Inserm UMR 1069 N2COx
@inserm-u1069-n2cox.bsky.social
Projects focused on lipids acting in/on tumor niches, particularly on energy/oxidative metabolism and calcium signaling, able to influence dysplasia, tumor progression and sensitivity of tumors to anti-cancer drugs
University of Tours - France
University of Tours - France
Excited to share our work in Cell Communication and Signalling @springernature.com rdcu.be/eJe8l
Groundbreaking approach using Ca²⁺ signatures to capture the unique characteristics of cancer cells. Collab with LIFAT
Tours University @inserm.fr @insermgrandouest.bsky.social @chrudetours.bsky.social
Groundbreaking approach using Ca²⁺ signatures to capture the unique characteristics of cancer cells. Collab with LIFAT
Tours University @inserm.fr @insermgrandouest.bsky.social @chrudetours.bsky.social
Investigation of the heterogeneity of cancer cells using single cell Ca2+ profiling
rdcu.be
October 10, 2025 at 2:32 PM
Excited to share our work in Cell Communication and Signalling @springernature.com rdcu.be/eJe8l
Groundbreaking approach using Ca²⁺ signatures to capture the unique characteristics of cancer cells. Collab with LIFAT
Tours University @inserm.fr @insermgrandouest.bsky.social @chrudetours.bsky.social
Groundbreaking approach using Ca²⁺ signatures to capture the unique characteristics of cancer cells. Collab with LIFAT
Tours University @inserm.fr @insermgrandouest.bsky.social @chrudetours.bsky.social
Delighted to share our new article www.sciencedirect.com/science/arti... in Clinical immunology @elsevierhms.bsky.social
@inserm.fr @insermgrandouest.bsky.social @chrudetours.bsky.social
in collaboration with Pr Delhommeau's team @sorbonne-universite.fr
#cytokines
#leukemia
#institut_Carnot_Opale
@inserm.fr @insermgrandouest.bsky.social @chrudetours.bsky.social
in collaboration with Pr Delhommeau's team @sorbonne-universite.fr
#cytokines
#leukemia
#institut_Carnot_Opale
A specific bone marrow cytokine pattern in de novo acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic cancers. Cytokines play an important role in the regulation of normal and patho…
www.sciencedirect.com
August 7, 2025 at 8:53 AM
Delighted to share our new article www.sciencedirect.com/science/arti... in Clinical immunology @elsevierhms.bsky.social
@inserm.fr @insermgrandouest.bsky.social @chrudetours.bsky.social
in collaboration with Pr Delhommeau's team @sorbonne-universite.fr
#cytokines
#leukemia
#institut_Carnot_Opale
@inserm.fr @insermgrandouest.bsky.social @chrudetours.bsky.social
in collaboration with Pr Delhommeau's team @sorbonne-universite.fr
#cytokines
#leukemia
#institut_Carnot_Opale
Reposted by Inserm UMR 1069 N2COx
🔬 @cnrs.fr
@inserm-u1069-n2cox.bsky.social
@inserm.fr
@igdrennes.bsky.social
@chunantes.bsky.social
@insermgrandouest.bsky.social
@cnrs-bretagneloire.bsky.social
#cancer #cancerologie #oncologie #recherche #grandouest #cancersein #cancerdusein #cancerprostate #cancerdelaprostate
@inserm-u1069-n2cox.bsky.social
@inserm.fr
@igdrennes.bsky.social
@chunantes.bsky.social
@insermgrandouest.bsky.social
@cnrs-bretagneloire.bsky.social
#cancer #cancerologie #oncologie #recherche #grandouest #cancersein #cancerdusein #cancerprostate #cancerdelaprostate
⏰24/11/25. Journée scientifique annuelle du réseau CasTHor du @canceropolego.bsky.social à #Nantes
ℹ️https://www.canceropole-grandouest.com/journee-scientifique-annuelle-du-reseau-cancers-des-tissus-hormono-dependants-du-cgo-nantes/
📣Appel à communications orales jeunes chercheurs jusqu'au 1/10/25
ℹ️https://www.canceropole-grandouest.com/journee-scientifique-annuelle-du-reseau-cancers-des-tissus-hormono-dependants-du-cgo-nantes/
📣Appel à communications orales jeunes chercheurs jusqu'au 1/10/25
July 24, 2025 at 8:08 AM
Thrilled to share our collaborative review exploring the resemblance of pulmonary arterial hypertension and cancers as channelopathies @cellpress.bsky.social Trends in Molecular Medicine
@inserm.fr Inserm UMR 999
@univparissaclay.bsky.social Université de Tours
www.sciencedirect.com/science/arti...
