Jack Humphrey
@jack-humphrey.bsky.social
Genetics and omics of neurodegeneration in Mount Sinai, NYC. www.humphreylab.org
Reposted by Jack Humphrey
EVERY ALS MND scientific conference needs to allow for those with ALS MND who want to attend to be there in person or virtually. It is simply wrong to exclude them.
May 30, 2025 at 11:40 AM
EVERY ALS MND scientific conference needs to allow for those with ALS MND who want to attend to be there in person or virtually. It is simply wrong to exclude them.
Reposted by Jack Humphrey
'Evidence suggesting that #microglia make #amyloid from neuronally expressed APP: a hypothesis'
John Hardy & Patrick Lewis
molecularneurodegeneration.biomedcentral.com/articles/10....
John Hardy & Patrick Lewis
molecularneurodegeneration.biomedcentral.com/articles/10....
Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis - Molecular Neurodegeneration
While APP is largely neuonally expressed, Aβ amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed.
molecularneurodegeneration.biomedcentral.com
May 9, 2025 at 9:39 PM
'Evidence suggesting that #microglia make #amyloid from neuronally expressed APP: a hypothesis'
John Hardy & Patrick Lewis
molecularneurodegeneration.biomedcentral.com/articles/10....
John Hardy & Patrick Lewis
molecularneurodegeneration.biomedcentral.com/articles/10....
Reposted by Jack Humphrey
With so many great tau researchers like @leatgrinberg.bsky.social @lucbuee.bsky.social @sjorsscheres.bsky.social @selinawray.bsky.social @karchlab.bsky.social on #SciSky could not help but put together my 1st starterpack⤵️
We are all fighting for you @curemaptftd.bsky.social 💙
go.bsky.app/KHno2VG
January 11, 2025 at 5:48 PM
With so many great tau researchers like @leatgrinberg.bsky.social @lucbuee.bsky.social @sjorsscheres.bsky.social @selinawray.bsky.social @karchlab.bsky.social on #SciSky could not help but put together my 1st starterpack⤵️
We are all fighting for you @curemaptftd.bsky.social 💙
go.bsky.app/KHno2VG
Reposted by Jack Humphrey
Happy to share our new study that was just published in Neuron! www.cell.com/neuron/fullt...
Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures
TDP-43 pathology characterizes neurodegenerative diseases. Scialò et al. use in vitro-generated
and patient-derived TDP-43 aggregates as seeds to show that seed-induced TDP-43 cytoplasmic
aggregation ...
www.cell.com
March 28, 2025 at 3:15 PM
Happy to share our new study that was just published in Neuron! www.cell.com/neuron/fullt...
www.biorxiv.org/content/10.1... New work from Humphrey and Raj labs, exploring the role of RNA editing in myeloid cells. Hopefully will be a useful resource for the field. Next stop: genetics!
Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells
Myeloid cells undergo large changes to their gene expression profile in response to inflammatory stimulation. This includes an increase in post-transcriptional modifications carried out by adenosine-t...
www.biorxiv.org
March 17, 2025 at 8:46 PM
www.biorxiv.org/content/10.1... New work from Humphrey and Raj labs, exploring the role of RNA editing in myeloid cells. Hopefully will be a useful resource for the field. Next stop: genetics!
Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics
This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...
www.nature.com
March 4, 2025 at 5:47 PM
Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...
Reposted by Jack Humphrey
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics
This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...
www.nature.com
March 4, 2025 at 1:31 AM
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Reposted by Jack Humphrey
This is important! Satellite rallies too!
Going sends a message.
Not going also sends a message.
It's not self-serving for scientists to protest the war on science. Millions of people depend on us.
A huge thank you to the early career scientists who are leading this!
🧪 #standupforscience
Going sends a message.
Not going also sends a message.
It's not self-serving for scientists to protest the war on science. Millions of people depend on us.
A huge thank you to the early career scientists who are leading this!
