IMPC is currently evaluating its future production and phenotyping priorities. To date, IMPC has focused on protein coding genes with human orthologs and little to no functional annotation, also referred to as “dark genes”. To date, the International Mouse Phenotyping Consortium- IMPC [which includes the NIH-funded Knockout Mouse Phenotyping Program (KOMP2)] has produced knockout mouse lines for 11,208 unique genes and conducted comprehensive phenotyping on 9,774 knockout lines, representing 9,073 genes. All data is accessible at www.mousephenotype.org and mice are available to order from public mouse repositories [e.g., Mutant Mouse Resource and Research Center (MMRRC)]. The purpose of this survey is to ascertain your level of interest and enthusiasm for IMPC to continue its production and phenotyping of knockout mouse lines for the remaining human orthologous genes in the mouse genome. In addition, this survey seeks your input on the scientific value of IMPC producing and phenotyping allele types other than knockouts. As a representative of your field of research, please consider and answer the following 9 questions…think broadly! Thank you for participating in this brief 10 minute survey.

The introduction of a genome browser on the gene and allele pages enables visualisation of how IMPC alleles impact gene models. By default, this tool shows the curated RefSeq gene models, but optional...

Training Workshops

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

The goal of systems biology is to gain a network level understanding of how gene interactions influence biological states, and ultimately inform upon human disease. Given the scale and scope of system...

The MRC National Mouse Genetics Network, in collaboration with the Cancer Research UK (CRUK) Scotland Institute, is organising Organoids Are Us 2025, a symposium that incorporates both basic and clini...

Location: Harwell Campus, Oxfordshire. Vacancy: Administrator - MLC 2617. Closing Date: 08/06/2025, 23:55

The IMPC has significantly impacted the advancement in biomedical research by systematically generating and phenotyping knockout mice for nearly every protein-coding gene. The data IMPC provided has led to major discoveries in gene function, enabled the development of new disease models, and provided an open-access resource that supports translational research and precision medicine.

We’re delighted to announce the upcoming 2025 Virtual IMPC conference:“International Mouse Phenotyping Consortium: Insights from the Past, Shaping the Future”! The virtual conference will take place o...

IMPC is currently evaluating its future production and phenotyping priorities. To date, IMPC has focused on protein coding genes with human orthologs and little to no functional annotation, also refe...

The IMPC has launched Data Release 23! With this release, we’re now providing more than 100 million data points. This release features phenotyping data for 9,277 genes from 9,994 mutant lines, adding ...