@gram-lab.bsky.social
Scientist, immigrant and Cell Biologist.
Hippo Pathway, Caveolae, Cancer, Regeneration, Mechanotransduction.
Tweets by PI. Views ≠ employers' RT ≠ endorse
IRR, Edinburgh, Scotland
www.gramhansenlab.com
Hippo Pathway, Caveolae, Cancer, Regeneration, Mechanotransduction.
Tweets by PI. Views ≠ employers' RT ≠ endorse
IRR, Edinburgh, Scotland
www.gramhansenlab.com
• Genetic Compensation Identified: Reveals adaptive responses that may limit inhibitor efficacy.
•. Highlight the importance of having genetic controls, when assessing hippo-pathway targeting compounds.
•. Highlight the importance of having genetic controls, when assessing hippo-pathway targeting compounds.
August 3, 2025 at 9:38 PM
• Genetic Compensation Identified: Reveals adaptive responses that may limit inhibitor efficacy.
•. Highlight the importance of having genetic controls, when assessing hippo-pathway targeting compounds.
•. Highlight the importance of having genetic controls, when assessing hippo-pathway targeting compounds.
• Advanced Morphological Profiling: Implements Cell Painting to analyse cellular changes and detect off-target effects.
• Scalable Drug Screening Tool: Provides a clinically relevant and adaptable framework for future Hippo pathway drug discovery.
• Scalable Drug Screening Tool: Provides a clinically relevant and adaptable framework for future Hippo pathway drug discovery.
August 3, 2025 at 9:38 PM
• Advanced Morphological Profiling: Implements Cell Painting to analyse cellular changes and detect off-target effects.
• Scalable Drug Screening Tool: Provides a clinically relevant and adaptable framework for future Hippo pathway drug discovery.
• Scalable Drug Screening Tool: Provides a clinically relevant and adaptable framework for future Hippo pathway drug discovery.
Some highlights
• Comprehensive Inhibitor Evaluation: Head-to-head comparison of existing #YAP/TAZ-TEAD inhibitors in a mesothelioma-relevant context.
• Isogenic Cell Models: Utilise matched genetic models to accurately assess drug specificity and on-target effects.
• Comprehensive Inhibitor Evaluation: Head-to-head comparison of existing #YAP/TAZ-TEAD inhibitors in a mesothelioma-relevant context.
• Isogenic Cell Models: Utilise matched genetic models to accurately assess drug specificity and on-target effects.
August 3, 2025 at 9:38 PM
Some highlights
• Comprehensive Inhibitor Evaluation: Head-to-head comparison of existing #YAP/TAZ-TEAD inhibitors in a mesothelioma-relevant context.
• Isogenic Cell Models: Utilise matched genetic models to accurately assess drug specificity and on-target effects.
• Comprehensive Inhibitor Evaluation: Head-to-head comparison of existing #YAP/TAZ-TEAD inhibitors in a mesothelioma-relevant context.
• Isogenic Cell Models: Utilise matched genetic models to accurately assess drug specificity and on-target effects.