Itay Inbar
@itayinbar.bsky.social
Data scientist @ BRAIN.Q | Computational neuroscience of visual perception @ BGU
What breaks proprioception after a stroke? Not just lesions, it’s the disconnectome. A new study maps how white matter network disconnections drive proprioceptive deficits.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Patterns of Structural Disconnection Driving Proprioceptive Deficits After Stroke
Background: Stroke is a leading cause of death and disability worldwide, with proprioceptive impairments affecting up to 64% of survivors. These impairments hinder sensorimotor function and motor reco...
www.biorxiv.org
May 27, 2025 at 2:04 PM
What breaks proprioception after a stroke? Not just lesions, it’s the disconnectome. A new study maps how white matter network disconnections drive proprioceptive deficits.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
This study finds that the visual system is tuned to the specific speed and duration of saccades, so much so that it filters out anything that looks like them.
A law of vision grounded in action.
www.nature.com/articles/s41...
A law of vision grounded in action.
www.nature.com/articles/s41...
Lawful kinematics link eye movements to the limits of high-speed perception - Nature Communications
Saccadic eye movements sample the visual world, but the retinal motion they entail goes unnoticed. This study shows that lawful saccade kinematics predict motion visibility, omitting saccade-like moti...
www.nature.com
May 26, 2025 at 3:21 PM
This study finds that the visual system is tuned to the specific speed and duration of saccades, so much so that it filters out anything that looks like them.
A law of vision grounded in action.
www.nature.com/articles/s41...
A law of vision grounded in action.
www.nature.com/articles/s41...
Impressive work, but representational alignment is tricky. Sometimes preserving global geometry is ideal, other times, distinctions matter more.
Philosophically, computational theories demand a more precise notion of representation than alignment alone.
arxiv.org/pdf/2505.12540
Philosophically, computational theories demand a more precise notion of representation than alignment alone.
arxiv.org/pdf/2505.12540
arxiv.org
May 24, 2025 at 5:14 PM
Impressive work, but representational alignment is tricky. Sometimes preserving global geometry is ideal, other times, distinctions matter more.
Philosophically, computational theories demand a more precise notion of representation than alignment alone.
arxiv.org/pdf/2505.12540
Philosophically, computational theories demand a more precise notion of representation than alignment alone.
arxiv.org/pdf/2505.12540
Incredible dataset and elegant analysis! Would love to see efforts toward making parts of this dataset openly accessible.
Even anonymized versions of this data could be a goldmine for perception research.
ai.meta.com/research/pub...
Even anonymized versions of this data could be a goldmine for perception research.
ai.meta.com/research/pub...
Emergence of Language in the Developing Brain | Research - AI at Meta
A few million words suffice for children to acquire language. Yet, the brain mechanisms underlying this unique ability remain poorly understood. To...
ai.meta.com
May 23, 2025 at 8:29 AM
Incredible dataset and elegant analysis! Would love to see efforts toward making parts of this dataset openly accessible.
Even anonymized versions of this data could be a goldmine for perception research.
ai.meta.com/research/pub...
Even anonymized versions of this data could be a goldmine for perception research.
ai.meta.com/research/pub...
Just had the pleasure of joining a panel on academia vs. industry hosted by the neuroscience department at Ben-Gurion University.
Grateful for the invitation and the thoughtful discussion about navigating career paths, and building things that matter.
Grateful for the invitation and the thoughtful discussion about navigating career paths, and building things that matter.
May 21, 2025 at 6:39 PM
Just had the pleasure of joining a panel on academia vs. industry hosted by the neuroscience department at Ben-Gurion University.
Grateful for the invitation and the thoughtful discussion about navigating career paths, and building things that matter.
Grateful for the invitation and the thoughtful discussion about navigating career paths, and building things that matter.
This new study shows ~0.6mm of error can stem from consistent misalignment in MNI space, detectable using anatomical fiducials (AFIDs).
direct.mit.edu/imag/article...
direct.mit.edu/imag/article...
The impact of localization and registration accuracy on estimates of deep brain stimulation electrode position in stereotactic space
Abstract. Effects of deep brain stimulation (DBS) depend on millimetric accuracy and are commonly studied across populations by registering patient scans to a stereotactic space. Multiple factors cont...
direct.mit.edu
May 20, 2025 at 3:09 PM
This new study shows ~0.6mm of error can stem from consistent misalignment in MNI space, detectable using anatomical fiducials (AFIDs).
direct.mit.edu/imag/article...
direct.mit.edu/imag/article...
