Jakub Morze, MD, PhD
@jakubmorze.bsky.social
Physician, Postdoc at #Chalmers 🇸🇪
Preventive and precision #CVD medicine 🫀
Preventive and precision #CVD medicine 🫀
Reposted by Jakub Morze, MD, PhD
Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025
May 7, 2025 at 1:39 PM
Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025
I couldn’t be more honored by this mention of our study!
Best lab assessment for coronary artery risk consists of ApoB particles and LP(a)
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
April 28, 2025 at 3:24 PM
I couldn’t be more honored by this mention of our study!
🫀 Our new study is now out in #EHJ @escardio.bsky.social
📣 Measuring both #apoB and #LipoproteinA provides the most accurate assessment of cardiovascular risk in primary prevention
doi.org/10.1093/eurh...
📣 Measuring both #apoB and #LipoproteinA provides the most accurate assessment of cardiovascular risk in primary prevention
doi.org/10.1093/eurh...
ApoB-containing lipoproteins: count, type, size, and risk of coronary artery disease
AbstractBackground and Aims. Apolipoprotein B concentration reflects the number of atherogenic lipoproteins and is recognized as a key lipid risk marker. W
doi.org
April 28, 2025 at 6:35 AM
🫀 Our new study is now out in #EHJ @escardio.bsky.social
📣 Measuring both #apoB and #LipoproteinA provides the most accurate assessment of cardiovascular risk in primary prevention
doi.org/10.1093/eurh...
📣 Measuring both #apoB and #LipoproteinA provides the most accurate assessment of cardiovascular risk in primary prevention
doi.org/10.1093/eurh...
Reposted by Jakub Morze, MD, PhD
Great collaborative work spearheaded by M. Ardissino showing that, among those sustaining early-onset myocardial infarction, a CAD polygenic risk score was the strongest among assessed predictors of recurrent events www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
November 30, 2024 at 2:24 PM
Great collaborative work spearheaded by M. Ardissino showing that, among those sustaining early-onset myocardial infarction, a CAD polygenic risk score was the strongest among assessed predictors of recurrent events www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
Reposted by Jakub Morze, MD, PhD
Our review led by @jsdron.bsky.social of the contributions of the Global Lipids Genetics Consortium (www.lipidgenetics.org) journals.lww.com/co-lipidolog...
November 30, 2024 at 2:17 PM
Our review led by @jsdron.bsky.social of the contributions of the Global Lipids Genetics Consortium (www.lipidgenetics.org) journals.lww.com/co-lipidolog...
Reposted by Jakub Morze, MD, PhD
Excited to share our latest in Nature Cardiovascular Research
led by ⭐️ @artschuermans.bsky.social ! #CardioSky #MedSky
Open access paper here: www.nature.com/articles/s44...
Great thread from Art below 👇
led by ⭐️ @artschuermans.bsky.social ! #CardioSky #MedSky
Open access paper here: www.nature.com/articles/s44...
Great thread from Art below 👇
November 21, 2024 at 12:50 PM
Excited to share our latest in Nature Cardiovascular Research
led by ⭐️ @artschuermans.bsky.social ! #CardioSky #MedSky
Open access paper here: www.nature.com/articles/s44...
Great thread from Art below 👇
led by ⭐️ @artschuermans.bsky.social ! #CardioSky #MedSky
Open access paper here: www.nature.com/articles/s44...
