Irina Dudanova
@irinadudanova.bsky.social
Neuroscientist, Professor at University Hospital Cologne, @unicologne.bsky.social
My lab studies molecular and circuit mechanisms of neurodegeneration.
My lab studies molecular and circuit mechanisms of neurodegeneration.
Pinned
Irina Dudanova
@irinadudanova.bsky.social
· Mar 14
Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotypes in #Huntington’sDisease models, showing its potential as an HD treatment.
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
Reposted by Irina Dudanova
Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp
November 12, 2025 at 5:42 PM
Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp
Reposted by Irina Dudanova
We are hiring a postdoc to work @istaresearch.bsky.social on an @erc.europa.eu funded project, investigating the control of behavior and physiology by the hypothalamus. Please apply and share! ist.ac.at/en/job/postd...
Postdoc Research Group Douglass
Our Group
Our newly established research group at ISTA is seeking a postdoctoral researcher to work on an ERC-funded project- HypoAdapt. We study how the brain controls bodily responses to environm...
ist.ac.at
September 29, 2025 at 11:05 AM
We are hiring a postdoc to work @istaresearch.bsky.social on an @erc.europa.eu funded project, investigating the control of behavior and physiology by the hypothalamus. Please apply and share! ist.ac.at/en/job/postd...
Reposted by Irina Dudanova
Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...
September 15, 2025 at 9:27 AM
Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...
Congratulations to Cole Sitron et al. from Ulrich Hartl's group @mpibiochem.bsky.social on this beautiful study exploring the interaction of α-synuclein aggregates with the ESCRT-III complex, now out in @cp-molcell.bsky.social - it was a pleasure to contribute to the project.
Online Now: α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation Online now:
α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
Neurodegeneration-associated aggregates, such as α-synuclein inclusions in Parkinson’s disease, often contain ESCRT-III proteins. Sitron et al. reveal how α-synuclein aggregates bind ESCRT-III proteins, immobilizing them and triggering their “collateral degradation.” This cascade functionally depletes ESCRT-III to initiate a toxic feedback loop.
dlvr.it
September 12, 2025 at 6:15 AM
Congratulations to Cole Sitron et al. from Ulrich Hartl's group @mpibiochem.bsky.social on this beautiful study exploring the interaction of α-synuclein aggregates with the ESCRT-III complex, now out in @cp-molcell.bsky.social - it was a pleasure to contribute to the project.
Reposted by Irina Dudanova
Trilled to share our new work🥳We show that age-related hyperactivation of the EPS8/RAC signaling pathway drives protein aggregation and neurodegeneration — hallmarks of Huntington’s disease and ALS. #proteostasis #aging #neurodegenerativediseases
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
www.nature.com
September 3, 2025 at 10:00 AM
Trilled to share our new work🥳We show that age-related hyperactivation of the EPS8/RAC signaling pathway drives protein aggregation and neurodegeneration — hallmarks of Huntington’s disease and ALS. #proteostasis #aging #neurodegenerativediseases
Reposted by Irina Dudanova
New lab preprint: Leveraging the updated AutoGaitA toolbox, we revealed distinct species-specific mechanisms to generate propulsion during walking and the conserved pattern of age-related propulsive decline from flies to humans. www.biorxiv.org/content/10.1...
AutoGaitA: A versatile quantitative framework for kinematic analyses across species, perturbations and behaviours
Individual behaviours require the nervous system to execute specialised motor programs, each characterised by unique patterns of coordinated movements across body parts. Deep learning approaches for b...
www.biorxiv.org
August 30, 2025 at 9:56 AM
New lab preprint: Leveraging the updated AutoGaitA toolbox, we revealed distinct species-specific mechanisms to generate propulsion during walking and the conserved pattern of age-related propulsive decline from flies to humans. www.biorxiv.org/content/10.1...
Reposted by Irina Dudanova
Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny.
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!
August 12, 2025 at 2:35 PM
Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny.
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!
Reposted by Irina Dudanova
We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
Postdoc Position (f/m/x)
We are looking to support our rapidly growing team as soon as possible:
jobs-uk-koeln.onlyfy.jobs
May 15, 2025 at 10:01 AM
We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
Reposted by Irina Dudanova
New work from our lab;)
C9orf72 ALS-causing mutations lead to nucleoporin Nup107 aggregation and subsequent pathological changes https://www.biorxiv.org/content/10.1101/2025.04.16.649118v1
April 18, 2025 at 10:22 AM
New work from our lab;)
Reposted by Irina Dudanova
🚨 Scholarship Alert! 🚨 Pursue your Master studies in Biology or Biochemistry with our #CGA Master Fellowship programme. 🧬👩🏽🔬💰 Explore ageing research at the Cologne Ageing Campus! Apply by July 15! 📅 🔗 Learn more: www.ageing-grad-school.de/master/maste...
