Sebastian Shaw
@millseba.bsky.social
Dad. Scientist. Interested in how Cryptosoridium tricks its host cells!
Pinned
Sebastian Shaw
@millseba.bsky.social
· Sep 18
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …
www.sciencedirect.com
🚨 New paper out! 🚨
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
Exciting news!!
I’ve been awarded an #SNSFStartingGrant and will join the Institute of Parasitology, University of Zurich as an Assistant Professor in summer 2026.
A dream come true! 🥺
October 31, 2025 at 2:39 PM
Exciting news!!
I’ve been awarded an #SNSFStartingGrant and will join the Institute of Parasitology, University of Zurich as an Assistant Professor in summer 2026.
A dream come true! 🥺
Reposted by Sebastian Shaw
✨ Searching for extraterrestrial life or combating speech disorders: The SNSF is awarding #SNSFStartingGrants to 41 outstanding researchers. They will receive a maximum of CHF 1 million to lead a project with their own #research team at a Swiss university. 🚀
ℹ️ sohub.io/aq26
ℹ️ sohub.io/aq26
October 31, 2025 at 9:30 AM
✨ Searching for extraterrestrial life or combating speech disorders: The SNSF is awarding #SNSFStartingGrants to 41 outstanding researchers. They will receive a maximum of CHF 1 million to lead a project with their own #research team at a Swiss university. 🚀
ℹ️ sohub.io/aq26
ℹ️ sohub.io/aq26
Reposted by Sebastian Shaw
Save the date, next Cryptosporidium meeting in Edinburgh May 24-26, 2026. Register for email updates via the QR code below.
October 13, 2025 at 11:42 AM
Save the date, next Cryptosporidium meeting in Edinburgh May 24-26, 2026. Register for email updates via the QR code below.
As an immigrant scientist in the U.S., travel bans and visa uncertainty are taking a toll | Science | AAAS www.science.org/content/arti...
As an immigrant scientist in the U.S., travel bans and visa uncertainty are taking a toll
“I began to question whether I truly belonged,” this postdoc writes
www.science.org
October 21, 2025 at 4:36 AM
As an immigrant scientist in the U.S., travel bans and visa uncertainty are taking a toll | Science | AAAS www.science.org/content/arti...
Reposted by Sebastian Shaw
The parasitesrule site has an archive of abstract books from the Molecular Parasitology Meeting (MPM) & the Kinetoplastid Molecular Cell Biology Meeting (KMCB). The book from the first MPM (1990) is also there!
🔗 parasitesrule.com/archive
🔗 parasitesrule.com/archive
October 15, 2025 at 1:41 PM
The parasitesrule site has an archive of abstract books from the Molecular Parasitology Meeting (MPM) & the Kinetoplastid Molecular Cell Biology Meeting (KMCB). The book from the first MPM (1990) is also there!
🔗 parasitesrule.com/archive
🔗 parasitesrule.com/archive
Our latest story on Clofazimine resistance in Cryptosporidium! What started as a side project turned into one of the most interesting stories.
Genetics 101 😊
#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch
www.biorxiv.org/content/10.1...
Genetics 101 😊
#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch
www.biorxiv.org/content/10.1...
Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes Cryptosporidium to clofazimine resistance
The parasite Cryptosporidium is a leading cause of life-threatening diarrheal disease, and effective treatment is not available. The discovery of potent anti-Cryptosporidium activity of clofazimine, o...
www.biorxiv.org
October 8, 2025 at 11:25 AM
Our latest story on Clofazimine resistance in Cryptosporidium! What started as a side project turned into one of the most interesting stories.
Genetics 101 😊
#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch
www.biorxiv.org/content/10.1...
Genetics 101 😊
#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch
www.biorxiv.org/content/10.1...
🚨 New paper out! 🚨
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …
www.sciencedirect.com
September 18, 2025 at 10:13 PM
🚨 New paper out! 🚨
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
How many red flags more will it take?
September 18, 2025 at 2:44 AM
How many red flags more will it take?
Happy #SwissNationalDay 🇨🇭
Meanwhile, Trump just slapped 39% tariffs on Swiss goods.
How am I supposed to keep up my essential intake of cheese and chocolate? 🧀🍫
Meanwhile, Trump just slapped 39% tariffs on Swiss goods.
How am I supposed to keep up my essential intake of cheese and chocolate? 🧀🍫
August 1, 2025 at 10:40 AM
Happy #SwissNationalDay 🇨🇭
Meanwhile, Trump just slapped 39% tariffs on Swiss goods.
How am I supposed to keep up my essential intake of cheese and chocolate? 🧀🍫
Meanwhile, Trump just slapped 39% tariffs on Swiss goods.
How am I supposed to keep up my essential intake of cheese and chocolate? 🧀🍫
No ERC Starting Grant this time 😔
7 great reviews — and 1 that… didn’t quite agree.
Time to go all in for the SNSF Starting Grant! 💪🏼 Interview in September 🤞🏻🤞🏻🤞🏻
7 great reviews — and 1 that… didn’t quite agree.
Time to go all in for the SNSF Starting Grant! 💪🏼 Interview in September 🤞🏻🤞🏻🤞🏻
July 16, 2025 at 8:21 AM
No ERC Starting Grant this time 😔
7 great reviews — and 1 that… didn’t quite agree.
Time to go all in for the SNSF Starting Grant! 💪🏼 Interview in September 🤞🏻🤞🏻🤞🏻
7 great reviews — and 1 that… didn’t quite agree.
