Georg Heinze
@georgheinze.bsky.social
Biostatistician, prognosis researcher, beginner.
Reposted by Georg Heinze
A new release of the mgcv #RStats 📦 is out on CRAN and Simon Wood (U Edinburgh) has added some significant new features despite the small bump in version number:
🌟 scasm() for estimating GAMs with shape constrained smooths. Can be used with any family & smoothness selection is via the EFS method
🌟 scasm() for estimating GAMs with shape constrained smooths. Can be used with any family & smoothness selection is via the EFS method
November 12, 2025 at 11:28 AM
A new release of the mgcv #RStats 📦 is out on CRAN and Simon Wood (U Edinburgh) has added some significant new features despite the small bump in version number:
🌟 scasm() for estimating GAMs with shape constrained smooths. Can be used with any family & smoothness selection is via the EFS method
🌟 scasm() for estimating GAMs with shape constrained smooths. Can be used with any family & smoothness selection is via the EFS method
They did not do an Initial data Analysis with the data they shared. They could have avoided a lot of trouble if they did. "Data sharing without regrets"... See some recommendations here: doi.org/10.1186/s128...
November 11, 2025 at 6:51 PM
They did not do an Initial data Analysis with the data they shared. They could have avoided a lot of trouble if they did. "Data sharing without regrets"... See some recommendations here: doi.org/10.1186/s128...
Reposted by Georg Heinze
You do not need to see the results in order to write ~2/3 of a quant. research paper in medicine/health.
November 10, 2025 at 5:03 PM
You do not need to see the results in order to write ~2/3 of a quant. research paper in medicine/health.
Reposted by Georg Heinze
Idea for a Christmas BMJ paper: submit loads of Christmas BMJ papers, then do a survival analysis of time to rejection. Then submit the survival analysis as a Christmas BMJ paper the following year
October 29, 2025 at 10:05 AM
Idea for a Christmas BMJ paper: submit loads of Christmas BMJ papers, then do a survival analysis of time to rejection. Then submit the survival analysis as a Christmas BMJ paper the following year
This commentary by John B. Carlin expresses many of the concerns that I have always had with 'prognostic factor (finding) studies' and the (weird) definition of 'independent predictors': doi.org/10.1016/j.jc...
Redirecting
doi.org
November 6, 2025 at 12:07 PM
This commentary by John B. Carlin expresses many of the concerns that I have always had with 'prognostic factor (finding) studies' and the (weird) definition of 'independent predictors': doi.org/10.1016/j.jc...
Reposted by Georg Heinze
There are lots of professional data repositories to share your data (see www.re3data.org) - if you want to share the code as well you can push to github and archive it on zenodo with a DOI.
Home | re3data.org
www.re3data.org
October 29, 2025 at 9:05 PM
There are lots of professional data repositories to share your data (see www.re3data.org) - if you want to share the code as well you can push to github and archive it on zenodo with a DOI.
Reposted by Georg Heinze
The distinction between causal, predictive, and descriptive research—there is still room for improvement - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
The distinction between causal, predictive, and descriptive research—there is still room for improvement
It has been proposed that medical research questions can be categorised into three
classes: causal, predictive, and descriptive. This distinction was proposed to encourage
researchers to think clearly...
www.jclinepi.com
September 18, 2025 at 7:29 PM
The distinction between causal, predictive, and descriptive research—there is still room for improvement - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Great experience with a novel format of an invited session of #stratos TG2 @biometricsociety.bsky.social Austro-Swiss region meeting (ROeS 2025 Graz) (1/n)
September 18, 2025 at 5:44 PM
Great experience with a novel format of an invited session of #stratos TG2 @biometricsociety.bsky.social Austro-Swiss region meeting (ROeS 2025 Graz) (1/n)
Reposted by Georg Heinze
#ISCB46 very nice talk by Michael Kammer on COVID-19 prognostic models, which involved a ‘deep dive’ into the pond life of modelling.
