Väinö Lithovius
@lithoviusv.bsky.social
Post-Doctoral Scientist (MD-PhD) at Helmholtz Zentrum München, Heiko Lickert group, previously Univ. Helsinki, Otonkoski Group
Making pancreatic islets from stem cells
Making pancreatic islets from stem cells
Reposted by Väinö Lithovius
Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....
Benchmarking porcine pancreatic ductal organoids for drug screening applications | EMBO Molecular Medicine
imageimageState-of-the-art single-cell RNA sequencing and proteomics approaches were employed
to benchmark porcine and human pancreatic ductal organoid systems for use as a drug
screening and testing ...
www.embopress.org
November 5, 2025 at 7:50 PM
Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....
Reporting on successful use of SC-islets in drug development for #congenitalhyperinsulinism! We identified ghrelin analogues as novel candidate drugs, demonstrating reversal of hypoglycaemia in mice, which was caused by the hyperinsulinaemic human SC-islets #PancSky www.biorxiv.org/content/10.1...
October 23, 2025 at 12:49 PM
Reporting on successful use of SC-islets in drug development for #congenitalhyperinsulinism! We identified ghrelin analogues as novel candidate drugs, demonstrating reversal of hypoglycaemia in mice, which was caused by the hyperinsulinaemic human SC-islets #PancSky www.biorxiv.org/content/10.1...
Reposted by Väinö Lithovius
Great work from my friend @lithoviusv.bsky.social with very nice combination of disease modeling and a drug gable solution to pair it with! @PancSky www.biorxiv.org/content/10.1...
Ghrelin and relamorelin alleviate hypoglycaemia in humanised mice with congenital hyperinsulinism
KATP-channel related hyperinsulinism (KATPHI) is a genetic disorder of the pancreatic beta cells, manifesting as life-threatening hypoglycaemia in neonates due to dysregulated insulin secretion. Manag...
www.biorxiv.org
October 15, 2025 at 6:43 PM
Great work from my friend @lithoviusv.bsky.social with very nice combination of disease modeling and a drug gable solution to pair it with! @PancSky www.biorxiv.org/content/10.1...
Reposted by Väinö Lithovius
Ghrelin and relamorelin alleviate hypoglycaemia in humanised mice with congenital hyperinsulinism https://www.biorxiv.org/content/10.1101/2025.10.02.680116v1
October 3, 2025 at 7:02 AM
Ghrelin and relamorelin alleviate hypoglycaemia in humanised mice with congenital hyperinsulinism https://www.biorxiv.org/content/10.1101/2025.10.02.680116v1
Reposted by Väinö Lithovius
Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1
Benchmarking porcine pancreatic ductal organoids for drug screening applications
Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...
www.biorxiv.org
March 14, 2025 at 8:29 AM
Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1
Reposted by Väinö Lithovius
We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...
Postdoctoral Research Fellow - Vancouver, British Columbia (CA) job with University of British Columbia Department of Surgery | 12837375
The successful candidate will work on a project developing cell-based therapies for those living with type 1 diabetes (T1D).
www.nature.com
March 10, 2025 at 11:48 PM
We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...
Reposted by Väinö Lithovius
Come listen to the superb speakers on session 5 of #EISG2025 - Modelling Human Islet Cell Devt :
- Francesca Spagnoli (@labspagnoli.bsky.social, Kings College London)
- Diego Balboa (@diegobalboa.bsky.social , @helsinkiuni.bsky.social)
- Limor Landsman (Tel Aviv U.)
Register now at eisg2025.se
- Francesca Spagnoli (@labspagnoli.bsky.social, Kings College London)
- Diego Balboa (@diegobalboa.bsky.social , @helsinkiuni.bsky.social)
- Limor Landsman (Tel Aviv U.)
Register now at eisg2025.se
January 21, 2025 at 1:48 PM
Come listen to the superb speakers on session 5 of #EISG2025 - Modelling Human Islet Cell Devt :
- Francesca Spagnoli (@labspagnoli.bsky.social, Kings College London)
- Diego Balboa (@diegobalboa.bsky.social , @helsinkiuni.bsky.social)
- Limor Landsman (Tel Aviv U.)
Register now at eisg2025.se
- Francesca Spagnoli (@labspagnoli.bsky.social, Kings College London)
- Diego Balboa (@diegobalboa.bsky.social , @helsinkiuni.bsky.social)
- Limor Landsman (Tel Aviv U.)
Register now at eisg2025.se
Reposted by Väinö Lithovius
Let's take a look at the amazing invited speakers at #EISG2025, shall we?
On Session 1 we will hear all about genomics of islet cells from:
Amélie Bonnefond (INSERM/CNRS),
Rohit Kulkarni (Harvard U.), and
Torben Hansen (U. of Copenhagen)
Register now at eisg2025.se
(Early bird until 13 March)
On Session 1 we will hear all about genomics of islet cells from:
Amélie Bonnefond (INSERM/CNRS),
Rohit Kulkarni (Harvard U.), and
Torben Hansen (U. of Copenhagen)
Register now at eisg2025.se
(Early bird until 13 March)
January 15, 2025 at 9:51 AM
Let's take a look at the amazing invited speakers at #EISG2025, shall we?
On Session 1 we will hear all about genomics of islet cells from:
Amélie Bonnefond (INSERM/CNRS),
Rohit Kulkarni (Harvard U.), and
Torben Hansen (U. of Copenhagen)
Register now at eisg2025.se
(Early bird until 13 March)
On Session 1 we will hear all about genomics of islet cells from:
Amélie Bonnefond (INSERM/CNRS),
Rohit Kulkarni (Harvard U.), and
Torben Hansen (U. of Copenhagen)
Register now at eisg2025.se
(Early bird until 13 March)
Reposted by Väinö Lithovius
Fancy joining our lab? apply here for a PhD student position, (DM me for potential postdoc opportunities)
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
PhD student in regeneration of insulin-producing beta-cells in diabetes models - Uppsala University
PhD student in regeneration of insulin-producing beta-cells in diabetes models, Institutionen för medicinsk cellbiologi, Uppsala University
www.uu.se
January 14, 2025 at 10:52 AM
Fancy joining our lab? apply here for a PhD student position, (DM me for potential postdoc opportunities)
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
Reposted by Väinö Lithovius
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism
The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.
doi.org
November 25, 2024 at 11:16 AM
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social