@gram-lab.bsky.social
Scientist, immigrant and Cell Biologist.
Hippo Pathway, Caveolae, Cancer, Regeneration, Mechanotransduction.
Tweets by PI. Views ≠ employers' RT ≠ endorse
IRR, Edinburgh, Scotland
www.gramhansenlab.com
Hippo Pathway, Caveolae, Cancer, Regeneration, Mechanotransduction.
Tweets by PI. Views ≠ employers' RT ≠ endorse
IRR, Edinburgh, Scotland
www.gramhansenlab.com
Pinned
Paper is out!
We establish evaluate compounds targeting the #Hippopathway.
We utilise an isogenic #mesothelioma model, functional assays, high-content & #Cellpainting to asses #YAP/TAZ-TEAD inhibitors.
@edinuni-irr.bsky.social @lsajournal.org
www.life-science-alliance.org/content/8/10...
We establish evaluate compounds targeting the #Hippopathway.
We utilise an isogenic #mesothelioma model, functional assays, high-content & #Cellpainting to asses #YAP/TAZ-TEAD inhibitors.
@edinuni-irr.bsky.social @lsajournal.org
www.life-science-alliance.org/content/8/10...
Reposted
High-content pipeline evaluating YAP/TAZ-TEAD inhibitors in mesothelioma using isogenic models,advanced morphological profiling & genetic response analysis,revealing drug specificity & compensatory pathways @gram-lab.bsky.social @edinuni-irr.bsky.social
August 8, 2025 at 3:04 PM
High-content pipeline evaluating YAP/TAZ-TEAD inhibitors in mesothelioma using isogenic models,advanced morphological profiling & genetic response analysis,revealing drug specificity & compensatory pathways @gram-lab.bsky.social @edinuni-irr.bsky.social
Paper is out!
We establish evaluate compounds targeting the #Hippopathway.
We utilise an isogenic #mesothelioma model, functional assays, high-content & #Cellpainting to asses #YAP/TAZ-TEAD inhibitors.
@edinuni-irr.bsky.social @lsajournal.org
www.life-science-alliance.org/content/8/10...
We establish evaluate compounds targeting the #Hippopathway.
We utilise an isogenic #mesothelioma model, functional assays, high-content & #Cellpainting to asses #YAP/TAZ-TEAD inhibitors.
@edinuni-irr.bsky.social @lsajournal.org
www.life-science-alliance.org/content/8/10...
August 3, 2025 at 9:38 PM
Paper is out!
We establish evaluate compounds targeting the #Hippopathway.
We utilise an isogenic #mesothelioma model, functional assays, high-content & #Cellpainting to asses #YAP/TAZ-TEAD inhibitors.
@edinuni-irr.bsky.social @lsajournal.org
www.life-science-alliance.org/content/8/10...
We establish evaluate compounds targeting the #Hippopathway.
We utilise an isogenic #mesothelioma model, functional assays, high-content & #Cellpainting to asses #YAP/TAZ-TEAD inhibitors.
@edinuni-irr.bsky.social @lsajournal.org
www.life-science-alliance.org/content/8/10...
Reposted
I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!
July 26, 2025 at 12:17 PM
I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!
Reposted
We've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.
December 12, 2024 at 4:22 PM
We've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.
Our #mesothelioma work featured
Dr. Carsten Hansen is advancing treatment for mesothelioma, a deadly cancer caused by asbestos. His team identified genetic mutations linked to worse outcomes, opening the door to tailored therapies.
Read more 👇
www.heraldscotland.com/news/2477596...
#CancerResearch #MesotheliomaAwareness
Read more 👇
www.heraldscotland.com/news/2477596...
#CancerResearch #MesotheliomaAwareness
Deadly dust stole my husband: fears grow for asbestos crisis in Scotland's buildings
They met as teenagers, married young, raised their family and saved hard for the future.
www.heraldscotland.com
December 10, 2024 at 5:38 PM
Our #mesothelioma work featured
Vienna anyone? IMP #GroupLeader position open!
Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025
November 20, 2024 at 11:09 AM
Vienna anyone? IMP #GroupLeader position open!
Reposted
If you’re working in animal comparative physiology or biomechanics and are within 5 years of setting up your first lab, apply for our JEB ECR Visiting Fellowships & Research Partnership Kickstart Travel Grants. Deadline 1 December
biologists.com/grants/kicks...
biologists.com/grants/ecr-v...
biologists.com/grants/kicks...
biologists.com/grants/ecr-v...
November 19, 2024 at 9:55 AM
If you’re working in animal comparative physiology or biomechanics and are within 5 years of setting up your first lab, apply for our JEB ECR Visiting Fellowships & Research Partnership Kickstart Travel Grants. Deadline 1 December
biologists.com/grants/kicks...
biologists.com/grants/ecr-v...
biologists.com/grants/kicks...
biologists.com/grants/ecr-v...
Our preprint from last week.
Development of a pipeline to evaluate YAP-TEAD inhibitor potential
www.biorxiv.org/content/10.1...
#mesothelioma, #cell-painting and #Hippopathway
Development of a pipeline to evaluate YAP-TEAD inhibitor potential
www.biorxiv.org/content/10.1...
#mesothelioma, #cell-painting and #Hippopathway
Development of a pipeline to evaluate YAP-TEAD inhibitor potential - direct TEAD inhibition represses cancerous growth in a NF2-mutant model of mesothelioma
As the core, tumorigenic downstream effectors of the Hippo signalling pathway, YAP/TAZ and the TEAD family of transcription factors represent attractive targets for drug discovery efforts within cance...
www.biorxiv.org
November 16, 2024 at 2:10 PM
Our preprint from last week.
Development of a pipeline to evaluate YAP-TEAD inhibitor potential
www.biorxiv.org/content/10.1...
#mesothelioma, #cell-painting and #Hippopathway
Development of a pipeline to evaluate YAP-TEAD inhibitor potential
www.biorxiv.org/content/10.1...
#mesothelioma, #cell-painting and #Hippopathway
Exciting #PhD openings. Please spread the word, and/or consider applying!
Excellent opportunities
1) UKRI AI based PhD program
www.ai4biomed.io/research/pro...
2) Precision Medicine Program
usher.ed.ac.uk/precision-me...
Excellent opportunities
1) UKRI AI based PhD program
www.ai4biomed.io/research/pro...
2) Precision Medicine Program
usher.ed.ac.uk/precision-me...
November 16, 2024 at 1:54 PM
Exciting #PhD openings. Please spread the word, and/or consider applying!
Excellent opportunities
1) UKRI AI based PhD program
www.ai4biomed.io/research/pro...
2) Precision Medicine Program
usher.ed.ac.uk/precision-me...
Excellent opportunities
1) UKRI AI based PhD program
www.ai4biomed.io/research/pro...
2) Precision Medicine Program
usher.ed.ac.uk/precision-me...
Back from the excellent #Hippopathway conference in Florida. What a lovely bunch of people, and exciting developments in the field. #Cancer, #Regeneration and #Fibrosis etc.
Great Science, and even saw a "rocket". Hard to beat for the next conference....
Great Science, and even saw a "rocket". Hard to beat for the next conference....
November 16, 2024 at 12:50 PM
Back from the excellent #Hippopathway conference in Florida. What a lovely bunch of people, and exciting developments in the field. #Cancer, #Regeneration and #Fibrosis etc.
Great Science, and even saw a "rocket". Hard to beat for the next conference....
Great Science, and even saw a "rocket". Hard to beat for the next conference....