbiotechnology.org/designerbiol...
Reposted by Jon Marles-Wright
First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group.
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239
PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University on FindAPhD.com
PhD Project - PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University, listed on FindAPhD.com
www.findaphd.com
January 6, 2025 at 9:14 PM
First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group.
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239
Day trip to Sheffield for a very enjoyable encapsulin viva with @perbullough.bsky.social
December 12, 2024 at 6:44 PM
Day trip to Sheffield for a very enjoyable encapsulin viva with @perbullough.bsky.social
Reposted by Jon Marles-Wright
Here we delve deeper into what makes a flagellin “silent” - see Michael Bell’s cryo-EM structure of a silent flagellin from the flagellum of Roseburia hominis- it has a different charge distribution compared to FliC and it dissociates rapidly from TLR5 www.biorxiv.org/content/10.1...
Kinetic and structure-based comparisons of silent and stimulatory flagellin interactions with TLR5
The bacterial protein flagellin is the sole ligand of the innate immune receptor Toll-like receptor 5 (TLR5). Flagellins with strong agonism bind TLR5 at their D1 and D0 domains, while poor agonist si...
www.biorxiv.org
December 10, 2024 at 2:20 PM
Here we delve deeper into what makes a flagellin “silent” - see Michael Bell’s cryo-EM structure of a silent flagellin from the flagellum of Roseburia hominis- it has a different charge distribution compared to FliC and it dissociates rapidly from TLR5 www.biorxiv.org/content/10.1...
A lovely winter graduation ceremony this afternoon. Posing here with some of the fab students I got to work with on the MRes Biotech and Biodesign last year. Always great to hear what they are all up to now.
December 3, 2024 at 7:17 PM
A lovely winter graduation ceremony this afternoon. Posing here with some of the fab students I got to work with on the MRes Biotech and Biodesign last year. Always great to hear what they are all up to now.