The Escherichia coli bacillus morphology is thought to be determined by the shape of the peptidoglycan macromolecule, although the underlying polymerization mechanism remains elusive. Anoyatis-Pelé et al. show that lateral cell wall expansion at a constant diameter depends upon the endopeptidase-dependent insertion of single glycan strands into the peptidoglycan mesh.

Bacterial genomes often contain extrachromosomal replicons (ERs), ranging from small, mobile plasmids to large, stably inherited elements, such as meg…

Acosta et al. find that ADP-ribosylation of the lipoic acid carrier protein GcvH-L promotes Staphylococcus aureus resistance to oxidative burst and facilitates infection. ADP-ribosylation leads to a structural shift within GcvH-L that safeguards lipoic acid sulfhydryls from detrimental oxidation and regulates its transfer to enzyme complexes required for growth.

Streptomyces venezuelae requires MreB1-dependent dispersed peptidoglycan cell wall synthesis and DivIVA-mediated polar cell wall synthesis during its rapid exploratory growth phase.

Author summary Bacterial endospores allow bacteria to survive stress, persist in the environment and seed new and recurring infections. Cell-cell signalling is a cornerstone of how bacteria develop in...

Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.

We report synthetic routes that yield prodrugs consisting of two carbapenems connected by benzyl carbonate linkers. A mass spectrometry assay was elaborated to monitor, in a single kinetic experiment...

Communications Biology - In Gram-negative bacterium Dickeya dadantii, an inner membrane protein OutB is covalently attached to peptidoglycan by the same catalytic mechanism as Braun’s...

Nature Communications - In Escherichia coli, lateral cell-wall expansion during growth occurs by crosslinking of new glycan chains to the existing peptidoglycan network. Here, Liang et al. show a...

Mycobacterium abscessus is a rapidly growing mycobacteria responsible for pulmonary diseases in patients suffering either from chronic obstructive pulmonary diseases or cystic fibrosis (1, 2). Smooth ...

AbstractObjectives. Mycobacterium abscessus is the most frequent of the rapidly growing mycobacteria responsible for lung infections in patients suffering

Registration and abstract submission open on January 15th, 2025.The organizers will select the final list of participants based on abstract submission, particularly for young scientist, and the applic...

The Braun lipoprotein is tethered to peptidoglycan independently from the insertion of newly-synthesized peptidoglycan subunits into the expanding cell wall generating a dynamic equilibrium between fr...

The bacterial alarmone (p)ppGpp induces β-lactam resistance through modification of RNA polymerase and ribosome function rather than regulation of peptidoglycan metabolism in Escherichia coli.

AbstractObjectives. Mycobacterium abscessus has emerged as an opportunistic pathogen responsible for lung infections, especially in cystic fibrosis patient

The rapid spread of antimicrobial resistance across bacterial pathogens poses a serious risk to the efficacy and sustainability of available treatments. This puts pressure on research concerning the d...