Marshall G Hussain Shuler Lab
@hushulab.bsky.social
Hopkins | Kavli NDI
Temporal Decision Making, Neural representations of time, timing, and time evolving value
https://sites.google.com/site/marshallshuler/
Kurt Golcuk, Elissa Sutlief, Charlie Walters, Rebekah Zhang, Shichen Zhang, Ziyi Guo, Jiayi Chen
Temporal Decision Making, Neural representations of time, timing, and time evolving value
https://sites.google.com/site/marshallshuler/
Kurt Golcuk, Elissa Sutlief, Charlie Walters, Rebekah Zhang, Shichen Zhang, Ziyi Guo, Jiayi Chen
Reposted by Marshall G Hussain Shuler Lab
JL found that OFC neurons are tuned to uncertainty (probabilistic outcomes) during learning and M2 neurons signal certainty instead. Miniscope imaging in rats 🐀 and causal chemogenetic experiments tell the same story. DREADDs experiments by amazing RA @alexyeghikian.bsky.social
October 8, 2025 at 1:20 PM
JL found that OFC neurons are tuned to uncertainty (probabilistic outcomes) during learning and M2 neurons signal certainty instead. Miniscope imaging in rats 🐀 and causal chemogenetic experiments tell the same story. DREADDs experiments by amazing RA @alexyeghikian.bsky.social
Reposted by Marshall G Hussain Shuler Lab
We are grateful 🙏🏽 to have our NIDA and NIMH funds unfrozen at UCLA! These grants support this ongoing work and exciting new directions.
October 8, 2025 at 1:31 PM
We are grateful 🙏🏽 to have our NIDA and NIMH funds unfrozen at UCLA! These grants support this ongoing work and exciting new directions.
Reposted by Marshall G Hussain Shuler Lab
🎇 Excited to finally share JL Romero Sosa’s publication! Results are from single-cell imaging in different subregions of rat frontal cortex during ✨de novo learning. Spoiler: everything is not everywhere all at once www.nature.com/articles/s41...
Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex - Nature Communications
Neural mechanisms underlying flexible learning and decision-making are not fully understood. Using single-cell calcium imaging, authors here found that neurons in orbitofrontal and secondary motor cortex exhibit complementary roles in reward learning, with neurons in the former exerting a sustained role in conditions of uncertainty.
www.nature.com
October 8, 2025 at 12:33 PM
🎇 Excited to finally share JL Romero Sosa’s publication! Results are from single-cell imaging in different subregions of rat frontal cortex during ✨de novo learning. Spoiler: everything is not everywhere all at once www.nature.com/articles/s41...
Reposted by Marshall G Hussain Shuler Lab
There is now strong, converging evidence that OFC neurons signal expected uncertainty. We manipulated probabilistic outcomes, and Zhang & Zhou changed reward delay and magnitude, finding OFC neurons dynamically modulate outcome-coding sensitivity based on variance www.science.org/doi/10.1126/...
🎇 Excited to finally share JL Romero Sosa’s publication! Results are from single-cell imaging in different subregions of rat frontal cortex during ✨de novo learning. Spoiler: everything is not everywhere all at once www.nature.com/articles/s41...
Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex - Nature Communications
Neural mechanisms underlying flexible learning and decision-making are not fully understood. Using single-cell calcium imaging, authors here found that neurons in orbitofrontal and secondary motor cortex exhibit complementary roles in reward learning, with neurons in the former exerting a sustained role in conditions of uncertainty.
www.nature.com
October 14, 2025 at 3:00 PM
There is now strong, converging evidence that OFC neurons signal expected uncertainty. We manipulated probabilistic outcomes, and Zhang & Zhou changed reward delay and magnitude, finding OFC neurons dynamically modulate outcome-coding sensitivity based on variance www.science.org/doi/10.1126/...
Reposted by Marshall G Hussain Shuler Lab
Excited to share our new preprint from my graduate work, a collaboration between the Brown lab and @srirams433.bsky.social and others in the Kolodkin lab! Our study investigated how patterned excitatory connectivity is generated in the development of the cerebral cortex (1/7)
Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex
The function of mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections. A subtype of excitatory neurons, layer 6 c...
www.biorxiv.org
August 19, 2025 at 4:22 PM
Excited to share our new preprint from my graduate work, a collaboration between the Brown lab and @srirams433.bsky.social and others in the Kolodkin lab! Our study investigated how patterned excitatory connectivity is generated in the development of the cerebral cortex (1/7)
Reposted by Marshall G Hussain Shuler Lab
Attractors are usually not mechanisms - new blog post: open.substack.com/pub/kording/...
Attractors are usually not mechanisms
The mathematical objects can not be. And the "attractor models" have not been established as mechanisms in mammals
open.substack.com
July 8, 2025 at 2:40 PM
Attractors are usually not mechanisms - new blog post: open.substack.com/pub/kording/...