@inserm.fr Inserm UMR 999
@univparissaclay.bsky.social Université de Tours
www.sciencedirect.com/science/arti...
Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies
Pulmonary arterial hypertension (PAH) and cancer may appear to be unrelated at first, but there is increasing evidence that they share many characteri…
www.sciencedirect.com
April 9, 2025 at 12:52 PM
Thrilled to share our collaborative review exploring the resemblance of pulmonary arterial hypertension and cancers as channelopathies @cellpress.bsky.social Trends in Molecular Medicine
@inserm.fr Inserm UMR 999
@univparissaclay.bsky.social Université de Tours
www.sciencedirect.com/science/arti...
@inserm.fr Inserm UMR 999
@univparissaclay.bsky.social Université de Tours
www.sciencedirect.com/science/arti...
Reposted by Inserm UMR 1069 N2COx
L’Inserm rejoint Bluesky !
Découvrez ici toutes les actualités de la recherche médicale menée par l’Inserm, pour la santé de toutes et tous.
Découvrez ici toutes les actualités de la recherche médicale menée par l’Inserm, pour la santé de toutes et tous.
February 25, 2025 at 4:11 PM
L’Inserm rejoint Bluesky !
Découvrez ici toutes les actualités de la recherche médicale menée par l’Inserm, pour la santé de toutes et tous.
Découvrez ici toutes les actualités de la recherche médicale menée par l’Inserm, pour la santé de toutes et tous.
Reposted by Inserm UMR 1069 N2COx
February 14, 2025 at 5:19 PM
Reposted by Inserm UMR 1069 N2COx
💫NEW: @zakbaker.bsky.social, Pagliarini & co show that #mitochondria stress recovery requires mobilization of #LipidDroplet triacylglycerol stores to facilitate #cardiolipin biosynthesis and mitochondrial biogenesis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Triacylglycerol mobilization underpins mitochondrial stress recovery - Nature Cell Biology
Baker et al. show that mitochondrial stress recovery requires mobilization of lipid droplet triacylglycerol stores to facilitate cardiolipin biosynthesis and mitochondrial biogenesis.
www.nature.com
February 17, 2025 at 2:48 PM
💫NEW: @zakbaker.bsky.social, Pagliarini & co show that #mitochondria stress recovery requires mobilization of #LipidDroplet triacylglycerol stores to facilitate #cardiolipin biosynthesis and mitochondrial biogenesis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Very pleased to share our last collaborative publication with Child team #CRCI2NA @inserm.fr @insermgrandouest.bsky.social #cancéropole_Grand_Ouest #Ewing_sarcoma #KCNA2 #Kv1.2 #EWS::FLI1 #YAP/Hippo
biosignaling.biomedcentral.com/articles/10....
biosignaling.biomedcentral.com/articles/10....
Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation - Cell Communication and Signaling
Background Ewing sarcoma (ES), the second main pediatric bone sarcoma, is characterised by a chromosomal translocation leading to the formation of fusion proteins like EWS::FLI1. While several studies...
biosignaling.biomedcentral.com
February 19, 2025 at 9:15 AM
Very pleased to share our last collaborative publication with Child team #CRCI2NA @inserm.fr @insermgrandouest.bsky.social #cancéropole_Grand_Ouest #Ewing_sarcoma #KCNA2 #Kv1.2 #EWS::FLI1 #YAP/Hippo
biosignaling.biomedcentral.com/articles/10....
biosignaling.biomedcentral.com/articles/10....
Reposted by Inserm UMR 1069 N2COx
Reposted by Inserm UMR 1069 N2COx
Our latest paper is out:
Unveiling the Functional Connectivity of Astrocytic Networks with AstroNet
Dive into how our graph reconstruction algorithm, paired with calcium image processing, deciphers astrocytic networks.
👉 doi.org/10.1038/s420...
#Astrocytes #Neuroscience #DataScience #Inserm
Unveiling the Functional Connectivity of Astrocytic Networks with AstroNet
Dive into how our graph reconstruction algorithm, paired with calcium image processing, deciphers astrocytic networks.
👉 doi.org/10.1038/s420...
#Astrocytes #Neuroscience #DataScience #Inserm
January 24, 2025 at 10:30 AM
Our latest paper is out:
Unveiling the Functional Connectivity of Astrocytic Networks with AstroNet
Dive into how our graph reconstruction algorithm, paired with calcium image processing, deciphers astrocytic networks.
👉 doi.org/10.1038/s420...
#Astrocytes #Neuroscience #DataScience #Inserm
Unveiling the Functional Connectivity of Astrocytic Networks with AstroNet
Dive into how our graph reconstruction algorithm, paired with calcium image processing, deciphers astrocytic networks.
