Stephanie Grach M.D. M.S.
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grachstephanie.bsky.social
Stephanie Grach M.D. M.S.
@grachstephanie.bsky.social
2.7K followers 330 following 34 posts
Physician specializing in ME/CFS, Long COVID, & associated complex disease | Assistant Professor of Medicine | She/Her/Hers | https://t.co/TkYm2MXvir
Posts Replies Media Videos
Reposted by Stephanie Grach M.D. M.S.
valebodi.bsky.social
21 October 2025
Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study

Brian T. Ruan, Sarojini Bulbule, Brooke Gile, Amy Reyes, Bela Chheda, Lucinda Bateman, Jennifer Bell, Brayden Yellman, @grachstephanie.bsky.social
Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study - Journal of Translational Medicine
Background mTOR activation is associated with chronic inflammation in ME/CFS. Previous studies have shown that sustained mTOR activation may cause chronic muscle fatigue by inhibiting ATG13-mediated a...
translational-medicine.biomedcentral.com
October 21, 2025 at 3:27 PM
grachstephanie.bsky.social
Truly honored to have lead the inaugural chapter on #MECFS management in the @elsevierconnect.bsky.social textbook Scientific Basis of Fatigue, "Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A New Narrative." The greatest honor of all was co-authoring with my role models--
Dr. Stephanie Grach, a Caucasian woman with brown eyes and (currently) shoulder-length brown hair, holding a textbook open to the mentioned chapter's first page. Wearing a blue suit jacket, red/blue shirt, and blue KN95 mask, against a purple-gray background.
October 7, 2025 at 4:34 PM
Reposted by Stephanie Grach M.D. M.S.
meactnet.bsky.social
Stellar new work from @grachstephanie.bsky.social, @exceedhergrasp1.bsky.social, @batemanhornecenter.bsky.social's Bell and Yellman & @raviganeshmd.bsky.social in the Elsevier text 'The Scientific Basis of Fatigue'! The book has chapters on #MECFS, COVID, Parkinson’s, stroke, and multiple sclerosis.
Text-based graphic with one photo. Text: New publication. Managing myalgic encephalomyelitis/chronic fatigue syndrome: a new narrative. a chapter in a new Elsevier textbook written by coauthors from #MEAction, Mayo Clinic Rochester and the Bateman-Horne Center. “I was honored to co-author this chapter with colleagues from Mayo Clinic and the Bateman-Horne Center to give clinicians and researchers the tools they need to better recognize, study and treat ME/CFS.” Jaime Seltzer, Scientific Director, #MEAction Photo: Jaime Seltzer (white woman with long, dark hair) wearing glasses and cream blazer and red top slightly smiling.
October 1, 2025 at 4:23 PM
Reposted by Stephanie Grach M.D. M.S.
exceedhergrasp1.bsky.social
The first paper that uses the Pacing Narrative Study data is now published!

@grachstephanie.bsky.social is building a case for vocal differences to detect #PEM. She found many discussed such issues during a crash.

Find the paper here: 🧪

www.mdpi.com/2077-0383/14...

#MECFS
www.mdpi.com
July 8, 2025 at 2:49 PM
grachstephanie.bsky.social
"Navigating uncertainty is not about waiting for perfect data—it is about using the best available knowledge, engaging in structured clinical reasoning, and remaining open to new insights..." (1/2)
batemanhornecenter.bsky.social Bateman Horne Center @batemanhornecenter.bsky.social · May 9
The Clinical Care Guide for #MECFS, #LongCOVID & IACCs is here! Download, share, and use it to support better care. BHC's approach is now freely available—designed to help providers manage complex conditions with clarity & compassion. Download it. Share it. Use it. bit.ly/432YdzF
Graphic with a stethoscope and a doctor’s arm, displaying the text 'CLINICAL CARE GUIDE Managing ME/CFS, Long COVID, & IACCs.' The Bateman Horne Center and MERC logos are at the bottom, with a background of a deep blue gradient.
May 10, 2025 at 8:43 PM
grachstephanie.bsky.social
Had the honor of presenting the initial patient-reported outcomes of the collaborative rapamycin study led by Simmaron at ACP #IM2025 today! Had an amazing time talking with clinicians from all over the country about advancing the knowledge and care of #MECFS
A poster with blue border and white background describing initial results of our rapamycin study.
April 3, 2025 at 10:04 PM
grachstephanie.bsky.social
Incredibly honored to have received the Mayo Model of Care Award tonight. I am so thankful to my friends and colleagues for their support of me and the patients we serve 💙
Dr. Grach, brown haired, Caucasian female smiling and holding an award.
December 6, 2024 at 3:27 AM
Reposted by Stephanie Grach M.D. M.S.
tomkindlon.bsky.social
Double-blinded, controlled study of oxaloacetate for improving fatigue in ME/CFS