Bottom line: “If looking for reliable models, don’t hold your breath.”
Bottom line: “If looking for reliable models, don’t hold your breath.”
August 25, 2025 at 2:25 PM
#ISCB46 very nice talk by Michael Kammer on COVID-19 prognostic models, which involved a ‘deep dive’ into the pond life of modelling.
Bottom line: “If looking for reliable models, don’t hold your breath.”
Bottom line: “If looking for reliable models, don’t hold your breath.”
Published: the paper 'On the uses and abuses of Regression Models: a Call for Reform of Statistical Practice and Teaching' by John Carlin and Margarita Moreno-Betancur in the latest issue of Statistics in Medicine onlinelibrary.wiley.com/doi/10.1002/... (1/8)
onlinelibrary.wiley.com
June 26, 2025 at 12:23 PM
Published: the paper 'On the uses and abuses of Regression Models: a Call for Reform of Statistical Practice and Teaching' by John Carlin and Margarita Moreno-Betancur in the latest issue of Statistics in Medicine onlinelibrary.wiley.com/doi/10.1002/... (1/8)
This is taking statistical education to the next level: www.youtube.com/watch?v=pZTL... by Rafael de Andrade Moral, Maynooth University
Summary Song #9 - Overfitting (Stats Parody - Charlie Puth Attention)
YouTube video by The Raf
www.youtube.com
June 20, 2025 at 9:30 AM
This is taking statistical education to the next level: www.youtube.com/watch?v=pZTL... by Rafael de Andrade Moral, Maynooth University
Reposted by Georg Heinze
Continuing our #BlackHistoryMonth series, we celebrate Sean Simpson, Professor of Biostatistics & Data Science, for his contributions to neuroimaging analysis, repeated measures, & covariance modeling. Outside of work, he enjoys time with his wife, statistician Felicia, and their daughter Sophia.
February 18, 2025 at 12:10 AM
Continuing our #BlackHistoryMonth series, we celebrate Sean Simpson, Professor of Biostatistics & Data Science, for his contributions to neuroimaging analysis, repeated measures, & covariance modeling. Outside of work, he enjoys time with his wife, statistician Felicia, and their daughter Sophia.
Reposted by Georg Heinze
It's amazing how far back ideas go.
This paper from 1984 by @f2harrell.bsky.social discusses the need for train/test data splits and the importance of assessing model calibration and discrimination and instability in variable selection methods.
onlinelibrary.wiley.com/doi/epdf/10....
This paper from 1984 by @f2harrell.bsky.social discusses the need for train/test data splits and the importance of assessing model calibration and discrimination and instability in variable selection methods.
onlinelibrary.wiley.com/doi/epdf/10....
Regression modelling strategies for improved prognostic prediction
Regression models such as the Cox proportional hazards model have had increasing use in modelling and estimating the prognosis of patients with a variety of diseases. Many applications involve a larg...
onlinelibrary.wiley.com
March 5, 2025 at 11:08 AM
It's amazing how far back ideas go.
This paper from 1984 by @f2harrell.bsky.social discusses the need for train/test data splits and the importance of assessing model calibration and discrimination and instability in variable selection methods.
onlinelibrary.wiley.com/doi/epdf/10....
This paper from 1984 by @f2harrell.bsky.social discusses the need for train/test data splits and the importance of assessing model calibration and discrimination and instability in variable selection methods.
onlinelibrary.wiley.com/doi/epdf/10....
Reposted by Georg Heinze
Five years ago @laurewynants.bsky.social and I started this living review. Within 1 year we reviewed >700 prediction models for COVID and we found many to be poor and decided to stop reviewing. Many external validation studies followed confirming many indeed were poor
www.bmj.com/content/369/...
www.bmj.com/content/369/...
March 7, 2025 at 8:22 AM
Five years ago @laurewynants.bsky.social and I started this living review. Within 1 year we reviewed >700 prediction models for COVID and we found many to be poor and decided to stop reviewing. Many external validation studies followed confirming many indeed were poor
www.bmj.com/content/369/...
www.bmj.com/content/369/...