👉 doi.org/10.1038/s420...
#Astrocytes #Neuroscience #DataScience #Inserm
Reposted by Inserm UMR 1069 N2COx
#Budget2025. Les universités font face à une crise financière sans précédent !
Université : vivre ou survivre ? Podcast de @franceculture.fr avec Edouard kaminski :
👉 www.radiofrance.fr/francecultur...
Université : vivre ou survivre ? Podcast de @franceculture.fr avec Edouard kaminski :
👉 www.radiofrance.fr/francecultur...
Université : vivre ou survivre ?
Avec près de 80% des universités en déficit, la France a-t-elle laissé tomber l’université ? Reste-t-il des raisons d’espérer pour l’enseignement supérieur public ?
www.radiofrance.fr
January 24, 2025 at 11:04 AM
#Budget2025. Les universités font face à une crise financière sans précédent !
Université : vivre ou survivre ? Podcast de @franceculture.fr avec Edouard kaminski :
👉 www.radiofrance.fr/francecultur...
Université : vivre ou survivre ? Podcast de @franceculture.fr avec Edouard kaminski :
👉 www.radiofrance.fr/francecultur...
Cancers les plus fréquents : le rôle du « gras » dans leur prévention et leur évolution @insermgrandouest.bsky.social
@france.theconversation.com #nutrition #cancer #lipides
#acides-gras #oméga-3
theconversation.com/cancers-les-...
@france.theconversation.com #nutrition #cancer #lipides
#acides-gras #oméga-3
theconversation.com/cancers-les-...
Cancers les plus fréquents : le rôle du « gras » dans leur prévention et leur évolution
Le gras influence certains cancers fréquents. Le rôle préventif des acides gras oméga-3 est bien documenté. Mais l'impact de la graisse en excès dans les situations d'obésité reste mal compris.
theconversation.com
January 24, 2025 at 12:24 PM
Cancers les plus fréquents : le rôle du « gras » dans leur prévention et leur évolution @insermgrandouest.bsky.social
@france.theconversation.com #nutrition #cancer #lipides
#acides-gras #oméga-3
theconversation.com/cancers-les-...
@france.theconversation.com #nutrition #cancer #lipides
#acides-gras #oméga-3
theconversation.com/cancers-les-...
Reposted by Inserm UMR 1069 N2COx
Online now!
Puigserver and team show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components.
👇
www.nature.com/articles/s43...
Puigserver and team show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components.
👇
www.nature.com/articles/s43...
Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity - Nature Cancer
Puigserver and colleagues show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of ...
www.nature.com
January 24, 2025 at 11:02 AM
Online now!
Puigserver and team show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components.
👇
www.nature.com/articles/s43...
Puigserver and team show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components.
👇
www.nature.com/articles/s43...
Reposted by Inserm UMR 1069 N2COx
Reposted by Inserm UMR 1069 N2COx
☣️ 𝗖𝗮𝗻𝗰𝗲𝗿𝘀 𝗱𝘂 𝗽𝗮𝗻𝗰𝗿𝗲́𝗮𝘀 𝗲𝘁 𝗽𝗲𝘀𝘁𝗶𝗰𝗶𝗱𝗲𝘀, 𝘂𝗻𝗲 𝗮𝗹𝗲𝗿𝘁𝗲 𝗲́𝗺𝗲𝗿𝗴𝗲𝗻𝘁𝗲 ? ☣️
Deux études françaises récentes, menées selon deux approches complémentaires par Mathias Brugel et ses collaborateurs, interrogent le rôle des pesticides dans la hausse des cas de cancers du pancréas.
Deux études françaises récentes, menées selon deux approches complémentaires par Mathias Brugel et ses collaborateurs, interrogent le rôle des pesticides dans la hausse des cas de cancers du pancréas.
January 23, 2025 at 8:33 AM
☣️ 𝗖𝗮𝗻𝗰𝗲𝗿𝘀 𝗱𝘂 𝗽𝗮𝗻𝗰𝗿𝗲́𝗮𝘀 𝗲𝘁 𝗽𝗲𝘀𝘁𝗶𝗰𝗶𝗱𝗲𝘀, 𝘂𝗻𝗲 𝗮𝗹𝗲𝗿𝘁𝗲 𝗲́𝗺𝗲𝗿𝗴𝗲𝗻𝘁𝗲 ? ☣️
Deux études françaises récentes, menées selon deux approches complémentaires par Mathias Brugel et ses collaborateurs, interrogent le rôle des pesticides dans la hausse des cas de cancers du pancréas.
