@fra-florini.bsky.social
Reposted
Publication alert! 🔔 Our recent work exploring how Plasmodium uses a Rad51 independent homologous recombination to diversify its var gene repertoire is now published in 🧬 Nucleic Acids Research! @oupprimary.bsky.social @narjournal.bsky.social Read more here.
tinyurl.com/794brb6h
tinyurl.com/794brb6h
Validate User
tinyurl.com
November 26, 2025 at 4:16 PM
Publication alert! 🔔 Our recent work exploring how Plasmodium uses a Rad51 independent homologous recombination to diversify its var gene repertoire is now published in 🧬 Nucleic Acids Research! @oupprimary.bsky.social @narjournal.bsky.social Read more here.
tinyurl.com/794brb6h
tinyurl.com/794brb6h
Reposted
New paper out !
Want to learn more about fascinating proteasome biology and Artemisinin resistance in Malaria parasites ? Check out our preprint:
www.biorxiv.org/content/10.1...
Want to learn more about fascinating proteasome biology and Artemisinin resistance in Malaria parasites ? Check out our preprint:
www.biorxiv.org/content/10.1...
Stage-specific regulation of the Plasmodium falciparum proteasome activity reveals adaptive rewiring in artemisinin resistance
The ubiquitin-proteasome system (UPS) is essential for Plasmodium falciparum to maintain protein homeostasis, adapt to proteotoxic stress, and regulate parasite growth and stage transitions. The prote...
www.biorxiv.org
November 26, 2025 at 11:21 PM
New paper out !
Want to learn more about fascinating proteasome biology and Artemisinin resistance in Malaria parasites ? Check out our preprint:
www.biorxiv.org/content/10.1...
Want to learn more about fascinating proteasome biology and Artemisinin resistance in Malaria parasites ? Check out our preprint:
www.biorxiv.org/content/10.1...
Reposted
Our latest story on Clofazimine resistance in Cryptosporidium! What started as a side project turned into one of the most interesting stories.
Genetics 101 😊
#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch
www.biorxiv.org/content/10.1...
Genetics 101 😊
#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch
www.biorxiv.org/content/10.1...
Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes Cryptosporidium to clofazimine resistance
The parasite Cryptosporidium is a leading cause of life-threatening diarrheal disease, and effective treatment is not available. The discovery of potent anti-Cryptosporidium activity of clofazimine, o...
www.biorxiv.org
October 8, 2025 at 11:25 AM
Our latest story on Clofazimine resistance in Cryptosporidium! What started as a side project turned into one of the most interesting stories.
Genetics 101 😊
#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch
www.biorxiv.org/content/10.1...
Genetics 101 😊
#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch
www.biorxiv.org/content/10.1...
Reposted
🚨 New paper out! 🚨
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …
www.sciencedirect.com
September 18, 2025 at 10:13 PM
🚨 New paper out! 🚨
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
Reposted
🎥 | WATCH | Dr Francesca Florini (@fra-florini.bsky.social | @weillcornell.bsky.social) discusses the immune evasion in malaria using insights from single-cell analysis of Plasmodium falciparum.
The full GRiP-ing seminar is now available on our YouTube channel:
📺 youtu.be/bKU2Cfv79K8?...
The full GRiP-ing seminar is now available on our YouTube channel:
📺 youtu.be/bKU2Cfv79K8?...
July 28, 2025 at 2:35 PM
🎥 | WATCH | Dr Francesca Florini (@fra-florini.bsky.social | @weillcornell.bsky.social) discusses the immune evasion in malaria using insights from single-cell analysis of Plasmodium falciparum.
The full GRiP-ing seminar is now available on our YouTube channel:
📺 youtu.be/bKU2Cfv79K8?...
The full GRiP-ing seminar is now available on our YouTube channel:
📺 youtu.be/bKU2Cfv79K8?...
Had such a wholesome experience this past week, helping with the One Health Research workshop at WACCBIP. So much passion and engagement from the students!
July 19, 2025 at 1:39 PM
Had such a wholesome experience this past week, helping with the One Health Research workshop at WACCBIP. So much passion and engagement from the students!
Preprint Alert 🚨 Check out the latest piece of work from the @kirkdeitsch.bsky.social lab, where we characterized the sophisticated molecular layers controlling var2csa expression and antigenic variation in P. falciparum
The molecular basis of coordinated antigen switching enabling chronic infection by human malaria parasites https://www.biorxiv.org/content/10.1101/2025.07.16.665170v1
July 17, 2025 at 9:38 AM
Preprint Alert 🚨 Check out the latest piece of work from the @kirkdeitsch.bsky.social lab, where we characterized the sophisticated molecular layers controlling var2csa expression and antigenic variation in P. falciparum
Reposted
🚨Out now!
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social
#MicroSky #Plasmodium 🦠🧬
www.nature.com/articles/s41...
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social
#MicroSky #Plasmodium 🦠🧬
www.nature.com/articles/s41...
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance - Nature Microbiology
Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive capacity to maintain chroni...
www.nature.com
May 20, 2025 at 2:50 PM
🚨Out now!
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social
#MicroSky #Plasmodium 🦠🧬
www.nature.com/articles/s41...
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social
#MicroSky #Plasmodium 🦠🧬
www.nature.com/articles/s41...
So proud of this work finally out in @natmicrobiol.nature.com! We examined antigenic variation in malaria parasites at single-cell level and found a surprising level of diversity. Make sure to check it out and don’t miss my talk on Thursday to hear about this story! #malaria #scRNA-Seq #EMBLMalaria
Very happy to congratulate @fra-florini.bsky.social and Joe Visone for the publication of their recent work on antigenic variation by malaria parasites: rdcu.be/emjbn and an earlier version here: www.biorxiv.org/content/10.1.... Francesca will present some of this work next week at BioMalPar 2025.
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance
Nature Microbiology - Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive...
rdcu.be
May 19, 2025 at 7:53 AM
So proud of this work finally out in @natmicrobiol.nature.com! We examined antigenic variation in malaria parasites at single-cell level and found a surprising level of diversity. Make sure to check it out and don’t miss my talk on Thursday to hear about this story! #malaria #scRNA-Seq #EMBLMalaria
Something fun (very much needed these days): the @kirkdeitsch.bsky.social and Kirkman labs crushing the CUIMC Team Relay Marathon!
April 28, 2025 at 4:01 PM
Something fun (very much needed these days): the @kirkdeitsch.bsky.social and Kirkman labs crushing the CUIMC Team Relay Marathon!
There’s a new doctor in the @kirkdeitsch.bsky.social lab and we couldn’t be prouder!
March 28, 2025 at 3:44 PM
There’s a new doctor in the @kirkdeitsch.bsky.social lab and we couldn’t be prouder!
March 7, 2025 at 8:02 PM
What an awesome opportunity it was to present my work today at #EMBLInfectionBiology and connect with so many amazing scientists studying #infectionbiology! Great thanks to the organizers for giving me this chance
November 15, 2024 at 8:15 PM
What an awesome opportunity it was to present my work today at #EMBLInfectionBiology and connect with so many amazing scientists studying #infectionbiology! Great thanks to the organizers for giving me this chance