1/
The FDA’s clearance of an Alzheimer’s blood test is huge, but it doesn’t mean other tools are obsolete.
If anything, it reveals how much we still need to understand about how pathology meets behavior.
www.fda.gov/news-events/...
The FDA’s clearance of an Alzheimer’s blood test is huge, but it doesn’t mean other tools are obsolete.
If anything, it reveals how much we still need to understand about how pathology meets behavior.
www.fda.gov/news-events/...
FDA Clears First Blood Test Used in Diagnosing Alzheimer’s Disease
The U.S. Food and Drug Administration cleared for marketing the first in vitro diagnostic device that tests blood, to aid in diagnosing Alzheimer’s disease.
www.fda.gov
May 18, 2025 at 4:57 PM
1/
The FDA’s clearance of an Alzheimer’s blood test is huge, but it doesn’t mean other tools are obsolete.
If anything, it reveals how much we still need to understand about how pathology meets behavior.
www.fda.gov/news-events/...
The FDA’s clearance of an Alzheimer’s blood test is huge, but it doesn’t mean other tools are obsolete.
If anything, it reveals how much we still need to understand about how pathology meets behavior.
www.fda.gov/news-events/...
A new study shows lipoamide dissolves stress granules in ALS via redox modulation of the methionine-rich SFPQ.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology
Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...
www.nature.com
May 18, 2025 at 6:14 AM
A new study shows lipoamide dissolves stress granules in ALS via redox modulation of the methionine-rich SFPQ.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neural markers (like N1 amplitude differences) say more about your listening-in-noise ability than behavior does.
Should hearing diagnostics move beyond the audiogram and include cognitive tests or EEG-based attention measures?
www.eneuro.org/content/12/4...
Should hearing diagnostics move beyond the audiogram and include cognitive tests or EEG-based attention measures?
www.eneuro.org/content/12/4...
Individual Differences in Cognition and Perception Predict Neural Processing of Speech in Noise for Audiometrically Normal Listeners
Individuals with normal hearing exhibit considerable variability in their capacity to understand speech in noisy environments. Previous research suggests the cause of this variance may be due to indiv...
www.eneuro.org
May 18, 2025 at 6:13 AM
Neural markers (like N1 amplitude differences) say more about your listening-in-noise ability than behavior does.
Should hearing diagnostics move beyond the audiogram and include cognitive tests or EEG-based attention measures?
www.eneuro.org/content/12/4...
Should hearing diagnostics move beyond the audiogram and include cognitive tests or EEG-based attention measures?
www.eneuro.org/content/12/4...
Can memories become precise without excitatory scaling? A beautiful model of how top-down inputs and interneuron diversity orchestrate memory refinement.
Happy to share our new preprint! We show how cell-type-specific synaptic scaling mechanisms shape memory representations during associative learning and highlight a critical role of top-down inputs in modulating this process. www.biorxiv.org/content/10.1...
Cell-type-specific synaptic scaling mechanisms differentially contribute to associative learning
Excitatory synaptic scaling regulates network dynamics by proportionally adjusting excitatory synaptic strengths after sensory perturbations. During associative learning, blocking excitatory scaling i...
www.biorxiv.org
May 16, 2025 at 2:48 PM
Can memories become precise without excitatory scaling? A beautiful model of how top-down inputs and interneuron diversity orchestrate memory refinement.
This paper proposes “Dynamical Independence” as a way to capture when macro-level neural dynamics become their own thing, no longer reducible to the microscale. Really exciting work!
doi.org/10.1371/journal.pcbi.1012572
doi.org/10.1371/journal.pcbi.1012572
Capturing the emergent dynamical structure in biophysical neural models
Complex neural systems can display structured emergent dynamics. Capturing this structure remains a significant scientific challenge. Using information theory, we apply Dynamical Independence (DI) to ...
doi.org
May 14, 2025 at 12:42 PM
This paper proposes “Dynamical Independence” as a way to capture when macro-level neural dynamics become their own thing, no longer reducible to the microscale. Really exciting work!
doi.org/10.1371/journal.pcbi.1012572
doi.org/10.1371/journal.pcbi.1012572
A beautiful work on how the amygdala bridges the time gap between taste and delayed gut feedback using neural reactivation.
Turns out, CGRP neurons trigger a replay of flavour codes in the amygdala. Taste, then tummy ache = memory
www.nature.com/articles/s41...
Turns out, CGRP neurons trigger a replay of flavour codes in the amygdala. Taste, then tummy ache = memory
www.nature.com/articles/s41...
