New study reveals how M. tuberculosis PdtaS, a constitutively active kinase, senses both copper and nitric oxide by inhibiting dimerization, not binding.
A fresh twist on two-component signaling!
✍️ @michaelglickman.bsky.social and coll. 👏👏👏
📖 shorturl.at/DiWXp
#Tuberculosis #MicroSky

Gram-negative efflux pumps play a major role in resistance to antibiotics and impede the development of new ones. With Marion Flipo we share our Viewpoint on current and future considerations for the development of efflux pump inhibitors for Gram-negative bacterial. revive.gardp.org/crippling-gr...

Join us in Tubingen as a Junior Research Group Leader if you do research on #ESKAPE pathogens and infections and are interested in the highly cooperative environment of @dzif.bsky.social‬ and @cmfi.bsky.social ! Please send your application or forward to colleagues!
uni-tuebingen.de/universitaet...

Happy World tuberculosis day! Thanks to amazing collaborations between medicinal chemistry and microbiology at @pasteurlille.bsky.social we do our best to develop novel anti-tuberculosis therapies such as through our collaborative effort on the novel antibiotic class of TricyclicSpirolactams .

Early reports to WHO from the 30 highest #tuberculosis (TB)-burden countries confirm that funding cuts from foreign aid, particularly from USAID, are already dismantling essential TB services.

Without urgent action, these setbacks will reverse decades of progress to #EndTB 🔗 bit.ly/4kvsu2i

Science, research & public health face unprecedented attacks in the U.S.

We stand with our American colleagues & support the Stand Up for Science call.

Join the global march tomorrow, incl. in Paris! 🧪✊

📍 March 7, 13:30 – Place Jussieu
🔗 More info: standupforscience.fr

#StandUpForScience