Jaime Buigues
@jbuigues.bsky.social
Biologist . MSc in Omics Data Analysis. Dealing with viral metagenomics data at Rafael Sanjuán’s Lab (I2SysBio, Valencia)
Pinned
Jaime Buigues
@jbuigues.bsky.social
· Nov 14
Phylogenetic evidence supporting the nonenveloped nature of hepadnavirus ancestors | PNAS
Reverse-transcribing animal DNA viruses include the hepadnaviruses, a well-characterized
family of small enveloped viruses that infect vertebrates ...
www.pnas.org
Excited to share our latest publication on a newly discovered ancestor of Hepadna and Nackednaviruses, found in bat feces in Spain! This discovery provides new insights into the evolution of these virus families and their origins.
Read more in PNAS: www.pnas.org/doi/abs/10.1...
Read more in PNAS: www.pnas.org/doi/abs/10.1...
Reposted by Jaime Buigues
Investigadores de la @ptisg.bsky.social pertenecientes al @i2sysbio.es participan en este estudio, en el que identifican que un coronavirus que infecta a los cerdos utiliza DPEP1 para entrar en las células
🐷 El @i2sysbio.es (#CSIC- @uv.es) descubre que un coronavirus porcino utiliza una vía inesperada para entrar en las células
⚠️ En el laboratorio, este virus porcino puede usar una proteína de las células humanas para entrar, planteando un posible salto entre especies
➡️ https://f.mtr.cool/ddbwwtytqc
⚠️ En el laboratorio, este virus porcino puede usar una proteína de las células humanas para entrar, planteando un posible salto entre especies
➡️ https://f.mtr.cool/ddbwwtytqc
November 26, 2025 at 9:43 AM
Investigadores de la @ptisg.bsky.social pertenecientes al @i2sysbio.es participan en este estudio, en el que identifican que un coronavirus que infecta a los cerdos utiliza DPEP1 para entrar en las células
Reposted by Jaime Buigues
New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Viro3D: a comprehensive database of virus protein structure predictions | Molecular Systems Biology
imageimageViro3D provides proteome-level, high confidence AI-protein structure predictions for
>4,400 viruses, allowing mapping of form and function across the human and animal
virosphere. Viro3D i...
www.embopress.org
September 28, 2025 at 5:39 AM
New exciting resource published!! The Viro3D paper is out, describing our comprehensive database of predicted virus protein structures! 💻🧬
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Work with @ulad-litvin.bsky.social , @grovearmada.bsky.social , Alex Jack, @bljog.bsky.social , @davidlrobertson.bsky.social
www.embopress.org/doi/full/10....
Reposted by Jaime Buigues
Virus researchers! Please consider participating in this project - it would be a huge help to our lab, and we think it'll lead to some really exciting synthesis. Plus, you'll get an invitation to participate in a workshop later in the project! 🦠😷
🧬🦠🌍 What are the big, cross-scale questions shaping the ecology and evolution of emerging viruses?
@torrelavelle.bsky.social and I are building a list of 100 questions + want your input. Help map the future of EEID — fill out & share our short survey!
🔗 airtable.com/appTW4ZoSFjR...
@torrelavelle.bsky.social and I are building a list of 100 questions + want your input. Help map the future of EEID — fill out & share our short survey!
🔗 airtable.com/appTW4ZoSFjR...
Airtable | Everyone's app platform
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airtable.com
June 17, 2025 at 5:27 PM
Virus researchers! Please consider participating in this project - it would be a huge help to our lab, and we think it'll lead to some really exciting synthesis. Plus, you'll get an invitation to participate in a workshop later in the project! 🦠😷
Reposted by Jaime Buigues
Some good news to push against the dark. Excited to share our latest pre-print from the lab.
www.biorxiv.org/content/10.1...
What started as a series of control experiments rapidly grew into a whole project. 🧪🔬🦠
www.biorxiv.org/content/10.1...
