Islet Biology Lab - UMH
@isletbiologylab.bsky.social
We're interested in islet cell function and survival in #type1diabetes. Headed by Laura Marroquí (IDiBE/UMH) and Reinaldo dos Santos (FISABIO and IDiBE/UMH). 🧪
For more info about our lab: linktr.ee/isletbiologylab
For more info about our lab: linktr.ee/isletbiologylab
Our PhD student Daniel Llorens is attending the EASD Scientists Training Course 2025 this week in Barcelona!
Great opportunity for learning, collaboration, and inspiration!
Wishing all participants a productive and inspiring week! 👏
#EASD #DiabetesResearch
Great opportunity for learning, collaboration, and inspiration!
Wishing all participants a productive and inspiring week! 👏
#EASD #DiabetesResearch
🎉 Happening Now! The EASD Scientists Training Course 2025 is in full swing this week @idibaps.bsky.social in beautiful Barcelona, Spain! 🇪🇸
📸 👇 Take a look at the image below and join us in wishing all participants continued success throughout the week!
Supported by Lilly Diabetes International
📸 👇 Take a look at the image below and join us in wishing all participants continued success throughout the week!
Supported by Lilly Diabetes International
November 12, 2025 at 3:43 PM
Our PhD student Daniel Llorens is attending the EASD Scientists Training Course 2025 this week in Barcelona!
Great opportunity for learning, collaboration, and inspiration!
Wishing all participants a productive and inspiring week! 👏
#EASD #DiabetesResearch
Great opportunity for learning, collaboration, and inspiration!
Wishing all participants a productive and inspiring week! 👏
#EASD #DiabetesResearch
In the Finnish #Type1Diabetes Prediction and Prevention study, Kuusela et al. compared how islet autoimmunity starts and progresses to diabetes in children with vs. without a first-degree relative with T1D. 🧪
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Islet autoimmunity and progression to type 1 diabetes in the Finnish DIPP study: comparison between genetically susceptible children with and without an affected first-degree relative - Diabetologia
Aims/hypothesis Islet autoimmunity during presymptomatic type 1 diabetes is heterogeneous. We hypothesised that a positive family history of type 1 diabetes is associated with specific characteristics...
link.springer.com
November 12, 2025 at 3:41 PM
In the Finnish #Type1Diabetes Prediction and Prevention study, Kuusela et al. compared how islet autoimmunity starts and progresses to diabetes in children with vs. without a first-degree relative with T1D. 🧪
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Islet Biology Lab - UMH
We are delighted to host the 2nd Annual Susie Clee Memorial Lecture this Thursday 4pm PST which will be given by Dr Melkem Kebede of the University of Sydney.
November 11, 2025 at 11:21 PM
We are delighted to host the 2nd Annual Susie Clee Memorial Lecture this Thursday 4pm PST which will be given by Dr Melkem Kebede of the University of Sydney.
Brown et al. demonstrated that stem cell–derived β cells can be engineered to express CD155 to preferentially promote T cell coinhibitory signaling through the CD155/TIGIT axis and restrain both NK cell and T cell activation. 🧪
#PancSky
www.science.org/doi/10.1126/...
#PancSky
www.science.org/doi/10.1126/...
Human stem cell-derived β cells expressing an optimized CD155 reduce cytotoxic immune cell function for application in type 1 diabetes
Engineered β cells with a mutant CD155 help evade immune attack, offering a promising therapeutic approach for type 1 diabetes.
www.science.org
November 10, 2025 at 8:00 PM
Brown et al. demonstrated that stem cell–derived β cells can be engineered to express CD155 to preferentially promote T cell coinhibitory signaling through the CD155/TIGIT axis and restrain both NK cell and T cell activation. 🧪
#PancSky
www.science.org/doi/10.1126/...
#PancSky
www.science.org/doi/10.1126/...
Gitelman et al. show that teplizumab was well tolerated and demonstrated a safety and tolerability profile consistent with that observed in participants aged ≥8 years in clinical trials and post-marketing experience to date. 🧪
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Safety and pharmacokinetics of teplizumab in children less than 8 years of age with stage 2 type 1 diabetes - Diabetologia
Aims/hypothesis Teplizumab is approved in the USA and seven other countries to delay stage 3 type 1 diabetes onset in individuals ≥8 years of age with stage 2 type 1 diabetes. As part of a US Food and...
link.springer.com
November 7, 2025 at 11:39 AM
Gitelman et al. show that teplizumab was well tolerated and demonstrated a safety and tolerability profile consistent with that observed in participants aged ≥8 years in clinical trials and post-marketing experience to date. 🧪
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Islet Biology Lab - UMH
⏰Reminder: Apply for EASD’s 1st Immunology School for Endocrinology focusing on #immunology in #T1D!
