IgnatovaLab
@ignatovalab.bsky.social
A lab of #RNA lovers, obsessed with #tRNA, #mRNA, #ribosomes, and #translational control in health and disease.
What a beatiful study: GCN2 is activated by ribosome collisions
Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling
During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...
www.science.org
October 4, 2025 at 8:58 PM
What a beatiful study: GCN2 is activated by ribosome collisions
Reposted by IgnatovaLab
Reposted by IgnatovaLab
Thrilled to announce our #preprint on a new factor in the last line of defense in #translation quality control out on #bioRXiv! Spearheaded by fantastic PhD student @kaushikiyer.bsky.social, supported by Chloé Walter, Alina Kraft, Max Müller and Lena Tittel.
Jlp2 is an RQC complex-independent release factor acting on aberrant peptidyl-tRNA, protecting cells against translation elongation stress https://www.biorxiv.org/content/10.1101/2025.09.04.673968v1
September 9, 2025 at 6:17 PM
Thrilled to announce our #preprint on a new factor in the last line of defense in #translation quality control out on #bioRXiv! Spearheaded by fantastic PhD student @kaushikiyer.bsky.social, supported by Chloé Walter, Alina Kraft, Max Müller and Lena Tittel.
Reposted by IgnatovaLab
Deep generative models design mRNA sequences with enhanced translational capacity and stability. #Science
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Deep generative models design mRNA sequences with enhanced translational capacity and stability
Despite the success of mRNA COVID-19 vaccines, extending this modality to more diseases necessitates substantial enhancements. We present GEMORNA, a generative RNA model that utilizes Transformer arch...
www.science.org
September 8, 2025 at 5:10 PM
Deep generative models design mRNA sequences with enhanced translational capacity and stability. #Science
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by IgnatovaLab
New Banksy artwork appears on court building showing judge attacking protester
New Banksy artwork appears on court building showing judge attacking protester
Banksy's mural shows a protester on the ground holding a blood-spattered placard, while the judge, in a wig and gown, looms over them wielding a gavel.
news.sky.com
September 8, 2025 at 5:47 PM
New Banksy artwork appears on court building showing judge attacking protester
A new review on suppressor-tRNA therapies, we wrote with Suki Albers 👇🏻
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Suppressor tRNAs as personalized therapy for nonsense mutation-associated pathologies
Nonsense mutations – associated with many devastating genetic disorders that currently lack effective treatments – prematurely terminate protein synth…
www.sciencedirect.com
August 28, 2025 at 9:01 PM
A new review on suppressor-tRNA therapies, we wrote with Suki Albers 👇🏻
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by IgnatovaLab
Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...
June 19, 2025 at 7:32 AM
Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...
Reposted by IgnatovaLab
Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org: www.embopress.org/doi/full/10....
August 26, 2025 at 11:00 AM
Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org: www.embopress.org/doi/full/10....
Reposted by IgnatovaLab
I am excited to share the second half of my postdoctoral work in the Yeo lab at UCSD! We found that neuronal aging leads to the accumulation of mitochondrial double-stranded RNA, which triggers the chronic stress response. 1/ www.biorxiv.org/content/10.1...
August 5, 2025 at 5:16 PM
I am excited to share the second half of my postdoctoral work in the Yeo lab at UCSD! We found that neuronal aging leads to the accumulation of mitochondrial double-stranded RNA, which triggers the chronic stress response. 1/ www.biorxiv.org/content/10.1...
Reposted by IgnatovaLab
Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions
rdcu.be/ezlhg
rdcu.be/ezlhg
A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies
Nature Communications - Here, the authors present a method to rapidly isolate actively translating ribosomes in a time- and cost-effective manner using poly-lysine. The method is compatible with a...
