Brian Fisher
@fishparade.bsky.social
Enzyme tinkerer, FFIX stan, 10-year ReadCube subscriber
4 x 4L bottle boxes are the GOAT of moving
October 21, 2025 at 3:02 PM
4 x 4L bottle boxes are the GOAT of moving
Reposted by Brian Fisher
This is such a neat idea from the @narayanlab.bsky.social and the @hartwiggroup.bsky.social now in #JACSasap fooling enzymes with a removable binding ligand to accept non-native substrates #ChemSky
Site-, Stereo-, and Chemoselective Enzymatic Halogenation of Terpenoids by a Substrate Masquerade
Enzymatic halogenation of C–H bonds is a promising approach to synthesize chlorine-containing compounds. However, few halogenases chlorinate C(sp3)–H bonds of molecules lacking a carrier protein, and ...
pubs.acs.org
September 27, 2025 at 6:24 PM
This is such a neat idea from the @narayanlab.bsky.social and the @hartwiggroup.bsky.social now in #JACSasap fooling enzymes with a removable binding ligand to accept non-native substrates #ChemSky
Larry Tesler, inventor of the cut, copy, and paste commands, dies at 74
Larry Tesler, inventor of the cut, copy, and paste commands, dies at 74
Larry Tesler, inventor of the cut, copy, and paste commands, dies at 74
September 16, 2025 at 1:07 AM
Larry Tesler, inventor of the cut, copy, and paste commands, dies at 74
The thing I love about taxonomy is that it never changes and everyone agrees on names for everything!!!
September 11, 2025 at 6:03 PM
The thing I love about taxonomy is that it never changes and everyone agrees on names for everything!!!
Reposted by Brian Fisher
Do you really need to stir your reactions? How do you know?
Stirring Bars are Superstition?
www.science.org
September 4, 2025 at 7:39 PM
Do you really need to stir your reactions? How do you know?
Reposted by Brian Fisher
"oh nothing matters because mr. trump won't let it matter" shut up
August 31, 2025 at 1:26 PM
"oh nothing matters because mr. trump won't let it matter" shut up
Getting into homeownership is really making me much more of a just-call-customer-service person than I expected
August 29, 2025 at 10:38 PM
Getting into homeownership is really making me much more of a just-call-customer-service person than I expected
A lot of people will believe this shit! Lots of suburban and rural folks truly think that US cities are literal war zones. They could easily be convinced that if they visit them and find them pleasant and safe that it was all Trump’s doing rather than them being fine the whole time.
Stephen Miller on DC residents: "For the first time in their lives, they can use the parks, they can walk on the streets. You have people who can walk freely at night without having to worry about being robbed or mugged. They are wearing their watches again."
August 25, 2025 at 5:18 PM
A lot of people will believe this shit! Lots of suburban and rural folks truly think that US cities are literal war zones. They could easily be convinced that if they visit them and find them pleasant and safe that it was all Trump’s doing rather than them being fine the whole time.
ACS 1996 is a fine starting point but imo you should probably manually tailor your ChemDraw object settings to whatever kinds of molecules you work most with. I worked with polypeptides through my PhD and I really didn’t like how its skinny bonds made these long molecules look like chicken scratches
August 10, 2025 at 12:50 AM
ACS 1996 is a fine starting point but imo you should probably manually tailor your ChemDraw object settings to whatever kinds of molecules you work most with. I worked with polypeptides through my PhD and I really didn’t like how its skinny bonds made these long molecules look like chicken scratches
Reposted by Brian Fisher
Oh so it does have phd level intelligence
Google Gemini doesn’t appear to be doing too well:
‘"I am a disgrace to this planet. I am a disgrace to this universe. I am a disgrace to all universes . . . I am a disgrace to all possible and impossible universes and all that is not a universe," the bot continued.’
‘"I am a disgrace to this planet. I am a disgrace to this universe. I am a disgrace to all universes . . . I am a disgrace to all possible and impossible universes and all that is not a universe," the bot continued.’
Google says it's working on a fix for Gemini's self-loathing 'I am a failure' comments
Google Gemini users said the bot is sharing self-loathing messages while attempting to solve tasks, including "I am a disgrace to this universe."
www.businessinsider.com
August 8, 2025 at 8:42 AM
Oh so it does have phd level intelligence
Trump take video game
Pricing on original Nintendo Switch family of systems and products in USA will change based on market conditions effective Aug 3.
Pricing for Switch 2 system, Switch/Switch 2 physical/digital games and NSO memberships remain unchanged at this time
www.nintendo.com/us/whatsnew/...
Pricing for Switch 2 system, Switch/Switch 2 physical/digital games and NSO memberships remain unchanged at this time
www.nintendo.com/us/whatsnew/...
