Nico Dantuma
@ubiquitinneuro.bsky.social
Professor of Molecular Cell Biology. The Dantuma lab at the Karolinska Institute studies protein degradation in Alzheimer's, Parkinson's and other neurodegenerative diseases as well as cancer. Interests: triathlon, kayaking, scuba diving, climbing, etc.
We are looking for a postdoc! Interested in protein degradation in cancer and neurodegeneration? Interested in the ubiquitin-proteasome system and autophagy? Application deadline Sept 26. #karolinskainstitutet #stockholm #postdocposition ki.varbi.com/en/what:job/...
Postdoctoral Researcher in Intracellular Protein Degradation in Cancer
Do you want to contribute to top quality medical research? The Dantuma lab at the Department of Cell and Molecular Biology has a long-standing interest in understanding the role of intracellular prote
ki.varbi.com
September 8, 2025 at 2:21 PM
We are looking for a postdoc! Interested in protein degradation in cancer and neurodegeneration? Interested in the ubiquitin-proteasome system and autophagy? Application deadline Sept 26. #karolinskainstitutet #stockholm #postdocposition ki.varbi.com/en/what:job/...
The Karolinska Institute announces 20 positions for Assistant Professors for outstanding early-career researchers. Positions include a startup package. Application deadline September 2nd. ki.varbi.com/en/what:job/...
Assistant Professor in Cell and Molecular Biology
Join a global community of excellence Karolinska Institutet, Department of Cell and Molecular Biology Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Insti
ki.varbi.com
June 27, 2025 at 11:52 AM
The Karolinska Institute announces 20 positions for Assistant Professors for outstanding early-career researchers. Positions include a startup package. Application deadline September 2nd. ki.varbi.com/en/what:job/...
The Karolinska Institute announces 20 positions for Assistant Professors in Biomedical Science for outstanding early-career researchers. Positions include a startup package. Application deadline September 2nd. ki.varbi.com/en/what:job/....
Assistant Professor in Biomedical Science
Join a global community of excellence Are you a bold, creative researcher ready to shape the future of medical science? Karolinska Institutet (KI), one of the world’s foremost medical universities,
ki.varbi.com
June 27, 2025 at 7:29 AM
The Karolinska Institute announces 20 positions for Assistant Professors in Biomedical Science for outstanding early-career researchers. Positions include a startup package. Application deadline September 2nd. ki.varbi.com/en/what:job/....
Reposted by Nico Dantuma
Congrats to Corentin Bouvier, awardee of the FEBS Journal prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febsj.bsky.social #ProteoCure2025
May 24, 2025 at 8:22 AM
Congrats to Corentin Bouvier, awardee of the FEBS Journal prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febsj.bsky.social #ProteoCure2025
Reposted by Nico Dantuma
Congrats to Mónica Pozo Rodriguez, awardee of the FEBS Open Bio Poster prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febspress.bsky.social #ProteoCure2025
May 24, 2025 at 8:23 AM
Congrats to Mónica Pozo Rodriguez, awardee of the FEBS Open Bio Poster prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febspress.bsky.social #ProteoCure2025
Reposted by Nico Dantuma
Congrats to Simon Tack, awardee of the FEBS Journal Oral Presentation prize at the annual COST ProteoCure meeting.
@costprogramme.bsky.social @febsj.bsky.social
#ProteoCure2025
@costprogramme.bsky.social @febsj.bsky.social
#ProteoCure2025
May 24, 2025 at 8:25 AM
Congrats to Simon Tack, awardee of the FEBS Journal Oral Presentation prize at the annual COST ProteoCure meeting.
@costprogramme.bsky.social @febsj.bsky.social
#ProteoCure2025
@costprogramme.bsky.social @febsj.bsky.social
#ProteoCure2025
Reposted by Nico Dantuma
An introduction into the role of mitochondrial dynamics in dealing with misfolded mitochondrial proteins by Luca Scorrano at the #ProteoCure2025 annual meeting. #COST
May 21, 2025 at 11:03 AM
An introduction into the role of mitochondrial dynamics in dealing with misfolded mitochondrial proteins by Luca Scorrano at the #ProteoCure2025 annual meeting. #COST
Michael Glickman presented his latest data on one of our favorite proteins UBB+1 and its role in Alzheimer's disease at the annual meeting of COST ProteoCure in Heraklion.
May 21, 2025 at 7:59 AM
Michael Glickman presented his latest data on one of our favorite proteins UBB+1 and its role in Alzheimer's disease at the annual meeting of COST ProteoCure in Heraklion.
Mitochondria a safe haven for aggregation-prone proteins? #neurodegeneration. #Parkinson. Find our latest manuscript in @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Mitochondria serve as a Holdout Compartment for Aggregation-Prone Proteins hindering Efficient Ubiquitin-Dependent Degradation
The accumulation of protein aggregates has been causatively linked to the pathogenesis of neurodegenerative diseases. In this study, we have conducted a genome-wide CRISPR-Cas9 screen to identify cell...
www.biorxiv.org
March 6, 2025 at 11:51 AM
Mitochondria a safe haven for aggregation-prone proteins? #neurodegeneration. #Parkinson. Find our latest manuscript in @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Reposted by Nico Dantuma
Fantastic new paper out @nature.com! @merbllab.bsky.social discovers proteasome-derived peptides that function as a defence against bacterial infections. I'm not an immunologist but even I can tell that this finding has huge implications for new therapeutic interventions!
👉 go.nature.com/43k1a0H
👉 go.nature.com/43k1a0H
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
www.nature.com
March 6, 2025 at 6:36 AM
Fantastic new paper out @nature.com! @merbllab.bsky.social discovers proteasome-derived peptides that function as a defence against bacterial infections. I'm not an immunologist but even I can tell that this finding has huge implications for new therapeutic interventions!