A neural mechanism for learning from delayed postingestive feedback - Nature
Illness signals from the gut reactivate and strengthen flavour representations in the amygdala to support learning from delayed postingestive feedback.
www.nature.com
May 14, 2025 at 12:25 PM
A beautiful work on how the amygdala bridges the time gap between taste and delayed gut feedback using neural reactivation.
Turns out, CGRP neurons trigger a replay of flavour codes in the amygdala. Taste, then tummy ache = memory
www.nature.com/articles/s41...
Turns out, CGRP neurons trigger a replay of flavour codes in the amygdala. Taste, then tummy ache = memory
www.nature.com/articles/s41...
Fascinating work shows how ketamine and dexmedetomidine converge on large-scale phase realignment. Love the idea of interhemispheric hyper-synchrony as a potential unconsciousness signature.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations
Bardon et al. show that different anesthetic drugs have similar effects on the phase
alignment of neural oscillations across cortical areas. Neighboring regions within
a hemisphere become misaligned, ...
www.cell.com
May 13, 2025 at 12:19 PM
Fascinating work shows how ketamine and dexmedetomidine converge on large-scale phase realignment. Love the idea of interhemispheric hyper-synchrony as a potential unconsciousness signature.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
People with psychosis receiving placebo show cortical thinning over 1st year of illness, but those receiving antipsychotics do not.
Could serotonergic modulation be the secret sauce behind the protective effect? PET-guided dosing next? 🧐
www.medrxiv.org/content/10.1...
Could serotonergic modulation be the secret sauce behind the protective effect? PET-guided dosing next? 🧐
www.medrxiv.org/content/10.1...
Differential effects of illness and antipsychotics on cortical thinning in first episode psychosis
Introduction: Cortical grey matter loss is a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and has been shown to progress with ongoing illness. A major unresolved...
www.medrxiv.org
May 12, 2025 at 7:34 AM
People with psychosis receiving placebo show cortical thinning over 1st year of illness, but those receiving antipsychotics do not.
Could serotonergic modulation be the secret sauce behind the protective effect? PET-guided dosing next? 🧐
www.medrxiv.org/content/10.1...
Could serotonergic modulation be the secret sauce behind the protective effect? PET-guided dosing next? 🧐
www.medrxiv.org/content/10.1...
An image goes from nonsense to “Oh, it’s a dog!” and suddenly VOTC flips its code, hippocampus fires, and the moment embeds itself in memory.
Turns out the best way to remember something might be to feel like you’ve just discovered it 👀
www.nature.com/articles/s41...
Turns out the best way to remember something might be to feel like you’ve just discovered it 👀
www.nature.com/articles/s41...
Insight predicts subsequent memory via cortical representational change and hippocampal activity - Nature Communications
Insight, involving representational change, can boost long-term memory. Here, in an fMRI study, the authors show that insight triggers stronger conceptual shifts in solution relevant brain regions and...
www.nature.com
May 11, 2025 at 5:38 AM
An image goes from nonsense to “Oh, it’s a dog!” and suddenly VOTC flips its code, hippocampus fires, and the moment embeds itself in memory.
Turns out the best way to remember something might be to feel like you’ve just discovered it 👀
www.nature.com/articles/s41...
Turns out the best way to remember something might be to feel like you’ve just discovered it 👀
www.nature.com/articles/s41...
Rodent vision seems to rely on a shared, low-D manifold that all areas sample differently. If true, model “layering” might be a bad metaphor? 👀
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Humans learn generalizable representations through efficient coding - Nature Communications
Reinforcement learning models of human behavior are limited in explaining the capacity for generalization. Here, the authors propose an efficient coding principle for reinforcement learning, whereby a...
www.nature.com
May 11, 2025 at 4:28 AM
Rodent vision seems to rely on a shared, low-D manifold that all areas sample differently. If true, model “layering” might be a bad metaphor? 👀
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MICrONS released a mouse visual cortex with dense EM + calcium imaging.
75K neurons, 0.5B synapses, open access.
If your model of V1 still uses toy stimuli and artificial connectivity, MICrONS just raised the bar 👀
www.nature.com/articles/s41...
75K neurons, 0.5B synapses, open access.
If your model of V1 still uses toy stimuli and artificial connectivity, MICrONS just raised the bar 👀
www.nature.com/articles/s41...
Functional connectomics spanning multiple areas of mouse visual cortex - Nature
Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neuron...
www.nature.com
May 11, 2025 at 4:27 AM
MICrONS released a mouse visual cortex with dense EM + calcium imaging.
