Gur Yaari
@guryaari.bsky.social
The AIRR-ML-2025 challenge is LIVE on
@Kaggle, but the real question is… are you up for it?
We’re challenging the best in #MachineLearning & #DataScience to decode the immune system. Think you have the skills? Prove it.
💰 $10,000 prize pool 📄 Co-author a @NatureMethods
paper
@Kaggle, but the real question is… are you up for it?
We’re challenging the best in #MachineLearning & #DataScience to decode the immune system. Think you have the skills? Prove it.
💰 $10,000 prize pool 📄 Co-author a @NatureMethods
paper
November 14, 2025 at 7:11 PM
The AIRR-ML-2025 challenge is LIVE on
@Kaggle, but the real question is… are you up for it?
We’re challenging the best in #MachineLearning & #DataScience to decode the immune system. Think you have the skills? Prove it.
💰 $10,000 prize pool 📄 Co-author a @NatureMethods
paper
@Kaggle, but the real question is… are you up for it?
We’re challenging the best in #MachineLearning & #DataScience to decode the immune system. Think you have the skills? Prove it.
💰 $10,000 prize pool 📄 Co-author a @NatureMethods
paper
Reposted by Gur Yaari
🧬 VDJbase and OGRDB: 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data.
LET'S CHANGE THE WAY WE UTILIZE IG/TR GENOMIC AND REPERTOIRE DATA! @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social
academic.oup.com/nar/advance-...
LET'S CHANGE THE WAY WE UTILIZE IG/TR GENOMIC AND REPERTOIRE DATA! @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social
academic.oup.com/nar/advance-...
The current landscape of adaptive immune receptor genomic and repertoire data: OGRDB and VDJbase
Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons
academic.oup.com
November 7, 2025 at 8:23 PM
🧬 VDJbase and OGRDB: 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data.
LET'S CHANGE THE WAY WE UTILIZE IG/TR GENOMIC AND REPERTOIRE DATA! @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social
academic.oup.com/nar/advance-...
LET'S CHANGE THE WAY WE UTILIZE IG/TR GENOMIC AND REPERTOIRE DATA! @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social
academic.oup.com/nar/advance-...
Reposted by Gur Yaari
Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors.
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social
www.cell.com/cell-genomic...
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social
www.cell.com/cell-genomic...
The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations
Genetic variation within immunoglobulin heavy chain constant (IGHC) genes modulates
interactions between antibodies and other immune receptors and effector cells, directing
cell killing and the cleara...
www.cell.com
October 28, 2025 at 2:35 PM
Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors.
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social
www.cell.com/cell-genomic...
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social
www.cell.com/cell-genomic...
Check it out!
Highly recommended for anyone passionate about ML/AI or computational biology and immunoogy.
Highly recommended for anyone passionate about ML/AI or computational biology and immunoogy.
📢 We are announcing the Adaptive Immune Profiling Challenge 2025!
Can you predict immune state labels from adaptive immune receptor repertoires?
💰 $10,000 prize pool!
🗓️ Launches Nov 5 on @kaggle.com
More Info: uio-bmi.github.io/adaptive_imm...
Can you predict immune state labels from adaptive immune receptor repertoires?
💰 $10,000 prize pool!
🗓️ Launches Nov 5 on @kaggle.com
More Info: uio-bmi.github.io/adaptive_imm...
October 23, 2025 at 10:36 PM
Check it out!
Highly recommended for anyone passionate about ML/AI or computational biology and immunoogy.
Highly recommended for anyone passionate about ML/AI or computational biology and immunoogy.
Reposted by Gur Yaari
Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
The gremlin in the works: why T cell receptor researchers need to pay more attention to germline reference sequences
The rise of T cell receptor (TCR) sequencing technologies is driving both new understandings of the immune system and the development of novel clinica…
www.sciencedirect.com
August 29, 2025 at 4:49 PM
Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social
🚨 Publication Alert!
AlignAIR is live, a deep learning–powered tool for aligning BCR/TCR sequences:
👉 alignair.ai
Explore the paper for results and methodological details:
📄 lnkd.in/dKY5fPZz
It’s been a long, creative, and rewarding journey with an amazing team.
We’d love to hear your feedback!
AlignAIR is live, a deep learning–powered tool for aligning BCR/TCR sequences:
👉 alignair.ai
Explore the paper for results and methodological details:
📄 lnkd.in/dKY5fPZz
It’s been a long, creative, and rewarding journey with an amazing team.
We’d love to hear your feedback!
AlignAIR AppHome
Immunoglobulin sequence alignment tool
alignair.ai
July 17, 2025 at 6:27 PM
🚨 Publication Alert!
