Islet Biology Lab - UMH
@isletbiologylab.bsky.social
We're interested in islet cell function and survival in #type1diabetes. Headed by Laura Marroquí (IDiBE/UMH) and Reinaldo dos Santos (FISABIO and IDiBE/UMH). 🧪
For more info about our lab: linktr.ee/isletbiologylab
For more info about our lab: linktr.ee/isletbiologylab
Miranda et al. used optogenetics in conjunction with hormone secretion measurements, electrophysiology, and cytoplasmic free Ca2+ concentration imaging to interrogate the relative roles of paracrine and electrical control of β-cells by δ-cells. 🧪
#PancSky
doi.org/10.2337/db25...
#PancSky
doi.org/10.2337/db25...
October 31, 2025 at 6:12 AM
Miranda et al. used optogenetics in conjunction with hormone secretion measurements, electrophysiology, and cytoplasmic free Ca2+ concentration imaging to interrogate the relative roles of paracrine and electrical control of β-cells by δ-cells. 🧪
#PancSky
doi.org/10.2337/db25...
#PancSky
doi.org/10.2337/db25...
Just a reminder — our 2nd CIBER-DZD joint webinar is happening next week! 🧪🔬
It’s free and packed with insights from leading researchers in Spain and Germany on metabolism and exercise.
🗓️ July 15 | 🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
It’s free and packed with insights from leading researchers in Spain and Germany on metabolism and exercise.
🗓️ July 15 | 🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
October 24, 2025 at 4:01 PM
Just a reminder — our 2nd CIBER-DZD joint webinar is happening next week! 🧪🔬
It’s free and packed with insights from leading researchers in Spain and Germany on metabolism and exercise.
🗓️ July 15 | 🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
It’s free and packed with insights from leading researchers in Spain and Germany on metabolism and exercise.
🗓️ July 15 | 🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
Don’t miss the 2nd CIBER-DZD joint webinar!
Join us as top researchers from Spain and Germany share the latest breakthroughs in metabolism and exercise.
🗓️ July 15
🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
Join us as top researchers from Spain and Germany share the latest breakthroughs in metabolism and exercise.
🗓️ July 15
🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
October 8, 2025 at 8:23 AM
Don’t miss the 2nd CIBER-DZD joint webinar!
Join us as top researchers from Spain and Germany share the latest breakthroughs in metabolism and exercise.
🗓️ July 15
🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
Join us as top researchers from Spain and Germany share the latest breakthroughs in metabolism and exercise.
🗓️ July 15
🕞 15:30–16:30 (CEST)
🔗 tinyurl.com/bdcu9wfz
dos Santos et al. provide novel insights into the molecular underpinnings of islet cell dysfunction in #type1diabetes, highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity. 🧪
#PancSky
www.jci.org/articles/vie...
#PancSky
www.jci.org/articles/vie...
October 3, 2025 at 12:49 PM
dos Santos et al. provide novel insights into the molecular underpinnings of islet cell dysfunction in #type1diabetes, highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity. 🧪
#PancSky
www.jci.org/articles/vie...
#PancSky
www.jci.org/articles/vie...
🚨 New paper alert!
In collaboration with our friends at Unibad/UMH and OCRC/UNICAMP, we demonstrate that TUDCA suppresses glucagon release in α-cells through the opening of the KATP channel and the activation of the S1PR2/PI3K pathway.
doi.org/10.1016/j.jn...
In collaboration with our friends at Unibad/UMH and OCRC/UNICAMP, we demonstrate that TUDCA suppresses glucagon release in α-cells through the opening of the KATP channel and the activation of the S1PR2/PI3K pathway.
doi.org/10.1016/j.jn...
September 10, 2025 at 11:00 AM
🚨 New paper alert!
In collaboration with our friends at Unibad/UMH and OCRC/UNICAMP, we demonstrate that TUDCA suppresses glucagon release in α-cells through the opening of the KATP channel and the activation of the S1PR2/PI3K pathway.
doi.org/10.1016/j.jn...
In collaboration with our friends at Unibad/UMH and OCRC/UNICAMP, we demonstrate that TUDCA suppresses glucagon release in α-cells through the opening of the KATP channel and the activation of the S1PR2/PI3K pathway.
doi.org/10.1016/j.jn...
🚨 New paper alert!
In collaboration with Dr. Elisa Fernández-Millán and her team, we show that the G protein-coupled free fatty acid receptors GPR41 & GPR43 regulate glucagon secretion, and GPR41 specifically drives α-cell proliferation. 🧪
#PancSky
🔗 doi.org/10.1016/j.lf...