🧪 #standupforscience
It’s time to #standupforscience2025 - We’re making our voice heard about the importance of the American science ecosystem, and want you to join us.
More information at www.standupforscience2025.org
#scienceforall #sciencenotsilence
More information at www.standupforscience2025.org
#scienceforall #sciencenotsilence
February 16, 2025 at 5:15 PM
This is important! Satellite rallies too!
Going sends a message.
Not going also sends a message.
It's not self-serving for scientists to protest the war on science. Millions of people depend on us.
A huge thank you to the early career scientists who are leading this!
🧪 #standupforscience
Going sends a message.
Not going also sends a message.
It's not self-serving for scientists to protest the war on science. Millions of people depend on us.
A huge thank you to the early career scientists who are leading this!
🧪 #standupforscience
Reposted by Jack Humphrey
The Genomic Code: the genome instantiates a generative model of the organism www.cell.com/trends/genet... - really delighted to see this in print in @cp-trendsgenetics.bsky.social! 😊
The Genomic Code: the genome instantiates a generative model of the organism
How does the genome encode the form of the organism? What is the nature of this genomic
code? Inspired by recent work in machine learning and neuroscience, we propose that
the genome encodes a generat...
www.cell.com
February 11, 2025 at 11:46 AM
The Genomic Code: the genome instantiates a generative model of the organism www.cell.com/trends/genet... - really delighted to see this in print in @cp-trendsgenetics.bsky.social! 😊
Reposted by Jack Humphrey
I fear that my crew of junior scientists are going to be absolutely decimated. We did postdocs during the pandemic (I had a 1.5 year old with no childcare!). Somehow, we got through that only to be met with an unprecedented freezing of the NIH.
January 23, 2025 at 3:20 AM
I fear that my crew of junior scientists are going to be absolutely decimated. We did postdocs during the pandemic (I had a 1.5 year old with no childcare!). Somehow, we got through that only to be met with an unprecedented freezing of the NIH.
Reposted by Jack Humphrey
If you do GWAS or rare variant association studies, check out this short thread on the concept of SPECIFICITY, and why it is a major determinant of what we find:
Why do association studies prioritize trait-specific variants???
A quick thread about the importance of thinking about all traits at once 👇 1/6 (🧪🧬)
A quick thread about the importance of thinking about all traits at once 👇 1/6 (🧪🧬)
December 17, 2024 at 3:41 PM
If you do GWAS or rare variant association studies, check out this short thread on the concept of SPECIFICITY, and why it is a major determinant of what we find:
Reposted by Jack Humphrey
🧪Thanks to @rbaltman.bsky.social for having me on The Future of Everything podcast to talk about treatments for Alzheimer's disease. Give a listen if you're interested in an (anti)anti-amyloid antibody argument and some promising new drug targets. #Alzheimers
engineering.stanford.edu/news/future-...
engineering.stanford.edu/news/future-...
The future of Alzheimer's treatment
A neurologist who studies Alzheimer’s disease says hopes are on the rise for new treatments that target tau proteins.
engineering.stanford.edu
December 14, 2024 at 8:51 PM
🧪Thanks to @rbaltman.bsky.social for having me on The Future of Everything podcast to talk about treatments for Alzheimer's disease. Give a listen if you're interested in an (anti)anti-amyloid antibody argument and some promising new drug targets. #Alzheimers
engineering.stanford.edu/news/future-...
engineering.stanford.edu/news/future-...
I've had a fantastic week in London meeting old friends and new back at Queen Square #UCL. Thanks to @adrianisaacs.bsky.social and @frattalab.bsky.social for letting me crash their Christmas parties and Johh Hardy for inviting me to give a talk.
December 14, 2024 at 2:18 PM
I've had a fantastic week in London meeting old friends and new back at Queen Square #UCL. Thanks to @adrianisaacs.bsky.social and @frattalab.bsky.social for letting me crash their Christmas parties and Johh Hardy for inviting me to give a talk.