Ed Griffen
@griffen-ed.bsky.social
husband, father, son, brother, computational medicinal chemist, anti-infective drug discovery, perpetually curious, apprentice akidoka, school governor @MedChemica, @covid_moonshot, @asap_discovery
Reposted by Ed Griffen
Save the date! Next year's European #RDKit UGM will take place from 16-18 September in Darmstadt, Germany.
Pre-registration will open in early 2026.
Pre-registration will open in early 2026.
October 21, 2025 at 3:25 PM
Save the date! Next year's European #RDKit UGM will take place from 16-18 September in Darmstadt, Germany.
Pre-registration will open in early 2026.
Pre-registration will open in early 2026.
Reposted by Ed Griffen
Reposted by Ed Griffen
Great news! 🎉
Following an independent expert review, we have formally nominated the broad-spectrum pan-coronavirus antiviral ASAP-0017445 as a pre-clinical drug candidate.
🔗Read the press release here: dndi.org/press-releas...
Following an independent expert review, we have formally nominated the broad-spectrum pan-coronavirus antiviral ASAP-0017445 as a pre-clinical drug candidate.
🔗Read the press release here: dndi.org/press-releas...
September 24, 2025 at 8:40 AM
Great news! 🎉
Following an independent expert review, we have formally nominated the broad-spectrum pan-coronavirus antiviral ASAP-0017445 as a pre-clinical drug candidate.
🔗Read the press release here: dndi.org/press-releas...
Following an independent expert review, we have formally nominated the broad-spectrum pan-coronavirus antiviral ASAP-0017445 as a pre-clinical drug candidate.
🔗Read the press release here: dndi.org/press-releas...
Reposted by Ed Griffen
I first wrote about some of the early stages of this project in March 2020 (cen.acs.org/pharmaceutic...).
I've been privileged to follow along since then (cen.acs.org/pharmaceutic...).
Congratulations to everyone who contributed.
I've been privileged to follow along since then (cen.acs.org/pharmaceutic...).
Congratulations to everyone who contributed.
September 24, 2025 at 12:03 PM
I first wrote about some of the early stages of this project in March 2020 (cen.acs.org/pharmaceutic...).
I've been privileged to follow along since then (cen.acs.org/pharmaceutic...).
Congratulations to everyone who contributed.
I've been privileged to follow along since then (cen.acs.org/pharmaceutic...).
Congratulations to everyone who contributed.
Reposted by Ed Griffen
ASAP is incredibly proud to work with superstar antiviral discovery scientists at Mount Sinai: Briana McGovern, Meg Gordon, Dr. Kris White, Dr. Suazo, and Jared Benjamin, among others!
Read about their important work here:
health.mountsinai.org/blog/stories...
Read about their important work here:
health.mountsinai.org/blog/stories...
September 10, 2025 at 7:22 PM
ASAP is incredibly proud to work with superstar antiviral discovery scientists at Mount Sinai: Briana McGovern, Meg Gordon, Dr. Kris White, Dr. Suazo, and Jared Benjamin, among others!
Read about their important work here:
health.mountsinai.org/blog/stories...
Read about their important work here:
health.mountsinai.org/blog/stories...
Reposted by Ed Griffen
Disease prevalence in US states before & after vaccine introduction 🧪
From Edward Tufte & graphics.wsj.com/infectious-d...
From Edward Tufte & graphics.wsj.com/infectious-d...
September 4, 2025 at 6:01 PM
Disease prevalence in US states before & after vaccine introduction 🧪
From Edward Tufte & graphics.wsj.com/infectious-d...
From Edward Tufte & graphics.wsj.com/infectious-d...
Reposted by Ed Griffen
Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):
September 1, 2025 at 7:32 PM
Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):
Ouch…
June 11, 2025 at 4:22 PM
Ouch…
AI advances are all about getting enough good data. For the first time this is data at the scale we need it for faster drug discovery. This could make a difference to so many diseases.
New OpenBind consortium to make the UK a leader in AI-driven drug discovery-slashing the cost of drug discovery & development.. & MedChemica are at the heart of it!
Click for the full gov.uk article and direct quote from our Technical Director @griffen-ed.bsky.social
www.gov.uk/government/n...
Click for the full gov.uk article and direct quote from our Technical Director @griffen-ed.bsky.social
www.gov.uk/government/n...
June 10, 2025 at 2:49 PM
AI advances are all about getting enough good data. For the first time this is data at the scale we need it for faster drug discovery. This could make a difference to so many diseases.
Reposted by Ed Griffen
If you weren’t able to attend our Symposium on Open Drug Discovery in Montreal in April, you’re in luck - the recordings are now on YouTube and the slides are on Zenodo!
🎥 Watch the recordings: www.youtube.com/playlist?lis...
📄 Access the slides: zenodo.org/communities/...
🎥 Watch the recordings: www.youtube.com/playlist?lis...
📄 Access the slides: zenodo.org/communities/...