In collaboration with Dr. Elisa Fernández-Millán and her team, we show that the G protein-coupled free fatty acid receptors GPR41 & GPR43 regulate glucagon secretion, and GPR41 specifically drives α-cell proliferation. 🧪
#PancSky
🔗 doi.org/10.1016/j.lf...
August 15, 2025 at 6:51 AM
🚨 New paper alert!
In collaboration with Dr. Elisa Fernández-Millán and her team, we show that the G protein-coupled free fatty acid receptors GPR41 & GPR43 regulate glucagon secretion, and GPR41 specifically drives α-cell proliferation. 🧪
#PancSky
🔗 doi.org/10.1016/j.lf...
In collaboration with Dr. Elisa Fernández-Millán and her team, we show that the G protein-coupled free fatty acid receptors GPR41 & GPR43 regulate glucagon secretion, and GPR41 specifically drives α-cell proliferation. 🧪
#PancSky
🔗 doi.org/10.1016/j.lf...
Join us TOMORROW for the 1st CIBER-DZD joint meeting!
We're diving into the latest developments on incretin agonists and their role in metabolic diseases, featuring speakers from Spain and Germany.
🗓️ July 15
🕞 15:30–16:30 (CEST)
🔗Registration: tinyurl.com/f8uzk2w2
We're diving into the latest developments on incretin agonists and their role in metabolic diseases, featuring speakers from Spain and Germany.
🗓️ July 15
🕞 15:30–16:30 (CEST)
🔗Registration: tinyurl.com/f8uzk2w2
July 14, 2025 at 1:56 PM
Join us TOMORROW for the 1st CIBER-DZD joint meeting!
We're diving into the latest developments on incretin agonists and their role in metabolic diseases, featuring speakers from Spain and Germany.
🗓️ July 15
🕞 15:30–16:30 (CEST)
🔗Registration: tinyurl.com/f8uzk2w2
We're diving into the latest developments on incretin agonists and their role in metabolic diseases, featuring speakers from Spain and Germany.
🗓️ July 15
🕞 15:30–16:30 (CEST)
🔗Registration: tinyurl.com/f8uzk2w2
Join us for the 1st CIBER-DZD joint meeting!
We're diving into the latest on incretin agonists and their role in metabolic diseases with speakers from Spain and Germany leading cutting-edge research.
🗓️ July 15
🕒 15:30–16:30 (CEST)
🔗 Free registration: tinyurl.com/f8uzk2w2
We're diving into the latest on incretin agonists and their role in metabolic diseases with speakers from Spain and Germany leading cutting-edge research.
🗓️ July 15
🕒 15:30–16:30 (CEST)
🔗 Free registration: tinyurl.com/f8uzk2w2
July 8, 2025 at 3:56 PM
Join us for the 1st CIBER-DZD joint meeting!
We're diving into the latest on incretin agonists and their role in metabolic diseases with speakers from Spain and Germany leading cutting-edge research.
🗓️ July 15
🕒 15:30–16:30 (CEST)
🔗 Free registration: tinyurl.com/f8uzk2w2
We're diving into the latest on incretin agonists and their role in metabolic diseases with speakers from Spain and Germany leading cutting-edge research.
🗓️ July 15
🕒 15:30–16:30 (CEST)
🔗 Free registration: tinyurl.com/f8uzk2w2
Bhushan and Thompson discussed β-cell stress responses implicated in #type1diabetes pathogenesis based on evidence from humans and highlighted existing knowledge gaps in their mechanisms. 🧪
#PanckSky
perspectivesinmedicine.cshlp.org/content/15/7...
#PanckSky
perspectivesinmedicine.cshlp.org/content/15/7...
July 4, 2025 at 10:13 AM
Bhushan and Thompson discussed β-cell stress responses implicated in #type1diabetes pathogenesis based on evidence from humans and highlighted existing knowledge gaps in their mechanisms. 🧪
#PanckSky
perspectivesinmedicine.cshlp.org/content/15/7...
#PanckSky
perspectivesinmedicine.cshlp.org/content/15/7...
Ayer celebramos la graduación del Máster en Biotecnología y Bioingeniería de la UMH 🎓.
¡Enhorabuena a Alejandro y Sara por este gran logro! 👏🧬
Ahora a por la defensa del TFM... ¡y a seguir brillando! 🚀✨
¡Enhorabuena a Alejandro y Sara por este gran logro! 👏🧬
Ahora a por la defensa del TFM... ¡y a seguir brillando! 🚀✨
June 21, 2025 at 4:47 PM
Ayer celebramos la graduación del Máster en Biotecnología y Bioingeniería de la UMH 🎓.
