Meghana Janardhanan
@j-megh.bsky.social
PhD Student at Dalhousie University | 🧠 & 🧬
Reposted by Meghana Janardhanan
1/n Out today in @jamapsychiatry.com: Interpretation Issues With the Patient Health Questionnaire Instructions. We find troubling variability in whether people think they should respond based on the frequency of the Sx or the frequency of being bothered by the Sx.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Interpretation Issues With the Patient Health Questionnaire Instructions
This survey study assesses whether responses to the Patient Health Questionnaire reflect symptom frequency and severity.
jamanetwork.com
December 17, 2025 at 5:11 PM
1/n Out today in @jamapsychiatry.com: Interpretation Issues With the Patient Health Questionnaire Instructions. We find troubling variability in whether people think they should respond based on the frequency of the Sx or the frequency of being bothered by the Sx.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Meghana Janardhanan
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult.
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Causal modelling of gene effects from regulators to programs to traits - Nature
Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.
www.nature.com
December 11, 2025 at 5:54 PM
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult.
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Reposted by Meghana Janardhanan
Here is another version of the Figure I made to summarize the study, showing both trait-level and factor-level genetic correlations
December 11, 2025 at 8:41 AM
Here is another version of the Figure I made to summarize the study, showing both trait-level and factor-level genetic correlations
Reposted by Meghana Janardhanan
1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...
Mapping the genetic landscape across 14 psychiatric disorders - Nature
Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders...
www.nature.com
December 10, 2025 at 4:22 PM
1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...