Jinrong Hu
@jinrong.bsky.social
Postdoc @Hadjantonakis lab@MSKCC. PhD w/ Rong Li & @AlexanderBersh1 @MBIsg. Cell bio, development, cytoskeleton, cardiomyocyte. Views mine. Twitter @HJRBio.
https://orcid.org/0000-0002-2400-4669
https://scholar.google.com/citations?user=Qfox
https://orcid.org/0000-0002-2400-4669
https://scholar.google.com/citations?user=Qfox
Reposted by Jinrong Hu
Extracellular matrix proteolysis maintains synapse plasticity during brain development.
Seems Hyaluronan turnover would be required for plasticity
www.nature.com/articles/s41...
Seems Hyaluronan turnover would be required for plasticity
www.nature.com/articles/s41...
Extracellular matrix proteolysis maintains synapse plasticity during brain development - Nature Neuroscience
This study demonstrates that the extracellular matrix (ECM) of the developing brain stabilizes recently born synapses. The authors identify a microglial metalloprotease that digests the ECM to increas...
www.nature.com
December 23, 2025 at 11:00 PM
Extracellular matrix proteolysis maintains synapse plasticity during brain development.
Seems Hyaluronan turnover would be required for plasticity
www.nature.com/articles/s41...
Seems Hyaluronan turnover would be required for plasticity
www.nature.com/articles/s41...
Reposted by Jinrong Hu
p53 preserves genome stability in dividing cells under hypo-osmotic stress https://www.biorxiv.org/content/10.64898/2025.12.17.694541v1
December 18, 2025 at 5:30 PM
p53 preserves genome stability in dividing cells under hypo-osmotic stress https://www.biorxiv.org/content/10.64898/2025.12.17.694541v1
Reposted by Jinrong Hu
✍️ The @bladoux.bsky.social / @rmmege.bsky.social Lab published a new article
📖 @pnas.org
📃 Regulation of epithelial tissue homeostasis by active transepithelial transport
🔗 www.pnas.org/doi/10.1073/...
📖 @pnas.org
📃 Regulation of epithelial tissue homeostasis by active transepithelial transport
🔗 www.pnas.org/doi/10.1073/...
November 14, 2025 at 2:18 PM
✍️ The @bladoux.bsky.social / @rmmege.bsky.social Lab published a new article
📖 @pnas.org
📃 Regulation of epithelial tissue homeostasis by active transepithelial transport
🔗 www.pnas.org/doi/10.1073/...
📖 @pnas.org
📃 Regulation of epithelial tissue homeostasis by active transepithelial transport
🔗 www.pnas.org/doi/10.1073/...
So amazed that fibroblast to cardiomyocyte reprogramming efficiency can be increased by inhibiting nuclear receptor Nr4a3, as it directly promotes SASP genes expression!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 20, 2025 at 3:50 AM
So amazed that fibroblast to cardiomyocyte reprogramming efficiency can be increased by inhibiting nuclear receptor Nr4a3, as it directly promotes SASP genes expression!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Jinrong Hu
Mechanoresilience of lysosomes conferred by TMEM63A https://www.biorxiv.org/content/10.64898/2025.12.18.695245v1
December 19, 2025 at 1:31 PM
Mechanoresilience of lysosomes conferred by TMEM63A https://www.biorxiv.org/content/10.64898/2025.12.18.695245v1
Reposted by Jinrong Hu
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
December 16, 2025 at 12:05 PM
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Reposted by Jinrong Hu
Good to see the peer reviewed version of this published
A chemo-optogenetic system for spatiotemporal control of gene expression
We use it to:
- Reconstruct SHH mediated neural tube patterning in vitro
- Measure extracellular half-life of Shh
www.cell.com/developmenta...
A chemo-optogenetic system for spatiotemporal control of gene expression
We use it to:
- Reconstruct SHH mediated neural tube patterning in vitro
- Measure extracellular half-life of Shh
www.cell.com/developmenta...
Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Benzinger et al. develop a chemo-optogenetic system for precise spatiotemporal control
of morphogen production in vitro. Using light-controlled Sonic hedgehog expression,
they recapitulate neural tube...
www.cell.com
December 16, 2025 at 1:45 AM
Good to see the peer reviewed version of this published
A chemo-optogenetic system for spatiotemporal control of gene expression
We use it to:
- Reconstruct SHH mediated neural tube patterning in vitro
- Measure extracellular half-life of Shh
www.cell.com/developmenta...