👉 go.nature.com/43k1a0H
👉 go.nature.com/43k1a0H
Today at 13:15 I will give a seminar at Uppsala Biomedical Centre entitled "Stimulating proteasomal degradation of neurodegeneration-associated proteins".
February 5, 2025 at 7:41 AM
Today at 13:15 I will give a seminar at Uppsala Biomedical Centre entitled "Stimulating proteasomal degradation of neurodegeneration-associated proteins".
Reposted by Nico Dantuma
A Perspective from Xiaoyu Zhang, Gabriel Simon, and Benjamin Cravatt discusses recent strategies to expand the E3 ligase landscape and the scope of targeted protein
degradation
www.nature.com/articles/s41...
degradation
www.nature.com/articles/s41...
Implications of frequent hitter E3 ligases in targeted protein degradation screens - Nature Chemical Biology
This Perspective discusses recent strategies to expand the scope of targeted protein degradation (TPD) and the implications of unexpected convergence of diverse screening efforts on a small subset of ...
www.nature.com
January 28, 2025 at 5:09 PM
A Perspective from Xiaoyu Zhang, Gabriel Simon, and Benjamin Cravatt discusses recent strategies to expand the E3 ligase landscape and the scope of targeted protein
degradation
www.nature.com/articles/s41...
degradation
www.nature.com/articles/s41...
Reposted by Nico Dantuma
Join us in Vienna 8-9 May for the #Ubiquitin & Friends Symposium 2025! Excellent line-up of guest speakers👇And many slots for talks from abstracts, plus flash-talks & posters! Lots of opportunities to network with peers & experts in a friendly atmosphere! ➡️ www.protein-degradation.org/symposium/
January 27, 2025 at 12:07 PM
Join us in Vienna 8-9 May for the #Ubiquitin & Friends Symposium 2025! Excellent line-up of guest speakers👇And many slots for talks from abstracts, plus flash-talks & posters! Lots of opportunities to network with peers & experts in a friendly atmosphere! ➡️ www.protein-degradation.org/symposium/
Reposted by Nico Dantuma
Looking forward to this year’s EMBO meeting about ESCRT proteins at the scenic Caux Palace, Montreux (CH) / To receive a notification when the website goes live, sign up here: coming-soon.embo.org/w25-75
ESCRT function, evolutionary diversity and mechanism of action
coming-soon.embo.org
January 28, 2025 at 1:58 AM
Looking forward to this year’s EMBO meeting about ESCRT proteins at the scenic Caux Palace, Montreux (CH) / To receive a notification when the website goes live, sign up here: coming-soon.embo.org/w25-75
Reposted by Nico Dantuma
More than 40 percent of #postdocs leave academia. Those who landed a coveted faculty position were more likely to have had a highly cited paper, changed their research topic between their #PhD and postdoc, or moved abroad after receiving their doctorate. www.pnas.org/doi/10.1073/... @pnas.org
More than 40% of postdocs leave academia, study reveals
Publishing highly cited papers helps postdoctoral researchers to land a faculty job.
www.nature.com
January 23, 2025 at 1:49 PM
More than 40 percent of #postdocs leave academia. Those who landed a coveted faculty position were more likely to have had a highly cited paper, changed their research topic between their #PhD and postdoc, or moved abroad after receiving their doctorate. www.pnas.org/doi/10.1073/... @pnas.org
Reposted by Nico Dantuma
Inspired by recent discoveries on ubiquitin-mediated condensates under physiological and stress conditions, we wrote this review on the intersection of protein quality control, phase separation, and function! #PQC #UPS #autophagy #ubiquitin #condensates
Now online - the Review "Protein quality control machinery: regulators of condensate architecture and functionality" from Anitha Rajendran and Carlos @castanedalab.bsky.social.
#PQC #condensates #phaseseparation #chaperones #therapeutics
Access here 👉 authors.elsevier.com/a/1kNRo3S6Gf...
#PQC #condensates #phaseseparation #chaperones #therapeutics
Access here 👉 authors.elsevier.com/a/1kNRo3S6Gf...
January 6, 2025 at 6:58 PM
Inspired by recent discoveries on ubiquitin-mediated condensates under physiological and stress conditions, we wrote this review on the intersection of protein quality control, phase separation, and function! #PQC #UPS #autophagy #ubiquitin #condensates
Reposted by Nico Dantuma
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn
November 15, 2024 at 7:38 PM
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn
In our latest study, we report on how the SARS-CoV-2 protease PLpro manipulates autophagy. Paper in the Journal #Autophagy. #Covid, #Ubiquitin, #Proteasome. bit.ly/3E7cByg
Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase
Viral proteases play critical roles in the host cell and immune remodeling that allows virus production. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) papain-like protease (PLpro...
bit.ly
January 22, 2025 at 1:08 PM
In our latest study, we report on how the SARS-CoV-2 protease PLpro manipulates autophagy. Paper in the Journal #Autophagy. #Covid, #Ubiquitin, #Proteasome. bit.ly/3E7cByg
I’ve just done my #eXit! the X exodus is massive. Don't lose any of your followers. Thanks to #HelloQuitX I've registered 1631 new passengers for a journey to #BlueSky & #Mastodon. Join us on app.helloquitx.com and automatically find your communities on #January20!
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app.helloquitx.com
January 22, 2025 at 12:30 PM
I’ve just done my #eXit! the X exodus is massive. Don't lose any of your followers. Thanks to #HelloQuitX I've registered 1631 new passengers for a journey to #BlueSky & #Mastodon. Join us on app.helloquitx.com and automatically find your communities on #January20!