IntAct
@intact-ebi.bsky.social
The Molecular Interactions Database at the EMBL-EBI. Open Source Framework for Molecular Interactions.
https://www.ebi.ac.uk/intact/home
Also follow➡️@complexportal.bsky.social
https://www.ebi.ac.uk/intact/home
Also follow➡️@complexportal.bsky.social
Registration is free but essential: tinyurl.com/4v3jf4e9
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
November 24, 2025 at 5:56 PM
Registration is free but essential: tinyurl.com/4v3jf4e9
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
November 5, 2025 at 12:10 PM
🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
🕸️ Explore the interactome on the IntAct tinyurl.com/35922511.
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
October 1, 2025 at 9:31 AM
🕸️ Explore the interactome on the IntAct tinyurl.com/35922511.
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
September 22, 2025 at 9:35 AM
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
#WorldAlzheimersDay #AlzheimersSociety
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
September 22, 2025 at 8:59 AM
💜🧠 World Alzheimer’s Day 🧠💜
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S
🧪 disrupting key pathways linked to Alzheimer’s.
🔗 Network: tinyurl.com/ynjwhy7y
Paper: doi.org/10.3390/ijms24032490
🧠 Alzheimer’s research meets precision medicine
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
September 8, 2025 at 1:11 PM
🧠 Alzheimer’s research meets precision medicine
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
📊 IMEx data from IntAct & Complex Portal
🧬 How AD mutations disrupt brain protein networks
🔍 Variant pathways, APP, miRNA
🚀 Toward targeted AD therapies
🔗 doi.org/10.1002/pmic...
#KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety
🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome.
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
September 8, 2025 at 10:15 AM
🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome.
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
Excited to share the global proximity interactome in the Human Macroautophagy Pathway! (See: tinyurl.com/bdfaeztn)
Study uncovers novel role of OSBPL family lipid transport proteins as new players in autophagy.See IntAct: tinyurl.com/34ksav36 #Macroautophagy #BrumellLab
Study uncovers novel role of OSBPL family lipid transport proteins as new players in autophagy.See IntAct: tinyurl.com/34ksav36 #Macroautophagy #BrumellLab
July 3, 2025 at 10:12 AM
Excited to share the global proximity interactome in the Human Macroautophagy Pathway! (See: tinyurl.com/bdfaeztn)
Study uncovers novel role of OSBPL family lipid transport proteins as new players in autophagy.See IntAct: tinyurl.com/34ksav36 #Macroautophagy #BrumellLab
Study uncovers novel role of OSBPL family lipid transport proteins as new players in autophagy.See IntAct: tinyurl.com/34ksav36 #Macroautophagy #BrumellLab
Excited to share the global proximity interactome in the Human Macroautophagy Pathway! (PMID: 34524948). Study uncovers novel putative connections including identification of OSBPL family lipid transport proteins as new players in autophagy.See IntAct: tinyurl.com/34ksav36 #Macroautophagy#BrumellLab
July 3, 2025 at 8:24 AM
Excited to share the global proximity interactome in the Human Macroautophagy Pathway! (PMID: 34524948). Study uncovers novel putative connections including identification of OSBPL family lipid transport proteins as new players in autophagy.See IntAct: tinyurl.com/34ksav36 #Macroautophagy#BrumellLab
IntAct's dataset of the month features 75 cancer-associated missense variants in the retinoblastoma tumor suppressor protein (PMID:39938803). Visit IntAct and explore detailed expert-curation of variants, binding domains and biophysical parameters (tinyurl.com/4rsx8754). #C..., #PPI, #IntActEBI
June 2, 2025 at 3:29 PM
IntAct's dataset of the month features 75 cancer-associated missense variants in the retinoblastoma tumor suppressor protein (PMID:39938803). Visit IntAct and explore detailed expert-curation of variants, binding domains and biophysical parameters (tinyurl.com/4rsx8754). #C..., #PPI, #IntActEBI
It is Skin Cancer awareness month! Explore manually curated interactomes of proteins associated with familial melanoma in IntAct. Access the network in IntAct (tinyurl.com/26tc7xtm). #IntAct-ebi, #ComplexPortal, #UniProt, #MelanomaAwareness, #HumanDisease, #SunSafety, #SpotSkinCancer,
May 21, 2025 at 9:38 AM
It is Skin Cancer awareness month! Explore manually curated interactomes of proteins associated with familial melanoma in IntAct. Access the network in IntAct (tinyurl.com/26tc7xtm). #IntAct-ebi, #ComplexPortal, #UniProt, #MelanomaAwareness, #HumanDisease, #SunSafety, #SpotSkinCancer,
Thrilled to announce that the protein–protein interactions of 396 SLC transporters, characterized by interaction proteomics from the RESOLUTE project, is now integrated into IntAct!