🗓 26 - 27 March 2026 |📍Vienna, Austria
Explore cutting-edge topics like early detection, disease-modifying therapies, and beta-cell replacement.
🔗 www.easd.org/education/me...
🗓 26 - 27 March 2026 |📍Vienna, Austria
Explore cutting-edge topics like early detection, disease-modifying therapies, and beta-cell replacement.
🔗 www.easd.org/education/me...
📢 EASD will host its 1st Immunology School for Endocrinology: #Immunology in #Type1Diabetes - bridging the science and clinical impact.
📅 26 - 27 March 2026 |📍Vienna, Austria
Open to EASD Members; doctors, researchers/pharmacists in endocrinology/diabetology.
Apply 👉 www.easd.org/education/me...
📅 26 - 27 March 2026 |📍Vienna, Austria
Open to EASD Members; doctors, researchers/pharmacists in endocrinology/diabetology.
Apply 👉 www.easd.org/education/me...
November 6, 2025 at 9:36 AM
⏰Reminder: Apply for EASD’s 1st Immunology School for Endocrinology focusing on #immunology in #T1D!
🗓 26 - 27 March 2026 |📍Vienna, Austria
Explore cutting-edge topics like early detection, disease-modifying therapies, and beta-cell replacement.
🔗 www.easd.org/education/me...
🗓 26 - 27 March 2026 |📍Vienna, Austria
Explore cutting-edge topics like early detection, disease-modifying therapies, and beta-cell replacement.
🔗 www.easd.org/education/me...
Reposted by Islet Biology Lab - UMH
Personal investigador #CIBEROBN descifra un mecanismo que evita la pérdida de actividad de tejido adiposo pardo durante el envejecimiento 👇
#RecercaUB | 🧓 Desxifrat un mecanisme que evita la pèrdua d’activitat del teixit adipós marró durant l’envelliment
➡️ Un bon funcionament d’aquest teixit, principal productor de calor corporal, és clau per evitar malalties metabòliques i cardiovasculars.
@biologiaub.bsky.social @ibub-ub.bsky.social
➡️ Un bon funcionament d’aquest teixit, principal productor de calor corporal, és clau per evitar malalties metabòliques i cardiovasculars.
@biologiaub.bsky.social @ibub-ub.bsky.social
Desxifrat un mecanisme que evita la pèrdua d’activitat del teixit adipós marró durant l’envelliment
web.ub.edu
November 5, 2025 at 2:01 PM
Personal investigador #CIBEROBN descifra un mecanismo que evita la pérdida de actividad de tejido adiposo pardo durante el envejecimiento 👇
Guthalu Kondegowda et al. investigated the role and mechanisms of circulating extracellular vesicles on #type1diabetes pathogenesis and β-cell cytotoxicity. 🧪
#PancSky
www.biorxiv.org/content/10.1...
#PancSky
www.biorxiv.org/content/10.1...
Proinflammatory circulating extracellular vesicles from type 1 diabetes patients contribute to beta cell cytotoxicity and disease pathogenicity
In Type 1 diabetes (T1D), β-cell loss and autoimmunity initiate years before disease diagnosis. However, the mechanisms remain unknown. Here, we investigated the role and mechanisms of circulating ext...
www.biorxiv.org
November 5, 2025 at 6:23 AM
Guthalu Kondegowda et al. investigated the role and mechanisms of circulating extracellular vesicles on #type1diabetes pathogenesis and β-cell cytotoxicity. 🧪
#PancSky
www.biorxiv.org/content/10.1...
#PancSky
www.biorxiv.org/content/10.1...
Reposted by Islet Biology Lab - UMH
🚀 Ready to launch your postdoc journey?
Check out WashU’s new Postdoc Passport for everything you need to get started. Register for the virtual event December 4th.
postdoc.wustl.edu/prospective-...
Check out WashU’s new Postdoc Passport for everything you need to get started. Register for the virtual event December 4th.
postdoc.wustl.edu/prospective-...
