Fred D Mast
@fredmast.bsky.social
I study how peroxisomes and infectious diseases shape pediatric health. Science, funding, and policy structure what is possible—and the path to improving lives.
Reposted by Fred D Mast
Great start to #CellBio2025 in Philadelphia with "The Peroxisome Renaissance: From Molecular Mechanisms to Cellular Functions" session organized by @fredmast.bsky.social.
Really enjoyed speaking alongside Bonnie Bartel, Michael Skowyra, Jie Sun, Francesca Di Cara, PhD, and Peter Kim. 🙌
Really enjoyed speaking alongside Bonnie Bartel, Michael Skowyra, Jie Sun, Francesca Di Cara, PhD, and Peter Kim. 🙌
December 7, 2025 at 11:25 AM
Great start to #CellBio2025 in Philadelphia with "The Peroxisome Renaissance: From Molecular Mechanisms to Cellular Functions" session organized by @fredmast.bsky.social.
Really enjoyed speaking alongside Bonnie Bartel, Michael Skowyra, Jie Sun, Francesca Di Cara, PhD, and Peter Kim. 🙌
Really enjoyed speaking alongside Bonnie Bartel, Michael Skowyra, Jie Sun, Francesca Di Cara, PhD, and Peter Kim. 🙌
Reposted by Fred D Mast
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier - Nature Cell Biology
Kozai, Fernandez-Martinez et al. use high-speed atomic force microscopy to study the permeability barrier of yeast nuclear pore complexes. They show that karyopherins remodel a central plug that shape...
www.nature.com
December 2, 2025 at 2:26 PM
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Fred D Mast
TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress - Nature Communications
Here, the authors show that peroxisome proliferation is a conserved response to proteotoxic stress that occurs through stimulation of biogenesis and mediated by TOR and HSR signaling. Importantly, per...
www.nature.com
December 1, 2025 at 3:28 PM
TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Fred D Mast
Reevaluating the roles of PPARs and nuclear receptors in human #peroxisome biology. New Viewpoint from Fred Mast (@fredmast.bsky.social), Richard Rachubinski, and John Aitchison @seattlechildrens.org: rupress.org/jcb/article/...
#Organelles #Development #Metabolism #CellSignaling #Peroxisomes
#Organelles #Development #Metabolism #CellSignaling #Peroxisomes
November 18, 2025 at 8:15 PM
Reevaluating the roles of PPARs and nuclear receptors in human #peroxisome biology. New Viewpoint from Fred Mast (@fredmast.bsky.social), Richard Rachubinski, and John Aitchison @seattlechildrens.org: rupress.org/jcb/article/...
#Organelles #Development #Metabolism #CellSignaling #Peroxisomes
#Organelles #Development #Metabolism #CellSignaling #Peroxisomes
This Viewpoint is now available @jcb.org. I had a lot of fun writing this one as it tackles a common misconception in biology and also points to exciting new research avenues for studying peroxisomes in humans.
Viewpoint: @fredmast.bsky.social, Rachubinski, and Aitchison @seattlechildrens.org challenge the PPAR paradigm and show human #peroxisomes expand via hominid-specific pathways that link specialization to immunometabolic functions. rupress.org/jcb/article/...
#Organelles #Development #Metabolism
#Organelles #Development #Metabolism
November 12, 2025 at 3:02 PM
This Viewpoint is now available @jcb.org. I had a lot of fun writing this one as it tackles a common misconception in biology and also points to exciting new research avenues for studying peroxisomes in humans.
Reposted by Fred D Mast
Viewpoint @jcb.org: @fredmast.bsky.social, Rachubinski, and Aitchison @seattlechildrens.org challenge the PPAR paradigm and show human #peroxisomes expand via hominid-specific pathways that link specialization to immunometabolic functions. rupress.org/jcb/article/...
#Organelles #Development
#Organelles #Development
November 11, 2025 at 5:00 PM
Viewpoint @jcb.org: @fredmast.bsky.social, Rachubinski, and Aitchison @seattlechildrens.org challenge the PPAR paradigm and show human #peroxisomes expand via hominid-specific pathways that link specialization to immunometabolic functions. rupress.org/jcb/article/...
#Organelles #Development
#Organelles #Development
I had a great time catching up and participating in the celebration of Rick Rachubinski’s career. Great to see familiar faces and see the phenomenal impact Rick has had over the years.
Fred Mast - graduate of the @ualberta.bsky.social #CellBiology undergraduate program and former PhD student with Rick Rachubinski tells up about kinases that regulate human #peroxisomes
June 27, 2025 at 10:33 PM
I had a great time catching up and participating in the celebration of Rick Rachubinski’s career. Great to see familiar faces and see the phenomenal impact Rick has had over the years.
Reposted by Fred D Mast
📢Exciting news from Bio-protocol!
We're expanding our scope to include more bioinformatics and computational biology protocols to support reproducible, data-driven research.
📲 Scan the QR code on the banner or visit our website to get started.
#Bioinformatics #ComputationalBiology
We're expanding our scope to include more bioinformatics and computational biology protocols to support reproducible, data-driven research.
📲 Scan the QR code on the banner or visit our website to get started.
#Bioinformatics #ComputationalBiology
June 11, 2025 at 9:17 AM
📢Exciting news from Bio-protocol!
We're expanding our scope to include more bioinformatics and computational biology protocols to support reproducible, data-driven research.
📲 Scan the QR code on the banner or visit our website to get started.
#Bioinformatics #ComputationalBiology
We're expanding our scope to include more bioinformatics and computational biology protocols to support reproducible, data-driven research.
📲 Scan the QR code on the banner or visit our website to get started.
#Bioinformatics #ComputationalBiology
Reposted by Fred D Mast
My editorial on the indirect cuts. This is an opportunity for campuses to come together to make the case for higher education. Leaders need to step up and ask for support and lead. www.science.org/doi/10.1126/...
A direct hit
Late last week, the Trump administration set off a frenzy in the US scientific community when the National Institutes of Health (NIH) announced that indirect cost reimbursement for federally funded re...
www.science.org
February 11, 2025 at 3:03 PM
My editorial on the indirect cuts. This is an opportunity for campuses to come together to make the case for higher education. Leaders need to step up and ask for support and lead. www.science.org/doi/10.1126/...
My thoughts on the recent decision to cap NIH indirect rates.
fmast.substack.com/p/the-nihs-n...
fmast.substack.com/p/the-nihs-n...
February 9, 2025 at 7:07 PM
My thoughts on the recent decision to cap NIH indirect rates.
fmast.substack.com/p/the-nihs-n...
fmast.substack.com/p/the-nihs-n...