rdcu.be
August 5, 2025 at 1:19 PM
Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions
rdcu.be/ezlhg
rdcu.be/ezlhg
Reposted by IgnatovaLab
Die #Exzellenzcluster stehen fest: Heute hat die Exzellenzkommission 70 Projekte zur Förderung ausgewählt. 45 Cluster werden fortgesetzt, 25 neu eingerichtet. Die Förderung beginnt ab 1. Jan. 2026 für 7 Jahre, die Fördersumme beträgt insg. 539 Mio. €/Jahr. Die Liste: www.dfg.de/resource/blo... 1/3
May 22, 2025 at 3:05 PM
Die #Exzellenzcluster stehen fest: Heute hat die Exzellenzkommission 70 Projekte zur Förderung ausgewählt. 45 Cluster werden fortgesetzt, 25 neu eingerichtet. Die Förderung beginnt ab 1. Jan. 2026 für 7 Jahre, die Fördersumme beträgt insg. 539 Mio. €/Jahr. Die Liste: www.dfg.de/resource/blo... 1/3
Delighted to share our newest publication - beautiful collaboration with Ya-Ming Hou’s lab. If you wonder whether bacterial mRNAs contain m6A (yes they do) and whether it matters (does not seem to) look here 👇🏻
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
m6A modification is incorporated into bacterial mRNA without specific functional benefit
Abstract. N6-Methyladenosine (m6A), the most abundant modification in eukaryotic messenger RNAs (mRNAs), has also been found at a low level in bacterial mR
academic.oup.com
May 22, 2025 at 8:50 PM
Delighted to share our newest publication - beautiful collaboration with Ya-Ming Hou’s lab. If you wonder whether bacterial mRNAs contain m6A (yes they do) and whether it matters (does not seem to) look here 👇🏻
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Reposted by IgnatovaLab
EMBO is #hiring a Scientific Editor (Absence cover) to join @emboreports.org. Apply by 8 June: buff.ly/seVUgYW 🧪
Scientific Editor (Absence cover) – EMBO
About us EMBO is a not-for-profit organization dedicated to promoting excellence in the life sciences in Europe and beyond. We fund talented researchers at all career stages, facilitate scientific…
buff.ly
May 16, 2025 at 9:06 AM
EMBO is #hiring a Scientific Editor (Absence cover) to join @emboreports.org. Apply by 8 June: buff.ly/seVUgYW 🧪
Reposted by IgnatovaLab
Mammalian cells eliminate nascent chains stalled during co-translational protein translocation by activating a ribosome UFMylation-dependent TAQC process at the ER. Ennis, Wang, Ye et al. establish a role for NEMF-mediated CAT tailing in TAQC. rupress.org/jcb/article/...
#ER_literature
#ER_literature
April 22, 2025 at 3:16 PM
Mammalian cells eliminate nascent chains stalled during co-translational protein translocation by activating a ribosome UFMylation-dependent TAQC process at the ER. Ennis, Wang, Ye et al. establish a role for NEMF-mediated CAT tailing in TAQC. rupress.org/jcb/article/...
#ER_literature
#ER_literature
Cells are swapping mitochondria. Wondering whether they also swap much smaller cellular entities, e.g. ribosomes?
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Cells are swapping their mitochondria. What does this mean for our health?
Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
www.nature.com
April 19, 2025 at 12:27 PM
Cells are swapping mitochondria. Wondering whether they also swap much smaller cellular entities, e.g. ribosomes?
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by IgnatovaLab
Very compelling study showing the association between herpes zoster vaccination and dementia prevention. The authors leveraged a unique cohort for this natural experiment which shows a reduction in dementia risk of 20% in vaccinated individuals. #MedSky #IDSky 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...
www.nature.com
April 2, 2025 at 5:49 PM
Very compelling study showing the association between herpes zoster vaccination and dementia prevention. The authors leveraged a unique cohort for this natural experiment which shows a reduction in dementia risk of 20% in vaccinated individuals. #MedSky #IDSky 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by IgnatovaLab
The CRC1678 is offering medical research fellowships for medical students! Conduct cutting-edge research & transition into a doctoral thesis under the mentorship of esteemed CRC1678 project leaders like @muellerrom.bsky.social Apply now! Find both calls 👉 uni.koeln/MUMFG
#MedicalResearch #Fellowship
#MedicalResearch #Fellowship
March 27, 2025 at 10:33 AM
The CRC1678 is offering medical research fellowships for medical students! Conduct cutting-edge research & transition into a doctoral thesis under the mentorship of esteemed CRC1678 project leaders like @muellerrom.bsky.social Apply now! Find both calls 👉 uni.koeln/MUMFG
#MedicalResearch #Fellowship
#MedicalResearch #Fellowship
Reposted by IgnatovaLab
“The most fundamental resource for progress in science is not the technologies or the buildings. It’s all the good people who do it,“ says former NIH director Francis Collins. “They are all of you who are here today to declare your support for this noble human enterprise.”
March 7, 2025 at 8:00 PM
“The most fundamental resource for progress in science is not the technologies or the buildings. It’s all the good people who do it,“ says former NIH director Francis Collins. “They are all of you who are here today to declare your support for this noble human enterprise.”
Reposted by IgnatovaLab
Retracted papers had a higher number of self-citations and higher co-authorship numbers - clearly not a causation, but an interesting correlation.
More than 8,000 of the world’s most-cited scientists have at least one retraction
https://go.nature.com/3WFabgy
https://go.nature.com/3WFabgy
Thousands of highly cited scientists have at least one retraction
Database shows that researchers with retracted papers had higher self-citation rates and published more than those without retractions.
go.nature.com
January 31, 2025 at 3:28 PM
Retracted papers had a higher number of self-citations and higher co-authorship numbers - clearly not a causation, but an interesting correlation.