PASSPoRT to WashU | Office of Postdoctoral Affairs | Washington University in St. Louis
Pathways to Advanced Scientific Skills through Postdoctoral Research Training (PASSPoRT) Register Here Thank you for considering WashU for your...
postdoc.wustl.edu
October 30, 2025 at 4:00 PM
🚀 Ready to launch your postdoc journey?
Check out WashU’s new Postdoc Passport for everything you need to get started. Register for the virtual event December 4th.
postdoc.wustl.edu/prospective-...
Check out WashU’s new Postdoc Passport for everything you need to get started. Register for the virtual event December 4th.
postdoc.wustl.edu/prospective-...
Miranda et al. used optogenetics in conjunction with hormone secretion measurements, electrophysiology, and cytoplasmic free Ca2+ concentration imaging to interrogate the relative roles of paracrine and electrical control of β-cells by δ-cells. 🧪
#PancSky
doi.org/10.2337/db25...
#PancSky
doi.org/10.2337/db25...
October 31, 2025 at 6:12 AM
Miranda et al. used optogenetics in conjunction with hormone secretion measurements, electrophysiology, and cytoplasmic free Ca2+ concentration imaging to interrogate the relative roles of paracrine and electrical control of β-cells by δ-cells. 🧪
#PancSky
doi.org/10.2337/db25...
#PancSky
doi.org/10.2337/db25...
Yu et al. integrated newly generated human single-cell RNA sequencing (RNA-seq) datasets (Carnegie stages 10–15) with existing data and mapped the gene co-expression networks (GCNs) underlying pancreatic lineage progression in humans and mice. 🧪
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reconstructing human pancreatic gene networks enhances stem cell-derived β cell induction
Generating functional β cells from stem cells remains a major challenge in regenerative medicine due to the incomplete recapitulation of human pancrea…
www.sciencedirect.com
October 29, 2025 at 3:23 PM
Yu et al. integrated newly generated human single-cell RNA sequencing (RNA-seq) datasets (Carnegie stages 10–15) with existing data and mapped the gene co-expression networks (GCNs) underlying pancreatic lineage progression in humans and mice. 🧪
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Islet Biology Lab - UMH
🚨Excited to kick off our online seminar series on Metabolism in Development and Physiology!
Please help us grow a collaborative and supportive community by joining (<1min): forms.gle/Y8QzucogKKrZ...
#Metabolism #Development #StemCells
Please RT! 🙏
Please help us grow a collaborative and supportive community by joining (<1min): forms.gle/Y8QzucogKKrZ...
#Metabolism #Development #StemCells
Please RT! 🙏
October 28, 2025 at 4:39 PM
🚨Excited to kick off our online seminar series on Metabolism in Development and Physiology!
Please help us grow a collaborative and supportive community by joining (<1min): forms.gle/Y8QzucogKKrZ...
#Metabolism #Development #StemCells
Please RT! 🙏
Please help us grow a collaborative and supportive community by joining (<1min): forms.gle/Y8QzucogKKrZ...
#Metabolism #Development #StemCells
Please RT! 🙏
Levi-D'Ancona et al. review the impact of mitophagy on β cell responses to (patho)physiologic stressors that underlie the development of type 1 and type 2 diabetes.
www.cell.com/trends/endoc...
www.cell.com/trends/endoc...
Mitophagy in the adaptation to pancreatic β cell stress in diabetes
Mitophagy is a crucial quality control process that preserves metabolic efficiency
by selectively targeting damaged mitochondria for removal. Given the high metabolic
demand of pancreatic β cells’ ins...
www.cell.com
October 27, 2025 at 11:11 AM
Levi-D'Ancona et al. review the impact of mitophagy on β cell responses to (patho)physiologic stressors that underlie the development of type 1 and type 2 diabetes.
www.cell.com/trends/endoc...
www.cell.com/trends/endoc...
Just a reminder — our 2nd CIBER-DZD joint webinar is happening next week! 🧪🔬
It’s free and packed with insights from leading researchers in Spain and Germany on metabolism and exercise.
🗓️ July 15 | 🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
It’s free and packed with insights from leading researchers in Spain and Germany on metabolism and exercise.
🗓️ July 15 | 🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
October 24, 2025 at 4:01 PM
Just a reminder — our 2nd CIBER-DZD joint webinar is happening next week! 🧪🔬
It’s free and packed with insights from leading researchers in Spain and Germany on metabolism and exercise.
