🚀 Many thanks to @SDSC_UCSD and @HPCwire for highlighting our work using @NSF supercomputers to uncover how “jumping genes” can transform #GeneEditing technologies!
www.sdsc.edu/news/2025/PR...
#Supercomputing #HPC #CRISPR #RNA #CompChem

✨Best way to end the week! Just learned from Kevin Freedman @ucriverside.bsky.social that, at the end of the exam, students in his Dynamics of Biological Systems class draw their favorite professor.
Guess who got picked...
♥️♥️♥️
#biophysics #TeachingJoy #STEM #LoveScience

🚀New from our lab @biorxivpreprint.bsky.social!
We reveal a cryptic metal binding pocket that dinamically forms in #CRISPR-Cas9 and regulates the metal-dependent activity of #Cas9.
#MarkovModels & #QuantumChemistry corroborated by biochem & #NMR experiments.
www.biorxiv.org/content/10.1...

So exciting to be @proteinsociety.bsky.social meeting with my lab!

🔬🧬 Excited to be at the @proteinsociety.bsky.social meeting in SF! Curious how #NeuralNetworks can decode biomolecular mechanisms? Don’t miss the poster by ChinmaiPindi and AmunPatel ! #Proteins #AI #CRISPR #DNA

New study @biorxivpreprint
We revea, how TnsC filaments form and grow in #CRISPR-associated transposons using #FreeEnergy sims & introduce #DeepLearning-based Graph Attention Networks for decoding biomolecular systems!
www.biorxiv.org/content/10.1...
#GNN #MolecularDynamics #StructuralBiology

New paper from our lab just out @pnas.org! 🚀
Using free energy simulations, #AIphaFold and #cryoEM refinement, we uncovered a key conformational change in a paradigm-shifting #CRISPR-associated #transposon capable of precise gene knock-ins. 🔍🧬
www.pnas.org/doi/epub/10....

Thrilled to join #ACSSpring2025 and meet my friends! Don't miss my talk on how #AI & #EnhancedSampling can describe gene editing & refine #cryoEM maps. We’ll be presenting our latest research on #CRISPR-associated transposon systems + other exciting advancements! #compchem #RNA
#compchem #RNA

🚀 Exciting new poster from our lab at #BPS2025!

🧬 @Ahsan09966804 showcases how #MolecularDynamics & #AI can enhance #CryoEM map refinement.

📍 Catch it at Board 18 (1824-Pos) today, don’t miss out! #Biophysics #CompBio

Carolina Sarto @carosarto.bsky.social, a brilliant student from the University of Buenos Aires, will be presenting her work on #RNA synthesis in #DengueVirus🦠 at #BPS2025.

Don’t miss her poster today L3074-Pos (LB13). She’s looking for a postdoc, and I have no doubt she’ll thrive!

Excited to be at #BPS2025! 🚀 Our lab is contributing to the #cryoEM symposium, showcasing how computational methods and AI are revolutionizing cryo-EM analysis. See you there! 🔬💡 #Biophysics #AI
Read our papers to know more:
www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...

New paper from our lab @elife.bsky.social . We show how #DirectedEvolution reshaped #CRISPR for expanding DNA recongition.
This is work by Kazi Hossain, an incredibly talented student visiting my lab from the Czub lab, now in Orozco's lab & Lukasz Nierzwicki.
doi.org/10.7554/eLif...

New paper from our lab @naturecomms.bsky.social!
We reveal the dynamics and mechanism of target DNA traversal in #CRISPR Cas12a, a conundrum in the field!
nature.com/articles/s41...
#compchem
We thank the amazing #HPC resources of PSC #Anton2 and SDSC