Great thread from Art below 👇
Reposted by Jakub Morze, MD, PhD
Zerlasiran, a small-interfering RNA, reduced time-averaged lipoprotein(a) concentrations by more than 80% during 36 weeks of treatment in patients with atherosclerotic cardiovascular disease. #AHA24
https://ja.ma/4fSsXYX
https://ja.ma/4fSsXYX
November 18, 2024 at 8:00 PM
Zerlasiran, a small-interfering RNA, reduced time-averaged lipoprotein(a) concentrations by more than 80% during 36 weeks of treatment in patients with atherosclerotic cardiovascular disease. #AHA24
https://ja.ma/4fSsXYX
https://ja.ma/4fSsXYX
Reposted by Jakub Morze, MD, PhD
The Duff lecture is underway! Come join us in S105 for an incredible perspective on the history and future directions of lipoprotein research by the legendary Alan Remaley @ahascience.bsky.social #AHA24 💯
November 17, 2024 at 2:13 PM
The Duff lecture is underway! Come join us in S105 for an incredible perspective on the history and future directions of lipoprotein research by the legendary Alan Remaley @ahascience.bsky.social #AHA24 💯
Reposted by Jakub Morze, MD, PhD
Invited Commentary on the FINEARTS-HF trial:
The Fine Art and Science of Translating Trials Results Into Clinical Practice
#AHA24
Read it now in JAMA Cardiology: https://ja.ma/4ex15bP
The Fine Art and Science of Translating Trials Results Into Clinical Practice
#AHA24
Read it now in JAMA Cardiology: https://ja.ma/4ex15bP
November 17, 2024 at 2:57 PM
Invited Commentary on the FINEARTS-HF trial:
The Fine Art and Science of Translating Trials Results Into Clinical Practice
#AHA24
Read it now in JAMA Cardiology: https://ja.ma/4ex15bP
The Fine Art and Science of Translating Trials Results Into Clinical Practice
#AHA24
Read it now in JAMA Cardiology: https://ja.ma/4ex15bP
Reposted by Jakub Morze, MD, PhD
Natural Language Processing to Adjudicate Heart Failure Hospitalizations in Global Clinical Trials
www.ahajournals.org/doi/10.1161/...
#Circulation #AHA24 #CardioSky #MesSky
@ahajournals.bsky.social @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
#Circulation #AHA24 #CardioSky #MesSky
@ahajournals.bsky.social @ahascience.bsky.social
November 17, 2024 at 12:55 AM
Natural Language Processing to Adjudicate Heart Failure Hospitalizations in Global Clinical Trials
www.ahajournals.org/doi/10.1161/...
#Circulation #AHA24 #CardioSky #MesSky
@ahajournals.bsky.social @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
#Circulation #AHA24 #CardioSky #MesSky
@ahajournals.bsky.social @ahascience.bsky.social
Why precision cardiology needs to improve ❤️🩹
„CHD PRSs that performed similarly at the population level demonstrated highly variable individual-level estimates of risk”
#CardioSky #MedSky #AHA24
„CHD PRSs that performed similarly at the population level demonstrated highly variable individual-level estimates of risk”
#CardioSky #MedSky #AHA24
🚀 Here are key takeaways from today's JAMA and JAMA Cardiology presentations a#AHA2424:
Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. ž¡️ ja.ma/4fKewpK
November 17, 2024 at 12:01 PM
Why precision cardiology needs to improve ❤️🩹
„CHD PRSs that performed similarly at the population level demonstrated highly variable individual-level estimates of risk”
#CardioSky #MedSky #AHA24
„CHD PRSs that performed similarly at the population level demonstrated highly variable individual-level estimates of risk”
#CardioSky #MedSky #AHA24
Reposted by Jakub Morze, MD, PhD
In 2050, it is projected that 2 in 3 American adults in most states will be obese! www.thelancet.com/journals/lan...
National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990–2021, and forecasts up to 2050
Existing policies have failed to address overweight and obesity. Without major reform,
the forecasted trends will be devastating at the individual and population level,
and the associated disease burd...
