The FEBS Journal
LightNews LightNews
banner
febsj.bsky.social
The FEBS Journal
@febsj.bsky.social
100 followers 47 following 13 posts
A scientific journal published by @febspress.bsky.social. We publish original articles and reviews in the molecular life sciences.

Posts by the editors.
Posts Replies Media Videos
Pinned
febsj.bsky.social
The FEBS Journal @febsj.bsky.social · Sep 25
Our Disease Mechanisms Focus Issue is out now 📗🪰 febs.onlinelibrary.wiley.com/toc/17424658...

Articles combine fundamental structural insight with mechanistic implications for disease, reinforcing how structural information is essential for unravelling the basis and guiding therapeutic strategies.
Reposted by The FEBS Journal
selimlab.bsky.social
The original publication:

Structural analysis of the NifL-NifA complex reveals the molecular basis of anti-activation of nitrogen fixation gene expression in Azotobacter vinelandii
@febsj.bsky.social

febs.onlinelibrary.wiley.com/doi/10.1111/...
febs.onlinelibrary.wiley.com
November 17, 2025 at 7:49 PM
Reposted by The FEBS Journal
evgenii-protasov.bsky.social
Distribution and activity of nitrate and nitrite reductases in the microbiota of the human intestinal tract
#biochemistry #GutMicrobiota
@febsj.bsky.social
febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
Nitrate from food is first converted to nitrite by oral bacteria and then further processed in the intestine. The gut microbiota reduces nitrate and nitrite to ammonia or nitric oxide, preventing the....
febs.onlinelibrary.wiley.com
November 9, 2025 at 10:04 AM
Reposted by The FEBS Journal
nccr-rna-disease.bsky.social
Paper by the Schneider lab( @schneian.bsky.social ) & collaborators w/co-first authors Corinne von Känel & Salome Aeschlimann "TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome" @febsj.bsky.social nccr-rna-and-disease.ch/news/article...
October 27, 2025 at 8:02 AM
Reposted by The FEBS Journal
helloeacr.bsky.social
Interested in a career in scientific publishing?

Gain valuable publishing insights with a 3-month remote placement at @febsj.bsky.social @moloncology.bsky.social & a visit to the Heidelberg office 🌍

Apply by 06 Nov 2025 for an EACR-Molecular Oncology Editorial Fellowship: eacr.org/eacr-molecul...
October 9, 2025 at 8:01 AM
Reposted by The FEBS Journal
evolvedbiofilm.bsky.social
Binding of Bacillus subtilis dynamin-like protein DynA to the bacterial membrane is essential for effective phage defense

@febsj.bsky.social from @bramkamplab.bsky.social

febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
The bacterial dynamin-like protein DynA from Bacillus subtilis plays a key role in phage defense. It binds the plasma membrane through a unique paddle domain in its D1 subunit. This membrane associat....
febs.onlinelibrary.wiley.com
October 10, 2025 at 11:54 AM
febsj.bsky.social
📗 The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis

Read the article from our Disease Mechanisms focus issue ➡️ febs.onlinelibrary.wiley.com/doi/10.1111/...
October 8, 2025 at 3:58 PM
febsj.bsky.social
We are pleased to spotlight a new #OA article from our Disease Mechanisms focus issue

🧠 Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

Read here ➡️
febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism dr...
febs.onlinelibrary.wiley.com
October 6, 2025 at 11:58 AM
Reposted by The FEBS Journal
yokoyama-ryo.bsky.social
Phylogenetic reconciliation provides new insights into the evolutionary diversification of the glutamine synthetase gene family in seed plants febs.onlinelibrary.wiley.com/doi/10.1111/... @febsj.bsky.social
FEBS Press
Phylogenetic analyses of glutamine synthetase (GS) in seed plants revealed that all three major evolutionary lineages (GS2, GS1a, and GS1b) must have been present in the common ancestor, with GS2 bei....
febs.onlinelibrary.wiley.com
October 1, 2025 at 1:40 PM
febsj.bsky.social
We are proud to share this new State-of-the-Art-Review from our recent Structural Insights into Disease Mechanisms focus issue 🪰🧪

