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Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
@fmp-berlin.de
180 followers 110 following 200 posts
Our Research: Creating knowledge as the basis of tomorrow's medicine!
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in #BrainCityBerlin. Part of Forschungsverbund Berlin e.V.
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fmp-berlin.de
May the (icy) force be with you ⚔️: This month's scientific picture comes from Abhirup Majumdar (Fiedler lab). This ice sculpture was formed at the base of a flask during an exothermic reaction at low temperatures 🧊. Great contribution!
November 4, 2025 at 8:46 AM
fmp-berlin.de
New study by @noalipstein.bsky.social and Nils Brose, @mpi-nat.bsky.social links UNC13A gene variants to a new developmental disorder — offering insights into ALS and potential therapies. 👏

Read the full paper: www.nature.com/articles/s41...
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function - Nature Genetics
Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and...
www.nature.com
October 22, 2025 at 11:57 AM
fmp-berlin.de
Congrats to Sigrid Milles, junior group leader at @fmp-berlin.de on receiving a Boehringer Ingelheim Stiftung Exploration Grant! 🎉 Her team studies how flexible, intrinsically disordered proteins form condensates to control clathrin-mediated endocytosis — combining NMR, smFRET & live-cell work. 🧫🫧
October 14, 2025 at 9:38 AM
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
rupi42ai.bsky.social
Neue Episode im Wirkstoffradio! WSR088 LNDW 2025: Depression & intrinsisch unstrukturierte Proteine mit Gästen aus dem @fmp-berlin.de
www.wirkstoffradio.de/2025/10/12/w...
#LNDW #Wissenschaftspodcast #Medizin #Podcast #Leibniz #Berlin #Depression #IDP
WSR088 LNDW 2025: Depression & intrinsisch unstrukturierte Proteine
Diese Episode wurde bei der LNDW 2025 aufgezeichnet. Darin sprechen Bernd Rupp und Ralf Schülein über Depressionen sowie Therapien mit Antidepressiva. Anschließend erläutert Sigrid Milles die Rolle in...
www.wirkstoffradio.de
October 13, 2025 at 12:49 PM
fmp-berlin.de
Our scientific picture of the month sets a spooky vibe 👻🎃
Thanks to the @broichhagenj.bsky.social lab for providing us with Chem o'lanterns
October 10, 2025 at 12:57 PM
fmp-berlin.de
Congratulations to @volkerhaucke-lab.bsky.social for receiving the prestigious Reinhart Koselleck Grant by the @dfg.de (German Research Foundation) once again! 🎉

www.linkedin.com/feed/update/...
Another award for Volker Haucke, Director at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Professor at Freie Universität Berlin: The Deutsche Forschungsgemeinschaft (DFG) -… ...
Another award for Volker Haucke, Director at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Professor at Freie Universität Berlin: The Deutsche Forschungsgemeinschaft (DFG) - G...
www.linkedin.com
October 7, 2025 at 11:21 AM
fmp-berlin.de
Congrats to Volker Haucke, Director at the Leibniz-FMP on being awarded the Ernst Schering Prize 2025 for his pioneering work on the function of signaling lipids that control how cells respond to hormones, nutrients and messengers.
September 23, 2025 at 7:59 AM
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
vincearafiles.bsky.social
🔥After years of hard work, it's finally out in @natchem.nature.com🔥 The Hackenberger group @fmp-berlin.de developed #🎯DarT-labeling, a #photocatalyticproximitylabeling method using deazaflavin - a ✅ biocompatible ✅ easily synthesized ✅ chemically benign #photocatalyst

www.nature.com/articles/s41...
Energy-transfer photoproximity labelling in live cells using an organic cofactor - Nature Chemistry
Current photoproximity labelling methods often require metal-based catalysts to map protein interactomes but, owing to their toxicity, they have limited intracellular applicability. A deazaflavin cofa...
www.nature.com
September 17, 2025 at 1:22 PM
fmp-berlin.de
Daniel Roderer and his group revealed the first high-res structure of Fap2 from Fusobacterium nucleatum (cryo-EM/ET). Fap2 binds immune cells (TIGIT) and colorectal cancer cells (Gal-GalNAc), showing how Fusobacteria colonize tumors and escape the immune system.
www.nature.com/articles/s41...
September 1, 2025 at 1:23 PM
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
mruwolt.bsky.social
Brace yourselves! Arif from the Fiedler lab discovered+characterized in collaboration with us & other groups within the @fmp-berlin.de a novel PTM: autocatalytic oligophosphorylation (up to 6 Phosphates 😲). Still mysterious in origin, function & regulation.

www.nature.com/articles/s41...
Nucleoside diphosphate kinase A (NME1) catalyses its own oligophosphorylation - Nature Chemistry
Our understanding of how post-translational modification—protein phosphorylation—impacts the complexity of eukaryotic signalling pathways is continuously expanding. Now, protein oligophosphorylation h...
www.nature.com
August 20, 2025 at 9:58 PM
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
millessigrid.bsky.social
I am happy to share our new article on dynamic Eps15 and Dab2 networks in endocytosis studied by #NMR, and forming #LLPS. Research was done at @fmp-berlin.de and at the Institut de Biologie Structurale (IBS).