¡Enhorabuena a Alejandro y Sara por este gran logro! 👏🧬
Ahora a por la defensa del TFM... ¡y a seguir brillando! 🚀✨
¡Enhorabuena a Alejandro y Sara por este gran logro! 👏🧬
Ahora a por la defensa del TFM... ¡y a seguir brillando! 🚀✨
Huge congrats to our amazing friend Mariana for presenting a great talk at the #EISG2025!!! 🧪🧬🔥
@eisg2025.bsky.social
@eisg2025.bsky.social
June 12, 2025 at 8:33 AM
Huge congrats to our amazing friend Mariana for presenting a great talk at the #EISG2025!!! 🧪🧬🔥
@eisg2025.bsky.social
@eisg2025.bsky.social
Islet Biology Lab, assemble!
¡Rumbo a A Coruña para el Congreso de la #SEDiab2025!
Con muchas ganas de aprender, compartir y reencontrarnos con grandes compañeros 🤝
✨ ¡Va a ser una experiencia increíble! 🚀
¡Rumbo a A Coruña para el Congreso de la #SEDiab2025!
Con muchas ganas de aprender, compartir y reencontrarnos con grandes compañeros 🤝
✨ ¡Va a ser una experiencia increíble! 🚀
April 23, 2025 at 8:09 AM
Islet Biology Lab, assemble!
¡Rumbo a A Coruña para el Congreso de la #SEDiab2025!
Con muchas ganas de aprender, compartir y reencontrarnos con grandes compañeros 🤝
✨ ¡Va a ser una experiencia increíble! 🚀
¡Rumbo a A Coruña para el Congreso de la #SEDiab2025!
Con muchas ganas de aprender, compartir y reencontrarnos con grandes compañeros 🤝
✨ ¡Va a ser una experiencia increíble! 🚀
✨This is pretty cool!✨
Our paper "Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function" has been featured on the cover of the January issue of the journal "Biomedicines"! 🧪
Check out our study here: www.mdpi.com/2227-9059/13...
#CoverStory #Science
Our paper "Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function" has been featured on the cover of the January issue of the journal "Biomedicines"! 🧪
Check out our study here: www.mdpi.com/2227-9059/13...
#CoverStory #Science
February 21, 2025 at 12:26 PM
✨This is pretty cool!✨
Our paper "Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function" has been featured on the cover of the January issue of the journal "Biomedicines"! 🧪
Check out our study here: www.mdpi.com/2227-9059/13...
#CoverStory #Science
Our paper "Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function" has been featured on the cover of the January issue of the journal "Biomedicines"! 🧪
Check out our study here: www.mdpi.com/2227-9059/13...
#CoverStory #Science
To conclude the session, our PI, Laura Marroquí, presents our findings on protecting beta cells by modulating the innate immune system. 🧪
#SEDCIBERDEM2025 #DiabetesResearch #BetaCellSky
#SEDCIBERDEM2025 #DiabetesResearch #BetaCellSky
February 14, 2025 at 4:25 PM
To conclude the session, our PI, Laura Marroquí, presents our findings on protecting beta cells by modulating the innate immune system. 🧪
#SEDCIBERDEM2025 #DiabetesResearch #BetaCellSky
#SEDCIBERDEM2025 #DiabetesResearch #BetaCellSky
Next, Dr. Eduard Montanya (CIBERDEM, Bellvitge University Hospital) talks about regeneration and sustaining beta cell identity. 🧪
#SEDCIBERDEM2025 #DiabetesResearch
#SEDCIBERDEM2025 #DiabetesResearch
February 14, 2025 at 3:57 PM
Next, Dr. Eduard Montanya (CIBERDEM, Bellvitge University Hospital) talks about regeneration and sustaining beta cell identity. 🧪
#SEDCIBERDEM2025 #DiabetesResearch
#SEDCIBERDEM2025 #DiabetesResearch
Dr. Luis Castaño (Hospital University of Cruces, University of the Basque Country) will discuss strategies to prevent and delay #type1diabetes. 🧪
#SEDCIBERDEM2025 #DiabetesResearch
#SEDCIBERDEM2025 #DiabetesResearch
February 14, 2025 at 3:40 PM
Dr. Luis Castaño (Hospital University of Cruces, University of the Basque Country) will discuss strategies to prevent and delay #type1diabetes. 🧪
#SEDCIBERDEM2025 #DiabetesResearch
#SEDCIBERDEM2025 #DiabetesResearch