Deux études françaises récentes, menées selon deux approches complémentaires par Mathias Brugel et ses collaborateurs, interrogent le rôle des pesticides dans la hausse des cas de cancers du pancréas.
Reposted by Inserm UMR 1069 N2COx
Voici un starter pack pour suivre la recherche en France : instituts, laboratoires, universités et agences.
N'hésitez pas à proposer des comptes à ajouter !
go.bsky.app/JSXcYqn
N'hésitez pas à proposer des comptes à ajouter !
go.bsky.app/JSXcYqn
January 22, 2025 at 3:15 PM
Voici un starter pack pour suivre la recherche en France : instituts, laboratoires, universités et agences.
N'hésitez pas à proposer des comptes à ajouter !
go.bsky.app/JSXcYqn
N'hésitez pas à proposer des comptes à ajouter !
go.bsky.app/JSXcYqn
Our research topics:
#Oncology/Hematological malignancies #lipids #prevention #redox/energy metabolism #Sensitization of tumors to anticancer treatments #biology of cancer cells #ion channels #calcium homeostasis #clinical nutrition #cachexia #mitochondria
www.lestudium-ias.com/regional-eco...
#Oncology/Hematological malignancies #lipids #prevention #redox/energy metabolism #Sensitization of tumors to anticancer treatments #biology of cancer cells #ion channels #calcium homeostasis #clinical nutrition #cachexia #mitochondria
www.lestudium-ias.com/regional-eco...
Niche, Nutrition, Cancer & métabolisme Oxidatif (N2COX) | LE STUDIUM
Notre projet de recherche est celui d’une monoéquipe multidisciplinaire centré sur les lipides agissant dans/sur les niches tumorales, plus particulièrement sur le métabolisme énergétique/oxydatif et ...
www.lestudium-ias.com
January 23, 2025 at 9:50 AM
Our research topics:
#Oncology/Hematological malignancies #lipids #prevention #redox/energy metabolism #Sensitization of tumors to anticancer treatments #biology of cancer cells #ion channels #calcium homeostasis #clinical nutrition #cachexia #mitochondria
www.lestudium-ias.com/regional-eco...
#Oncology/Hematological malignancies #lipids #prevention #redox/energy metabolism #Sensitization of tumors to anticancer treatments #biology of cancer cells #ion channels #calcium homeostasis #clinical nutrition #cachexia #mitochondria
www.lestudium-ias.com/regional-eco...
Reposted by Inserm UMR 1069 N2COx
A cancer cell with three nuclei (cyan) videoed through a microscope. Mitochondria (yellow) and the actin cytoskeleton (red) are also shown. #Science #Biology #CellBiology #microscopy
January 20, 2025 at 1:47 PM
A cancer cell with three nuclei (cyan) videoed through a microscope. Mitochondria (yellow) and the actin cytoskeleton (red) are also shown. #Science #Biology #CellBiology #microscopy
New publication "Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling" @natureportfolio.bsky.social fruitful collaborative project with CRCI2NA @insermgrandouest.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling - Oncogene
Oncogene - Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling
www.nature.com
January 20, 2025 at 2:48 PM
New publication "Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling" @natureportfolio.bsky.social fruitful collaborative project with CRCI2NA @insermgrandouest.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pleased to share our article @insermgrandouest.bsky.social @CHRU Tours @Etablissement Français du Sang
Peripheral blood lactate kinetics may reflect immune cells activation and be useful for bedside monitoring in non-Hodgkin lymphoma
#immunometabolism
onlinelibrary.wiley.com/doi/10.1111/...
Peripheral blood lactate kinetics may reflect immune cells activation and be useful for bedside monitoring in non-Hodgkin lymphoma
#immunometabolism
onlinelibrary.wiley.com/doi/10.1111/...
Glycolytic activity following anti‐CD19 CAR‐T cell infusion in non‐Hodgkin lymphoma
Energy metabolism of chimeric antigen receptor-T cells (CAR-T) activation in humans remains unexplored. As a glycolytic activity surrogate, we investigated the dynamics of peripheral blood (PB) lacta...
onlinelibrary.wiley.com
January 20, 2025 at 2:38 PM
Pleased to share our article @insermgrandouest.bsky.social @CHRU Tours @Etablissement Français du Sang
Peripheral blood lactate kinetics may reflect immune cells activation and be useful for bedside monitoring in non-Hodgkin lymphoma
#immunometabolism
onlinelibrary.wiley.com/doi/10.1111/...
