Jitendra Meena
@jitendrakmeena.bsky.social
Studying RNA degradation mechanisms, ribonucleotide homeostasis, their role in human diseases, and investigating therapeutic strategies to target these processes.
Pinned
MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer
MYC induces a previously uncharacterized type of oncogenic stress by increasing global RNA degradation and downstream ribonucleotide catabolism and ROS accumulation; this catabolic vulnerability can b...
aacrjournals.org
What are the consequences of excessive RNA production?
We found that MYC hyper activation that increases RNA synthesis, also accelerates RNA decay, resulting in a new type of oncogenic stress- RNA catabolic stress. Happy to share this work was featured on the cover. aacrjournals.org/cancerdiscov...
We found that MYC hyper activation that increases RNA synthesis, also accelerates RNA decay, resulting in a new type of oncogenic stress- RNA catabolic stress. Happy to share this work was featured on the cover. aacrjournals.org/cancerdiscov...
Reposted by Jitendra Meena
An intuitive visualization of the regulatory layers influencing the stoichiometry of a protein complex.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
May 20, 2025 at 11:24 AM
An intuitive visualization of the regulatory layers influencing the stoichiometry of a protein complex.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Jitendra Meena
Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
www.nature.com
April 25, 2025 at 5:19 AM
Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jitendra Meena
Two updates with this project! First, this work is now published here: academic.oup.com/nar/article/...
Second, our software for identifying 8-oxoguanosine via RNAseq, PIGPEN, is now installable via bioconda: anaconda.org/bioconda/pig...
Second, our software for identifying 8-oxoguanosine via RNAseq, PIGPEN, is now installable via bioconda: anaconda.org/bioconda/pig...
March 21, 2025 at 3:25 PM
Two updates with this project! First, this work is now published here: academic.oup.com/nar/article/...
Second, our software for identifying 8-oxoguanosine via RNAseq, PIGPEN, is now installable via bioconda: anaconda.org/bioconda/pig...
Second, our software for identifying 8-oxoguanosine via RNAseq, PIGPEN, is now installable via bioconda: anaconda.org/bioconda/pig...
Reposted by Jitendra Meena
🧪 Wnt signaling restores evolutionary loss of regenerative potential in Hydra. Our recently released study establishes a comparative framework for understanding the molecular basis of regeneration and its evolutionary loss in closely-related species.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
March 19, 2025 at 4:22 AM
🧪 Wnt signaling restores evolutionary loss of regenerative potential in Hydra. Our recently released study establishes a comparative framework for understanding the molecular basis of regeneration and its evolutionary loss in closely-related species.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jitendra Meena
Check out our new & improved V2 manuscript for RiboNN, with new analyses to further sharpen the results!! www.biorxiv.org/content/10.1...
January 20, 2025 at 1:57 PM
Check out our new & improved V2 manuscript for RiboNN, with new analyses to further sharpen the results!! www.biorxiv.org/content/10.1...
Reposted by Jitendra Meena
mRNA 5'UTR functions, large scale, and feature detection to predict effect on translation - IN VIVO 🔥
awesome work from the awesome Madalena Reimão-Pinto & Alex Schier and colleagues 👏
MPRAs in multicellular organisms
translation specificity 🤝 cell type specificity
www.cell.com/developmenta...
awesome work from the awesome Madalena Reimão-Pinto & Alex Schier and colleagues 👏
MPRAs in multicellular organisms
translation specificity 🤝 cell type specificity
www.cell.com/developmenta...
www.cell
January 15, 2025 at 10:25 PM
mRNA 5'UTR functions, large scale, and feature detection to predict effect on translation - IN VIVO 🔥
awesome work from the awesome Madalena Reimão-Pinto & Alex Schier and colleagues 👏
MPRAs in multicellular organisms
translation specificity 🤝 cell type specificity
www.cell.com/developmenta...
awesome work from the awesome Madalena Reimão-Pinto & Alex Schier and colleagues 👏
MPRAs in multicellular organisms
translation specificity 🤝 cell type specificity
www.cell.com/developmenta...
Reposted by Jitendra Meena
#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology
Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...
www.nature.com
January 8, 2025 at 12:11 PM
#1 Happy to share our last work published in @NatureCellBio about a new cell cycle checkpoint that senses nuclear shape & mechanics to guarantee genome integrity
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
www.nature.com/articles/s41.... Great work from @sol-herve.bsky.social & Andrea Scelfo in close collaboration with @katemiro.bsky.social
Reposted by Jitendra Meena
How do 250k regulatory sequences coordinate 15k genes in mammalian development?