🗓️ July 15 | 🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
It’s free and packed with insights from leading researchers in Spain and Germany on metabolism and exercise.
🗓️ July 15 | 🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
Reposted by Islet Biology Lab - UMH
#dkNET is hiring a motivated Postdoctoral Researcher in AI/ML to advance diabetes research at University of California Los Angeles (UCLA) under the supervision of Dr. Wei Wang. Excited to make an impact? Apply today: dknet.org/about/positi...
#AI #MachineLearning #Diabetes #hiring
#AI #MachineLearning #Diabetes #hiring
October 23, 2025 at 11:50 PM
#dkNET is hiring a motivated Postdoctoral Researcher in AI/ML to advance diabetes research at University of California Los Angeles (UCLA) under the supervision of Dr. Wei Wang. Excited to make an impact? Apply today: dknet.org/about/positi...
#AI #MachineLearning #Diabetes #hiring
#AI #MachineLearning #Diabetes #hiring
Reposted by Islet Biology Lab - UMH
New from the @heikolickert.bsky.social clan and great work from Carina together with all collaborators and the Theis lab to study pancreas development across species, bringing new insights into conserved pathways using multimodal computational analysis www.nature.com/articles/s41... #PancSky
A multimodal cross-species comparison of pancreas development - Nature Communications
This study establishes the pig as a complementary model for studying human pancreas development. It shows pigs mimic human developmental tempo, gene regulation, and endocrine cell emergence, offering ...
www.nature.com
October 23, 2025 at 7:03 PM
New from the @heikolickert.bsky.social clan and great work from Carina together with all collaborators and the Theis lab to study pancreas development across species, bringing new insights into conserved pathways using multimodal computational analysis www.nature.com/articles/s41... #PancSky
Reposted by Islet Biology Lab - UMH
Our November issue is online now! link.springer.com/journal/125/... @easdnews.bsky.social @springernature.com @springermedicine.com @hinmul.bsky.social
October 23, 2025 at 5:35 PM
Our November issue is online now! link.springer.com/journal/125/... @easdnews.bsky.social @springernature.com @springermedicine.com @hinmul.bsky.social
Reposted by Islet Biology Lab - UMH
Reporting on successful use of SC-islets in drug development for #congenitalhyperinsulinism! We identified ghrelin analogues as novel candidate drugs, demonstrating reversal of hypoglycaemia in mice, which was caused by the hyperinsulinaemic human SC-islets #PancSky www.biorxiv.org/content/10.1...
October 23, 2025 at 12:49 PM
Reporting on successful use of SC-islets in drug development for #congenitalhyperinsulinism! We identified ghrelin analogues as novel candidate drugs, demonstrating reversal of hypoglycaemia in mice, which was caused by the hyperinsulinaemic human SC-islets #PancSky www.biorxiv.org/content/10.1...
McCallion et al. used non-viral CRISPR editing to disrupt B2M and CIITA while inserting an HLA-E–B2M fusion, generating hypoimmunogenic Tregs capable of evading both T-cell and NK-cell attacks. 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model - Nature Communicat...
Adoptive regulatory T cell (Treg) therapy holds promise for the treatment of a range of immunopathological conditions. Here the authors explore the HLA engineering of allogenic Treg products that avoi...
www.nature.com
October 23, 2025 at 3:41 PM
McCallion et al. used non-viral CRISPR editing to disrupt B2M and CIITA while inserting an HLA-E–B2M fusion, generating hypoimmunogenic Tregs capable of evading both T-cell and NK-cell attacks. 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Islet Biology Lab - UMH
✨📢 Share your thoughts!
@easdnews.bsky.social has released its 1st evidence-based #clinical practice #guideline on the assessment & management of #diabetes #distress in adults with #t1d & #t2d.
The consultation period is open until 31 October 2025!
Scan QR or click👉 www.easd.org/guidelines/s...
@easdnews.bsky.social has released its 1st evidence-based #clinical practice #guideline on the assessment & management of #diabetes #distress in adults with #t1d & #t2d.
The consultation period is open until 31 October 2025!
Scan QR or click👉 www.easd.org/guidelines/s...
October 16, 2025 at 12:49 PM
✨📢 Share your thoughts!
@easdnews.bsky.social has released its 1st evidence-based #clinical practice #guideline on the assessment & management of #diabetes #distress in adults with #t1d & #t2d.
