gsbardella.bsky.social
@gsbardella.bsky.social
Medicinal Chemist/Chemical Biologist; Professor at the University of Salerno; epigenetics; EFMC EC Secretary; ChemMedChem EB Chair; cooking, food, and wine lover; opinions are my own
ORCID: orcid.org/0000-0003-0748-1145
ORCID: orcid.org/0000-0003-0748-1145
Join @youngscinet.bsky.social for "Under Pressure: A Mental Health Conversation for the Academic Community," a virtual workshop aimed at building resilience, support and creating a healthier future for yourself and academia.
October 10 - 1PM
🔗 us06web.zoom.us/webinar/regi...
October 10 - 1PM
🔗 us06web.zoom.us/webinar/regi...
September 30, 2025 at 6:54 AM
Join @youngscinet.bsky.social for "Under Pressure: A Mental Health Conversation for the Academic Community," a virtual workshop aimed at building resilience, support and creating a healthier future for yourself and academia.
October 10 - 1PM
🔗 us06web.zoom.us/webinar/regi...
October 10 - 1PM
🔗 us06web.zoom.us/webinar/regi...
Reposted by gsbardella.bsky.social
👩🔬 Have you read our latest #MedChemBioConversation ?
Get to know Maria Letizia Barreca from University of Perugia, Italy.🔍
Dive into our monthly talks with specialists to explore the latest breakthroughs in drug discovery and pick up some valuable advice.
🔗https://buff.ly/63Jy5As
Get to know Maria Letizia Barreca from University of Perugia, Italy.🔍
Dive into our monthly talks with specialists to explore the latest breakthroughs in drug discovery and pick up some valuable advice.
🔗https://buff.ly/63Jy5As
August 27, 2025 at 3:03 PM
👩🔬 Have you read our latest #MedChemBioConversation ?
Get to know Maria Letizia Barreca from University of Perugia, Italy.🔍
Dive into our monthly talks with specialists to explore the latest breakthroughs in drug discovery and pick up some valuable advice.
🔗https://buff.ly/63Jy5As
Get to know Maria Letizia Barreca from University of Perugia, Italy.🔍
Dive into our monthly talks with specialists to explore the latest breakthroughs in drug discovery and pick up some valuable advice.
🔗https://buff.ly/63Jy5As
The report of the FiMC, co-organized by the Med Chem Division of the @gdch.de, the #DPhG and the @scs-dmccb.bsky.social, has been just published in #ChemMedChem (@chemistryeurope.bsky.social)
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
August 27, 2025 at 6:58 AM
The report of the FiMC, co-organized by the Med Chem Division of the @gdch.de, the #DPhG and the @scs-dmccb.bsky.social, has been just published in #ChemMedChem (@chemistryeurope.bsky.social)
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
A new
#ChemMedChem (@chemistryeurope.bsky.social) article explores the effect of modified bifunctional antisense oligonucleotides (BASOs) on the phenotype of cancer cells, evaluated by real-time measurement of cell proliferation and motility. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
#ChemMedChem (@chemistryeurope.bsky.social) article explores the effect of modified bifunctional antisense oligonucleotides (BASOs) on the phenotype of cancer cells, evaluated by real-time measurement of cell proliferation and motility. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Modified Nucleotides in Bifunctional Antisense Oligonucleotides: Exploring their Anticancer Potential
bifunctional antisense oligonucleotide (BASO) modulates pre-mRNA splicing by using two functional domains: an antisense region that hybridizes with target sequences and a regulatory region that recru...
chemistry-europe.onlinelibrary.wiley.com
August 27, 2025 at 6:35 AM
A new
#ChemMedChem (@chemistryeurope.bsky.social) article explores the effect of modified bifunctional antisense oligonucleotides (BASOs) on the phenotype of cancer cells, evaluated by real-time measurement of cell proliferation and motility. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
#ChemMedChem (@chemistryeurope.bsky.social) article explores the effect of modified bifunctional antisense oligonucleotides (BASOs) on the phenotype of cancer cells, evaluated by real-time measurement of cell proliferation and motility. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...) with a Front Cover illustrating the crystal structure of the N-terminal domain of clathrin with the known binding sites colored and a selection of Pitstop 2 analogues.
August 26, 2025 at 9:10 AM
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...) with a Front Cover illustrating the crystal structure of the N-terminal domain of clathrin with the known binding sites colored and a selection of Pitstop 2 analogues.
An Highlight article just accepted in #ChemMedChem (@chemistryeurope.bsky.social) spotlights #balinatunfib, an orally available small molecule jointly developed by Sanofi and UCB preventing TNFα from effectively binding to its receptors.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
June 21, 2025 at 9:27 AM
An Highlight article just accepted in #ChemMedChem (@chemistryeurope.bsky.social) spotlights #balinatunfib, an orally available small molecule jointly developed by Sanofi and UCB preventing TNFα from effectively binding to its receptors.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...)!
June 18, 2025 at 7:33 AM
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...)!