Conscience Symposium on Open Drug Discovery 2025 - YouTube
Recordings of the talks that took place at the Conscience Symposium on Open Drug Discovery on April 7-8, 2025 in Montreal.
www.youtube.com
June 2, 2025 at 5:32 PM
If you weren’t able to attend our Symposium on Open Drug Discovery in Montreal in April, you’re in luck - the recordings are now on YouTube and the slides are on Zenodo!
🎥 Watch the recordings: www.youtube.com/playlist?lis...
📄 Access the slides: zenodo.org/communities/...
🎥 Watch the recordings: www.youtube.com/playlist?lis...
📄 Access the slides: zenodo.org/communities/...
Learning about European approaches to Pandemic Preparedness “We’re not safe till we’re all safe”:
@asapdiscovery.bsky.social
at: health.ec.europa.eu/events/hera-... #HealthUnion
@asapdiscovery.bsky.social
at: health.ec.europa.eu/events/hera-... #HealthUnion
health.ec.europa.eu
June 2, 2025 at 8:19 AM
Learning about European approaches to Pandemic Preparedness “We’re not safe till we’re all safe”:
@asapdiscovery.bsky.social
at: health.ec.europa.eu/events/hera-... #HealthUnion
@asapdiscovery.bsky.social
at: health.ec.europa.eu/events/hera-... #HealthUnion
Brilliant explainer from Pascale how to use patents as enablers in preparing for the next pandemic.
Did you know that we can manage patents in a way that serves the public good?
Our Intellectual Property & Access Leader shares why, together with our partners from the @asapdiscovery.bsky.social, we are filing a #patent for a promising new #molecule that we developed together.
shorturl.at/IgL80
Our Intellectual Property & Access Leader shares why, together with our partners from the @asapdiscovery.bsky.social, we are filing a #patent for a promising new #molecule that we developed together.
shorturl.at/IgL80
How patents can serve the common good
YouTube video by Drugs for Neglected Diseases initiative (DNDi)
youtube.com
April 10, 2025 at 12:58 PM
Brilliant explainer from Pascale how to use patents as enablers in preparing for the next pandemic.
Reposted by Ed Griffen
Today, @griffen-ed.bsky.social explains at the Open Drug Discovery Symposium how @asapdiscovery.bsky.social has developed a hybrid intellectual property model that counterintuitively uses patents to support open science innovation and ensure affordability & global access.
🔗 shorturl.at/gMY0t
🔗 shorturl.at/gMY0t
shorturl.at
April 8, 2025 at 8:11 PM
Today, @griffen-ed.bsky.social explains at the Open Drug Discovery Symposium how @asapdiscovery.bsky.social has developed a hybrid intellectual property model that counterintuitively uses patents to support open science innovation and ensure affordability & global access.
🔗 shorturl.at/gMY0t
🔗 shorturl.at/gMY0t
If this sparks your interest there's more of our background thinking published on open access in Wellcome Open Science: wellcomeopenresearch.org/articles/9-374
April 4, 2025 at 8:17 AM
If this sparks your interest there's more of our background thinking published on open access in Wellcome Open Science: wellcomeopenresearch.org/articles/9-374
Reposted by Ed Griffen
Here’s a post on this molecule, and good luck to all involved!
March 31, 2025 at 6:56 PM
Here’s a post on this molecule, and good luck to all involved!
Massive credit to all members of @asapdiscovery.bsky.social :- drug discovery is a massive team sport. Especially the chemists at Enamine working through the war.
At #ACSSpring2025, Ed Griffen of MedChemica disclosed the structure of a pancoronavirus antiviral that targets the main protease of the two different coronaviruses that cause Middle East respiratory syndrome (MERS) and COVID-19. cen.acs.org/acs-news/acs... 🧪
Antiviral unveiled that goes after multiple coronaviruses
Open-science consortium discloses its lead candidate to fight SARS-CoV-2 and MERS-CoV
cen.acs.org
March 28, 2025 at 10:01 PM
Massive credit to all members of @asapdiscovery.bsky.social :- drug discovery is a massive team sport. Especially the chemists at Enamine working through the war.
Reposted by Ed Griffen
If you, like me, do not particularly want to die by bleeding out of your eye sockets from diseases like Ebola, and think it's dumb to cut funding for viral countermeasures for future pandemics "because the COVID pandemic is over", here's something you can do about it:
resist.bot/petitions/PX...
resist.bot/petitions/PX...
Reinstate funding for pandemic prevention research and preparedness
Text SIGN PXNIDH to 50409 to send this to your officials.
resist.bot
March 28, 2025 at 12:48 AM
If you, like me, do not particularly want to die by bleeding out of your eye sockets from diseases like Ebola, and think it's dumb to cut funding for viral countermeasures for future pandemics "because the COVID pandemic is over", here's something you can do about it:
resist.bot/petitions/PX...
resist.bot/petitions/PX...
Reposted by Ed Griffen
New pancoronavirus antiviral targets the main protease (Mpro) of the two different coronaviruses that cause Middle East respiratory syndrome (MERS) and COVID-19. Via @laurahowes.bsky.social @cenmag.bsky.social cen.acs.org/acs-news/acs...