April 1, 2025 at 11:56 AM
🚨 Scholarship Alert! 🚨 Pursue your Master studies in Biology or Biochemistry with our #CGA Master Fellowship programme. 🧬👩🏽🔬💰 Explore ageing research at the Cologne Ageing Campus! Apply by July 15! 📅 🔗 Learn more: www.ageing-grad-school.de/master/maste...
Delighted to be part of the new Research Unit on Organismal Proteostasis.
Thanks to @thevilchezlab.bsky.social for all the hard work on putting together this consortium, and to the #DFG for funding our research!
Thanks to @thevilchezlab.bsky.social for all the hard work on putting together this consortium, and to the #DFG for funding our research!
Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding!
March 31, 2025 at 5:13 PM
Delighted to be part of the new Research Unit on Organismal Proteostasis.
Thanks to @thevilchezlab.bsky.social for all the hard work on putting together this consortium, and to the #DFG for funding our research!
Thanks to @thevilchezlab.bsky.social for all the hard work on putting together this consortium, and to the #DFG for funding our research!
Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotypes in #Huntington’sDisease models, showing its potential as an HD treatment.
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
March 14, 2025 at 8:08 AM
Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotypes in #Huntington’sDisease models, showing its potential as an HD treatment.
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social
Reposted by Irina Dudanova
Mitochondria a safe haven for aggregation-prone proteins? #neurodegeneration. #Parkinson. Find our latest manuscript in @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Mitochondria serve as a Holdout Compartment for Aggregation-Prone Proteins hindering Efficient Ubiquitin-Dependent Degradation
The accumulation of protein aggregates has been causatively linked to the pathogenesis of neurodegenerative diseases. In this study, we have conducted a genome-wide CRISPR-Cas9 screen to identify cell...
www.biorxiv.org
March 6, 2025 at 11:51 AM
Mitochondria a safe haven for aggregation-prone proteins? #neurodegeneration. #Parkinson. Find our latest manuscript in @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Reposted by Irina Dudanova
Interested in the molecular mechanisms of neurodegeneration?
📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response!
Apply via this fantastic PhD Programme until April 3 👇
📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response!
Apply via this fantastic PhD Programme until April 3 👇
The summer call of our International PhD programme is open! 📢
Ready to advance your scientific career? If you're passionate about #RNAbiology, #Bioinformatics, or #Immunology, apply to our open calls and join our global community of over 200 #PhD students! 🌍
www.imb.de/phd
Ready to advance your scientific career? If you're passionate about #RNAbiology, #Bioinformatics, or #Immunology, apply to our open calls and join our global community of over 200 #PhD students! 🌍
www.imb.de/phd
February 17, 2025 at 2:37 PM
Interested in the molecular mechanisms of neurodegeneration?
📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response!
Apply via this fantastic PhD Programme until April 3 👇
📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response!
Apply via this fantastic PhD Programme until April 3 👇
Reposted by Irina Dudanova
Our new paper shows that targeted stimulation of a subtype of cortical inhibitory neurons can ameliorate motor deficits in Huntington’s disease mice. A great collab with @irinadudanova.bsky.social www.biorxiv.org/content/10.1...
Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice
Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral symptom...
www.biorxiv.org
February 10, 2025 at 5:41 AM
Our new paper shows that targeted stimulation of a subtype of cortical inhibitory neurons can ameliorate motor deficits in Huntington’s disease mice. A great collab with @irinadudanova.bsky.social www.biorxiv.org/content/10.1...
How do different cortical neuron types contribute to circuit dysfunction in #Huntington’s disease?
Check out our new collaborative study with @takakikomiyama.bsky.social, spearheaded by Sonja Blumenstock, now out as a preprint.
www.biorxiv.org/content/10.1...
Check out our new collaborative study with @takakikomiyama.bsky.social, spearheaded by Sonja Blumenstock, now out as a preprint.
www.biorxiv.org/content/10.1...
Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice
Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral symptom...
www.biorxiv.org
February 9, 2025 at 1:04 PM
How do different cortical neuron types contribute to circuit dysfunction in #Huntington’s disease?
Check out our new collaborative study with @takakikomiyama.bsky.social, spearheaded by Sonja Blumenstock, now out as a preprint.
www.biorxiv.org/content/10.1...
Check out our new collaborative study with @takakikomiyama.bsky.social, spearheaded by Sonja Blumenstock, now out as a preprint.
www.biorxiv.org/content/10.1...