Time to go all in for the SNSF Starting Grant! 💪🏼 Interview in September 🤞🏻🤞🏻🤞🏻
“Coachella of molecular parasitologists” 😜
Registration and Abstract submission for MPMXXXVI are now open! Abstract submission deadline is June 27th, get yours in quickly. @rmc9z.bsky.social @mjgubbels.bsky.social @omarharb.org
🔗https://www.parasitesrule.com/mpm-xxxvi
🔗https://www.parasitesrule.com/mpm-xxxvi
June 6, 2025 at 12:32 AM
“Coachella of molecular parasitologists” 😜
Just had my ERC Starting grant interview. Now the wait is on! 🤞🏻🤞🏻🤞🏻
June 4, 2025 at 7:32 PM
Just had my ERC Starting grant interview. Now the wait is on! 🤞🏻🤞🏻🤞🏻
Reposted by Sebastian Shaw
Here's the NIH's proposed budget - from $48 billion to $27 billion. NIAID, current ~$7 billion cut to ~$4.2 billion.
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
May 30, 2025 at 9:52 PM
Here's the NIH's proposed budget - from $48 billion to $27 billion. NIAID, current ~$7 billion cut to ~$4.2 billion.
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
Reposted by Sebastian Shaw
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection https://www.biorxiv.org/content/10.1101/2025.05.20.655157v1
May 22, 2025 at 3:32 AM
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection https://www.biorxiv.org/content/10.1101/2025.05.20.655157v1
🚨 Preprint Alert 🚨
We performed genetic crosses between phenotypically different Cryptosporidium strains and identified genomic loci responsible for their differences!
#Cryptosporidium #Genomics #Parasitology #InfectiousDiseases #Preprint #BioRxiv
www.biorxiv.org/content/10.1...
We performed genetic crosses between phenotypically different Cryptosporidium strains and identified genomic loci responsible for their differences!
#Cryptosporidium #Genomics #Parasitology #InfectiousDiseases #Preprint #BioRxiv
www.biorxiv.org/content/10.1...
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. An array of parasites with similar genomes produce...
www.biorxiv.org
May 22, 2025 at 3:52 PM
🚨 Preprint Alert 🚨
We performed genetic crosses between phenotypically different Cryptosporidium strains and identified genomic loci responsible for their differences!
#Cryptosporidium #Genomics #Parasitology #InfectiousDiseases #Preprint #BioRxiv
www.biorxiv.org/content/10.1...
We performed genetic crosses between phenotypically different Cryptosporidium strains and identified genomic loci responsible for their differences!
#Cryptosporidium #Genomics #Parasitology #InfectiousDiseases #Preprint #BioRxiv
www.biorxiv.org/content/10.1...
Reposted by Sebastian Shaw
🚨Out now!
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social
#MicroSky #Plasmodium 🦠🧬
www.nature.com/articles/s41...
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social
#MicroSky #Plasmodium 🦠🧬
www.nature.com/articles/s41...
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance - Nature Microbiology
Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive capacity to maintain chroni...
www.nature.com
May 20, 2025 at 2:50 PM
🚨Out now!
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social
#MicroSky #Plasmodium 🦠🧬
www.nature.com/articles/s41...
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social
#MicroSky #Plasmodium 🦠🧬
www.nature.com/articles/s41...
Reposted by Sebastian Shaw
Very happy to congratulate @fra-florini.bsky.social and Joe Visone for the publication of their recent work on antigenic variation by malaria parasites: rdcu.be/emjbn and an earlier version here: www.biorxiv.org/content/10.1.... Francesca will present some of this work next week at BioMalPar 2025.
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance
Nature Microbiology - Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive...
rdcu.be
May 16, 2025 at 2:08 PM
Very happy to congratulate @fra-florini.bsky.social and Joe Visone for the publication of their recent work on antigenic variation by malaria parasites: rdcu.be/emjbn and an earlier version here: www.biorxiv.org/content/10.1.... Francesca will present some of this work next week at BioMalPar 2025.
Reposted by Sebastian Shaw
Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites!
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Postdoctoral Research Associate
This project will seek to understand the basis of increased virulence after long term coinfection by a combination of genomic, transcriptomic and laboratory manipulation of the selected parasite lines...
elxw.fa.em3.oraclecloud.com
May 16, 2025 at 10:48 AM
Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites!
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Two toddlers in a sandbox, flinging toys at each other because one wouldn’t share a shovel — each tantrum louder than the last, while the whole playground suffers from the mess.
April 11, 2025 at 10:51 AM
Two toddlers in a sandbox, flinging toys at each other because one wouldn’t share a shovel — each tantrum louder than the last, while the whole playground suffers from the mess.
Had a wonderful time in New York attending Joe’s defense (he rocked it!) and seeing my PhD buddies Francesca and Shubha and many more 😍
March 28, 2025 at 5:16 PM
Had a wonderful time in New York attending Joe’s defense (he rocked it!) and seeing my PhD buddies Francesca and Shubha and many more 😍
On my way back to Philadelphia after an amazing two-week trip! Spent time with family & friends in Switzerland, then headed to Würzburg for a joint parasitology meeting—caught up with old friends and made new ones. Great science, great people!
March 18, 2025 at 5:04 AM
On my way back to Philadelphia after an amazing two-week trip! Spent time with family & friends in Switzerland, then headed to Würzburg for a joint parasitology meeting—caught up with old friends and made new ones. Great science, great people!
I wouldn’t sprint like it’s the Olympics for free food after a seminar.
March 14, 2025 at 1:44 PM
I wouldn’t sprint like it’s the Olympics for free food after a seminar.