Reposted by Marshall G Hussain Shuler Lab
If you're interested in moving to Montreal for a postdoc in #NeuroAI or related topics, check out this scholarship opportunity at @fasudem.bsky.social : fas.umontreal.ca/postdoctoral...
And let me know if you'd like to chat about it.
And let me know if you'd like to chat about it.
Postdoctoral training
The Faculty of Arts and Science of the Université de Montréal, thanks to a generous donation from the Courtois Foundation, is pleased to launch the Courtois Scientific Vanguard Fund of the Faculty of Arts and Science, aimed at research talents working outside of Canada.
fas.umontreal.ca
June 26, 2025 at 8:18 PM
If you're interested in moving to Montreal for a postdoc in #NeuroAI or related topics, check out this scholarship opportunity at @fasudem.bsky.social : fas.umontreal.ca/postdoctoral...
And let me know if you'd like to chat about it.
And let me know if you'd like to chat about it.
Reposted by Marshall G Hussain Shuler Lab
It's not just #NIH. It's not just #NSF. It's not just #NASA.
The whole scientific community has to make clear that all science across fed agencies is being destroyed in the US.
We can't just ask for our particular piece of the pie. The whole pie is being thrown out - saving your bit won't work.
The whole scientific community has to make clear that all science across fed agencies is being destroyed in the US.
We can't just ask for our particular piece of the pie. The whole pie is being thrown out - saving your bit won't work.
June 25, 2025 at 2:11 PM
Reposted by Marshall G Hussain Shuler Lab
NEW: NSF will be kicked out of their building. Announcement will be made tomorrow by HUD Sec. and Governor of VA. HUD will take over the NSF building over the next two years.
NSF staffer: "There is no planning for NSF, no identified future location, appropriation for a new building or a move."
NSF staffer: "There is no planning for NSF, no identified future location, appropriation for a new building or a move."
June 24, 2025 at 10:20 PM
NEW: NSF will be kicked out of their building. Announcement will be made tomorrow by HUD Sec. and Governor of VA. HUD will take over the NSF building over the next two years.
NSF staffer: "There is no planning for NSF, no identified future location, appropriation for a new building or a move."
NSF staffer: "There is no planning for NSF, no identified future location, appropriation for a new building or a move."
Reposted by Marshall G Hussain Shuler Lab
BREAKING: A federal judge has ordered the Trump administration to restore millions of dollars in canceled grants to University of California researchers, calling the terminations flagrantly illegal and unconstitutional. storage.courtlistener.com/recap/gov.us...
June 24, 2025 at 1:07 AM
BREAKING: A federal judge has ordered the Trump administration to restore millions of dollars in canceled grants to University of California researchers, calling the terminations flagrantly illegal and unconstitutional. storage.courtlistener.com/recap/gov.us...
Reposted by Marshall G Hussain Shuler Lab
Joined #BaltimorePride50 last week to celebrate #PrideMonth and the idea that everyone must be free to be who they are and love who they love.
I stand with the LGBTQ community in face of attacks from Trump and his cronies. Bullies only succeed when others retreat. We will not.
I stand with the LGBTQ community in face of attacks from Trump and his cronies. Bullies only succeed when others retreat. We will not.
Celebrating Pride in Baltimore
YouTube video by Senator Chris Van Hollen
youtube.com
June 21, 2025 at 9:50 PM
Joined #BaltimorePride50 last week to celebrate #PrideMonth and the idea that everyone must be free to be who they are and love who they love.
I stand with the LGBTQ community in face of attacks from Trump and his cronies. Bullies only succeed when others retreat. We will not.
I stand with the LGBTQ community in face of attacks from Trump and his cronies. Bullies only succeed when others retreat. We will not.
Reposted by Marshall G Hussain Shuler Lab
Important update about local impacts of funding cuts.
Depressing but compelling...
Thanks to @joshuasweitz.bsky.social and his team for putting this together.
scienceimpacts.org
Depressing but compelling...
Thanks to @joshuasweitz.bsky.social and his team for putting this together.
scienceimpacts.org
SCIMaP - Impacts of Federal Cuts to Science and Medical Research
Developed by an interdisciplinary research team, this website shows how funding cuts reduce economic activity and employment nationwide
scienceimpacts.org
June 19, 2025 at 8:29 PM
Important update about local impacts of funding cuts.
Depressing but compelling...
Thanks to @joshuasweitz.bsky.social and his team for putting this together.
scienceimpacts.org
Depressing but compelling...
Thanks to @joshuasweitz.bsky.social and his team for putting this together.
scienceimpacts.org
Great opportunity here-check it!