75K neurons, 0.5B synapses, open access.
If your model of V1 still uses toy stimuli and artificial connectivity, MICrONS just raised the bar 👀
www.nature.com/articles/s41...
75K neurons, 0.5B synapses, open access.
If your model of V1 still uses toy stimuli and artificial connectivity, MICrONS just raised the bar 👀
www.nature.com/articles/s41...
This might be the cleanest computational model of learning I’ve seen.
skill plateaus seems to emerge from dynamic micro-decisions to work or rest.
Feels like a step toward better modeling.
www.nature.com/articles/s44...
skill plateaus seems to emerge from dynamic micro-decisions to work or rest.
Feels like a step toward better modeling.
www.nature.com/articles/s44...
A first-principles mathematical model integrates the disparate timescales of human learning - npj Complexity
npj Complexity - A first-principles mathematical model integrates the disparate timescales of human learning
www.nature.com
May 11, 2025 at 4:12 AM
This might be the cleanest computational model of learning I’ve seen.
skill plateaus seems to emerge from dynamic micro-decisions to work or rest.
Feels like a step toward better modeling.
www.nature.com/articles/s44...
skill plateaus seems to emerge from dynamic micro-decisions to work or rest.
Feels like a step toward better modeling.
www.nature.com/articles/s44...
What if hearing voices isn’t about extra activity, but broken calibration?
Schizophrenia patients with AVHs have both no suppression and a wrong enhancement.
Motor signals go rogue, and the brain listens.
journals.plos.org/plosbiology/...
Schizophrenia patients with AVHs have both no suppression and a wrong enhancement.
Motor signals go rogue, and the brain listens.
journals.plos.org/plosbiology/...
Impaired motor-to-sensory transformation mediates auditory hallucinations
Can the absence of inhibition lead to auditory hallucinations? This study shows that the impairment of motor-based sensory predictions causes erroneous monitoring of imprecise internal auditory repres...
journals.plos.org
May 11, 2025 at 4:11 AM
What if hearing voices isn’t about extra activity, but broken calibration?
Schizophrenia patients with AVHs have both no suppression and a wrong enhancement.
Motor signals go rogue, and the brain listens.
journals.plos.org/plosbiology/...
Schizophrenia patients with AVHs have both no suppression and a wrong enhancement.
Motor signals go rogue, and the brain listens.
journals.plos.org/plosbiology/...
Turns out epithelial cells can spike, slowly.
Injury triggers propagating voltage waves across cell layers, relying on mechanosensitive ion channels.
How does this impact how we think about wound healing, morphogenesis, and body-wide communication? 👀
www.pnas.org/doi/10.1073/...
Injury triggers propagating voltage waves across cell layers, relying on mechanosensitive ion channels.
How does this impact how we think about wound healing, morphogenesis, and body-wide communication? 👀
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
May 11, 2025 at 4:10 AM
Turns out epithelial cells can spike, slowly.
Injury triggers propagating voltage waves across cell layers, relying on mechanosensitive ion channels.
How does this impact how we think about wound healing, morphogenesis, and body-wide communication? 👀
www.pnas.org/doi/10.1073/...
Injury triggers propagating voltage waves across cell layers, relying on mechanosensitive ion channels.
How does this impact how we think about wound healing, morphogenesis, and body-wide communication? 👀
www.pnas.org/doi/10.1073/...
Reposted by Itay Inbar
Hello Bluesky! I am an engineer/scientist currently working at the MRC LMB in Cambridge UK. During my PhD I developed new imaging technologies to shed light on the dynamics of living cells e.g. here is a movie of 6 organelles in live human cancer cells. Follow for more updates! #science #biology
November 20, 2024 at 9:16 PM
Reposted by Itay Inbar
November 21, 2024 at 8:34 PM
Reposted by Itay Inbar
Happy #FluorescenceFriday !
Let's celebrate with a colorful image of a developing ventral spinal cord of a 🐣 embryo.
#neuroscience #microscopy
Let's celebrate with a colorful image of a developing ventral spinal cord of a 🐣 embryo.
#neuroscience #microscopy
November 22, 2024 at 7:35 AM
Happy #FluorescenceFriday !
Let's celebrate with a colorful image of a developing ventral spinal cord of a 🐣 embryo.
#neuroscience #microscopy
Let's celebrate with a colorful image of a developing ventral spinal cord of a 🐣 embryo.
#neuroscience #microscopy
Hey! Just giving this platform a shot 👀
November 23, 2024 at 1:11 AM
Hey! Just giving this platform a shot 👀