Mutant Mouse Resource & Research Centers (MMRRC)
@mmrrc.bsky.social
An NIH-funded consortium, providing a national repository for genetically engineered mouse strains and embryonic stem cell lines. Researchers worldwide can access these high-quality, well-characterized mouse models to advance studies.
Pinned
The FDA has approved Kygevvi (doxecitine + doxribtimine) as the first-ever treatment for Thymidine Kinase 2 Deficiency (TK2d), offering hope to patients with this devastating mitochondrial disease. https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-1st-
November 12, 2025 at 9:48 AM
The FDA has approved Kygevvi (doxecitine + doxribtimine) as the first-ever treatment for Thymidine Kinase 2 Deficiency (TK2d), offering hope to patients with this devastating mitochondrial disease. https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-1st-
Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. https://postly.click/ABY
November 10, 2025 at 1:38 PM
Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. https://postly.click/ABY
James D. Watson, part of the team that uncovered the double-helix structure of DNA in 1953 with Francis Crick, Rosalind Franklin and Maurice Wilkins, has died at 97. His work marked a notable moment in biology.
https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n
https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n
November 7, 2025 at 11:43 PM
James D. Watson, part of the team that uncovered the double-helix structure of DNA in 1953 with Francis Crick, Rosalind Franklin and Maurice Wilkins, has died at 97. His work marked a notable moment in biology.
https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n
https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n
As oocytes grow, H2A.Z shifts from marking active genes to spreading across broader, silent DNA regions, working hand-in-hand with another modification to support healthy meiosis and prepare the egg’s epigenetic blueprint for early embryonic life. .nature.com/articles/s41594-025-01573-xMore Info:
November 7, 2025 at 6:24 PM
As oocytes grow, H2A.Z shifts from marking active genes to spreading across broader, silent DNA regions, working hand-in-hand with another modification to support healthy meiosis and prepare the egg’s epigenetic blueprint for early embryonic life. .nature.com/articles/s41594-025-01573-xMore Info:
IMPC Strategic Conference
‘Insights from the Past, Shaping the Future’
Program and key information
👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/
Free Registration
👉https://tinyurl.com/yz7znkde
‘Insights from the Past, Shaping the Future’
Program and key information
👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/
Free Registration
👉https://tinyurl.com/yz7znkde
October 30, 2025 at 10:04 PM
IMPC Strategic Conference
‘Insights from the Past, Shaping the Future’
Program and key information
👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/
Free Registration
👉https://tinyurl.com/yz7znkde
‘Insights from the Past, Shaping the Future’
Program and key information
👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/
Free Registration
👉https://tinyurl.com/yz7znkde
🎉 Big congrats to Dr. Eric Green for receiving the American Society of Human Genetics Leadership Award — a standing ovation for visionary leadership in genomics! Read About it here: https://www.genengnews.com/topics/omics/eric-green-receives-ashg-leadership-award-to-standing-ovation/
October 22, 2025 at 4:21 PM
🎉 Big congrats to Dr. Eric Green for receiving the American Society of Human Genetics Leadership Award — a standing ovation for visionary leadership in genomics! Read About it here: https://www.genengnews.com/topics/omics/eric-green-receives-ashg-leadership-award-to-standing-ovation/
"Animal models provide insights that alternative approaches can’t. A heated debate about which method is better is distracting researchers from doing good science."
https://EcKc5wILd4%3D
https://EcKc5wILd4%3D
October 20, 2025 at 8:17 PM
"Animal models provide insights that alternative approaches can’t. A heated debate about which method is better is distracting researchers from doing good science."
https://EcKc5wILd4%3D
https://EcKc5wILd4%3D
MMRRC is in Boston at ASHG for the next 3 days - booth 1327! For more info: https://meetings.ashg.org/event/ASHG25/program/schedule
October 15, 2025 at 6:38 PM
MMRRC is in Boston at ASHG for the next 3 days - booth 1327! For more info: https://meetings.ashg.org/event/ASHG25/program/schedule
What Baby KJ’s CRISPR Breakthrough Really Tells Us. Reflections on the balance between hope and realism — new therapies are exciting, but they’re not universal cures yet. Read More: https://www.statnews.com/2025/10/09/crispr-cure-baby-kj-rare-diseases-personalized-gene-editing-drugs/?_hsmi=38470699
October 13, 2025 at 1:18 PM
What Baby KJ’s CRISPR Breakthrough Really Tells Us. Reflections on the balance between hope and realism — new therapies are exciting, but they’re not universal cures yet. Read More: https://www.statnews.com/2025/10/09/crispr-cure-baby-kj-rare-diseases-personalized-gene-editing-drugs/?_hsmi=38470699
Congratulations to Drs. Brunkow, Ramsdell, & Sakaguchi! For More information: https://postly.click/ECH
October 6, 2025 at 5:28 PM
Congratulations to Drs. Brunkow, Ramsdell, & Sakaguchi! For More information: https://postly.click/ECH
“...the first step out of the maze for young men begins by reasserting to them the virtue of hard work — an often grueling but indispensable part of finding the right answers in science.”
Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...
Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...
October 3, 2025 at 6:20 PM
“...the first step out of the maze for young men begins by reasserting to them the virtue of hard work — an often grueling but indispensable part of finding the right answers in science.”
Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...
Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...
Some good research "food for thought... " https://www.nature.com/articles/d41586-025-02920-0?utm_source=Live+Audience&utm_campaign=b2c87a0562-nature-briefing-daily-20250916&utm_medium=email&utm_term=0_-33f35e09ea-49915704
September 18, 2025 at 10:25 PM
🌟 We’re proud to support the Rare Diseases Are Not Rare! Challenge—working together for faster treatments.
