IntAct
@intact-ebi.bsky.social
The Molecular Interactions Database at the EMBL-EBI. Open Source Framework for Molecular Interactions.
https://www.ebi.ac.uk/intact/home
Also follow➡️@complexportal.bsky.social
https://www.ebi.ac.uk/intact/home
Also follow➡️@complexportal.bsky.social
Pinned
Registration is free but essential: tinyurl.com/4v3jf4e9
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Reposted by IntAct
Registration is free but essential: tinyurl.com/4v3jf4e9
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
November 24, 2025 at 5:56 PM
Registration is free but essential: tinyurl.com/4v3jf4e9
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Reposted by IntAct
Would you like to learn more about molecular interactions and how to explore them across organisms?
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
November 24, 2025 at 5:56 PM
Would you like to learn more about molecular interactions and how to explore them across organisms?
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
Reposted by IntAct
From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology:
“AI is showing how vital data curation really is.”
www.ebi.ac.uk/about/news/p...
🖥️🧬
“AI is showing how vital data curation really is.”
www.ebi.ac.uk/about/news/p...
🖥️🧬
Sandra Orchard: what I’ve learned
EMBL-EBI Team Leader Sandra Orchard reflects on a life in protein science, UniProt data curation, and championing open data standards.
www.ebi.ac.uk
November 25, 2025 at 3:15 PM
From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology:
“AI is showing how vital data curation really is.”
www.ebi.ac.uk/about/news/p...
🖥️🧬
“AI is showing how vital data curation really is.”
www.ebi.ac.uk/about/news/p...
🖥️🧬
Reposted by IntAct
Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work on important open data resources including:
UniProt
Complex Portal @complexportal.bsky.social
Gene Ontology @geneontology.bsky.social
IntAct @intact-ebi.bsky.social
InterPro @interprodb.bsky.social
UniProt
Complex Portal @complexportal.bsky.social
Gene Ontology @geneontology.bsky.social
IntAct @intact-ebi.bsky.social
InterPro @interprodb.bsky.social
November 25, 2025 at 3:21 PM
Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work on important open data resources including:
UniProt
Complex Portal @complexportal.bsky.social
Gene Ontology @geneontology.bsky.social
IntAct @intact-ebi.bsky.social
InterPro @interprodb.bsky.social
UniProt
Complex Portal @complexportal.bsky.social
Gene Ontology @geneontology.bsky.social
IntAct @intact-ebi.bsky.social
InterPro @interprodb.bsky.social
Would you like to learn more about molecular interactions and how to explore them across organisms?
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
November 24, 2025 at 5:56 PM
Would you like to learn more about molecular interactions and how to explore them across organisms?
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
Reposted by IntAct
🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
November 5, 2025 at 12:10 PM
🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
✨🧬New on IntAct! ✨
Interaction data from the study
📖“Global fungal–host interactome mapping identifies host targets of candidalysin” - Shanghai Jiao Tong University, Tongji University, and the Chinese Academy of Sciences. 🎉
Interaction data from the study
📖“Global fungal–host interactome mapping identifies host targets of candidalysin” - Shanghai Jiao Tong University, Tongji University, and the Chinese Academy of Sciences. 🎉
November 5, 2025 at 12:10 PM
✨🧬New on IntAct! ✨
Interaction data from the study
📖“Global fungal–host interactome mapping identifies host targets of candidalysin” - Shanghai Jiao Tong University, Tongji University, and the Chinese Academy of Sciences. 🎉
Interaction data from the study
📖“Global fungal–host interactome mapping identifies host targets of candidalysin” - Shanghai Jiao Tong University, Tongji University, and the Chinese Academy of Sciences. 🎉
Reposted by IntAct
Let’s make your science more FAIR - Findable, Accessible, Interoperable, and Reusable.
#Biocuration #FromBenchToDatabase #FAIRdata #ProteinInteractions #EMBL-EBI #IntAct-EBI #OpenScience #UniProt #DataMatters
#Biocuration #FromBenchToDatabase #FAIRdata #ProteinInteractions #EMBL-EBI #IntAct-EBI #OpenScience #UniProt #DataMatters
October 19, 2025 at 1:25 PM
Let’s make your science more FAIR - Findable, Accessible, Interoperable, and Reusable.