What started as a series of control experiments rapidly grew into a whole project. 🧪🔬🦠
The producer cell type of HSV-1 alters the proteomic contents and infectious capacity of virions
The cell that a virus replicates in i.e., the producer cell, can alter the macromolecular composition and infectious capacity of the virions that are produced. Herpes Simplex virus type 1 (HSV-1) prim...
www.biorxiv.org
April 7, 2025 at 6:29 PM
Some good news to push against the dark. Excited to share our latest pre-print from the lab.
www.biorxiv.org/content/10.1...
What started as a series of control experiments rapidly grew into a whole project. 🧪🔬🦠
www.biorxiv.org/content/10.1...
What started as a series of control experiments rapidly grew into a whole project. 🧪🔬🦠
Reposted by Jaime Buigues
By mining GISAID, researchers from I2SysBio uncover sequencing artifacts in SARS-CoV-2. Many repair mutations in the spike protein were due to errors in data processing. #covid19 #viruses #microsky🧪🦠💻🧬 More info: www.i2sysbio.es/communicatio... ⬇️
April 3, 2025 at 8:35 AM
By mining GISAID, researchers from I2SysBio uncover sequencing artifacts in SARS-CoV-2. Many repair mutations in the spike protein were due to errors in data processing. #covid19 #viruses #microsky🧪🦠💻🧬 More info: www.i2sysbio.es/communicatio... ⬇️
Reposted by Jaime Buigues
People do forget how common zoonotic exposure is. In this study 12% of people working in the guano industry in Myanmar were seropositive for sarbecoviruses: pmc.ncbi.nlm.nih.gov/articles/PMC...
March 19, 2025 at 8:36 PM
People do forget how common zoonotic exposure is. In this study 12% of people working in the guano industry in Myanmar were seropositive for sarbecoviruses: pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Jaime Buigues
🚨Job offer at our research institute I2SysBio 🇪🇸: Contract for International Program Management, specialized in ERC @erc.europa.eu programs 🧪 #science #researchgrants #JOBOFFER #i2sysbio @ucciuv.bsky.social @csic.es @uv.es
i2sysbio.es/position/4/
i2sysbio.es/position/4/
i2sysbio - Position
i2sysbio.es
March 11, 2025 at 7:26 PM
🚨Job offer at our research institute I2SysBio 🇪🇸: Contract for International Program Management, specialized in ERC @erc.europa.eu programs 🧪 #science #researchgrants #JOBOFFER #i2sysbio @ucciuv.bsky.social @csic.es @uv.es
i2sysbio.es/position/4/
i2sysbio.es/position/4/
Reposted by Jaime Buigues
Our recent collaborative work showing the promising broad-spectrum antiviral activity of chitosan sulfate derivatives against SARS-CoV-2, RSV, and Sindbis virus is finally online. Check it out! Detailed mechanisms and in vivo characterization included! rdcu.be/eb9IQ
Synthetic heparan sulfate mimics based on chitosan derivatives show broad-spectrum antiviral activity
Communications Biology - Identification of safe and effective broad-spectrum antivirals based on modified chitosan sulfate derivatives.
rdcu.be
March 4, 2025 at 12:03 PM
Our recent collaborative work showing the promising broad-spectrum antiviral activity of chitosan sulfate derivatives against SARS-CoV-2, RSV, and Sindbis virus is finally online. Check it out! Detailed mechanisms and in vivo characterization included! rdcu.be/eb9IQ
Reposted by Jaime Buigues
🚨 Preprint alter - bis 🚨
I am thrilled to share our last preprint where we identify and characterize a new coronavirus receptor! 🦠
This work was done in collaboration with the team of Félix Rey at the Institut Pasteur.
A 🧵 below...
www.biorxiv.org/content/10.1...
I am thrilled to share our last preprint where we identify and characterize a new coronavirus receptor! 🦠
This work was done in collaboration with the team of Félix Rey at the Institut Pasteur.
A 🧵 below...
www.biorxiv.org/content/10.1...
Dipeptidase 1 is a functional receptor for coronavirus PHEV
Coronaviruses of the subgenus Embecovirus include several relevant pathogens such as the human seasonal coronaviruses HKU1 and OC43, bovine coronavirus, and porcine hemagglutinating encephalomyelitis ...
www.biorxiv.org
January 10, 2025 at 5:32 PM
🚨 Preprint alter - bis 🚨
I am thrilled to share our last preprint where we identify and characterize a new coronavirus receptor! 🦠
This work was done in collaboration with the team of Félix Rey at the Institut Pasteur.