www.thelancet.com
November 17, 2024 at 12:20 AM
Reposted by Jakub Morze, MD, PhD
Great panel discussion ongoing at the AHA Women in Cardiology luncheon. #AHA24 #AHAWIC
@ahascience.bsky.social
@ahascience.bsky.social
November 16, 2024 at 6:36 PM
Great panel discussion ongoing at the AHA Women in Cardiology luncheon. #AHA24 #AHAWIC
@ahascience.bsky.social
@ahascience.bsky.social
A towering pioneer who has shaped the very foundations of modern #cardiology with unwavering brilliance and dedication - a true inspiration to generations 🌟🫀
#CardioSky #AHA24 @ahascience.bsky.social
📷: #TIMI group
#CardioSky #AHA24 @ahascience.bsky.social
📷: #TIMI group
November 16, 2024 at 6:50 PM
A towering pioneer who has shaped the very foundations of modern #cardiology with unwavering brilliance and dedication - a true inspiration to generations 🌟🫀
#CardioSky #AHA24 @ahascience.bsky.social
📷: #TIMI group
#CardioSky #AHA24 @ahascience.bsky.social
📷: #TIMI group
Reposted by Jakub Morze, MD, PhD
Another incredible win for GLP-1RA/GIP Tirzepatide in SUMMIT! 38% reduction in CVD death/worsening HF and improved patient-reported outcomes. Time for policy change to get these therapies to patients with #obesity #hfpef #aha2024 #cardiosky
November 16, 2024 at 3:50 PM
Another incredible win for GLP-1RA/GIP Tirzepatide in SUMMIT! 38% reduction in CVD death/worsening HF and improved patient-reported outcomes. Time for policy change to get these therapies to patients with #obesity #hfpef #aha2024 #cardiosky
Reposted by Jakub Morze, MD, PhD
Excited to be at #AHA24! Please check out our short presentation tomorrow on the role of LV anisotropy in the outcome of MI. www.ahajournals.org/doi/abs/10.1...
November 16, 2024 at 12:46 PM
Excited to be at #AHA24! Please check out our short presentation tomorrow on the role of LV anisotropy in the outcome of MI. www.ahajournals.org/doi/abs/10.1...
Reposted by Jakub Morze, MD, PhD
Joy & 🙏@ahascience.bsky.social #Science #Communicators #AHA24
Such fun team🙌
@dramitkhera.bsky.social
@pnatarajanmd.bsky.social
@vietheartpa.bsky.social
@moradishayan.bsky.social
@seanmwu.bsky.social
@garimasharmamd.bsky.social
@shelbycarignan.bsky.social
@joslynh.bsky.social & ++ #CardioSky
Such fun team🙌
@dramitkhera.bsky.social
@pnatarajanmd.bsky.social
@vietheartpa.bsky.social
@moradishayan.bsky.social
@seanmwu.bsky.social
@garimasharmamd.bsky.social
@shelbycarignan.bsky.social
@joslynh.bsky.social & ++ #CardioSky
November 16, 2024 at 3:18 AM
Joy & 🙏@ahascience.bsky.social #Science #Communicators #AHA24
Such fun team🙌
@dramitkhera.bsky.social
@pnatarajanmd.bsky.social
@vietheartpa.bsky.social
@moradishayan.bsky.social
@seanmwu.bsky.social
@garimasharmamd.bsky.social
@shelbycarignan.bsky.social
@joslynh.bsky.social & ++ #CardioSky
Such fun team🙌
@dramitkhera.bsky.social
@pnatarajanmd.bsky.social
@vietheartpa.bsky.social
@moradishayan.bsky.social
@seanmwu.bsky.social
@garimasharmamd.bsky.social
@shelbycarignan.bsky.social
@joslynh.bsky.social & ++ #CardioSky
Reposted by Jakub Morze, MD, PhD
Welcome to societies/journals joined 🦋👇 #AHA24 #CardioSky
ACC @accintouch.bsky.social
AHA Sciences @ahascience.bsky.social
AHA Journals @ahajournals.bsky.social
JAMA @jamacurrent.bsky.social
ASPC @aspcardio.bsky.social
Am J Prev Card @ajpcardio.bsky.social
J Card Fail @jcardfail.bsky.social
ACC @accintouch.bsky.social
AHA Sciences @ahascience.bsky.social
AHA Journals @ahajournals.bsky.social
JAMA @jamacurrent.bsky.social
ASPC @aspcardio.bsky.social
Am J Prev Card @ajpcardio.bsky.social
J Card Fail @jcardfail.bsky.social