www.nature.com/articles/s41...
Promiscuous and multivalent interactions between Eps15 and partner protein Dab2 generate a complex interaction network - Nature Communications
Eps15, a protein involved in endocytosis initiation, uses small folded EH domains to bind disordered partner proteins and its own disordered tail, thus forming a dynamic network via phase separation t...
www.nature.com
August 21, 2025 at 7:53 AM
fmp-berlin.de
Great work by @broichhagenj.bsky.social at Leibniz-FMP, David Hodson at @rdm.ox.ac.uk and the whole team!
August 19, 2025 at 1:05 PM
fmp-berlin.de
⏰Join us for the NMR Symposium, Nov 26–27, 2025, celebrating our new 1.2 GHz NMR spectrometer. To present a poster, send your abstract to NMR2025@fmp-berlin.de. Registrations are open until September 15th!
August 14, 2025 at 8:07 AM
fmp-berlin.de
Great cover art by @barthvanrossum.bsky.social for @jacs.acspublications.org: Influenza lifecycle showing M2’s roles, from activation in the low-pH endosome to viral uncoating, RNA release, and budding of new particles. View the article from the Lange lab here: pubs.acs.org/doi/10.1021/...
August 13, 2025 at 9:41 AM
fmp-berlin.de
Thanks to Yanwei Su from @volkerhaucke-lab.bsky.social, we have a new scientific image of the month: When morphology gets romantic 🫶- this is a U2OS cell overexpressing Sec61b (ER), stained with LAMP1 (lysosome) and DAPI (nuclei), to test lysosome–ER membrane contact sites.
August 12, 2025 at 3:00 PM
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
nmr900.bsky.social
PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET, Dr. Sigrid Milles, The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmp-berlin.de Berlin, Germany leibniz-fmp.softgarden.io/job/58144047... #NMRjobs #NMRchat #NMR 🧲
PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET (f/m/d) at Leibniz-Forschungsinstitut für Molekulare Pharmakologie
We're looking for: PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET (f/m/d) (Part Time) • Berlin, Deutschland
leibniz-fmp.softgarden.io
August 11, 2025 at 4:52 PM
fmp-berlin.de
Our scientific image of the month July comes from Kati Fischermanns, @broichhagenj.bsky.social lab and is titled: "96 wells celebrate diversity" 🌈 It was created by scaling up tunable photocontrol over cells.
July 4, 2025 at 11:41 AM
fmp-berlin.de
With his exceptional work, Prof. Dr. Volker Haucke @volkerhaucke-lab.bsky.social has made it onto the #FallingWallsFoundation shortlist for the #ScienceBreakthrough of the Year 2025 in the #LifeSciences category. Congratulations!
July 3, 2025 at 8:27 AM
fmp-berlin.de
The #LongNightoftheSciences at @fmp-berlin.de was a great success: Many visitors took a look behind the scenes during the lab tours and were inspired by research.

Thanks to everyone who came and see you around next year!
July 2, 2025 at 11:42 AM
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
leibniz-gemeinschaft.de
Kampf dem Kunststoff!
In der Forschung fallen Unmengen #Plastikmüll an. Lässt sich das ändern?
www.leibniz-magazin.de/alle-artikel...
#LeibnizMagazin #Müll #Nachhaltigkeit #Forschung @fmp-berlin.de
June 24, 2025 at 7:51 AM
fmp-berlin.de
New in @jacs.acspublications.org:

New insights into the flu virus: The Lange lab used proton-detected solid-state NMR combined with the Sun lab's expertise in QM/MM+MD simulations to reveal how pH changes drive conformational shifts in the influenza A M2 channel.

pubs.acs.org/doi/10.1021/...
June 23, 2025 at 10:56 AM
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
chrischmied.bsky.social
Wonderful to present my work leading a large European consortium around @fmp-berlin.de and @eu-openscreen.bsky.social at #ELMI2025. We produce large-scale #open-source high quality Cell Painting data for drug discovery 💊. First dataset published: doi.org/10.1016/j.is...

Stay tuned for more!
June 6, 2025 at 9:17 AM
fmp-berlin.de
Get ready for this upcoming event:

Lecture series on Allostery in Drug Discovery 💊

www.linkedin.com/feed/update/...
Get ready for this upcoming event, a lecture series on Allostery in Drug… | Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
Get ready for this upcoming event, a lecture series on Allostery in Drug Discovery (ALLODD) - hosted by Prof. Dr. Marc Nazaré from Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Dr....
www.linkedin.com
May 28, 2025 at 10:15 AM
fmp-berlin.de
The lab of noalipstein.bsky.social introduced a new mouse line to label presynaptic terminals with chemical dyes, enabling imaging of fixed & live neurons at confocal & super-res. They synthesized & validated a cell-impermeable dye, BG-SiR-d12, improving image quality!

pubs.acs.org/doi/10.1021/...
Endogenous SNAP-Tagging of Munc13-1 for Monitoring Synapse Nanoarchitecture
Synaptic function is governed by highly regulated protein machineries, whose abundance and spatial localization change continually. Studies to determine dynamic changes in synaptic protein nanoarchit...
pubs.acs.org
May 26, 2025 at 2:02 PM
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
chrischmied.bsky.social
Big step for open science! 🎉 Our @eu-openscreen.bsky.social consortium drops their first open Cell Painting dataset.

Wolff et al. 2025: doi.org/10.1016/j.is...

FAIR, high-quality & ready to power AI in drug discovery. 100K+ compounds coming in 2025!
#OpenData #CellPainting #DrugDiscovery
May 14, 2025 at 11:02 AM