A 🧵 below...
www.biorxiv.org/content/10.1...
I am thrilled to share our last preprint where we identify and characterize a new coronavirus receptor! 🦠
This work was done in collaboration with the team of Félix Rey at the Institut Pasteur.
A 🧵 below...
www.biorxiv.org/content/10.1...
Reposted by Jaime Buigues
To get 2025 off to a good start, I'm delighted to share with you our study published today in @naturemicrobiol.bsky.social 🎉 We studied the ability of the receptor-binding proteins (RBP) of >100 animal viruses to mediate entry into human cells. A short thread below.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors - Nature Microbiology
Functional systematic pseudotype virus-based analysis of the ability of diverse animal viruses to enter into a panel of well-characterized human cell lines shows a broad compatibility between animal v...
www.nature.com
January 2, 2025 at 12:14 PM
To get 2025 off to a good start, I'm delighted to share with you our study published today in @naturemicrobiol.bsky.social 🎉 We studied the ability of the receptor-binding proteins (RBP) of >100 animal viruses to mediate entry into human cells. A short thread below.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jaime Buigues
In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Deep mutational scanning of rabies glycoprotein defines mutational constraint and antibody-escape mutations
Rabies virus causes nearly 60,000 human deaths annually. Antibodies that target the rabies glycoprotein (G) are being developed as post-exposure prophylactics, but mutations in G can render such antib...
www.biorxiv.org
December 18, 2024 at 8:39 PM
In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Reposted by Jaime Buigues
Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists www.science.org/content/arti...
Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists
Origins and spread of the vaccine-derived viruses remain mysterious
www.science.org
December 12, 2024 at 5:13 PM
Poliovirus keeps popping up in European wastewater, perplexing and worrying scientists www.science.org/content/arti...
Reposted by Jaime Buigues
👀👀👀👀👀👀 We should sample more cute animals for weird viruses!!! 🐼🐼
Identification and genomic characterization of a novel bisegmented coronavirus in the lesser panda
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Identification and genomic characterization of a novel bisegmented coronavirus in the lesser panda
Coronaviruses (CoVs) are enveloped positive-sense single-stranded RNA viruses and are renowned for their capacity to infect a diverse range of animals, including humans. In this study, we report the i...
www.biorxiv.org
November 30, 2024 at 2:24 AM
👀👀👀👀👀👀 We should sample more cute animals for weird viruses!!! 🐼🐼
Reposted by Jaime Buigues
Our research institute I2SysBio🇪🇸 has created a starter pack for researchers in systems biology, everybody is welcome, write us if you want to be added 🔬🧫🧬🖥🦑🦠🌱🦟🪳🪸🌾
November 20, 2024 at 5:44 PM
Our research institute I2SysBio🇪🇸 has created a starter pack for researchers in systems biology, everybody is welcome, write us if you want to be added 🔬🧫🧬🖥🦑🦠🌱🦟🪳🪸🌾
Excited to share our latest publication on a newly discovered ancestor of Hepadna and Nackednaviruses, found in bat feces in Spain! This discovery provides new insights into the evolution of these virus families and their origins.
Read more in PNAS: www.pnas.org/doi/abs/10.1...
Read more in PNAS: www.pnas.org/doi/abs/10.1...
Phylogenetic evidence supporting the nonenveloped nature of hepadnavirus ancestors | PNAS
Reverse-transcribing animal DNA viruses include the hepadnaviruses, a well-characterized
family of small enveloped viruses that infect vertebrates ...
www.pnas.org
November 14, 2024 at 10:45 AM
Excited to share our latest publication on a newly discovered ancestor of Hepadna and Nackednaviruses, found in bat feces in Spain! This discovery provides new insights into the evolution of these virus families and their origins.
Read more in PNAS: www.pnas.org/doi/abs/10.1...
Read more in PNAS: www.pnas.org/doi/abs/10.1...