Anirudh Jakhmola
@funnirudh.bsky.social
I engineer and manipulate viruses, in the literal sense.
#Cdiff #phage #CryoEM
MRC DiMeN DTP PhD Student @University of Sheffield | Int BS-MS @NISER Bhubaneswar | Former Intern @MPI Evol Bio, Plön
#Cdiff #phage #CryoEM
MRC DiMeN DTP PhD Student @University of Sheffield | Int BS-MS @NISER Bhubaneswar | Former Intern @MPI Evol Bio, Plön
Reposted by Anirudh Jakhmola
Thrilled to present the findings from my 2025 #SUREscheme project - 'Investigating the influence of latent bacteriophages on healthcare-associated C. difficile lysogens' - at the showcase yesterday evening. Huge thanks to @funnirudh.bsky.social and @robfagan.bsky.social for making this possible!
November 7, 2025 at 12:49 PM
Thrilled to present the findings from my 2025 #SUREscheme project - 'Investigating the influence of latent bacteriophages on healthcare-associated C. difficile lysogens' - at the showcase yesterday evening. Huge thanks to @funnirudh.bsky.social and @robfagan.bsky.social for making this possible!
Reposted by Anirudh Jakhmola
🚨 Fully funded PhD studentships 🚨
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
Clostridial Cell Biology Group
We are the Clostridial Cell Biology Group at the University of Sheffield. We study all aspects of cell biology, including the architecture and biogenesis of surface structures on both vegetative cells...
sites.google.com
October 31, 2025 at 3:44 PM
🚨 Fully funded PhD studentships 🚨
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an application
Look at this beautiful CsCl gradient.
I’m lying, my gradient crashed. I lost my phages and I am going home.
I’m lying, my gradient crashed. I lost my phages and I am going home.
October 16, 2025 at 3:13 PM
Look at this beautiful CsCl gradient.
I’m lying, my gradient crashed. I lost my phages and I am going home.
I’m lying, my gradient crashed. I lost my phages and I am going home.
Reposted by Anirudh Jakhmola
You know that antibiotic use can exert pressure on bacterial populations to evolve resistance.
So are vaccines exerting similar pressure on viruses?
Let's talk about how vaccines MIGHT make viruses evolve to be LESS harmful over time.
Warning: I'm speaking broadly here & biology loves exceptions.
So are vaccines exerting similar pressure on viruses?
Let's talk about how vaccines MIGHT make viruses evolve to be LESS harmful over time.
Warning: I'm speaking broadly here & biology loves exceptions.
September 7, 2025 at 9:57 PM
You know that antibiotic use can exert pressure on bacterial populations to evolve resistance.
So are vaccines exerting similar pressure on viruses?
Let's talk about how vaccines MIGHT make viruses evolve to be LESS harmful over time.
Warning: I'm speaking broadly here & biology loves exceptions.
So are vaccines exerting similar pressure on viruses?
Let's talk about how vaccines MIGHT make viruses evolve to be LESS harmful over time.
Warning: I'm speaking broadly here & biology loves exceptions.
Reposted by Anirudh Jakhmola
Lab on tour - the wonderful #ClostPath2025 organisers have arranged great walking tours. Guess where we are?
September 3, 2025 at 5:23 PM
Lab on tour - the wonderful #ClostPath2025 organisers have arranged great walking tours. Guess where we are?
We’re here, and we’re square.
September 2, 2025 at 8:13 PM
We’re here, and we’re square.
Reposted by Anirudh Jakhmola
A novel two-component system controls vancomycin resistance in epidemic Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.08.21.671617v1
August 22, 2025 at 3:16 AM
A novel two-component system controls vancomycin resistance in epidemic Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.08.21.671617v1
Me seeing the price of booking the cryo-EM for 3 days.
Me every month when the tissue culture and mouse facility invoices drop.
#academia
#academia
July 25, 2025 at 9:10 PM
Me seeing the price of booking the cryo-EM for 3 days.
Reposted by Anirudh Jakhmola
Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
June 12, 2025 at 8:31 PM
Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!
Reposted by Anirudh Jakhmola
Now engineering phages with Anirudh Jakhmola from @robfagan.bsky.social lab at @sheffielduni.bsky.social #3cdf
June 5, 2025 at 10:57 AM
Now engineering phages with Anirudh Jakhmola from @robfagan.bsky.social lab at @sheffielduni.bsky.social #3cdf
Reposted by Anirudh Jakhmola
Prophage induction - nice study, inducers other than MitC, but also that inducer concentration matters. Search for optimum needed to get highest titers ☝️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
High-throughput screening reveals diverse lambdoid prophage inducers
Prophages; dormant bacteriophage genomes integrated within the bacterial chromosome, play pivotal roles in shaping microbial communities when awakened. Our current understanding of prophage activation...
www.biorxiv.org
May 30, 2025 at 9:51 AM
Prophage induction - nice study, inducers other than MitC, but also that inducer concentration matters. Search for optimum needed to get highest titers ☝️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Managed to nab a signed copy of Everything is Tuberculosis by @johngreensbluesky.bsky.social. Quite excited to read this.
May 11, 2025 at 1:58 PM
Managed to nab a signed copy of Everything is Tuberculosis by @johngreensbluesky.bsky.social. Quite excited to read this.
The mutagenesis gods were with us this week.
Ended the scientific week on a high with word of 4 new tricky mutants successfully made! Hannah made two C. sporogenes mutants on first try and @funnirudh.bsky.social managed to make two 55kb deletions in C. diff - a new lab size record!
