Islam Elkholi
@iselkholi.bsky.social
MD, PhD｜Oncology Research Fellow, McGill U.｜ Metastasis, Dormancy & Targeted Therapies｜Writing｜Coffee｜Jazz/blues ｜🇪🇬➡️🇨🇦 Views are my own.
Looking forward to sharing our work in this meeting!
🚀 Two weeks to go!
The ECR Meeting brings together early-career scientists driving the next wave of metastasis research.
⚡ Don’t miss:
💡 Inspiring talks from rising leaders
💬 Community-led discussions
🌍 A global metastasis community
🗓️ Register by Nov 18 ➜ bit.ly/4qyxE0o
Program ➜ bit.ly/4qtpVR9
The ECR Meeting brings together early-career scientists driving the next wave of metastasis research.
⚡ Don’t miss:
💡 Inspiring talks from rising leaders
💬 Community-led discussions
🌍 A global metastasis community
🗓️ Register by Nov 18 ➜ bit.ly/4qyxE0o
Program ➜ bit.ly/4qtpVR9
2nd MRS Early Career Research Virtual Meeting | Metastasis Research
The 2025 MRS Early Career Research Virtual Meeting is a two day meeting aimed at engaging trainees and early career researchers from around the world and highlighting recent advances in metastasis research through keynote presentations, invited talks, panel discussions, and selected talks from abstracts. The meeting is organized and hosted by the Early Career Leadership Council (ECLC) of the MRS. Abstracts are being accepted for consideration for oral presentations. Abstract submission is open to graduate students, postdoctoral fellows, medical students, residents, clinical fellows, and researchers within 3 years of starting their own independent research group. Registration for this meeting is free for MRS Members!
metastasis-research.org
November 3, 2025 at 7:48 PM
Looking forward to sharing our work in this meeting!
Stuck at home? Time to revisit the record collection! A record I caught this year in Chicago…
September 13, 2025 at 5:20 PM
Stuck at home? Time to revisit the record collection! A record I caught this year in Chicago…
It has been fun editing this issue focused on Cell Signaling in JoVE! Check this protocol by Vianney and Lee on proximity labelling in Drosophila melanogaster.
app.jove.com/v/68193/in-v...
app.jove.com/v/68193/in-v...
<em>In Vivo</em> Application of TurboID-based Proximity Labeling in <em>Drosophila melanogaster</em>
Proximity labeling (PL) is a powerful method for mapping protein-protein interaction networks. Advances in labeling enzymes, especially TurboID, have ...
app.jove.com
August 28, 2025 at 11:05 PM
It has been fun editing this issue focused on Cell Signaling in JoVE! Check this protocol by Vianney and Lee on proximity labelling in Drosophila melanogaster.
app.jove.com/v/68193/in-v...
app.jove.com/v/68193/in-v...
CIHR will finally allow international PhD students to apply! A big step forward!
August 21, 2025 at 2:15 PM
CIHR will finally allow international PhD students to apply! A big step forward!
Reposted by Islam Elkholi
NEW content online!
Ageing, immune fitness and cancer
Nature Reviews Cancer, Published online: 14 August 2025; doi:10.1038/s41568-025-00858-zAgeing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.
www.nature.com
August 14, 2025 at 10:53 AM
NEW content online!
Reposted by Islam Elkholi
Thrilled to share our first clinical trial paper on prostate cancer cell dormancy induction using an epigenetic and differentiation strategy. This was a strong team effort between physicians and basic scientists leading to this innovative clinical trial. www.medrxiv.org/content/10.1...
A Pilot Study of the Combination of 5-Azacitidine and All-trans Retinoic Acid in Biochemically Recurrent Prostate Cancer.
Purpose: Biochemical recurrence (BCR) after definitive local therapy remains a major clinical challenge in prostate cancer (PCa), with heterogeneous disease trajectories and few established strategies...
www.medrxiv.org
August 12, 2025 at 2:31 PM
Thrilled to share our first clinical trial paper on prostate cancer cell dormancy induction using an epigenetic and differentiation strategy. This was a strong team effort between physicians and basic scientists leading to this innovative clinical trial. www.medrxiv.org/content/10.1...
I am very grateful to CCS for not only supporting my fellowship work but also investing in my career development and being part of academic journey!
Weekly #cancerresearch highlight: @iselkholi.bsky.social is investigating multiple mutations in a gene called BRAF to understand how they promote #cancer growth and treatment resistance. This could lead to new treatments and better survival for people with these mutations.
Learn more: is.gd/eiibhA
Learn more: is.gd/eiibhA
August 9, 2025 at 2:15 PM
I am very grateful to CCS for not only supporting my fellowship work but also investing in my career development and being part of academic journey!
Excited to share our latest discovery just published in Cancer Research.
lnkd.in/e_vNXXJC
⭐ We revealed that dormancy-prone or dormant breast cancer (BC) cells might be eliminated by targeting PIK3C3 (the 3rd class PI3K), hence less #metastasis burden in #breastcancer.
@jf-cotelab.bsky.social
lnkd.in/e_vNXXJC
⭐ We revealed that dormancy-prone or dormant breast cancer (BC) cells might be eliminated by targeting PIK3C3 (the 3rd class PI3K), hence less #metastasis burden in #breastcancer.
@jf-cotelab.bsky.social
May 27, 2025 at 1:39 PM
Excited to share our latest discovery just published in Cancer Research.
lnkd.in/e_vNXXJC
⭐ We revealed that dormancy-prone or dormant breast cancer (BC) cells might be eliminated by targeting PIK3C3 (the 3rd class PI3K), hence less #metastasis burden in #breastcancer.