Congratulations to #Superti-FurgaLab, #FabianFrommelt
Explore the interactome at www.ebi.ac.uk/intact/searc...
Congratulations to #Superti-FurgaLab, #FabianFrommelt
Explore the interactome at www.ebi.ac.uk/intact/searc...
May 20, 2025 at 10:21 AM
Thrilled to announce that the protein–protein interactions of 396 SLC transporters, characterized by interaction proteomics from the RESOLUTE project, is now integrated into IntAct!
Congratulations to #Superti-FurgaLab, #FabianFrommelt
Explore the interactome at www.ebi.ac.uk/intact/searc...
Congratulations to #Superti-FurgaLab, #FabianFrommelt
Explore the interactome at www.ebi.ac.uk/intact/searc...
Excited to have integrated data from ‘Systematic discovery of mutation-directed neo-protein-protein interactions in cancer’ in IntAct (PMID: 35512704). #tumor #PPI #mutations
Explore the interactome at ebi.ac.uk/intact/search?
Explore the interactome at ebi.ac.uk/intact/search?
May 2, 2025 at 4:18 PM
Excited to have integrated data from ‘Systematic discovery of mutation-directed neo-protein-protein interactions in cancer’ in IntAct (PMID: 35512704). #tumor #PPI #mutations
Explore the interactome at ebi.ac.uk/intact/search?
Explore the interactome at ebi.ac.uk/intact/search?
IntAct is expanding its Inflammatory Bowel Disease dataset (lnkd.in/ejkr8tKx)! Our latest addition is the lncRNA GATA6-AS1 interactome, generated by K.E. Sosnovski et al. (2023) in human-derived Caco-2 cells (lnkd.in/eiYaFSdK).
➡️ Learn more about this interactome on IntAct! (lnkd.in/e2RSQEZZ)
➡️ Learn more about this interactome on IntAct! (lnkd.in/e2RSQEZZ)
May 1, 2025 at 10:46 AM
IntAct is expanding its Inflammatory Bowel Disease dataset (lnkd.in/ejkr8tKx)! Our latest addition is the lncRNA GATA6-AS1 interactome, generated by K.E. Sosnovski et al. (2023) in human-derived Caco-2 cells (lnkd.in/eiYaFSdK).
➡️ Learn more about this interactome on IntAct! (lnkd.in/e2RSQEZZ)
➡️ Learn more about this interactome on IntAct! (lnkd.in/e2RSQEZZ)
👩🔬 Today is International Women and Girls in Science day! 🧪 To celebrate we’re shining the spotlight on IntAct's Kalpana and Susie!!
February 12, 2025 at 9:33 AM
👩🔬 Today is International Women and Girls in Science day! 🧪 To celebrate we’re shining the spotlight on IntAct's Kalpana and Susie!!
👩🔬 Today is International Women and Girls in Science day! 🧪 To celebrate we’re shining the spotlight on IntAct's Kalpana and Susie!!
February 12, 2025 at 9:32 AM
👩🔬 Today is International Women and Girls in Science day! 🧪 To celebrate we’re shining the spotlight on IntAct's Kalpana and Susie!!
Start 2025 with a look at the Prefoldin-like co-chaperone complex (tinyurl.com/3p8b2arh), it’s multi-functional with roles in proteostasis, protein folding, assembly and stabilization. Visit us to learn more about this and Prefoldin (CPX-6149) & PAQosome (CPX-6145) complexes!