A chemo-optogenetic system for spatiotemporal control of gene expression
We use it to:
- Reconstruct SHH mediated neural tube patterning in vitro
- Measure extracellular half-life of Shh
www.cell.com/developmenta...
Reposted by Jinrong Hu
Great to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic
Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions
www.pnas.org/doi/10.1073/...
Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions
www.pnas.org/doi/10.1073/...
Reconstructing Waddington’s landscape from data | PNAS
The development of a zygote into a functional organism requires that this single progenitor
cell gives rise to numerous distinct cell types. Attemp...
www.pnas.org
December 4, 2025 at 6:29 AM
Great to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic
Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions
www.pnas.org/doi/10.1073/...
Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions
www.pnas.org/doi/10.1073/...
Reposted by Jinrong Hu
🧪⚛️ Surface tension—driven by non-equilibrium currents not forces—in pattern formation leads to the same type of interface laws as in liquid foams: Plateau laws, von Neumann evolution; and a new emergent phenomenon: domain splitting akin to cell division. nature.com/articles/s4156…
December 6, 2025 at 8:12 AM
🧪⚛️ Surface tension—driven by non-equilibrium currents not forces—in pattern formation leads to the same type of interface laws as in liquid foams: Plateau laws, von Neumann evolution; and a new emergent phenomenon: domain splitting akin to cell division. nature.com/articles/s4156…
Reposted by Jinrong Hu
How do cells recognize matrix topography? In this preprint we show that α5β1-integrin fibrillar adhesions rapidly form in response to topographic cues like electrospun nanofibers- no actomyosin contractility, focal adhesions or fibronectin secretion needed
doi.org/10.1101/2025...
doi.org/10.1101/2025...
December 3, 2025 at 7:57 AM
How do cells recognize matrix topography? In this preprint we show that α5β1-integrin fibrillar adhesions rapidly form in response to topographic cues like electrospun nanofibers- no actomyosin contractility, focal adhesions or fibronectin secretion needed
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Jinrong Hu
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 8:25 AM
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
Reposted by Jinrong Hu
Do you see any underlying driver/correlator for these numbers?
Number of canceled NIH grants by institution:
1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3
Source: taggs.hhs.gov/Content/Data...
Number of canceled NIH grants by institution:
1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3
Source: taggs.hhs.gov/Content/Data...
March 24, 2025 at 9:56 PM
Do you see any underlying driver/correlator for these numbers?
Number of canceled NIH grants by institution:
1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3
Source: taggs.hhs.gov/Content/Data...
Number of canceled NIH grants by institution:
1 Columbia U 163
2 Johns Hopkins 12
3 Emory 6
4 U. Michigan 5
5 U. Minnesota 5
6 U Miami Med Sch. 4
7 UCSF 4
8 U Chicago 3
Source: taggs.hhs.gov/Content/Data...
A funny paper linking DNA damage response to nuclear actin polymerization😆 wondering how nuclear actin affect cell migration in general🤔
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
ATR-hippo drives force signaling to nuclear F-actin and links mechanotransduction to neurological disorders
Genetic defects of mechanotransduction are identified as a psychiatric-prone syndrome.
www.science.org
March 15, 2025 at 3:32 PM
A funny paper linking DNA damage response to nuclear actin polymerization😆 wondering how nuclear actin affect cell migration in general🤔
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Jinrong Hu
Happy to share our new publication in
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...
March 14, 2025 at 12:10 PM
Happy to share our new publication in
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...
Reposted by Jinrong Hu
Membrane projections from muscle cells enable signaling in the developing mouse heart @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 13, 2025 at 6:14 PM
Membrane projections from muscle cells enable signaling in the developing mouse heart @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Jinrong Hu
This is now published in @biologyopen.bsky.social! It was my first experience with this journal & it was outstanding. Their goal is to publish "rigorously conducted high-quality research across the breadth of biological/biomedical science "1/n
journals.biologists.com/bio/article/...
journals.biologists.com/bio/article/...
January 31, 2025 at 12:22 PM
This is now published in @biologyopen.bsky.social! It was my first experience with this journal & it was outstanding. Their goal is to publish "rigorously conducted high-quality research across the breadth of biological/biomedical science "1/n
journals.biologists.com/bio/article/...
journals.biologists.com/bio/article/...