#Biocuration #FromBenchToDatabase #FAIRdata #ProteinInteractions #EMBL-EBI #IntAct-EBI #OpenScience #UniProt #DataMatters
#Biocuration #FromBenchToDatabase #FAIRdata #ProteinInteractions #EMBL-EBI #IntAct-EBI #OpenScience #UniProt #DataMatters
Reposted by IntAct
📥 Submit your data here:
🔹 IntAct: tinyurl.com/zzrcx742
🔹 IntAct: tinyurl.com/zzrcx742
October 19, 2025 at 1:25 PM
📥 Submit your data here:
🔹 IntAct: tinyurl.com/zzrcx742
🔹 IntAct: tinyurl.com/zzrcx742
Reposted by IntAct
Want your PPI or structural data to make an impact?
✅ Use Identifierss
✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713)
✅ Submit to EMBL-EBI's data resources - IntAct
👉 See Niri’s dataset in IntAct:
tinyurl.com/yp8ddheh
✅ Use Identifierss
✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713)
✅ Submit to EMBL-EBI's data resources - IntAct
👉 See Niri’s dataset in IntAct:
tinyurl.com/yp8ddheh
October 19, 2025 at 1:25 PM
Want your PPI or structural data to make an impact?
✅ Use Identifierss
✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713)
✅ Submit to EMBL-EBI's data resources - IntAct
👉 See Niri’s dataset in IntAct:
tinyurl.com/yp8ddheh
✅ Use Identifierss
✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713)
✅ Submit to EMBL-EBI's data resources - IntAct
👉 See Niri’s dataset in IntAct:
tinyurl.com/yp8ddheh
Reposted by IntAct
Don’t just publish - be found! 🔍
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
October 19, 2025 at 1:25 PM
Don’t just publish - be found! 🔍
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
Reposted by IntAct
🕸️ Explore the interactome on the IntAct tinyurl.com/35922511.
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
October 1, 2025 at 9:31 AM
🕸️ Explore the interactome on the IntAct tinyurl.com/35922511.
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
🧬 “A physical wiring diagram for the human immune system” by the Wright Lab, University of York.
🔎 Study provides a systematic & quantitative view of the cell-surface proteins that enable immune cells to dynamically wire their interactions.
🔎 Study provides a systematic & quantitative view of the cell-surface proteins that enable immune cells to dynamically wire their interactions.
October 1, 2025 at 9:31 AM
🧬 “A physical wiring diagram for the human immune system” by the Wright Lab, University of York.
🔎 Study provides a systematic & quantitative view of the cell-surface proteins that enable immune cells to dynamically wire their interactions.
🔎 Study provides a systematic & quantitative view of the cell-surface proteins that enable immune cells to dynamically wire their interactions.
Reposted by IntAct
See also @wojtekgalej.bsky.social and
tinyurl.com/3sfthabb
#MinorSpliceosome #RNAsplicing #snRNP #U12Introns
tinyurl.com/3sfthabb
#MinorSpliceosome #RNAsplicing #snRNP #U12Introns
October 1, 2025 at 8:27 AM
Reposted by IntAct
The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development.
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
October 1, 2025 at 8:27 AM
The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development.
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf
🔬 More info: tinyurl.com/47ed3er6
Reposted by IntAct
October 1, 2025 at 7:00 AM
Reposted by IntAct
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
September 22, 2025 at 9:35 AM
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
Reposted by IntAct
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
September 22, 2025 at 10:31 AM
🧠 Today is #WorldAlzheimersDay.
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression
(tinyurl.com/37exu532).
#WorldAlzheimersDay #AlzheimersSociety
#Complexportal
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
September 22, 2025 at 9:35 AM
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
September 22, 2025 at 8:59 AM
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
IntAct release 251 is out! 1,726,205 binary interactions from 23,716 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_03)
September 12, 2025 at 9:08 AM
IntAct release 251 is out! 1,726,205 binary interactions from 23,716 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_03)
🧠 Alzheimer’s research meets precision medicine
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
September 8, 2025 at 1:11 PM
🧠 Alzheimer’s research meets precision medicine
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome.
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
September 8, 2025 at 10:15 AM
🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome.
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
Reposted by IntAct
🧠 Ever wonder how your tongue detects umami or sweetness?
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
#TasteReceptors #GPCR
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
#TasteReceptors #GPCR
August 28, 2025 at 2:24 PM
🧠 Ever wonder how your tongue detects umami or sweetness?
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
#TasteReceptors #GPCR
🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3.
🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond).
🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9
#TasteReceptors #GPCR
Reposted by IntAct
Complex Portal release 251 is out! 5,190 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2025_03)
Complex Portal
EMBL-EBI
www.ebi.ac.uk
August 28, 2025 at 1:16 PM
Complex Portal release 251 is out! 5,190 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2025_03)