Rob Illingworth
@illingworth-lab.bsky.social
Group leader at the Centre for Regenerative Medicine (IRR), University of Edinburgh. Exploring the epigenetic mechanisms the control neurodevelopment. Scientist, Dad and lover of all things outdoors!
Reposted by Rob Illingworth
Paper accepted!!!!
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
September 23, 2025 at 9:25 PM
Paper accepted!!!!
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
Reposted by Rob Illingworth
Handsup 🙌, who is coming to @blizardinstitute.bsky.social to attend the @illingworth-lab.bsky.social seminar this Friday on "polycomb repression in development and disease"? Also, who is joining online for this @qmulepigenetics.bsky.social seminar.
Our next guest speaker webinar is happening on Friday, September 12th at 15:30 GMT. Robert Illingworth will give a talk on 'Passive Yet Essential, Polycomb Repression in Development and Disease’.
To join, please follow this link: qmul.ac.uk/epigenetics/...
To join, please follow this link: qmul.ac.uk/epigenetics/...
September 9, 2025 at 9:06 AM
Handsup 🙌, who is coming to @blizardinstitute.bsky.social to attend the @illingworth-lab.bsky.social seminar this Friday on "polycomb repression in development and disease"? Also, who is joining online for this @qmulepigenetics.bsky.social seminar.
Reposted by Rob Illingworth
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 2:59 PM
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
Reposted by Rob Illingworth
"Honey, wake up. New CUT protocol just dropped" www.biorxiv.org/content/10.1...
CUT&TIME captures the history of open chromatin in developing neurons
Chromatin structure plays a central role in defining cell identity by regulating gene expression. During development, shifts in chromatin structure facilitate changes in gene expression needed to spec...
www.biorxiv.org
September 1, 2025 at 9:19 AM
"Honey, wake up. New CUT protocol just dropped" www.biorxiv.org/content/10.1...
Reposted by Rob Illingworth
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
NIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusion
Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...
www.biorxiv.org
August 16, 2025 at 3:03 AM
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
Reposted by Rob Illingworth
Our next guest speaker webinar is happening on Friday, September 12th at 15:30 GMT. Robert Illingworth will give a talk on 'Passive Yet Essential, Polycomb Repression in Development and Disease’.
To join, please follow this link: qmul.ac.uk/epigenetics/...
To join, please follow this link: qmul.ac.uk/epigenetics/...
August 15, 2025 at 8:24 AM
Our next guest speaker webinar is happening on Friday, September 12th at 15:30 GMT. Robert Illingworth will give a talk on 'Passive Yet Essential, Polycomb Repression in Development and Disease’.
To join, please follow this link: qmul.ac.uk/epigenetics/...
To join, please follow this link: qmul.ac.uk/epigenetics/...
Terrific to be involved in Edinburgh's 2025 line-up. Thanks to all of the organisers of @pintofscience.uk and the Monkey Barrel for making this such a great event.
Last night's Pint of Science featured Dr Reynolds-Wright discussing male contraception, while Simran Kapoor explored the role of mast cells in immune responses. At the Monkey Barrel, Dr Illingworth focused on epigenetics & brain development. #pint25 @pintofscience.uk🍺 🧠
📰 edin.ac/3H1qnE1...
📰 edin.ac/3H1qnE1...
August 10, 2025 at 11:52 AM
Terrific to be involved in Edinburgh's 2025 line-up. Thanks to all of the organisers of @pintofscience.uk and the Monkey Barrel for making this such a great event.
Reposted by Rob Illingworth
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
August 7, 2025 at 4:20 PM
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
Reposted by Rob Illingworth
☣️🐀 Pesticide exposure in rats changes epigenetic signatures in different brain regions!
Latest paper from our fruitful collaboration with Emily Rocha and Tim Greenamyre, linking epigenetic signatures of exposure to toxicants to Parkinson's disease:
www.nature.com/articles/s41...
Latest paper from our fruitful collaboration with Emily Rocha and Tim Greenamyre, linking epigenetic signatures of exposure to toxicants to Parkinson's disease:
www.nature.com/articles/s41...
Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model - npj Parkinson's Disease
npj Parkinson's Disease - Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model
www.nature.com
July 24, 2025 at 10:57 AM
☣️🐀 Pesticide exposure in rats changes epigenetic signatures in different brain regions!
Latest paper from our fruitful collaboration with Emily Rocha and Tim Greenamyre, linking epigenetic signatures of exposure to toxicants to Parkinson's disease:
www.nature.com/articles/s41...
Latest paper from our fruitful collaboration with Emily Rocha and Tim Greenamyre, linking epigenetic signatures of exposure to toxicants to Parkinson's disease:
www.nature.com/articles/s41...
Reposted by Rob Illingworth
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 23, 2025 at 11:38 PM
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to share our hot-off-the-press @biorxivpreprint.bsky.social
that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬
www.biorxiv.org/content/10.1...
that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬
www.biorxiv.org/content/10.1...
H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain
The PRC1 complex regulates developmental gene expression in mammals by ubiquitinating histones (H2AK119ub) and nucleating repressive chromatin interactions. Human genetic data and functional experimen...
www.biorxiv.org
July 12, 2025 at 12:50 AM
Excited to share our hot-off-the-press @biorxivpreprint.bsky.social
that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬
www.biorxiv.org/content/10.1...
that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬
www.biorxiv.org/content/10.1...