August 1, 2025 at 2:00 PM
Trump take video game
Hope the estate of Henrietta Lacks is on this
July 31, 2025 at 1:21 PM
Hope the estate of Henrietta Lacks is on this
Baby’s first Nanopore run
July 30, 2025 at 3:29 PM
Baby’s first Nanopore run
Reposted by Brian Fisher
The 2010 paper claiming arsenic-based life has been retracted by Science today. 🧪
Embattled 'arsenic life' paper retracted by journal Science 15 years after publication
A controversial 2010 study that suggested bacteria could grow using arsenic instead of phosphorus has been retracted by the research journal Science.
www.livescience.com
July 24, 2025 at 6:05 PM
The 2010 paper claiming arsenic-based life has been retracted by Science today. 🧪
Reposted by Brian Fisher
Follow @wario64.bsky.social and repost for a chance to win 1 of 15 Steam codes for Dungeons & Dragons Neverwinter Nights 2: Enhanced Edition courtesy of @aspyr.com. Giveaway ends on July 20th, 6 PM PT
game is available now on PC and consoles store.steampowered.com/app/2738630/...
game is available now on PC and consoles store.steampowered.com/app/2738630/...
July 16, 2025 at 7:44 PM
Follow @wario64.bsky.social and repost for a chance to win 1 of 15 Steam codes for Dungeons & Dragons Neverwinter Nights 2: Enhanced Edition courtesy of @aspyr.com. Giveaway ends on July 20th, 6 PM PT
game is available now on PC and consoles store.steampowered.com/app/2738630/...
game is available now on PC and consoles store.steampowered.com/app/2738630/...
Pedagogy is often worse at more elite institutions, even. Place like Indiana University have faculty that publish in J Chem Ed. More elite institutions just wanna hire more faculty who’ll publish in CNS, their teaching skills be damned.
I learned a lot at the elite institutions I attended (despite being Asian and poor). I loved my education. But once I was at Harvard I could no longer avoid the reality that the quality of pedagogy was not the important part, it was the proximity to power that I was locked out of by virtue of birth
July 17, 2025 at 12:29 PM
Pedagogy is often worse at more elite institutions, even. Place like Indiana University have faculty that publish in J Chem Ed. More elite institutions just wanna hire more faculty who’ll publish in CNS, their teaching skills be damned.
Something anybody who’s set up parallel heterogeneous catalysis experiments—or reactions limited by gas transfer rates—has probably run into at some point. Good to see this phenomenon highlighted!
Magnetic stirrers could be a significant source of variation between reactions, making procedures harder to reproduce. cen.acs.org/research-int... #chemsky 🧪
How magnetic stirrers could be reducing your yield
From the lab that found impurities on your stir bar—your flask’s placement on a stirrer plate can mess with your reaction too
cen.acs.org
June 20, 2025 at 3:57 PM
Something anybody who’s set up parallel heterogeneous catalysis experiments—or reactions limited by gas transfer rates—has probably run into at some point. Good to see this phenomenon highlighted!
Even worse is cafes that make their own oat milk. Oatly is good, just buy that! The only two lattes I’ve ever tossed because they were so bad had homemade oat milk.
have we won the war. is it finally over. have restaurants stopped trying to do "homemade ketchup"
June 16, 2025 at 7:12 PM
Even worse is cafes that make their own oat milk. Oatly is good, just buy that! The only two lattes I’ve ever tossed because they were so bad had homemade oat milk.
Reposted by Brian Fisher
My team and I at the Crowd Counting Consortium (@djpressman@bsky.social, Soha Hammam, & Chris Shay) have a new piece out: wagingnonviolence.org/2025/06/amer.... In it, we show that through May 2025, the size and scale of anti-Trump protests have dwarfed those in 2017. 🧵
June 13, 2025 at 2:25 AM
My team and I at the Crowd Counting Consortium (@djpressman@bsky.social, Soha Hammam, & Chris Shay) have a new piece out: wagingnonviolence.org/2025/06/amer.... In it, we show that through May 2025, the size and scale of anti-Trump protests have dwarfed those in 2017. 🧵
Fun times with @nanoporetech.com ahead!
June 10, 2025 at 8:51 PM
Fun times with @nanoporetech.com ahead!
Loving the new macOS design language
June 9, 2025 at 5:46 PM
Loving the new macOS design language
Reposted by Brian Fisher
not the main issue here but i'd really appreciate it if democratic politicians spoke out in support of big-city life and culture with the same energy and reverence that all politicians have for small towns
los angeles is "real america" and so are all the other big cities the president hates
los angeles is "real america" and so are all the other big cities the president hates
June 8, 2025 at 10:48 PM
not the main issue here but i'd really appreciate it if democratic politicians spoke out in support of big-city life and culture with the same energy and reverence that all politicians have for small towns
los angeles is "real america" and so are all the other big cities the president hates
los angeles is "real america" and so are all the other big cities the president hates
My third video game midnight release: Halo 3, Super Smash Bros. for 3DS, and now the Switch 2. Surprisingly well organized!
June 5, 2025 at 4:01 AM
My third video game midnight release: Halo 3, Super Smash Bros. for 3DS, and now the Switch 2. Surprisingly well organized!
Babe it’s such a good deal, I’ll find a use for them I swear
52 qty of Amazon Basics High-Speed 4K Ultra HD HDMI 2.0 Cable, 10 feet is $146.84 on Woot buff.ly/40OWGnM #ad
June 4, 2025 at 12:34 AM
Babe it’s such a good deal, I’ll find a use for them I swear