November 16, 2024 at 3:39 AM
Welcome to societies/journals joined 🦋👇 #AHA24 #CardioSky
ACC @accintouch.bsky.social
AHA Sciences @ahascience.bsky.social
AHA Journals @ahajournals.bsky.social
JAMA @jamacurrent.bsky.social
ASPC @aspcardio.bsky.social
Am J Prev Card @ajpcardio.bsky.social
J Card Fail @jcardfail.bsky.social
ACC @accintouch.bsky.social
AHA Sciences @ahascience.bsky.social
AHA Journals @ahajournals.bsky.social
JAMA @jamacurrent.bsky.social
ASPC @aspcardio.bsky.social
Am J Prev Card @ajpcardio.bsky.social
J Card Fail @jcardfail.bsky.social
Reposted by Jakub Morze, MD, PhD
Statins are effective in reducing anthracycline-related cardiac dysfunction. Read more at ow.ly/rlzA50TXw0z
November 15, 2024 at 4:40 PM
Statins are effective in reducing anthracycline-related cardiac dysfunction. Read more at ow.ly/rlzA50TXw0z
When reserve engineering of #GRADE goes wrong 🤨:
“The criteria for a highly suggestive association were met if: P<10−6, >1,000 participants, and largest study in the meta-analysis presented a nominally significant estimate (i.e., P<.05)”
“The criteria for a highly suggestive association were met if: P<10−6, >1,000 participants, and largest study in the meta-analysis presented a nominally significant estimate (i.e., P<.05)”
New review suggests fertility treatment causes cancer. It pools unadjusted estimates from non-randomised studies "to ensure the comprehensiveness of the analysis and maximize the statistical power". Fertility and Sterility drops the ball again imo: www.fertstert.org/article/S001...
DEFINE_ME
www.fertstert.org
November 16, 2024 at 7:37 AM
When reserve engineering of #GRADE goes wrong 🤨:
“The criteria for a highly suggestive association were met if: P<10−6, >1,000 participants, and largest study in the meta-analysis presented a nominally significant estimate (i.e., P<.05)”
“The criteria for a highly suggestive association were met if: P<10−6, >1,000 participants, and largest study in the meta-analysis presented a nominally significant estimate (i.e., P<.05)”
Where is #ESC? 😄
Welcome @accintouch.bsky.social to BlueSky network! 🦋 Happy to see our cardiology professional societies joining us over here. #CardioSky 🫀
November 15, 2024 at 11:25 PM
Where is #ESC? 😄
Reposted by Jakub Morze, MD, PhD
Engage with the editors of #AHAJournals every day at #AHA24! These interactive sessions will provide invaluable insights into the latest trends, future directions, and the editorial process.
Go to www.ahajournals.org/AHASessions and mark your calendars today!
Go to www.ahajournals.org/AHASessions and mark your calendars today!
AHA Sessions | AHA/ASA Journals
www.ahajournals.org
November 15, 2024 at 2:19 PM
Engage with the editors of #AHAJournals every day at #AHA24! These interactive sessions will provide invaluable insights into the latest trends, future directions, and the editorial process.
Go to www.ahajournals.org/AHASessions and mark your calendars today!
Go to www.ahajournals.org/AHASessions and mark your calendars today!
Reposted by Jakub Morze, MD, PhD
Hope to see all of #cardiosky at #AHA24
It's almost time for #AHA24!
November 15, 2024 at 2:25 PM
Hope to see all of #cardiosky at #AHA24
Reposted by Jakub Morze, MD, PhD
And @eschiffrin.bsky.social - THANK YOU for your thoughtful editorial published along with our manuscript.
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
November 15, 2024 at 1:20 PM
And @eschiffrin.bsky.social - THANK YOU for your thoughtful editorial published along with our manuscript.
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...