The big reveal starts. #escmidglobal

Following up, Gunnar also shows the problems with the screening tests. It's a challenge in high R area #escmidglobal #escmid2025

Gunnar from EUCAST talking about the complexities of susceptibility testing using oxacillin disc screening. #escmid2025

NEW PREPRINT!

Enjoyed working with @tom-parks.bsky.social and @petedodd24.bsky.social on immortal time bias

In its simplest form, ITB results from misallocation of person time, i.e. pre treatment time in intervention group being counted as time on treatment

www.medrxiv.org/content/10.1...

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We are looking for patient, clinician and researcher insight into priorities for community acquired pneumonia!

This is a JLA Priority Setting Partnership and will drive the UK research agenda for years to come - please share!!

⛄🎄⛄🎄!!

forms.office.com/Pages/Respon...

Just a short piece on FQ prescribing. Basically, it's gone downhill, in relation to comparator antibiotics and absolutely. Still waiting for the MHRA to release the report with new information...

NEW LETTER! Me and @gushamilton.bsky.social argue that, if you want to demonstrate all oral treatment for pneumonia is adequate, then systematically excluding from sample people who are switched to IV after failing oral therapy is problematic

www.clinicalmicrobiologyandinfection.com/article/S119...

Just really cool.

What an absolutely lovely paper. Important topic. I wonder what it would cost today and how much the total cost was. Such a lovely bit of work. Will keep this for talks and presentations.

Interesting trial. If we took the point estimates, then we would accept 0.9 days less abx per person, for a 1.6% absolute mortality increase. Not sure I would take that. Obviously, imprecision means both of these are less precise; but I think not a clear 'win' for PCT
jamanetwork.com/journals/jam...

Not gonna disagree with a Nobel prize winner on the economics here, but people underestimate Trump and the power being crazy has. If people think he will do something crazy, they change their behaviour in funny ways(and sometimes in his favour). I don't think it's a rational play, that's the point.

What's the best book for understanding LLMs and their ilk? I understand basic statistics and computing (i.e. I can use bash, python, and HPC clusters). So something that works from there upwards. Like explains transformers.

Reposting for anyone who hasn't clocked this paper yet- fab analysis by @gushamilton.bsky.social @gpollara.bsky.social and team - persuaded anti-IL6 unlikely to increase TB risk , and now need to test it's potential as therapeutic to reduce immunopath. What else can we infer about TB immunology?

uh huh

New research article in The Lancet Microbe

Altered IL-6 signalling and risk of #tuberculosis: a multi-ancestry mendelian randomisation study

www.thelancet.com/journals/lan...

#IDSky #MicroSky #TB #OpenAccess #OA

🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨

We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.

Lead author @gushamilton.bsky.social

#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
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NEW PAPER! Work led by @gushamilton.bsky.social and @gpollara.bsky.social finds reduced IL-6 signalling may REDUCE risk of TB disease

Challenges idea that IL-6 plays essential role in immunity to Mtb, and suggests that IL-6 drives immunopathology

Great use of data from ITHGC

#IDSky #EpiSky