Peripheral blood lactate kinetics may reflect immune cells activation and be useful for bedside monitoring in non-Hodgkin lymphoma
#immunometabolism
onlinelibrary.wiley.com/doi/10.1111/...
Recherche à Tours en Région Centre Val-de-Loire @inserm.fr @insermgrandouest.bsky.social Université de Tours
Sardines, maquereaux et autres poissons gras : contre le cancer, l’intérêt des oméga-3 et lipides du milieu marin theconversation.com/sardines-maq...
#FDS2024
Sardines, maquereaux et autres poissons gras : contre le cancer, l’intérêt des oméga-3 et lipides du milieu marin theconversation.com/sardines-maq...
#FDS2024
Sardines, maquereaux et autres poissons gras : contre le cancer, l’intérêt des oméga-3 et lipides du milieu marin
Les lipides issus du milieu marin se révèlent prometteurs contre les cancers. Soit en prévention à l’image des oméga-3 présents dans certains aliments (sardines, maquereaux…). Soit pour développer des...
theconversation.com
January 20, 2025 at 12:26 PM
Recherche à Tours en Région Centre Val-de-Loire @inserm.fr @insermgrandouest.bsky.social Université de Tours
Sardines, maquereaux et autres poissons gras : contre le cancer, l’intérêt des oméga-3 et lipides du milieu marin theconversation.com/sardines-maq...
#FDS2024
Sardines, maquereaux et autres poissons gras : contre le cancer, l’intérêt des oméga-3 et lipides du milieu marin theconversation.com/sardines-maq...
#FDS2024
Thrilled to share our research "MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development" in @plosbiology.org ! Hard work of Inserm N2COx team in Tours and our collaborators at Inserm MITOVASC team in Angers journals.plos.org/plosbiology/...
January 20, 2025 at 12:21 PM
Thrilled to share our research "MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development" in @plosbiology.org ! Hard work of Inserm N2COx team in Tours and our collaborators at Inserm MITOVASC team in Angers journals.plos.org/plosbiology/...
Save the date !
From June 23 to 26, Ion channel Signaling in Health and Disease conference @insermgrandouest.bsky.social to be held at Château Belmont, Tours. Under the patronage of LE STUDIUM Loire Valley Institute for Advanced Studies
www.lestudium-ias.com/events/ion-c...
From June 23 to 26, Ion channel Signaling in Health and Disease conference @insermgrandouest.bsky.social to be held at Château Belmont, Tours. Under the patronage of LE STUDIUM Loire Valley Institute for Advanced Studies
www.lestudium-ias.com/events/ion-c...
Ion channel signaling in health and disease | LE STUDIUM
Mohamed Trebak, Marie Potier-Cartereau & Chistophe Vandier
www.lestudium-ias.com
January 20, 2025 at 12:14 PM
Save the date !
From June 23 to 26, Ion channel Signaling in Health and Disease conference @insermgrandouest.bsky.social to be held at Château Belmont, Tours. Under the patronage of LE STUDIUM Loire Valley Institute for Advanced Studies
www.lestudium-ias.com/events/ion-c...
From June 23 to 26, Ion channel Signaling in Health and Disease conference @insermgrandouest.bsky.social to be held at Château Belmont, Tours. Under the patronage of LE STUDIUM Loire Valley Institute for Advanced Studies
www.lestudium-ias.com/events/ion-c...
Pleased to share this article on medicinal chemistry @insermgrandouest.bsky.social @inserm.fr Université de Tours www.sciencedirect.com/science/arti...
#inhibitors #tri-heterocyclic #colorectal #cancer !
Thanks to Ligue contre le cancer, Labex SynOrg and @frm-officiel.bsky.social ImPACcell KissF
#inhibitors #tri-heterocyclic #colorectal #cancer !
Thanks to Ligue contre le cancer, Labex SynOrg and @frm-officiel.bsky.social ImPACcell KissF
Synthesis and biological evaluation of new tri-heterocyclic derivatives as anti-colorectal cancer agents
Colorectal cancer is a major health problem, with a poor prognosis if not detected at early stage. It is the third most common cancer worldwide and th…
www.sciencedirect.com
January 20, 2025 at 12:08 PM
Pleased to share this article on medicinal chemistry @insermgrandouest.bsky.social @inserm.fr Université de Tours www.sciencedirect.com/science/arti...
#inhibitors #tri-heterocyclic #colorectal #cancer !
Thanks to Ligue contre le cancer, Labex SynOrg and @frm-officiel.bsky.social ImPACcell KissF
#inhibitors #tri-heterocyclic #colorectal #cancer !
Thanks to Ligue contre le cancer, Labex SynOrg and @frm-officiel.bsky.social ImPACcell KissF