January 31, 2025 at 2:07 PM
Start 2025 with a look at the Prefoldin-like co-chaperone complex (tinyurl.com/3p8b2arh), it’s multi-functional with roles in proteostasis, protein folding, assembly and stabilization. Visit us to learn more about this and Prefoldin (CPX-6149) & PAQosome (CPX-6145) complexes!
IntAct is now on LinkedIn..come follow us!
December 12, 2024 at 2:37 PM
IntAct is now on LinkedIn..come follow us!
Featured dataset: @GoosHelka and @varjosalo_lab deposited protein-protein interactions for 109 different human transcription factors from BioID and AP-MS experiments with @intact_project and @imexconsortium
ebi.ac.uk/intact/search?…
ebi.ac.uk/intact/search?…
December 9, 2024 at 11:55 AM
Featured dataset: @GoosHelka and @varjosalo_lab deposited protein-protein interactions for 109 different human transcription factors from BioID and AP-MS experiments with @intact_project and @imexconsortium
ebi.ac.uk/intact/search?…
ebi.ac.uk/intact/search?…
The latest IntAct @imexconsortium @NAR_Open paper is out! >1.15million interactions from almost 23000 papers, with detailed descriptions including our mutation/#Variant set. Learn more about our #coronavirus network. Navigate the updated website
doi.org/10.1093/nar/gk…
doi.org/10.1093/nar/gk…
December 9, 2024 at 11:54 AM
The latest IntAct @imexconsortium @NAR_Open paper is out! >1.15million interactions from almost 23000 papers, with detailed descriptions including our mutation/#Variant set. Learn more about our #coronavirus network. Navigate the updated website
doi.org/10.1093/nar/gk…
doi.org/10.1093/nar/gk…
Our new website is out:Supported by a brand new webservice:
ebi.ac.uk/intact/documen… ebi.ac.uk/intact/home
ebi.ac.uk/intact/documen… ebi.ac.uk/intact/home
December 9, 2024 at 11:54 AM
Our new website is out:Supported by a brand new webservice:
ebi.ac.uk/intact/documen… ebi.ac.uk/intact/home
ebi.ac.uk/intact/documen… ebi.ac.uk/intact/home
New #IntActBeta website out!:Try out our new looks and functionality and let us know what you think
ebi.ac.uk/support/intact wwwdev.ebi.ac.uk/intact.beta
ebi.ac.uk/support/intact wwwdev.ebi.ac.uk/intact.beta
December 9, 2024 at 11:54 AM
New #IntActBeta website out!:Try out our new looks and functionality and let us know what you think
ebi.ac.uk/support/intact wwwdev.ebi.ac.uk/intact.beta
ebi.ac.uk/support/intact wwwdev.ebi.ac.uk/intact.beta
We have curated 223 binary interactions with @ensembl's #Geneoftheweek MTR3, a member of the eukaryotic exosome complex.
#InternationalWomensDay #IWD2021 #ChooseToChallenge
x.com/ensembl/status…
#InternationalWomensDay #IWD2021 #ChooseToChallenge
x.com/ensembl/status…
December 9, 2024 at 11:54 AM
We have curated 223 binary interactions with @ensembl's #Geneoftheweek MTR3, a member of the eukaryotic exosome complex.
#InternationalWomensDay #IWD2021 #ChooseToChallenge
x.com/ensembl/status…
#InternationalWomensDay #IWD2021 #ChooseToChallenge
x.com/ensembl/status…
We have curated >3,600 interactions with exosome proteins. Find these using the search term GO:0000178:
#InternationalWomensDay #IWD2021
x.com/complexportal/…
#InternationalWomensDay #IWD2021
x.com/complexportal/…
December 9, 2024 at 11:54 AM
We have curated >3,600 interactions with exosome proteins. Find these using the search term GO:0000178:
#InternationalWomensDay #IWD2021
x.com/complexportal/…
#InternationalWomensDay #IWD2021
x.com/complexportal/…