With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge
With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge
September 15, 2025 at 11:59 PM
🌟 We’re proud to support the Rare Diseases Are Not Rare! Challenge—working together for faster treatments.
With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge
With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge
We're taking efforts to improve the information of new strains at the MMRRC, with our new Strain Quality Control. To view an example of one, visit this strain: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=75745#gene_info_Strain_Quality_Control
MMRRC:075745-JAX
Strain Detail Sheet for C57BL/6-<i>Clptm1<sup>tm1a(KOMP)Wtsi</i></sup>/AmcrMmjax
www.mmrrc.org
September 2, 2025 at 10:14 PM
We're taking efforts to improve the information of new strains at the MMRRC, with our new Strain Quality Control. To view an example of one, visit this strain: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=75745#gene_info_Strain_Quality_Control
"To be clear, there is no replacement yet for animal research in biomedical science...it remains to be seen how faithfully these [stem cell] reprogrammed cells and organoids mimic various complex biological processes.
July 17, 2025 at 7:01 PM
"To be clear, there is no replacement yet for animal research in biomedical science...it remains to be seen how faithfully these [stem cell] reprogrammed cells and organoids mimic various complex biological processes.
Mice treated with a copper drug repaired faulty brain proteins, reversing Parkinson’s symptoms and offering new hope. Source: https://www.goodnewsnetwork.org/scientists-reverse-parkinsons-symptoms-in-mice-we-were-astonished-by-the-success/
July 7, 2025 at 7:25 PM
Mice treated with a copper drug repaired faulty brain proteins, reversing Parkinson’s symptoms and offering new hope. Source: https://www.goodnewsnetwork.org/scientists-reverse-parkinsons-symptoms-in-mice-we-were-astonished-by-the-success/
What happens when lifesaving research quietly disappears? A look at critical NIH-funded projects lost to sudden budget cuts: projects.propublica.org/nih-cuts-res...
June 13, 2025 at 7:04 PM
What happens when lifesaving research quietly disappears? A look at critical NIH-funded projects lost to sudden budget cuts: projects.propublica.org/nih-cuts-res...
Imagine a future where the smell of menthol could alleviate some of the worst symptoms of Alzheimer’s disease. Read More: https://theconversation.com/when-mice-with-alzheimers-inhaled-menthol-their-cognitive-abilities-improved-230330
May 29, 2025 at 5:27 PM
Imagine a future where the smell of menthol could alleviate some of the worst symptoms of Alzheimer’s disease. Read More: https://theconversation.com/when-mice-with-alzheimers-inhaled-menthol-their-cognitive-abilities-improved-230330
Scientists used gene-edited mice to test a custom therapy for a deadly infant liver disease—then saved a real child! (P.S., A MMRRC Center Director is an author on this paper!) Source: www.nejm.org/doi/full/10....
May 20, 2025 at 9:04 PM
Scientists used gene-edited mice to test a custom therapy for a deadly infant liver disease—then saved a real child! (P.S., A MMRRC Center Director is an author on this paper!) Source: www.nejm.org/doi/full/10....
Food for thought - "There’s no mystery to innovation and economic growth; the US must nurture its scientists or find out the hard way.
May 16, 2025 at 8:16 PM
Food for thought - "There’s no mystery to innovation and economic growth; the US must nurture its scientists or find out the hard way.
Something different: 3D-printing inside a living mouse’s bladder using sound waves! No cuts. Just ultrasound. Curious? Find out in Science: www.science.org/doi/10.1126/...
May 14, 2025 at 7:05 PM
Something different: 3D-printing inside a living mouse’s bladder using sound waves! No cuts. Just ultrasound. Curious? Find out in Science: www.science.org/doi/10.1126/...
Scientists can now guide how cells self-organize using internal forces. Imagine using this to grow tissues in mice faster to test new therapies. Source: journals.aps.org/prl/abstract/10.1103/PhysRevLett.134.148301
May 7, 2025 at 6:37 PM
Scientists can now guide how cells self-organize using internal forces. Imagine using this to grow tissues in mice faster to test new therapies. Source: journals.aps.org/prl/abstract/10.1103/PhysRevLett.134.148301
Mouse studies reveal gut viruses help antibiotics — without them, bacteria resist treatment. 🐭🦠Source: cell.com/cell-host-microbe/abstract/S1931-3128(25)00135-0
April 28, 2025 at 5:01 PM
Mouse studies reveal gut viruses help antibiotics — without them, bacteria resist treatment. 🐭🦠Source: cell.com/cell-host-microbe/abstract/S1931-3128(25)00135-0
Sweden launches PROMISE, a national initiative to integrate large-scale multi-omics data with healthcare and research. By bridging fragmented datasets and improving data access, Sweden aims to unlock the full potential of precision medicine.
April 14, 2025 at 6:15 PM
Sweden launches PROMISE, a national initiative to integrate large-scale multi-omics data with healthcare and research. By bridging fragmented datasets and improving data access, Sweden aims to unlock the full potential of precision medicine.
In an era where chronic illnesses are on the rise and research funding faces unprecedented challenges, the role of the MMRRC has never been more critical.
April 11, 2025 at 6:16 PM
In an era where chronic illnesses are on the rise and research funding faces unprecedented challenges, the role of the MMRRC has never been more critical.