Dr. Felipe Javier from INCLIVA (Valencia) will talk about how to integrate genetic and epigenetic screening to predict diabetes risk. 🧪
#SEDCIBERDEM2025 #DiabetesResearch
#SEDCIBERDEM2025 #DiabetesResearch
February 14, 2025 at 3:03 PM
Dr. Felipe Javier from INCLIVA (Valencia) will talk about how to integrate genetic and epigenetic screening to predict diabetes risk. 🧪
#SEDCIBERDEM2025 #DiabetesResearch
#SEDCIBERDEM2025 #DiabetesResearch
The 1st SED-CIBERDEM Joint Symposium is about to start! 🧪✨
Stay tuned for groundbreaking insights and discussions in diabetes research. #SEDCIBERDEM2025 #DiabetesResearch
Stay tuned for groundbreaking insights and discussions in diabetes research. #SEDCIBERDEM2025 #DiabetesResearch
February 14, 2025 at 2:39 PM
The 1st SED-CIBERDEM Joint Symposium is about to start! 🧪✨
Stay tuned for groundbreaking insights and discussions in diabetes research. #SEDCIBERDEM2025 #DiabetesResearch
Stay tuned for groundbreaking insights and discussions in diabetes research. #SEDCIBERDEM2025 #DiabetesResearch
Hemos aprovechado la ocasión para mirar islotes pancreáticos, aprender sobre nuestros modelos animales, y hacer unos cuantos experimentos de cuantificación de proteinas...
February 8, 2025 at 8:21 AM
Hemos aprovechado la ocasión para mirar islotes pancreáticos, aprender sobre nuestros modelos animales, y hacer unos cuantos experimentos de cuantificación de proteinas...
Nuestra doctoranda Atenea y nuestra estudiante de máster Sara han disfrutado mucho hablando con estudiantes de primaria, secundaria y bachirelato sobre el trabajo que hacemos en lab y sobre la #diabetes tipo 1.
February 8, 2025 at 8:21 AM
Nuestra doctoranda Atenea y nuestra estudiante de máster Sara han disfrutado mucho hablando con estudiantes de primaria, secundaria y bachirelato sobre el trabajo que hacemos en lab y sobre la #diabetes tipo 1.
Ayer, nuestro lab participó en las Primeras Jornadas de la Mujer y la Niña en la Ciencia del programa "Estimula tu mente @umh.es".
#mujeryniñaenlaciencia #DiabetesAwareness #Ciencia
#mujeryniñaenlaciencia #DiabetesAwareness #Ciencia
February 8, 2025 at 8:21 AM
Ayer, nuestro lab participó en las Primeras Jornadas de la Mujer y la Niña en la Ciencia del programa "Estimula tu mente @umh.es".
#mujeryniñaenlaciencia #DiabetesAwareness #Ciencia
#mujeryniñaenlaciencia #DiabetesAwareness #Ciencia
Big celebrations today! 🎉
We hit a Japanese restaurant (run by Chinese 👀) to toast our latest article 🖋️ and even got a head start on Chinese New Year 🐉 with mandarins for good luck. 🍊
#Science #Celebration
We hit a Japanese restaurant (run by Chinese 👀) to toast our latest article 🖋️ and even got a head start on Chinese New Year 🐉 with mandarins for good luck. 🍊
#Science #Celebration
January 28, 2025 at 11:14 PM
Big celebrations today! 🎉
We hit a Japanese restaurant (run by Chinese 👀) to toast our latest article 🖋️ and even got a head start on Chinese New Year 🐉 with mandarins for good luck. 🍊
#Science #Celebration
We hit a Japanese restaurant (run by Chinese 👀) to toast our latest article 🖋️ and even got a head start on Chinese New Year 🐉 with mandarins for good luck. 🍊
#Science #Celebration
🧪 Arowosegbe et al. sought to delineate type I interferon-independent mechanisms that drive diabetes using type I IFN α/β receptor knockout rats. Their findings underscore the promise of JAK inhibition for preventing human #type1diabetes.
doi.org/10.1016/j.ja...
doi.org/10.1016/j.ja...
January 25, 2025 at 12:24 PM
🧪 Arowosegbe et al. sought to delineate type I interferon-independent mechanisms that drive diabetes using type I IFN α/β receptor knockout rats. Their findings underscore the promise of JAK inhibition for preventing human #type1diabetes.
doi.org/10.1016/j.ja...
doi.org/10.1016/j.ja...