Ilaria Bellantuono
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ibellantuono.bsky.social
Ilaria Bellantuono
@ibellantuono.bsky.social
38 followers 65 following 11 posts
Geroscientist interested in healthspan, frailty, multimorbidity
Posts Replies Media Videos
Reposted by Ilaria Bellantuono
americanaging.bsky.social
New NIH research shows even 15 minutes of brisk walking a day can reduce risks of multiple age-related diseases in adults 60+.
pubmed.ncbi.nlm.nih.gov/29402653/

At AGE, we’re committed to advancing science that extends healthspan.

#HealthyAging #Healthspan
November 18, 2025 at 10:46 PM
ibellantuono.bsky.social
Even if the message try to be positive I am not sure there is much reason to be onlinelibrary.wiley.com/doi/full/10....
Rapamycin Does Not Compromise Exercise‐Induced Muscular Adaptations in Female Mice
Rapamycin is largely compatible with the physical and skeletal muscle benefits of progressive weighted wheel running (PoWeR). The detrimental effects of rapamycin on glucose metabolism in the context...
onlinelibrary.wiley.com
October 9, 2025 at 9:49 AM
ibellantuono.bsky.social
This is the first evidence I see that accelerated biological ageing increased risk of multimorbidity doi.org/10.1111/acel...
The Association Between Accelerated Biological Aging and the Physical, Psychological, and Cognitive Multimorbidity and Life Expectancy: Cohort Study
Accelerated biological aging (KDM-BA/PhenoAge) predicts higher multimorbidity risks and 5.3–7.0 life-years lost in 332,012 UK adults. Those with accelerated aging face 12%–37% increased transition ri...
doi.org
September 11, 2025 at 9:51 AM
Reposted by Ilaria Bellantuono
vivensa.bsky.social
In case you missed our news yesterday...we have funded five places for our Academy members on Zinc's upcoming Inflection Fellowship Programme for mid-career professionals. More info here: vivensafoundation.org.uk/news/five-fu...
#midcareeropportunity #FundingForAgeingWell
August 7, 2025 at 9:29 AM
Reposted by Ilaria Bellantuono
medicine.stitches.today
Education boosts memory and brain volume in aging but doesn't shield against cognitive decline, suggesting early-life factors are key.

by Fjell AM, Rogeberg O (...) Vidal-Piñeiro D et 20 al. in Nat Med #MedSky

👉 get more here

📖 read the article:
Reevaluating the role of education on cognitive decline and brain aging in longitudinal cohorts across 33 Western countries - Nature Medicine
In a large cross-national study, education was linked to better memory and larger brain volumes but not to slower cognitive or brain decline with age, suggesting that the association reflects early-life factors rather than neuroprotective effects in aging.
www.nature.com
August 6, 2025 at 4:45 PM
Reposted by Ilaria Bellantuono
nature.com
Nature research paper: Lithium deficiency and the onset of Alzheimer’s disease

go.nature.com/4ftdsb2
Lithium deficiency and the onset of Alzheimer’s disease - Nature
Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.
go.nature.com
August 6, 2025 at 5:08 PM
Reposted by Ilaria Bellantuono
labwaggoner.bsky.social
TERT (telomerase) can regulate physiological levels of inflammatory signals independently of its catalytic functions
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 6, 2025 at 5:24 PM
Reposted by Ilaria Bellantuono
erictopol.bsky.social
A wearable sensor that measures multiple hormones simultaneously in sweat to provide continuous real-time metrics and dynamics of stress
www.science.org/doi/10.1126/...
Stressomic: A wearable microfluidic biosensor for dynamic profiling of multiple stress hormones in sweat
A wearable sensor enables dynamic and noninvasive monitoring of multiple stress hormones to personalize stress management.
www.science.org
August 6, 2025 at 6:10 PM
Reposted by Ilaria Bellantuono
lamminglab.bsky.social
"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...
Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease - Nature Communications
Caloric restriction improves Alzheimer’s Disease outcomes in mice, but this diet not only reduces calories, but imposes a prolonged fast between meals. Here, the authors show this fast is essential to...
www.nature.com
August 4, 2025 at 7:27 PM
Reposted by Ilaria Bellantuono
erictopol.bsky.social
Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...
Low-dose metformin requires brain Rap1 for its antidiabetic action
Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.
www.science.org
July 31, 2025 at 6:52 PM
Reposted by Ilaria Bellantuono
macesari.bsky.social
Break the selective silence on the #genocide in #Gaza.

"...Silence is not an option..."

#Palestine #EthnicCleansing #Israel #Humanitarian

www.thelancet.com/journals/lan...
Break the selective silence on the genocide in Gaza
Substantial and well-documented evidence indicates a catastrophic public health emergency in Gaza (appendix pp 1–5), marked by severe food insecurity and alarming levels of malnutrition-related deaths...
www.thelancet.com
July 31, 2025 at 2:02 PM
Reposted by Ilaria Bellantuono
erictopol.bsky.social
A Swedish cohort with long term follow-up once again highlights the link between diet and chronic diseases in older adults
www.nature.com/articles/s43...
Dietary patterns and accelerated multimorbidity in older adults - Nature Aging
In a Swedish cohort, Abbad-Gomez et al. report that diet quality is inversely associated with the rate of accumulation of total, cardiovascular and neuropsychiatric chronic diseases in older adults, s...
www.nature.com
July 28, 2025 at 7:50 PM
ibellantuono.bsky.social
Happy to share our response to the cancellation of the UK’s Medicines repurposing programme and the implication for geroscience www.thelancet.com/journals/lan... @nikrat.bsky.social
A geroscience response to cancellation of the UK’s Medicines Repurposing Programme: challenges and opportunities
After just 4 years of operation, the discontinuation of the UK’s Medicines Repurposing Programme in April, 2025,1 marks a concerning shift in drug development—particularly for geroscience. The program...
www.thelancet.com
July 28, 2025 at 8:19 PM
Reposted by Ilaria Bellantuono
narita-lab.bsky.social
Spread the news! We are excited to expand our research team, working on cellular senescence, at the Cancer Research UK Cambridge Institute, University of Cambridge.

