Federico Uliana
@fedeuliana.bsky.social
"Systems, therefore relationships. More than just a sum of parts. Because everything is connected."
Applying proteomics to understand mechanisms leading to condensates and aggregates. MSCA fellow
(Dormann lab, JGU Mainz)
Applying proteomics to understand mechanisms leading to condensates and aggregates. MSCA fellow
(Dormann lab, JGU Mainz)
Reposted by Federico Uliana
Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding
@dormannlab.bsky.social
www.embopress.org/doi/full/10....
@dormannlab.bsky.social
www.embopress.org/doi/full/10....
October 20, 2025 at 11:40 AM
Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding
@dormannlab.bsky.social
www.embopress.org/doi/full/10....
@dormannlab.bsky.social
www.embopress.org/doi/full/10....
Reposted by Federico Uliana
SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism linking COVID-19 infection to thrombosis.
doi.org/10.1038/s420...
doi.org/10.1038/s420...
The main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII - Communications Biology
SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism linking COVID-19 infection to thr...
doi.org
August 7, 2025 at 3:01 PM
SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism linking COVID-19 infection to thrombosis.
doi.org/10.1038/s420...
doi.org/10.1038/s420...
New work out in @commsbio.nature.com @natureportfolio.nature.com! With Anna Pagotto, we show SARS-CoV-2 Mpro has a secondary preference for R↓ beyond LQ↓. This broader specificity can directly activate the coagulation cascade. #Biochem & #Proteomics all in!
www.nature.com/articles/s42... (1/2)
www.nature.com/articles/s42... (1/2)
The main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII - Communications Biology
SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism linking COVID-19 infection to thr...
www.nature.com
August 2, 2025 at 6:53 AM
New work out in @commsbio.nature.com @natureportfolio.nature.com! With Anna Pagotto, we show SARS-CoV-2 Mpro has a secondary preference for R↓ beyond LQ↓. This broader specificity can directly activate the coagulation cascade. #Biochem & #Proteomics all in!
www.nature.com/articles/s42... (1/2)
www.nature.com/articles/s42... (1/2)
Reposted by Federico Uliana
Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding www.biorxiv.org/content/10.1...
July 20, 2025 at 9:01 PM
Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding www.biorxiv.org/content/10.1...
Reposted by Federico Uliana
Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding https://www.biorxiv.org/content/10.1101/2025.07.07.662960v1
July 11, 2025 at 12:45 AM
Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding https://www.biorxiv.org/content/10.1101/2025.07.07.662960v1
Reposted by Federico Uliana
PKA regulates stress granule maturation to allow timely recovery after prolonged starvation https://www.biorxiv.org/content/10.1101/2025.07.06.663161v1
July 9, 2025 at 3:30 PM
PKA regulates stress granule maturation to allow timely recovery after prolonged starvation https://www.biorxiv.org/content/10.1101/2025.07.06.663161v1
Reposted by Federico Uliana
Hello Bluesky! 🌤️
We're on the Molecular Cell cover!
How are ribosome levels adjusted?
Stm1 not only protects ribosomes from degradation, it also promotes their biogenesis in nutrient-rich conditions.
Two roles, one protein - tuned by nutrient availability.
🔗 www.cell.com/molecular-ce...
We're on the Molecular Cell cover!
How are ribosome levels adjusted?
Stm1 not only protects ribosomes from degradation, it also promotes their biogenesis in nutrient-rich conditions.
Two roles, one protein - tuned by nutrient availability.
🔗 www.cell.com/molecular-ce...
May 2, 2025 at 9:26 AM
Hello Bluesky! 🌤️
We're on the Molecular Cell cover!
How are ribosome levels adjusted?
Stm1 not only protects ribosomes from degradation, it also promotes their biogenesis in nutrient-rich conditions.
Two roles, one protein - tuned by nutrient availability.
🔗 www.cell.com/molecular-ce...
We're on the Molecular Cell cover!
How are ribosome levels adjusted?
Stm1 not only protects ribosomes from degradation, it also promotes their biogenesis in nutrient-rich conditions.
Two roles, one protein - tuned by nutrient availability.
🔗 www.cell.com/molecular-ce...
Reposted by Federico Uliana
🚨Registration for the 13th Symposium on Structural Proteomics is open!
Milan, Oct 6–8 | Cutting-edge science and vibrant discussions.
ssp2025.squarespace.com
Proud to co-organize the SSP in Italy with Andrea Graziadei and Lolita Piersimoni @humantechnopole.bsky.social #ChiesiFarmaceutici #univaq
Milan, Oct 6–8 | Cutting-edge science and vibrant discussions.
ssp2025.squarespace.com
Proud to co-organize the SSP in Italy with Andrea Graziadei and Lolita Piersimoni @humantechnopole.bsky.social #ChiesiFarmaceutici #univaq
13th Symposium on Structural Proteomics, 6-8 October 2025
ssp2025.squarespace.com
April 24, 2025 at 10:30 AM
🚨Registration for the 13th Symposium on Structural Proteomics is open!
Milan, Oct 6–8 | Cutting-edge science and vibrant discussions.
ssp2025.squarespace.com
Proud to co-organize the SSP in Italy with Andrea Graziadei and Lolita Piersimoni @humantechnopole.bsky.social #ChiesiFarmaceutici #univaq
Milan, Oct 6–8 | Cutting-edge science and vibrant discussions.
ssp2025.squarespace.com
Proud to co-organize the SSP in Italy with Andrea Graziadei and Lolita Piersimoni @humantechnopole.bsky.social #ChiesiFarmaceutici #univaq
Reposted by Federico Uliana
Interested in the molecular mechanisms of neurodegeneration?
📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response!
Apply via this fantastic PhD Programme until April 3 👇
📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response!
Apply via this fantastic PhD Programme until April 3 👇
The summer call of our International PhD programme is open! 📢
Ready to advance your scientific career? If you're passionate about #RNAbiology, #Bioinformatics, or #Immunology, apply to our open calls and join our global community of over 200 #PhD students! 🌍
www.imb.de/phd
Ready to advance your scientific career? If you're passionate about #RNAbiology, #Bioinformatics, or #Immunology, apply to our open calls and join our global community of over 200 #PhD students! 🌍
www.imb.de/phd
February 17, 2025 at 2:37 PM
Interested in the molecular mechanisms of neurodegeneration?
📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response!
Apply via this fantastic PhD Programme until April 3 👇
📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response!
Apply via this fantastic PhD Programme until April 3 👇
Reposted by Federico Uliana
One more day to apply!
📢 The Dormann Lab is looking for a PhD student interested in the molecular mechanisms of neurodegeneration and biomolecular condensation!
Interested in one of our research projects on disease-linked RNA-binding proteins, such as TDP-43 and FUS?
Apply to this fantastic PhD program by February 7 👇
Interested in one of our research projects on disease-linked RNA-binding proteins, such as TDP-43 and FUS?
Apply to this fantastic PhD program by February 7 👇
We are on the home stretch! 🏁
Only 1.5 weeks left to #apply for our #gradschool!
Don't miss this great opportunity if you are looking for a #PhD student position in the life sciences! Get your documents ready and apply now!
👉 imprs-cbp.mpg.de/call-for-app...
#imprs_cbp #imprs2impress #science
Only 1.5 weeks left to #apply for our #gradschool!
Don't miss this great opportunity if you are looking for a #PhD student position in the life sciences! Get your documents ready and apply now!
👉 imprs-cbp.mpg.de/call-for-app...
#imprs_cbp #imprs2impress #science
February 6, 2025 at 3:29 PM
One more day to apply!
Hi Blueskyers! Excited to share our work in @naturecomms.bsky.social. With the group of Michel Steinmetz(PSI) we combined quantitative XL-MS and biophysics to reveal how Bik1 dynamically rearranges in dilute and phase separated state.
www.nature.com/articles/s41...
(1/2) #TeamMassSpec#idp#PhaseSep
www.nature.com/articles/s41...
(1/2) #TeamMassSpec#idp#PhaseSep
Phase separation of a microtubule plus-end tracking protein into a fluid fractal network - Nature Communications
Here, the authors characterize the structural organization and condensate behavior of the microtubule plus-end tracking protein Bik1, employing SAXS, computational modeling, microscopy, and crosslinki...
www.nature.com
January 30, 2025 at 8:44 AM
Hi Blueskyers! Excited to share our work in @naturecomms.bsky.social. With the group of Michel Steinmetz(PSI) we combined quantitative XL-MS and biophysics to reveal how Bik1 dynamically rearranges in dilute and phase separated state.
www.nature.com/articles/s41...
(1/2) #TeamMassSpec#idp#PhaseSep
www.nature.com/articles/s41...
(1/2) #TeamMassSpec#idp#PhaseSep
Reposted by Federico Uliana
📢 The Dormann Lab is looking for a PhD student interested in the molecular mechanisms of neurodegeneration and biomolecular condensation!
Interested in one of our research projects on disease-linked RNA-binding proteins, such as TDP-43 and FUS?
Apply to this fantastic PhD program by February 7 👇
Interested in one of our research projects on disease-linked RNA-binding proteins, such as TDP-43 and FUS?
Apply to this fantastic PhD program by February 7 👇
We are on the home stretch! 🏁
Only 1.5 weeks left to #apply for our #gradschool!
Don't miss this great opportunity if you are looking for a #PhD student position in the life sciences! Get your documents ready and apply now!
👉 imprs-cbp.mpg.de/call-for-app...
#imprs_cbp #imprs2impress #science
Only 1.5 weeks left to #apply for our #gradschool!
Don't miss this great opportunity if you are looking for a #PhD student position in the life sciences! Get your documents ready and apply now!
👉 imprs-cbp.mpg.de/call-for-app...
#imprs_cbp #imprs2impress #science
January 29, 2025 at 7:36 PM
📢 The Dormann Lab is looking for a PhD student interested in the molecular mechanisms of neurodegeneration and biomolecular condensation!
Interested in one of our research projects on disease-linked RNA-binding proteins, such as TDP-43 and FUS?
Apply to this fantastic PhD program by February 7 👇
Interested in one of our research projects on disease-linked RNA-binding proteins, such as TDP-43 and FUS?
Apply to this fantastic PhD program by February 7 👇
Reposted by Federico Uliana
Pericentromeric #heterochromatin clusters into chromocenters. @skrutlnize.bsky.social &co use quantitative mass spec to characterize the chromocenter proteome in multiple tissues, identifying a link between satellite DNA-binding proteins & #transposon repression🧪 @plosbiology.org plos.io/4akuNAi
January 16, 2025 at 1:13 PM
Pericentromeric #heterochromatin clusters into chromocenters. @skrutlnize.bsky.social &co use quantitative mass spec to characterize the chromocenter proteome in multiple tissues, identifying a link between satellite DNA-binding proteins & #transposon repression🧪 @plosbiology.org plos.io/4akuNAi