Reposted by gsbardella.bsky.social
I have poked the @rsc.org on X/Twitter a bit over the years (sorry folks...), but huge kudos to them for leaving what has become even more of a toxic and hateful platform www.rsc.org/news-events/... 👏 #chemsky
Social media and connecting with our community
www.rsc.org
June 16, 2025 at 8:49 AM
I have poked the @rsc.org on X/Twitter a bit over the years (sorry folks...), but huge kudos to them for leaving what has become even more of a toxic and hateful platform www.rsc.org/news-events/... 👏 #chemsky
Reposted by gsbardella.bsky.social
Only two weeks left to apply for a Flash Talk at the 5th Virtual @chembiotalks.bsky.social!
If you are a PhD or postdoc and want a chance to present to a global #ChemBio audience, make sure to check out our abstract challenge: chemistry-europe.onlinelibrary.wiley.com/hub/journal/...
If you are a PhD or postdoc and want a chance to present to a global #ChemBio audience, make sure to check out our abstract challenge: chemistry-europe.onlinelibrary.wiley.com/hub/journal/...
June 17, 2025 at 7:46 AM
Only two weeks left to apply for a Flash Talk at the 5th Virtual @chembiotalks.bsky.social!
If you are a PhD or postdoc and want a chance to present to a global #ChemBio audience, make sure to check out our abstract challenge: chemistry-europe.onlinelibrary.wiley.com/hub/journal/...
If you are a PhD or postdoc and want a chance to present to a global #ChemBio audience, make sure to check out our abstract challenge: chemistry-europe.onlinelibrary.wiley.com/hub/journal/...
Another great edition of @youngscinet.bsky.social #MedChemBioOnline is going to start in 1 hour and a half. Do not miss the opportunity to learn about "Best Practices in Discovering PROTACs" with experts in the field!
Swipe to discover our speakers!
Join us in 2 weeks for the 21st EFMC-YSN MedChemBioOnline on June 17, 2025, from 15:30 to 17:30 CET. Learn about “Best Practices in Discovering PROTACs” with experts.
💻 Online via Zoom
🔗 Free, but registration is mandatory
Thanks to our sponsor Advion.
Join us in 2 weeks for the 21st EFMC-YSN MedChemBioOnline on June 17, 2025, from 15:30 to 17:30 CET. Learn about “Best Practices in Discovering PROTACs” with experts.
💻 Online via Zoom
🔗 Free, but registration is mandatory
Thanks to our sponsor Advion.
June 17, 2025 at 12:11 PM
Another great edition of @youngscinet.bsky.social #MedChemBioOnline is going to start in 1 hour and a half. Do not miss the opportunity to learn about "Best Practices in Discovering PROTACs" with experts in the field!
The last talk of the day at the 11th Novalix Conference “Biophysics in Drug Discovery” was the terrific keynote lecture by Stefan Knapp on "Comprehensive Characterization of Chemical Tools and New Modalities such as PROTACs".
@thesgc.bsky.social
@thesgc.bsky.social
May 21, 2025 at 10:04 PM
The last talk of the day at the 11th Novalix Conference “Biophysics in Drug Discovery” was the terrific keynote lecture by Stefan Knapp on "Comprehensive Characterization of Chemical Tools and New Modalities such as PROTACs".
@thesgc.bsky.social
@thesgc.bsky.social
Amazing keynote lecture by Amanda Garner at the 11th Novalix Conference—Biophysics in Drug Discovery in Strasbourg.
Amanda delivered a brilliant talk on "Enabling Technologies for Revealing Druggable Paths in RNA Biology".
@acsmedi.bsky.social
Amanda delivered a brilliant talk on "Enabling Technologies for Revealing Druggable Paths in RNA Biology".
@acsmedi.bsky.social
May 21, 2025 at 9:59 PM
Amazing keynote lecture by Amanda Garner at the 11th Novalix Conference—Biophysics in Drug Discovery in Strasbourg.
Amanda delivered a brilliant talk on "Enabling Technologies for Revealing Druggable Paths in RNA Biology".
@acsmedi.bsky.social
Amanda delivered a brilliant talk on "Enabling Technologies for Revealing Druggable Paths in RNA Biology".
@acsmedi.bsky.social
Great talk by @mariaduca-cnrs.bsky.social at the 11th Novalix Conference about Biophysics in Drug Discovery. Maria presented a few of her group projects, talking on how to target RNA using synthetic small molecules and how to discover an characterize RNA binders. Brilliant!
May 21, 2025 at 9:56 PM
Great talk by @mariaduca-cnrs.bsky.social at the 11th Novalix Conference about Biophysics in Drug Discovery. Maria presented a few of her group projects, talking on how to target RNA using synthetic small molecules and how to discover an characterize RNA binders. Brilliant!
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
May 21, 2025 at 9:53 PM
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
Reposted by gsbardella.bsky.social
No orders for supplies/reagents/equipment (already a huge bottleneck after earlier cuts). No travel or conference registrations. And certainly no hiring.
So this could be a total freeze, in everything but name. Is that the new workaround the administration is trying? Isn't that illegal? (2/2)
So this could be a total freeze, in everything but name. Is that the new workaround the administration is trying? Isn't that illegal? (2/2)
April 2, 2025 at 6:55 PM
No orders for supplies/reagents/equipment (already a huge bottleneck after earlier cuts). No travel or conference registrations. And certainly no hiring.