jobs.cam.ac.uk/job/52026/
jobs.cam.ac.uk/job/52027/
a yellow sign that says we 're hiring
ALT: a yellow sign that says we 're hiring
media.tenor.com
July 25, 2025 at 10:06 PM
Reposted by Ilaria Bellantuono
nature.com
An analysis of how various tissues age is the latest to suggest that ageing does not march to a steady beat.

go.nature.com/4lVWZ1t
Ageing accelerates around age 50 ― some organs faster than others
An analysis of how various tissues age is the latest to suggest that ageing does not march to a steady beat.
go.nature.com
July 25, 2025 at 3:35 PM
Reposted by Ilaria Bellantuono
erictopol.bsky.social
The human proteome and organ age clocks across the lifespan, a tour de force report @cellpress.bsky.social
www.cell.com/cell/abstrac...
Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures
A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying circulating senoproteins co...
www.cell.com
July 25, 2025 at 2:51 PM
Reposted by Ilaria Bellantuono
erictopol.bsky.social
What's the optimal number of steps of physical activity this is associated with multiple (9) favorable outcomes?
The largest, systematic review of 57 studies, 35 cohorts.
7,000 steps is clinically meaningful, benefit also seen for 4,000 steps cf 2,000 steps
thelancet.com/journals/lan...
Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis
Although 10 000 steps per day can still be a viable target for those who are more active, 7000 steps per day is associated with clinically meaningful improvements in health outcomes and might be a mor...
thelancet.com
July 23, 2025 at 10:34 PM
ibellantuono.bsky.social
This is not surprising considering previous studies in mice. The real worry is that this is not just confined to the brain and we are heading for a sharp increase in #multimorbidity and #frailty in 10-15 years in a much younger population for which we are unprepared www.nature.com/articles/s41...
Accelerated brain ageing during the COVID-19 pandemic - Nature Communications
This study shows that the COVID-19 pandemic accelerated brain ageing in UK adults, even without infection. The effect was stronger in older individuals, in men, and those from deprived backgrounds. Co...
www.nature.com
July 22, 2025 at 10:53 PM
Reposted by Ilaria Bellantuono
nature.com
A sugary diet in early life rewires the brains of mice, affecting their learning as adults

go.nature.com/4lAjFnZ
How sugar overload in early life affects the brain later
A study in mice finds that a high-sucrose diet during youth has long-term implications for learning and brain connectivity.
go.nature.com
July 17, 2025 at 4:07 PM
Reposted by Ilaria Bellantuono
erictopol.bsky.social
A gut microbiome metabolite promotes atherosclerosis by hijacking the immune system
@nature.com
nature.com/articles/s41...
www.nature.com/articles/d41...
July 16, 2025 at 3:59 PM
Reposted by Ilaria Bellantuono
nature.com
Social inequality and weak democratic institutions are linked to faster ageing

go.nature.com/44KplEp
Why do ageing rates vary by country? Massive study says politics play a part
Social inequality and the decay of democratic institutions are linked to accelerated ageing — but education seems to slow the process.
go.nature.com
July 14, 2025 at 4:38 PM
Reposted by Ilaria Bellantuono
macesari.bsky.social
Chiediamo la Nomina di Francesca #Albanese al Premio #Nobel per la #Pace

#Genocidio #Israele #Palestina #PuliziaEtnica

chng.it/Dq5NH4sj6D
Firma la petizione
Chiediamo la Nomina di Francesca Albanese al Premio Nobel per la Pace
chng.it
July 13, 2025 at 11:51 AM
Reposted by Ilaria Bellantuono
nature.com
Exercise helps the immune system to fight tumours by stimulating microbes in the gut to make a compound known as formate

go.nature.com/4lIZx2m
Workouts can help gut microbes to quell cancer
Mice that exercised produced higher levels of an immune-cell-stimulating molecule than sedentary rodents did.
go.nature.com
July 10, 2025 at 9:09 AM
Reposted by Ilaria Bellantuono
erictopol.bsky.social
On the first report of estrogen slowing the pace of aging of the immune system, with the background of flawed and misinterpreted clinical trials of hormone replacement therapy
erictopol.substack.com/p/new-anti-a...
New Anti-Aging Evidence For Estrogen
Organ Clocks Add to the Benefits of Replacement After Menopause
erictopol.substack.com
July 7, 2025 at 1:57 PM
Reposted by Ilaria Bellantuono
erictopol.bsky.social
Can senolytics reverse or slow aging?
Table of companies pursuing this goal.
So far the results are questionable.
@natbiotech.nature.com
www.nature.com/articles/s41...
July 6, 2025 at 6:41 PM