AlignAIR is live, a deep learning–powered tool for aligning BCR/TCR sequences:
👉 alignair.ai
Explore the paper for results and methodological details:
📄 lnkd.in/dKY5fPZz
It’s been a long, creative, and rewarding journey with an amazing team.
We’d love to hear your feedback!
AlignAIR is live, a deep learning–powered tool for aligning BCR/TCR sequences:
👉 alignair.ai
Explore the paper for results and methodological details:
📄 lnkd.in/dKY5fPZz
It’s been a long, creative, and rewarding journey with an amazing team.
We’d love to hear your feedback!
Reposted by Gur Yaari
Turns out...just like in the antibody heavy chain repertoire, germline variants in the immunoglobulin lambda and kappa loci influence the composition of light chain B cell receptors!
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...
Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire
Variation in antibody (Ab) responses contributes to disease outcomes and therapeutic responsiveness, the determinants of which remain incompletely understood. This study demonstrates that polymorphism...
www.biorxiv.org
June 2, 2025 at 1:13 AM
Turns out...just like in the antibody heavy chain repertoire, germline variants in the immunoglobulin lambda and kappa loci influence the composition of light chain B cell receptors!
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...
A truly enjoyable and collaborative effort—this is what science should be all about!
Very proud of this collective effort to enhance understanding of immunoglobulin diversity in rhesus macaque @guryaari.bsky.social @williamlees.bsky.social
www.biorxiv.org/content/10.1...
--> NEW and IMPROVED germline sets for this important animal model...explore here: vdjbase.org/reference_bo...
www.biorxiv.org/content/10.1...
--> NEW and IMPROVED germline sets for this important animal model...explore here: vdjbase.org/reference_bo...
A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques
Rhesus macaques (RMs) are a vital model for studying human disease and invaluable to pre-clinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies ...
www.biorxiv.org
March 6, 2025 at 7:51 PM
A truly enjoyable and collaborative effort—this is what science should be all about!
Reposted by Gur Yaari
Did you know that human immunoglobulin constant genes are crazy diverse? It's got me thinking...Proud of Uddalok Jana! And grateful for collabs @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @e-engelbrecht1.bsky.social @yscientist.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The human immunoglobulin heavy chain constant gene locus is enriched for large complex structural variants and coding polymorphisms that vary in frequency among human populations
The immunoglobulin heavy chain constant (IGHC) domain of antibodies (Ab) is responsible for a variety of effector functions critical to Ab mediated immunity. In human, this domain is encoded by genes ...
www.biorxiv.org
February 13, 2025 at 1:18 PM
Did you know that human immunoglobulin constant genes are crazy diverse? It's got me thinking...Proud of Uddalok Jana! And grateful for collabs @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @e-engelbrecht1.bsky.social @yscientist.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Gur Yaari
Looking forward to hearing from the great speakers lined up for the “2025 Immcantation Users Group Meeting!” Check out the program and register for this free virtual meeting 1/30/25 10AM-1:40PM (ET) at: immcantation.github.io/users-meetin... @immcantation.bsky.social
January 17, 2025 at 1:51 PM
Looking forward to hearing from the great speakers lined up for the “2025 Immcantation Users Group Meeting!” Check out the program and register for this free virtual meeting 1/30/25 10AM-1:40PM (ET) at: immcantation.github.io/users-meetin... @immcantation.bsky.social
Reposted by Gur Yaari
Check out long-read sequencing results in human IGH! HUGE duplications in constant gene regions...and 7 copies of IGHV3-23 on one haplotype! @lossiusandreas.bsky.social @williamlees.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy chain locus
Genetic diversity within the human immunoglobulin heavy chain (IGH) locus influences the expressed antibody repertoire and susceptibility to infectious and autoimmune diseases. However, repetitive seq...
www.biorxiv.org
December 18, 2024 at 3:21 PM
Check out long-read sequencing results in human IGH! HUGE duplications in constant gene regions...and 7 copies of IGHV3-23 on one haplotype! @lossiusandreas.bsky.social @williamlees.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Check out our new publication: An unbiased comparison of immunoglobulin sequence aligners.
academic.oup.com/bib/article/...
academic.oup.com/bib/article/...
An unbiased comparison of immunoglobulin sequence aligners
Abstract. Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) is critical for our understanding of the adaptive immune system’s dynamics in health an
academic.oup.com
November 26, 2024 at 6:08 PM
Check out our new publication: An unbiased comparison of immunoglobulin sequence aligners.
academic.oup.com/bib/article/...
academic.oup.com/bib/article/...