An early morning explosion rocked a Moscow neighborhood, ending the life of one of the Russian military’s top planners.

Bei der serbischen Belagerung von Sarajevo fielen viele Zivilisten eigens angereisten Scharfschützen zum Opfer. Der taz-Korrespondent erinnert sich.

scenes from a batshit speech

YouTube video by Jimmy Kimmel Live

Cytokines are signaling molecules that coordinate complex immune processes and are frequently dysregulated in disease. While cytokine blockade has become a common therapeutic modality, cytokine agonism has had limited utility due to the widespread expression of cytokine receptors with pleiotropic effects. To overcome this limitation, we devise an approach to engineer molecular switches, termed cytokine adaptors, that transform one cytokine signal into an alternative signal with a different functional output. Endogenous cytokines act to nucleate the adaptors, converting the cytokine–adaptor complex into a surrogate agonist for a different cytokine pathway. In this way, cytokine adaptors, which have no intrinsic agonist activity, can function as conditional, context-dependent agonists. We develop cytokine adaptors that convert IL-10 or TGF-β into IL-2 receptor agonists to reverse T cell suppression. We also convert the pro-inflammatory cytokines IL-23 or IL-17 into immunosuppressive IL-1

Surface Water and Ocean Topography (SWOT) Prior Lake Database (PLD) provides the foundation for generating SWOT lake vector products including area, height, and storage change PLD inventories ∼6 ...