@jf-cotelab.bsky.social
lnkd.in/e_vNXXJC
⭐ We revealed that dormancy-prone or dormant breast cancer (BC) cells might be eliminated by targeting PIK3C3 (the 3rd class PI3K), hence less #metastasis burden in #breastcancer.
@jf-cotelab.bsky.social
Reposted by Islam Elkholi
New vulnerability of dormant breast cancer cells dependent on a specific isoform of PI3K revealed by Islam Elkholi, JF Cote and team @ircm.bsky.social. Really happy to see this paper out and to have been of service!
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Abstract. Halting breast cancer metastatic relapse following primary tumor removal remains challenging due to a lack of specific vulnerabilities to target during the clinical dormancy phase. To identi...
aacrjournals.org
May 20, 2025 at 2:09 AM
New vulnerability of dormant breast cancer cells dependent on a specific isoform of PI3K revealed by Islam Elkholi, JF Cote and team @ircm.bsky.social. Really happy to see this paper out and to have been of service!
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Repainting the sky..
April 1, 2025 at 11:46 PM
Repainting the sky..
Glad to announce the 1st Basic & Clinical Oncology (BCO) conference on May 7 at the IRCM/Montreal as a partnership between 9 institutes/networks across Quebec! Clinical and basic cancer research abstracts are welcome (deadline April 6). More details: www.ircm.qc.ca/en/events/de...
#Montreal #Quebec
#Montreal #Quebec
March 27, 2025 at 11:45 PM
Glad to announce the 1st Basic & Clinical Oncology (BCO) conference on May 7 at the IRCM/Montreal as a partnership between 9 institutes/networks across Quebec! Clinical and basic cancer research abstracts are welcome (deadline April 6). More details: www.ircm.qc.ca/en/events/de...
#Montreal #Quebec
#Montreal #Quebec
Reposted by Islam Elkholi
🌕🌖🌗🌘🌑🌒🌓🌔Surveillez le ciel dans la nuit du 13 au 14 mars : une éclipse totale de Lune sera au rendez-vous! Cet événement astronomique sera visible depuis le Québec et débutera à 1 h 09 pour se terminer à 4 h 47. L’éclipse atteindra son apogée entre 2 h 59 et 3 h 31.
Voici notre photo prise en 2015.
Voici notre photo prise en 2015.
March 13, 2025 at 4:23 PM
🌕🌖🌗🌘🌑🌒🌓🌔Surveillez le ciel dans la nuit du 13 au 14 mars : une éclipse totale de Lune sera au rendez-vous! Cet événement astronomique sera visible depuis le Québec et débutera à 1 h 09 pour se terminer à 4 h 47. L’éclipse atteindra son apogée entre 2 h 59 et 3 h 31.
Voici notre photo prise en 2015.
Voici notre photo prise en 2015.
Reposted by Islam Elkholi
So happy to share the newest pre-print from the lab where we show that old age significantly changes the traits that evolve in established lung adenocarcinoma. This work sheds light into the importance of modeling age-related cancers in the context of old age. www.biorxiv.org/content/10.1...
Aging directs the differential evolution of KRAS-driven lung adenocarcinoma
Lung adenocarcinoma (LUAD), the most common histological subtype of lung cancer( [1][1], [2][2] ), is a disease of the elderly, with an average age of diagnosis of about 70 years of age( [3][3] ). Old...
www.biorxiv.org
February 3, 2025 at 7:13 PM
So happy to share the newest pre-print from the lab where we show that old age significantly changes the traits that evolve in established lung adenocarcinoma. This work sheds light into the importance of modeling age-related cancers in the context of old age. www.biorxiv.org/content/10.1...
Join us this Thursday on Zoom. Basic and Clinical Oncology Bench ↔️ Bedside Seminar Series. #cancer #oncology
On February 6 at 3 p.m., don't miss the two virtual conferences offered by Drs. Lorenzo Ferri and Véronique Giroux as part of the next fundamental and clinical oncology seminar.
📍Info and registration: bit.ly/3PYvaay
📍Info and registration: bit.ly/3PYvaay
February 3, 2025 at 10:57 PM
Reposted by Islam Elkholi
I wanted to write briefly about a very pleasant experience we recently had coordinating and collaborating closely on competing publications with 2 other teams. 1/
January 24, 2025 at 7:36 PM
I wanted to write briefly about a very pleasant experience we recently had coordinating and collaborating closely on competing publications with 2 other teams. 1/
Kicking off with sharing our latest discussion on breast cancer dormancy & how to bridge the gap between the bench & bedside! tinyurl.com/msctvab2
P.S. I post about metastasis/signaling, Jazz/Egyptian classics & interesting reads. Looking fwd to connecting with people disseminating from Twitter 😊
P.S. I post about metastasis/signaling, Jazz/Egyptian classics & interesting reads. Looking fwd to connecting with people disseminating from Twitter 😊
November 18, 2024 at 11:22 PM
Kicking off with sharing our latest discussion on breast cancer dormancy & how to bridge the gap between the bench & bedside! tinyurl.com/msctvab2
P.S. I post about metastasis/signaling, Jazz/Egyptian classics & interesting reads. Looking fwd to connecting with people disseminating from Twitter 😊
P.S. I post about metastasis/signaling, Jazz/Egyptian classics & interesting reads. Looking fwd to connecting with people disseminating from Twitter 😊