Steven Kleinstein
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skleinstein.bsky.social
Steven Kleinstein
@skleinstein.bsky.social
Computational immunologist; Professor at Yale School of Medicine; Co-Director, Computational Biology & Biomedical Informatics; B cell receptor sequencing analysis, http://immcantation.org + multi-omics signatures of infection, vaccination & autoimmunity.
Pinned
🚨 Immcantation.org user or interested in #Bcell repertoire analysis?
🗓️ Join the FREE virtual 2026 Immcantation Users Group Meeting
📅 Jan 22, 2026 | ⏰ 10AM–1:30PM ET
📢 Abstracts due Oct 1, 2025
🔗 immcantation.github.io/users-meeting/2026

#AIRRseq #Immcantation
Interested in pursuing a PhD in Computational Biology and Biomedical Informatics (CBB) at Yale?

Join us for a CBB PhD Virtual Open House
Tuesday, November 11 | 8:00–9:00 PM ET

👉 Register here: yalesurvey.ca1.qualtrics.com/jfe/form/SV_...

@yalecbb.bsky.social
October 31, 2025 at 10:43 PM
Reposted by Steven Kleinstein
excited to announce that this January we are relocating to Yale to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI): @yalecsei.bsky.social

looking to hire 2 postdocs to join us in this endeavor.

more details can be found here: sites.google.com/uw.edu/statp...
SPE - join us
Postdoctoral position: In January 2026, we are relocating to Yale university to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI). We are looking for talented postd...
sites.google.com
October 27, 2025 at 8:47 PM
Interested in pursuing a PhD in Computational Biology and Biomedical Informatics (CBB) at Yale?

Join us for the CBB PhD Virtual Open House
Tuesday, October 21 | 8:00–9:00 PM ET

👉 Register here: yalesurvey.ca1.qualtrics.com/jfe/form/SV_...

@yalecbb.bsky.social
October 16, 2025 at 1:26 AM
TODAY is the deadline for abstract submission for the 2026 Immcantation Users Group Meeting!

immcantation.github.io/users-meetin...
October 1, 2025 at 1:12 PM
🚨 Immcantation.org user or interested in #Bcell repertoire analysis?
🗓️ Join the FREE virtual 2026 Immcantation Users Group Meeting
📅 Jan 22, 2026 | ⏰ 10AM–1:30PM ET
📢 Abstracts due Oct 1, 2025
🔗 immcantation.github.io/users-meeting/2026

#AIRRseq #Immcantation
September 24, 2025 at 12:05 PM
Reposted by Steven Kleinstein
🚨 One week left! 🚨 Don’t forget to submit your 250-word abstract by October 1st! Share how you use Immcantation and contribute to building a supportive, collaborative research community. 🔗 2026 Immcantation Users Group Meeting immcantation.github.io/users-meeting/2026 #airrseq #immunosky
September 24, 2025 at 7:57 AM
Reposted by Steven Kleinstein
🚨 Immcantation.org user or interested in #Bcell repertoire analysis?
🗓️ Join the FREE virtual 2026 Immcantation Users Group Meeting
📅 Jan 22, 2026 | ⏰ 10AM–1:30PM ET
📢 Abstracts due Oct 1, 2025
🔗 immcantation.github.io/users-meeting/2026

#AIRRseq #Immcantation
August 28, 2025 at 1:38 PM
Reposted by Steven Kleinstein
Our condolences to family and friends of our long collaborator Atul Butte. Word of his death came from Euan Ashley of @stanfordmedicine.bsky.social
#memorial
www.linkedin.com/posts/euanas...
Atul Butte died yesterday. | Euan Ashley
Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he wa...
www.linkedin.com
June 14, 2025 at 11:01 PM
Reposted by Steven Kleinstein
Our collaborators @camilahcoelho.bsky.social @vivianasimonlab.bsky.social (+ others)
show that monovalent XBB.1.5 vaccines recall mostly cross-reactive antibodies to ancestral SARS-CoV-2, not robust de novo responses.
@lancetmicrobe.bsky.social
#ImmuneSky
www.thelancet.com/journals/lan...
Mapping of human monoclonal antibody responses to XBB.1.5 COVID-19 monovalent vaccines: a B cell analysis
Our findings offer key molecular insights into whether strain-specific boosters elicit sufficient protection against SARS-CoV-2 emerging variants. This knowledge can inform decisions on booster design...
www.thelancet.com
June 2, 2025 at 3:48 PM
Reposted by Steven Kleinstein
Next week, we are hosting an international scientific workshop focused on the pathogenesis of #LongCovid at
@yalemed.bsky.social.