Reposted by Jinrong Hu
Hear hear, our 4 keynote speakers! #MAYosis
May 7th: Elvan Böke @crg.eu
May 14th: Felicity Jones @unigroningen.bsky.social
May 21st : Ofer Rog @theroglab.bsky.social @utah.edu
May 28th: Francesca Cole @francescacole.bsky.social @mdanderson.bsky.social
meiosis.cornell.edu/mayosis2025/...
🧵⬇️
May 7th: Elvan Böke @crg.eu
May 14th: Felicity Jones @unigroningen.bsky.social
May 21st : Ofer Rog @theroglab.bsky.social @utah.edu
May 28th: Francesca Cole @francescacole.bsky.social @mdanderson.bsky.social
meiosis.cornell.edu/mayosis2025/...
🧵⬇️
January 30, 2025 at 10:28 AM
Hear hear, our 4 keynote speakers! #MAYosis
May 7th: Elvan Böke @crg.eu
May 14th: Felicity Jones @unigroningen.bsky.social
May 21st : Ofer Rog @theroglab.bsky.social @utah.edu
May 28th: Francesca Cole @francescacole.bsky.social @mdanderson.bsky.social
meiosis.cornell.edu/mayosis2025/...
🧵⬇️
May 7th: Elvan Böke @crg.eu
May 14th: Felicity Jones @unigroningen.bsky.social
May 21st : Ofer Rog @theroglab.bsky.social @utah.edu
May 28th: Francesca Cole @francescacole.bsky.social @mdanderson.bsky.social
meiosis.cornell.edu/mayosis2025/...
🧵⬇️
Elegant work to show stress granule component DCP5 in plant senses osmolarity😆
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A cytoplasmic osmosensing mechanism mediated by molecular crowding–sensitive DCP5
Plants are frequently challenged by osmotic stresses. How plant cells sense environmental osmolarity changes is not fully understood. We report that Arabidopsis Decapping 5 (DCP5) functions as a multi...
www.science.org
January 26, 2025 at 10:32 AM
Elegant work to show stress granule component DCP5 in plant senses osmolarity😆
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Jinrong Hu
Here is an early #FluorescenceFriday post - a 3D render of a developing mouse neural tube showing a signaling filopodium (cytoneme) reaching toward a primary cilium (green) to deliver a cellular signal (SHH, magenta). See alt text for details. Research supported by #NIH #NIGMS 🔬 by Eric Hall. 🧪
January 23, 2025 at 8:12 PM
Here is an early #FluorescenceFriday post - a 3D render of a developing mouse neural tube showing a signaling filopodium (cytoneme) reaching toward a primary cilium (green) to deliver a cellular signal (SHH, magenta). See alt text for details. Research supported by #NIH #NIGMS 🔬 by Eric Hall. 🧪
Reposted by Jinrong Hu
Exciting work by Martin Beck’s group @mpibp.bsky.social providing further evidence for nuclear pores responding to mechanical stress. The work includes some nice modeling estimating the fluid flow across nuclear pores as a function of (osmotic) pressure.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Nuclear pore permeability and fluid flow are modulated by its dilation state
Hoffmann et al. describe within cells how the Dictyostelium discoideum nuclear pore complex structure constricts and dilates as a consequence of osmotic stress. Based on their experimental findings, they propose a hydrodynamics model and quantify fluid flow across nuclear pore complexes under conditions when nuclei change their volume rapidly.
www.cell.com
December 29, 2024 at 8:50 AM
Exciting work by Martin Beck’s group @mpibp.bsky.social providing further evidence for nuclear pores responding to mechanical stress. The work includes some nice modeling estimating the fluid flow across nuclear pores as a function of (osmotic) pressure.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Jinrong Hu
Most recent work from our lab!🥰We use mouse young ovarian somatic cells (granulosa cells) to rejuvenate mouse aged oocytes!
Link here:
www.nature.com/articles/s43...
Link here:
www.nature.com/articles/s43...
Rejuvenation of aged oocyte through exposure to young follicular microenvironment - Nature Aging
Oocyte quality declines during aging. Here the authors show that oocytes from aged mice cultured within follicles from young mice have improved developmental potential. Aged oocytes cultured within yo...
www.nature.com
September 10, 2024 at 11:32 AM
Most recent work from our lab!🥰We use mouse young ovarian somatic cells (granulosa cells) to rejuvenate mouse aged oocytes!
Link here:
www.nature.com/articles/s43...
Link here:
www.nature.com/articles/s43...
Reposted by Jinrong Hu
We have just moved over from X. Hope the air is cleaner here😊
August 14, 2024 at 5:55 AM
We have just moved over from X. Hope the air is cleaner here😊