May 11, 2025 at 1:13 PM
The mutagenesis gods were with us this week.
Reposted by Anirudh Jakhmola
The do’s and don’ts of scientific image editing
Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.
@sarareardon.bsky.social reports
www.nature.com/articles/d41...
Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.
@sarareardon.bsky.social reports
www.nature.com/articles/d41...
The do’s and don’ts of scientific image editing
Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.
www.nature.com
April 30, 2025 at 6:54 AM
The do’s and don’ts of scientific image editing
Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.
@sarareardon.bsky.social reports
www.nature.com/articles/d41...
Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.
@sarareardon.bsky.social reports
www.nature.com/articles/d41...
Reposted by Anirudh Jakhmola
Happy to announce 2nd #3CdF Cross-channel C. difficile Forum in Newcastle, June 4-5 for #Cdiff researchers from UK, France and Europe, w/ strong emphasis on ECRs! Thanks to @microbiologysociety.org support!
event.fourwaves.com/3cdf-2025/pa...
Registration & abstract submission still open! #MicroSky
event.fourwaves.com/3cdf-2025/pa...
Registration & abstract submission still open! #MicroSky
3CdF 2025
Fourwaves - 3CdF 2025
event.fourwaves.com
April 30, 2025 at 10:14 AM
Happy to announce 2nd #3CdF Cross-channel C. difficile Forum in Newcastle, June 4-5 for #Cdiff researchers from UK, France and Europe, w/ strong emphasis on ECRs! Thanks to @microbiologysociety.org support!
event.fourwaves.com/3cdf-2025/pa...
Registration & abstract submission still open! #MicroSky
event.fourwaves.com/3cdf-2025/pa...
Registration & abstract submission still open! #MicroSky
Pip can be a physicist if that’s her thing. I bet she’ll be a good physicist.
Pip crashed our lab meeting this morning. Didn't seem all that interested in AFM though - there's no pleasing some dogs. Lab alum @buddlejess.bsky.social also joined us to discuss her next vancomycin resistance paper (and meet Pip!)
April 25, 2025 at 9:54 PM
Pip can be a physicist if that’s her thing. I bet she’ll be a good physicist.
Screening some mutant phages and can’t help but feel bad about this guy who:
1. Had his head burst (Red selection is where the head was supposed to be)
2. Tail tube broke in half
RIP unnamed phage. You will be missed.
1. Had his head burst (Red selection is where the head was supposed to be)
2. Tail tube broke in half
RIP unnamed phage. You will be missed.
April 22, 2025 at 9:10 AM
Screening some mutant phages and can’t help but feel bad about this guy who:
1. Had his head burst (Red selection is where the head was supposed to be)
2. Tail tube broke in half
RIP unnamed phage. You will be missed.
1. Had his head burst (Red selection is where the head was supposed to be)
2. Tail tube broke in half
RIP unnamed phage. You will be missed.
Extinction is permanent.
Inside me there are two wolves. One of them has a 15 genome edits the other 20 genome edits. Neither of them is a dire wolf.
April 8, 2025 at 6:54 PM
Extinction is permanent.
Presented my work in the Science Graduate Showcase at the University of Sheffield. A bit subtle in design compared to my past posters but there’s always tomorrow. #phage
April 6, 2025 at 8:45 AM
Presented my work in the Science Graduate Showcase at the University of Sheffield. A bit subtle in design compared to my past posters but there’s always tomorrow. #phage
Reposted by Anirudh Jakhmola
New paper alert 🚨
We've solved the complete structure of a C. difficile-infecting phage using cryo-EM, in both extended and contracted conformations - published today in Life Science Alliance
www.life-science-alliance.org/content/8/6/...
We've solved the complete structure of a C. difficile-infecting phage using cryo-EM, in both extended and contracted conformations - published today in Life Science Alliance
www.life-science-alliance.org/content/8/6/...
Molecular mechanism of bacteriophage contraction structure of an S-layer–penetrating bacteriophage
The molecular details of phage tail contraction and bacterial cell envelope penetration remain poorly understood and are completely unknown for phages infecting bacteria enveloped by proteinaceous S-l...
www.life-science-alliance.org
March 26, 2025 at 2:21 PM
New paper alert 🚨
We've solved the complete structure of a C. difficile-infecting phage using cryo-EM, in both extended and contracted conformations - published today in Life Science Alliance
www.life-science-alliance.org/content/8/6/...
We've solved the complete structure of a C. difficile-infecting phage using cryo-EM, in both extended and contracted conformations - published today in Life Science Alliance
www.life-science-alliance.org/content/8/6/...
NCBI has the most sassy server I’ve ever come across. What do you mean that the error code is NO_ERROR? Real helpful NCBI.
March 10, 2025 at 1:00 PM
NCBI has the most sassy server I’ve ever come across. What do you mean that the error code is NO_ERROR? Real helpful NCBI.
Reposted by Anirudh Jakhmola
Introducing Pip! 4 weeks old and doing brilliantly
March 8, 2025 at 4:03 PM
Introducing Pip! 4 weeks old and doing brilliantly
Spending the last few days at my home and I can never get used to this view. The himalayan range in the background steals the show.
Pretty curious about the phage diversity here though.
Pretty curious about the phage diversity here though.
January 14, 2025 at 1:40 PM
Spending the last few days at my home and I can never get used to this view. The himalayan range in the background steals the show.
Pretty curious about the phage diversity here though.
Pretty curious about the phage diversity here though.