Please join us on May 15th to learn about what we know and what we need to investigate next to get to the root causes to accelerate therapies 👇🏼👇🏼
May 10, 2025 at 8:18 PM
Reposted by Steven Kleinstein
Don’t forget! 🌺🧪 Our HIPC symposium is happening tomorrow — join us for a great lineup of talks from
@bjoernpeters.bsky.social, @lungdrc.bsky.social, @settelab.bsky.social, Victoria Zyulina & Thomas Hagan
Tues May 6th | 8:30-10:30 am | Room 313C #Immunology #AAI2025 #HIPC
May 5, 2025 at 11:36 PM
Reposted by Steven Kleinstein
What if LLMs could “read” & “write” biology? 🤔
Introducing C2S‑Scale—a Yale and Google collab: we scaled LLMs (up to 27B!) to analyze & generate single‑cell data 🧬 ➡️ 📝
🔗 Blog: research.google/blog/teachin...
🔗 Preprint: biorxiv.org/content/10.1...
Teaching machines the language of biology: Scaling large language models for next-generation single-cell analysis
research.google
April 18, 2025 at 2:14 PM
Reposted by Steven Kleinstein
Below, from earlier today, confirmed @statnews.com www.statnews.com/2025/04/18/n...
April 18, 2025 at 9:42 PM
Reposted by Steven Kleinstein
Exciting news!! We are happy to announce that we will have a HIPC Symposium at @aai.org on Tues, May 6th. HIPC will also have a Super Booth at #AAI2025 along with @iedb.bsky.social
and the iAKC Project. Check out the full Symposia list, and see you there! 🔗: immunology2025.aai.org/guest-sympos...
Guest Symposia - IMMUNOLOGY2025™
Information and details about Guest Symposia to be presented at IMMUNOLOGY2025™!
immunology2025.aai.org
April 3, 2025 at 10:07 PM
Reposted by Steven Kleinstein
Great to have our latest review "The cellular factors that impair the germinal center in advanced age" out @jimmunol.bsky.social.

Work led by @wsfoster.bsky.social and Edith Marcial-Juárez. With @sanmarti92.bsky.social creating the beautiful GC images in figure 2.

doi.org/10.1093/jimm...
March 17, 2025 at 9:42 PM
Reposted by Steven Kleinstein
WHERE WILL YOU BE ON MARCH 7TH!?

Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one!

#standupforscience2025
March 2, 2025 at 2:04 AM
Reposted by Steven Kleinstein
🚨☀️ Hey Bluesky! Know anyone near the following cities that would be willing to help us Stand Up for Science? ☀️🚨

Annapolis, MD
Bismarck, ND
Boise, ID
Charleston, WV
Dover, DE
Jackson, MS
Anchorage or Juneau, AK
Montpelier, VT
Richmond, VA

Send them our way!

#standupforscience2025
February 21, 2025 at 9:15 PM
Reposted by Steven Kleinstein
Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence
February 12, 2025 at 5:04 PM
Reposted by Steven Kleinstein
Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals.

So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD
‘I really wanted something to happen.’ The students behind the Stand Up for Science protests
New group hopes to turn out researchers for 7 March demonstrations against Trump administration policies
scim.ag
February 19, 2025 at 4:54 PM
Reposted by Steven Kleinstein
Presentations from the 2025 Immcantation Users Group Meeting are now available on the Immcantation YouTube channel! Thank you to our speakers and participants! www.youtube.com/playlist?lis... #immcantation #airrseq #immunosky
2025 Immcantation Users Group Meeting - YouTube
The 2025 Immcantation Users Group Meeting (https://immcantation.github.io/users-meeting/2025/index.html) took place on January 30th, 2025. It served as a vir...
www.youtube.com
February 19, 2025 at 4:36 PM
Reposted by Steven Kleinstein
Our collaborators @rgottardo.bsky.social and Ken Stuart (+ others) describe tagtango, an application to compare #single-cell annotations.
#bioinformatics
academic.oup.com/bioinformati...
tagtango: an application to compare single-cell annotations
AbstractSummary. In this article, we present tagtango, an innovative R package and web application designed for robust and intuitive comparison of single-c
academic.oup.com
February 17, 2025 at 9:34 PM
Reposted by Steven Kleinstein
Unlocking new insights with nipalsMCIA. This tool speeds up data analysis for big datasets by clustering and visualizing info faster than before. Check it out for both bulk and single cell data on Bioconductor with how-to guides and extras online.
nipalsMCIA: Flexible Multi-Block Dimensionality Reduction in R via Nonlinear Iterative Partial Least Squares.
Published in Bioinformatics (Oxford, England)
doi.org
January 13, 2025 at 2:04 AM
Reposted by Steven Kleinstein
nipalsMCIA: Flexible Multi-Block Dimensionality Reduction in R via Nonlinear Iterative Partial Least Squares https://www.biorxiv.org/content/10.1101/2024.06.07.597819v1
nipalsMCIA: Flexible Multi-Block Dimensionality Reduction in R via Nonlinear Iterative Partial Least Squares https://www.biorxiv.org/content/10.1101/2024.06.07.597819v1
Motivation: With the increased reliance on multi-omics data for bulk and single cell analyses, the a
www.biorxiv.org
June 10, 2024 at 5:47 PM