Reposting this as a reminder that we have an open Research Assistant position - appreciate reposts and passing along to colleagues who may know people who are interested!
Details and link to apply are in the second post!
Details and link to apply are in the second post!
New posting for a Research Assistant in our division. Ideal position for recent graduate looking for experience in molecular neurobiology and microscopy. Team-oriented environment working across projects generating spatial transcriptomics data in human 🧠 tissue and human-derived neuronal cell models
June 16, 2025 at 6:55 PM
Great opportunity here-check it!
Reposted by Marshall G Hussain Shuler Lab
Neuronal computation in the cerebellum via a vector calculus.
Work of Mohammad Amin Fakharian, Alden Shoup, Paul Hage, and Hisham Elseweifi
www.science.org/doi/10.1126/...
Work of Mohammad Amin Fakharian, Alden Shoup, Paul Hage, and Hisham Elseweifi
www.science.org/doi/10.1126/...
A vector calculus for neural computation in the cerebellum
Null space theory predicts that neurons generate spikes not only to produce behavior but also to prevent the undesirable effect of other neurons on behavior. In this work, we show that this competitiv...
www.science.org
May 22, 2025 at 6:56 PM
Neuronal computation in the cerebellum via a vector calculus.
Work of Mohammad Amin Fakharian, Alden Shoup, Paul Hage, and Hisham Elseweifi
www.science.org/doi/10.1126/...
Work of Mohammad Amin Fakharian, Alden Shoup, Paul Hage, and Hisham Elseweifi
www.science.org/doi/10.1126/...
Reposted by Marshall G Hussain Shuler Lab
🚨MAJOR BREAKING: The Canada PM had enough of Trump blabbering bullshit and just cut short the press conference.
I don’t blame him.
I don’t blame him.
June 16, 2025 at 5:41 PM
🚨MAJOR BREAKING: The Canada PM had enough of Trump blabbering bullshit and just cut short the press conference.
I don’t blame him.
I don’t blame him.
Reposted by Marshall G Hussain Shuler Lab
“The university is totally keeping us on life support,” said Dr. Daniela Matei, a Northwestern oncologist. “The big question is for how long they can do this.”
www.wsj.com/us-news/educ...
www.wsj.com/us-news/educ...
How Trump Blew Up Northwestern’s Business Model
The federal government froze the university’s research funding. It hasn’t offered the school a way to get it back.
www.wsj.com
June 16, 2025 at 12:38 PM
“The university is totally keeping us on life support,” said Dr. Daniela Matei, a Northwestern oncologist. “The big question is for how long they can do this.”
www.wsj.com/us-news/educ...
www.wsj.com/us-news/educ...
Reposted by Marshall G Hussain Shuler Lab
SEN. PADILLA: “Saying I lunged is a lie, but that’s par for the course for this administration… I was behind the cameras listening, and at a certain point hearing Noem say they had to rescue LA from the Governor and Mayor was too much to take. So I raise my voice to ask a question.”
June 12, 2025 at 11:35 PM
SEN. PADILLA: “Saying I lunged is a lie, but that’s par for the course for this administration… I was behind the cameras listening, and at a certain point hearing Noem say they had to rescue LA from the Governor and Mayor was too much to take. So I raise my voice to ask a question.”
Reposted by Marshall G Hussain Shuler Lab
BREAKING: Judge Breyer orders Trump to return control of the National Guard back to California, saying the call-up was illegal. storage.courtlistener.com/recap/gov.us...
June 13, 2025 at 12:59 AM
BREAKING: Judge Breyer orders Trump to return control of the National Guard back to California, saying the call-up was illegal. storage.courtlistener.com/recap/gov.us...
Reposted by Marshall G Hussain Shuler Lab
"The Court is troubled by the implication inherent in Defendants’ argument that protest against the federal government, a core civil liberty protected by the First Amendment, can justify a finding of rebellion."
![Moreover, the Court is troubled by the implication inherent in Defendants’ argument that protest against the federal government, a core civil liberty protected by the First Amendment, can justify a finding of rebellion. The U.S. Reports are chock-full of language explaining the importance of individuals’ right to speak out against the government—even when doing so is uncomfortable, even when doing so is provocative, even when doing so causes inconvenience. See, e.g., Cohen v. California, 403 U.S. 15, 24–25 (1972) (“To many, the immediate consequence of this freedom may often appear to be only verbal tumult, discord, and even offensive utterance. … That the air may at times seem filled with verbal cacophony is, in this sense not a sign of weakness but of strength.”); Tinker v. Des Moines Indep. Cmty. Sch. Dist., 393 U.S. 503, 508 (“But, in our system, undifferentiated fear or apprehension of disturbance is not enough to overcome the right to freedom of expression. Any departure from absolute regimentation may cause trouble. … Any word spoken … that deviates from the views of another person may start an argument or cause a disturbance. But our Constitution says we must take this risk.”); Cox v. Louisiana, 379 U.S. 536, 550–51 (rejecting the argument that a conviction for breach of the peace “should be sustained because of fear expressed by some [onlookers] that ‘violence was about to erupt’ because of the demonstration” and explaining “that constitutional rights may not be denied simply because of hostility to their assertion or](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:qrllvid7s54k4hnwtqxwetrf/bafkreicef73mhdhdkllvz3c36u6jystthou7yxo5m2hknejk7koc76oefq@jpeg)
June 13, 2025 at 1:08 AM
"The Court is troubled by the implication inherent in Defendants’ argument that protest against the federal government, a core civil liberty protected by the First Amendment, can justify a finding of rebellion."