The consultation period is open until 31 October 2025!
Scan QR or click👉 www.easd.org/guidelines/s...
@easdnews.bsky.social has released its 1st evidence-based #clinical practice #guideline on the assessment & management of #diabetes #distress in adults with #t1d & #t2d.
The consultation period is open until 31 October 2025!
Scan QR or click👉 www.easd.org/guidelines/s...
Shibue et al. performed a genome-wide CRISPR screen and identified Sec31A, a gene involved in transporting proteins from the endoplasmic reticulum, as a key regulator of alpha cell survival under stress. 🧪
#PancSky
www.nature.com/articles/s41...
#PancSky
www.nature.com/articles/s41...
Genome-wide CRISPR Screen Identifies Sec31A as a Key Regulator of Alpha Cell Survival - Nature Communications
Pancreatic alpha cells resist stress better than beta cells, but the mechanisms underlying this observation are unclear. Here, the authors show that Sec31A regulates alpha but not beta cell survival u...
www.nature.com
October 16, 2025 at 10:23 AM
Shibue et al. performed a genome-wide CRISPR screen and identified Sec31A, a gene involved in transporting proteins from the endoplasmic reticulum, as a key regulator of alpha cell survival under stress. 🧪
#PancSky
www.nature.com/articles/s41...
#PancSky
www.nature.com/articles/s41...
Suleiman et al. examined whether #type2diabetes β cell dysfunction can be rescued, charted the underlying molecular mechanisms by RNA sequencing, and mined transcriptomes for drug targets. 🧪
#PancSky
www.science.org/doi/10.1126/...
#PancSky
www.science.org/doi/10.1126/...
Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches
Human T2D beta cell function was restored, the rescuing mechanisms disentangled, and hits identified to promote T2D remission.
www.science.org
October 15, 2025 at 5:44 AM
Suleiman et al. examined whether #type2diabetes β cell dysfunction can be rescued, charted the underlying molecular mechanisms by RNA sequencing, and mined transcriptomes for drug targets. 🧪
#PancSky
www.science.org/doi/10.1126/...
#PancSky
www.science.org/doi/10.1126/...
Reposted by Islet Biology Lab - UMH
🗓️Hoy a las 13:00 un nuevo #CIBERNEDWORKSHOPs para Personal Investigador Joven:
"Consejos para orientar proyectos de investigación"
🔗 teams.microsoft.com/l/meetup-joi...
#CIBER #formación
"Consejos para orientar proyectos de investigación"
🔗 teams.microsoft.com/l/meetup-joi...
#CIBER #formación
October 14, 2025 at 5:31 AM
🗓️Hoy a las 13:00 un nuevo #CIBERNEDWORKSHOPs para Personal Investigador Joven:
"Consejos para orientar proyectos de investigación"
🔗 teams.microsoft.com/l/meetup-joi...
#CIBER #formación
"Consejos para orientar proyectos de investigación"
🔗 teams.microsoft.com/l/meetup-joi...
#CIBER #formación
Reposted by Islet Biology Lab - UMH
🗓️Hoy a las 16h "Webinar Grupo Parasitología molecular e infecciones emergentes" coordinado por Pedro José Alcolea
🗣️ Hernando del Portillo Obando
✍️ https://f.mtr.cool/qjhiglpqks
▶️ Síguelo en directo: https://f.mtr.cool/smeyiagrvf
🗣️ Hernando del Portillo Obando
✍️ https://f.mtr.cool/qjhiglpqks
▶️ Síguelo en directo: https://f.mtr.cool/smeyiagrvf
October 14, 2025 at 7:45 AM
🗓️Hoy a las 16h "Webinar Grupo Parasitología molecular e infecciones emergentes" coordinado por Pedro José Alcolea
🗣️ Hernando del Portillo Obando
✍️ https://f.mtr.cool/qjhiglpqks
▶️ Síguelo en directo: https://f.mtr.cool/smeyiagrvf
🗣️ Hernando del Portillo Obando
✍️ https://f.mtr.cool/qjhiglpqks
▶️ Síguelo en directo: https://f.mtr.cool/smeyiagrvf
Reposted by Islet Biology Lab - UMH
🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔
In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...
In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...
TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy
TRAF6 bridges innate immune signaling to mitophagy to promote glucose control during metabolic stress.
www.science.org
October 8, 2025 at 8:28 PM
🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔
In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...
In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...