www.frontiersin.org/journals/neu...

Great to see this sort of trial being done. Results seem quite modest given it's so expensive

#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME

1/
Background: The energy metabolite oxaloacetate is significantly lower in the blood plasma of ME/CFS subjects. A previous open-label trial with oxaloacetate supplementation demonstrated a significant reduction in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-related fatigue. Methods: In this follow-up trial, 82 ME/CFS subjects were enrolled in a 3-month randomized, double-blinded, controlled study, receiving either 2,000 mg of oxaloacetate or control per day. The primary endpoints were safety and reduction in fatigue from baseline. Secondary and exploratory endpoints included functional capacity and general health status. Results: Anhydrous enol-oxaloacetate (oxaloacetate) was well tolerated at the tested doses. Oxaloacetate significantly reduced fatigue by more than 25% from baseline, while the control group showed a non-significant reduction of approximately 10%. Intergroup analysis showed a significant decrease in fatigue levels in the oxaloacetate group (p = 0.0039) with no notable change in the control group. A greater proportion of subjects in the oxaloacetate group achieved a reduction in fatigue greater than 25% compared to the control group (p < 0.05). Additionally, 40.5% of the oxaloacetate group were classified as “enhanced responders,” with an average fatigue reduction of 63%. Both physical and mental fatigue improved with oxaloacetate supplementation. Conclusion: Oxaloacetate is well tolerated and effectively helps reduce fatigue in ME/CFS patients.
December 1, 2024 at 6:52 PM
Reposted by Stephanie Grach M.D. M.S.
meactnet.bsky.social
Great news! #MEAction & the Mayo Clinic have been awarded the Sigma 2024 American Nurses Credentialing Center Evidence-Based Practice Implementation Grant awarded by The STTI Honor Society of Nursing.

Details: www.meaction.net/2024/11/18/m...

#pwME #MECFS #MyalgicEncephalomyelitis
#MEAction & Mayo Clinic Projects Continue - New Grant Awarded
A new grant awarded by Sigma
www.meaction.net
November 18, 2024 at 6:34 PM
Reposted by Stephanie Grach M.D. M.S.
chromatowski.bsky.social
I have this link saved so I can watch @exceedhergrasp1.bsky.social @grachstephanie.bsky.social & coauthors’ excellent ME review continue to climb the Altmetric ranks, for a steady supply of good news :)

www.altmetric.com/details/1549...
exceedhergrasp1.bsky.social It's ME(Jaime) @exceedhergrasp1.bsky.social · Oct 9
It’s in the top✨< 1%✨ most shared of all Mayo Clinic publications.

It’s the ✨most shared paper✨ amongst its contemporaries at Mayo Clinic Proceedings.

It’s in the ✨top 0.2%✨ most shared research products of all time.

It’s been live less than a week.

tinyurl.com/ywd3kmjs
October 11, 2023 at 12:09 AM
Reposted by Stephanie Grach M.D. M.S.
exceedhergrasp1.bsky.social
Overjoyed to announce my Concise Clinical Review of ME/CFS in Mayo Clinic Proceedings (with updated diagrams!) Very glad to have worked with
Stephanie Grach, and Ravi Ganesh and Tony Chon on this! #MedEd #MedTwitter 🧵 www.mayoclinicproceedings.org/article/S002...
Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic neurologic disease often preceded by infection. There has been increased interest in ME/CFS recently because of its significant...
www.mayoclinicproceedings.org
October 7, 2023 at 4:03 PM