Reposted by Marshall G Hussain Shuler Lab
Intro👩🏻🔬
I’m a cognitive computational neuroscienctist 🧠 & AI researcher. I combine RL, NN, ML w behavioral & neuro methods to study:
1-how brains learn models of env to plan & remember
2-collective cognition
3-evolution of learning
&
4-build & evaluate AI inspired by 1-3
New: Ecological intelligence🌍
I’m a cognitive computational neuroscienctist 🧠 & AI researcher. I combine RL, NN, ML w behavioral & neuro methods to study:
1-how brains learn models of env to plan & remember
2-collective cognition
3-evolution of learning
&
4-build & evaluate AI inspired by 1-3
New: Ecological intelligence🌍
November 12, 2024 at 4:56 PM
Intro👩🏻🔬
I’m a cognitive computational neuroscienctist 🧠 & AI researcher. I combine RL, NN, ML w behavioral & neuro methods to study:
1-how brains learn models of env to plan & remember
2-collective cognition
3-evolution of learning
&
4-build & evaluate AI inspired by 1-3
New: Ecological intelligence🌍
I’m a cognitive computational neuroscienctist 🧠 & AI researcher. I combine RL, NN, ML w behavioral & neuro methods to study:
1-how brains learn models of env to plan & remember
2-collective cognition
3-evolution of learning
&
4-build & evaluate AI inspired by 1-3
New: Ecological intelligence🌍
Reposted by Marshall G Hussain Shuler Lab
US senators grilled NIH director Jayanta Bhattacharya at a hearing today about how his professed support for science squares with unprecedented grant terminations at the agency and enormous cuts that have been proposed for its 2026 budget.
https://go.nature.com/3FWM2wN
https://go.nature.com/3FWM2wN
NIH chief stands by funding cuts to ‘politicized science’ at tense hearing
Jayanta Bhattacharya says the US biomedical agency can’t continue ‘business as usual’ if it wants to restore its reputation.
go.nature.com
June 11, 2025 at 2:13 AM
US senators grilled NIH director Jayanta Bhattacharya at a hearing today about how his professed support for science squares with unprecedented grant terminations at the agency and enormous cuts that have been proposed for its 2026 budget.
https://go.nature.com/3FWM2wN
https://go.nature.com/3FWM2wN
Reposted by Marshall G Hussain Shuler Lab
These clowns are exhausting…
The rescinded the rescission…
Within 24 hours…
www.statnews.com/2025/06/10/n...
The rescinded the rescission…
Within 24 hours…
www.statnews.com/2025/06/10/n...
NIH restores DEI prohibition for grant recipients within hours of rescinding it
The NIH rescinded a 7-week-old DEI directive on Monday, only to reinstate it hours later without explanation.
www.statnews.com
June 11, 2025 at 5:00 AM
These clowns are exhausting…
The rescinded the rescission…
Within 24 hours…
www.statnews.com/2025/06/10/n...
The rescinded the rescission…
Within 24 hours…
www.statnews.com/2025/06/10/n...
Reposted by Marshall G Hussain Shuler Lab
My message to Trump’s NIH Director? No one in America wants us to do LESS cancer research.
No one is asking Trump to make it harder to cure Alzheimer's disease.
Yet Trump is cutting all of this NOW and demanding an $18 BILLION cut to NIH next year. Not on my watch.
No one is asking Trump to make it harder to cure Alzheimer's disease.
Yet Trump is cutting all of this NOW and demanding an $18 BILLION cut to NIH next year. Not on my watch.
June 10, 2025 at 6:53 PM
My message to Trump’s NIH Director? No one in America wants us to do LESS cancer research.
No one is asking Trump to make it harder to cure Alzheimer's disease.
Yet Trump is cutting all of this NOW and demanding an $18 BILLION cut to NIH next year. Not on my watch.
No one is asking Trump to make it harder to cure Alzheimer's disease.
Yet Trump is cutting all of this NOW and demanding an $18 BILLION cut to NIH next year. Not on my watch.