Antiviral unveiled that goes after multiple coronaviruses
Open-science consortium discloses its lead candidate to fight SARS-CoV-2 and MERS-CoV
cen.acs.org
March 26, 2025 at 7:55 PM
New pancoronavirus antiviral targets the main protease (Mpro) of the two different coronaviruses that cause Middle East respiratory syndrome (MERS) and COVID-19. Via @laurahowes.bsky.social @cenmag.bsky.social cen.acs.org/acs-news/acs...
Reposted by Ed Griffen
Three days to go until the unveiling of our MERS-CoV/SARS-CoV-2 oral antiviral candidate for preclinical development!
Lead medicinal chemist Ed Griffen (@griffen-ed.bsky.social) will be disclosing the new ASAP MERS-CoV/SARS-CoV-2 oral antiviral at @acs.org on Tue 25 Mar! Tune in to this virtual session to hear about its discovery and development!
acs.digitellinc.com/live/34/sess...
acs.digitellinc.com/live/34/sess...
March 22, 2025 at 7:22 PM
Three days to go until the unveiling of our MERS-CoV/SARS-CoV-2 oral antiviral candidate for preclinical development!
Reposted by Ed Griffen
Lead medicinal chemist Ed Griffen (@griffen-ed.bsky.social) will be disclosing the new ASAP MERS-CoV/SARS-CoV-2 oral antiviral at @acs.org on Tue 25 Mar! Tune in to this virtual session to hear about its discovery and development!
acs.digitellinc.com/live/34/sess...
acs.digitellinc.com/live/34/sess...
March 21, 2025 at 4:55 PM
Lead medicinal chemist Ed Griffen (@griffen-ed.bsky.social) will be disclosing the new ASAP MERS-CoV/SARS-CoV-2 oral antiviral at @acs.org on Tue 25 Mar! Tune in to this virtual session to hear about its discovery and development!
acs.digitellinc.com/live/34/sess...
acs.digitellinc.com/live/34/sess...
Reposted by Ed Griffen
✨Another symposium session reveal✨ Featuring Max Morgan and @griffen-ed.bsky.social, this session features speakers inventing and actively implementing new strategies that centre open science and collaboration to drive drug discovery! Register here: conscience.ca/symposium2025
February 17, 2025 at 10:09 PM
✨Another symposium session reveal✨ Featuring Max Morgan and @griffen-ed.bsky.social, this session features speakers inventing and actively implementing new strategies that centre open science and collaboration to drive drug discovery! Register here: conscience.ca/symposium2025
Reposted by Ed Griffen
3 weeks to go🚀
@griffen-ed.bsky.social is presenting at #ICAR2025 the highlights of the discovery, in vitro and in vivo profile of the ASAP AViIDD Center’s pre-clinical candidate for treating 6 lethal coronavirus infections: ASAP-0017445. Register now 🔗 lnkd.in/gbBRZSz2 @asapdiscovery.bsky.social
@griffen-ed.bsky.social is presenting at #ICAR2025 the highlights of the discovery, in vitro and in vivo profile of the ASAP AViIDD Center’s pre-clinical candidate for treating 6 lethal coronavirus infections: ASAP-0017445. Register now 🔗 lnkd.in/gbBRZSz2 @asapdiscovery.bsky.social
February 25, 2025 at 10:32 AM
3 weeks to go🚀
@griffen-ed.bsky.social is presenting at #ICAR2025 the highlights of the discovery, in vitro and in vivo profile of the ASAP AViIDD Center’s pre-clinical candidate for treating 6 lethal coronavirus infections: ASAP-0017445. Register now 🔗 lnkd.in/gbBRZSz2 @asapdiscovery.bsky.social
@griffen-ed.bsky.social is presenting at #ICAR2025 the highlights of the discovery, in vitro and in vivo profile of the ASAP AViIDD Center’s pre-clinical candidate for treating 6 lethal coronavirus infections: ASAP-0017445. Register now 🔗 lnkd.in/gbBRZSz2 @asapdiscovery.bsky.social
Reposted by Ed Griffen
5 weeks to go🚀
@griffen-ed.bsky.social is presenting at the @conscience-network.bsky.social Symposium. Talk Title; "Balancing Open Science and Intellectual Property to Discover and Develop Medicines” @asapdiscovery.bsky.social
Register now: conscience.ca/symposium202...
@griffen-ed.bsky.social is presenting at the @conscience-network.bsky.social Symposium. Talk Title; "Balancing Open Science and Intellectual Property to Discover and Develop Medicines” @asapdiscovery.bsky.social
Register now: conscience.ca/symposium202...
March 5, 2025 at 5:56 PM
5 weeks to go🚀
@griffen-ed.bsky.social is presenting at the @conscience-network.bsky.social Symposium. Talk Title; "Balancing Open Science and Intellectual Property to Discover and Develop Medicines” @asapdiscovery.bsky.social
Register now: conscience.ca/symposium202...
@griffen-ed.bsky.social is presenting at the @conscience-network.bsky.social Symposium. Talk Title; "Balancing Open Science and Intellectual Property to Discover and Develop Medicines” @asapdiscovery.bsky.social
Register now: conscience.ca/symposium202...