Just out: A genomic evidence board to decode the chaos by mapping enhancer-gene interactions across embryonic mouse tissues
New resource with Miao Yu, Ming Hu, Bing Ren, and more.
www.nature.com/articles/s41...
Just out: A genomic evidence board to decode the chaos by mapping enhancer-gene interactions across embryonic mouse tissues
New resource with Miao Yu, Ming Hu, Bing Ren, and more.
www.nature.com/articles/s41...
December 17, 2024 at 2:36 PM
How do 250k regulatory sequences coordinate 15k genes in mammalian development?
Just out: A genomic evidence board to decode the chaos by mapping enhancer-gene interactions across embryonic mouse tissues
New resource with Miao Yu, Ming Hu, Bing Ren, and more.
www.nature.com/articles/s41...
Just out: A genomic evidence board to decode the chaos by mapping enhancer-gene interactions across embryonic mouse tissues
New resource with Miao Yu, Ming Hu, Bing Ren, and more.
www.nature.com/articles/s41...
Reposted by Jitendra Meena
My first first-author paper was published this morning! Did you know eye lenses grow in layers throughout life and can be analyzed to study movement and foraging ecology. But eye lenses differ in bio molecular composition across fish taxa, especially for sharks! 🧪🌎🦑
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Investigating eye lens composition for stable isotope analysis in fishes: a comparison between Chondrichthyes and Actinopterygii - Environmental Biology of Fishes
Life history ecology provides a framework for understanding the complex interactions between organisms and their environments but is challenging to resolve for long-lived and migratory species. In fis...
link.springer.com
December 17, 2024 at 4:02 PM
My first first-author paper was published this morning! Did you know eye lenses grow in layers throughout life and can be analyzed to study movement and foraging ecology. But eye lenses differ in bio molecular composition across fish taxa, especially for sharks! 🧪🌎🦑
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Jitendra Meena
"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 12, 2024 at 10:21 PM
"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jitendra Meena
🧪 #RNASky #RNABiology Our paper is now on bioRxiv.
A short thread.
This is the work of 2 former students (& me) - Sandipan dasgupta and Anand Ravi
The whole project originated more than a decade ago during my postdoc days. I found that mRNAs can transfer between mammalian cells, not by exosomes>>
A short thread.
This is the work of 2 former students (& me) - Sandipan dasgupta and Anand Ravi
The whole project originated more than a decade ago during my postdoc days. I found that mRNAs can transfer between mammalian cells, not by exosomes>>
Complementation of a human disease phenotype in vitro by intercellular mRNA transfer https://www.biorxiv.org/content/10.1101/2024.11.06.622258v1
Complementation of a human disease phenotype in vitro by intercellular mRNA transfer https://www.biorxiv.org/content/10.1101/2024.11.06.622258v1
There is growing evidence that full-length mRNAs undergo intercellular transfer through long, thin c
www.biorxiv.org
November 7, 2024 at 7:10 AM
🧪 #RNASky #RNABiology Our paper is now on bioRxiv.
A short thread.
This is the work of 2 former students (& me) - Sandipan dasgupta and Anand Ravi
The whole project originated more than a decade ago during my postdoc days. I found that mRNAs can transfer between mammalian cells, not by exosomes>>
A short thread.
This is the work of 2 former students (& me) - Sandipan dasgupta and Anand Ravi
The whole project originated more than a decade ago during my postdoc days. I found that mRNAs can transfer between mammalian cells, not by exosomes>>
What are the consequences of excessive RNA production?
We found that MYC hyper activation that increases RNA synthesis, also accelerates RNA decay, resulting in a new type of oncogenic stress- RNA catabolic stress. Happy to share this work was featured on the cover. aacrjournals.org/cancerdiscov...
We found that MYC hyper activation that increases RNA synthesis, also accelerates RNA decay, resulting in a new type of oncogenic stress- RNA catabolic stress. Happy to share this work was featured on the cover. aacrjournals.org/cancerdiscov...
MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer
MYC induces a previously uncharacterized type of oncogenic stress by increasing global RNA degradation and downstream ribonucleotide catabolism and ROS accumulation; this catabolic vulnerability can b...
aacrjournals.org
November 13, 2024 at 7:40 PM
What are the consequences of excessive RNA production?
We found that MYC hyper activation that increases RNA synthesis, also accelerates RNA decay, resulting in a new type of oncogenic stress- RNA catabolic stress. Happy to share this work was featured on the cover. aacrjournals.org/cancerdiscov...
We found that MYC hyper activation that increases RNA synthesis, also accelerates RNA decay, resulting in a new type of oncogenic stress- RNA catabolic stress. Happy to share this work was featured on the cover. aacrjournals.org/cancerdiscov...