So this could be a total freeze, in everything but name. Is that the new workaround the administration is trying? Isn't that illegal? (2/2)
So this could be a total freeze, in everything but name. Is that the new workaround the administration is trying? Isn't that illegal? (2/2)
Reposted by gsbardella.bsky.social
I'm getting word that the latest attempt to strangle what's left of the NIH is that purchasing agents have been mostly/completely cut, with the purchasing to be done by centralized GSA staff. Who either don't exist or aren't assigned.
That means in practice no spending at all! (1/2)
That means in practice no spending at all! (1/2)
April 2, 2025 at 6:55 PM
I'm getting word that the latest attempt to strangle what's left of the NIH is that purchasing agents have been mostly/completely cut, with the purchasing to be done by centralized GSA staff. Who either don't exist or aren't assigned.
That means in practice no spending at all! (1/2)
That means in practice no spending at all! (1/2)
Reposted by gsbardella.bsky.social
If you love drug candidates but weren't able to attend the #FirstTimeDisclosures symposium at #ACSSpring2025, check out my story about the session for @cenmag.bsky.social - with lots of cool-looking molecules.
cen.acs.org/acs-news/acs...
cen.acs.org/acs-news/acs...
12 drug candidates debut in San Diego
Structures unveiled during first-time disclosures symposium
cen.acs.org
March 28, 2025 at 4:53 PM
If you love drug candidates but weren't able to attend the #FirstTimeDisclosures symposium at #ACSSpring2025, check out my story about the session for @cenmag.bsky.social - with lots of cool-looking molecules.
cen.acs.org/acs-news/acs...
cen.acs.org/acs-news/acs...
An amazing, totally inspirational and emotional journey! The @acs.org Priestley Medal talk by @francesarnold.bsky.social at #ACSSpring2025
March 24, 2025 at 12:13 AM
An amazing, totally inspirational and emotional journey! The @acs.org Priestley Medal talk by @francesarnold.bsky.social at #ACSSpring2025
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
March 9, 2025 at 9:27 PM
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
Reposted by gsbardella.bsky.social
New on @science.org's daily Trump Tracker: A key influenza vaccine meeting gets abruptly canceled, and more than 90% of all USAID grants are terminated.
www.science.org/content/arti...
www.science.org/content/arti...
Trump Tracker: Firings, lawsuits, and U.S. science in chaos
Follow President Donald Trump’s impact on U.S. research and science globally
www.science.org
February 27, 2025 at 2:21 PM
New on @science.org's daily Trump Tracker: A key influenza vaccine meeting gets abruptly canceled, and more than 90% of all USAID grants are terminated.
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by gsbardella.bsky.social
A new White House freeze on using government-issued credit cards is the latest shock for federal scientists, potentially affecting everything from conference travel to needed purchases for clinical care or lab work. scim.ag/4hV9oRb
Trump credit card freeze sparks alarm at health agencies
“Cost efficiency” order could block travel, supplies for labs and patient care
scim.ag
February 27, 2025 at 11:12 PM
A new White House freeze on using government-issued credit cards is the latest shock for federal scientists, potentially affecting everything from conference travel to needed purchases for clinical care or lab work. scim.ag/4hV9oRb
A Career doing STUFF, a Guest Editorial by Mike Hann for the #ChemMedChem (@chemistryeurope.bsky.social) MedChem Musings series, summarises the many things he did during his 45 year-career in drug discovery. Practical advices and inspiration for future generations of researchers.
lnkd.in/dNNy7FaE
lnkd.in/dNNy7FaE
February 27, 2025 at 12:21 PM
A Career doing STUFF, a Guest Editorial by Mike Hann for the #ChemMedChem (@chemistryeurope.bsky.social) MedChem Musings series, summarises the many things he did during his 45 year-career in drug discovery. Practical advices and inspiration for future generations of researchers.
lnkd.in/dNNy7FaE
lnkd.in/dNNy7FaE
The Hit to Lead process is an integral part of contemporary drug discovery.
A perspective just published in #ChemMedChem (@chemistryeurope.bsky.social), highlight the new set of @euromedchem.bsky.social best practices focused on H2L.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
A perspective just published in #ChemMedChem (@chemistryeurope.bsky.social), highlight the new set of @euromedchem.bsky.social best practices focused on H2L.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit to Lead
Best practices for the Hit-to-Lead phase of drug discovery are exemplified in this article, with links to further materials and references as a learning resource. This consensus output was produced b....
chemistry-europe.onlinelibrary.wiley.com
February 21, 2025 at 8:07 AM
The Hit to Lead process is an integral part of contemporary drug discovery.
A perspective just published in #ChemMedChem (@chemistryeurope.bsky.social), highlight the new set of @euromedchem.bsky.social best practices focused on H2L.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
A perspective just published in #ChemMedChem (@chemistryeurope.bsky.social), highlight the new set of @euromedchem.bsky.social best practices focused on H2L.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
February 21, 2025 at 7:58 AM
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...