I was just wondering what would have happened if the development had been the other way around. If machine learning had existed beforehand and regression analysis had only been invented afterwards.
January 30, 2025 at 4:18 PM
I was just wondering what would have happened if the development had been the other way around. If machine learning had existed beforehand and regression analysis had only been invented afterwards.
Reposted by Georg Heinze
I can’t count how many of Ian White’s papers have improved my practice of #Statistics. #StatsSky
January 8, 2025 at 12:09 PM
I can’t count how many of Ian White’s papers have improved my practice of #Statistics. #StatsSky
Reposted by Georg Heinze
We have two vacancies for a postdoctoral and PhD researcher at Maastricht University. They will work on the development and application of value-of-information methods for the validation of clinical risk prediction models and medical AI.
links below
links below
PhD in Epidemiology on value-of-information from validating clinical prediction models and AI
PhD in Epidemiology on value-of-information from validating clinical prediction models and AI
vacancies.maastrichtuniversity.nl
December 20, 2024 at 3:43 PM
We have two vacancies for a postdoctoral and PhD researcher at Maastricht University. They will work on the development and application of value-of-information methods for the validation of clinical risk prediction models and medical AI.
links below
links below
Reposted by Georg Heinze
Another exciting STRATOS session at #IBC2024ATL
December 10, 2024 at 7:01 PM
Another exciting STRATOS session at #IBC2024ATL
Reposted by Georg Heinze
Statistical Thinking Across Borders: Building Bridges and Expanding Horizons in Clinical Biostatistics at the 46th Annual Conference of the ISCB (International Society for Clinical Biostatistics), this time in the Trinational Eurodistrict of Basel, Switzerland, from August 24th to 28th, 2025.
December 11, 2024 at 6:34 AM
Statistical Thinking Across Borders: Building Bridges and Expanding Horizons in Clinical Biostatistics at the 46th Annual Conference of the ISCB (International Society for Clinical Biostatistics), this time in the Trinational Eurodistrict of Basel, Switzerland, from August 24th to 28th, 2025.
Meeting @marchenrion.bsky.social at the poster session #IBC2024ATL #atlanta #internationalbiometricconference #STRATOS
December 11, 2024 at 2:11 PM
Meeting @marchenrion.bsky.social at the poster session #IBC2024ATL #atlanta #internationalbiometricconference #STRATOS
After many online meetings, it feels great to meet fellow #Stratos colleagues in person #internationalbiometricconference #atlanta
December 11, 2024 at 2:07 PM
After many online meetings, it feels great to meet fellow #Stratos colleagues in person #internationalbiometricconference #atlanta
Reposted by Georg Heinze
Very exciting to attend a Sander Greenland talk and being lectured on bad practices in epidemiology and biostatistics - and how to do better and change practice in the next generation of researchers. #IBC2024ATL
December 9, 2024 at 2:42 PM
Very exciting to attend a Sander Greenland talk and being lectured on bad practices in epidemiology and biostatistics - and how to do better and change practice in the next generation of researchers. #IBC2024ATL
Reposted by Georg Heinze
Great STRATOS TG2 session with @georgheinze.bsky.social at #IBC2024ATL. Another session this afternoon at 2pm.
December 9, 2024 at 5:33 PM
Great STRATOS TG2 session with @georgheinze.bsky.social at #IBC2024ATL. Another session this afternoon at 2pm.
Two AIs talking about our paper on phases of methodological research in biostatistics doi.org/10.1002/bimj..., created with minimum effort - fascinating and a bit fearsome notebooklm.google.com/notebook/85f...
Sign in - Google Accounts
notebooklm.google.com
November 29, 2024 at 10:03 PM
Two AIs talking about our paper on phases of methodological research in biostatistics doi.org/10.1002/bimj..., created with minimum effort - fascinating and a bit fearsome notebooklm.google.com/notebook/85f...