📗 In vivo and in silico models of #drosophila for #parkinsonsdisease

Read the review #openaccess here ➡️ febs.onlinelibrary.wiley.com/doi/10.1111/...
October 1, 2025 at 11:40 AM
Reposted by The FEBS Journal
crismunozp.bsky.social
Excellent review in the FEBS Journal (@febsj.bsky.social)
"Emerging roles for integrated stress response signaling in homeostasis"
Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan
febs.onlinelibrary.wiley.com/doi/full/10....
FEBS Press
Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress-adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of l...
febs.onlinelibrary.wiley.com
September 30, 2025 at 3:08 PM
Reposted by The FEBS Journal
gustavssonlab.bsky.social
Excited that our work led by the Dere Lab is now published! This study is the first to identify KDM4A as a centrosome protein, revealing its chromatin-independent function in maintaining centrosome integrity and genomic stability!
#microscopy #nanoscale @febsj.bsky.social
doi.org/10.1111/febs...
September 30, 2025 at 4:57 PM
febsj.bsky.social
🩺 Małgorzata Kosla and her husband Piotr established the PACS2 Research Foundation when their daughter was diagnosed with this ultrarare syndrome.

Read the interview with FEBSJ Editor @hajrah-khawaja.bsky.social and Malgorzata Kosla, here ➡️ febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
In this issue of The FEBS Journal, we interviewed Małgorzata ‘Gosia’ Kosla, who together with her husband Piotr, established the PACS2 Research Foundation when their daughter Lena was diagnosed with ...
febs.onlinelibrary.wiley.com
September 29, 2025 at 2:47 PM
febsj.bsky.social
Our Disease Mechanisms Focus Issue is out now 📗🪰 febs.onlinelibrary.wiley.com/toc/17424658...

Articles combine fundamental structural insight with mechanistic implications for disease, reinforcing how structural information is essential for unravelling the basis and guiding therapeutic strategies.
September 25, 2025 at 2:58 PM
Reposted by The FEBS Journal
haitinlab.bsky.social
Excited to share our new paper in @febsj.bsky.social! 🎉
We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation
🔗 doi.org/10.1111/febs...
@peterslab1.bsky.social
July 7, 2025 at 2:36 PM
Reposted by The FEBS Journal
petermace.bsky.social
Excited to see this work led by Cameron Reddington and Annabel Walsh out in @febsj.bsky.social — ASXL proteins share a PHD domain that is not a PHD domain, evolved to bind an MBD domain that is not an MBD domain!

febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
A plant homeodomain (PHD) at the C terminus of additional sex combs-like (ASXL) proteins is recurrently truncated in disease. In the current study, the ASXL PHD was shown not to bind histone modifica...
febs.onlinelibrary.wiley.com
July 29, 2025 at 10:01 PM
Reposted by The FEBS Journal
yokoyama-ryo.bsky.social
Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐FAD charge transfer and catalytic asymmetry in a homodimer febs.onlinelibrary.wiley.com/doi/10.1111/... @febsj.bsky.social
FEBS Press
Ferredoxin-dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyano...
febs.onlinelibrary.wiley.com
August 25, 2025 at 5:35 PM
Reposted by The FEBS Journal
elodie-lafont.bsky.social
Out in @febsj.bsky.social, comment written with @tonyavril.bsky.social from @csignaling.bsky.social.
https://doi:10.1111/febs.70259
The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR
September 22, 2025 at 2:36 PM
febsj.bsky.social
🩸 Register today for the FEBS Workshop on Aging in Hematopoiesis that will take place in ☀️ Crete on October 20-24, 2025!

🩸 An outstanding scientific program in a beautiful location! More info: buff.ly/bSHhzR3
July 29, 2025 at 11:24 AM
febsj.bsky.social
⏱️ ONE WEEK LEFT!
Travel Grants available for the FEBS Workshop on Aging in Hematopoiesis that will take place in Crete on October 20-24, 2025!
Phenomenal speakers, beautiful location & lots of opportunities to network!

⏱️ Deadline for applications: July 31. To apply ▶️: buff.ly/C1Ar5Sx
July 24, 2025 at 11:24 AM
Reposted by The FEBS Journal
msuskiewicz.bsky.social
Very happy that our SIAH1 article - published online in February - was now chosen for the cover of the new issue of the @febsj.bsky.social . Thank you @spartelab.bsky.social for the wonderful collaboration and the lovely cellular images. febs.onlinelibrary.wiley.com/toc/17424658...
June 5, 2025 at 5:49 AM
febsj.bsky.social
🍬 Looking for #WeekendReads?
Our latest issue is ready!

🍬 #CancerMetabolism takes centre-stage in our Reviews section
🕸️ A new Viewpoint discusses #ECM preparations' effects on the environment
📰 Rich crop of #MolecularLifeSicences research articles

🍬 buff.ly/wRbis26
May 9, 2025 at 11:24 AM
Reposted by The FEBS Journal
jplopez-atalaya.bsky.social
New review out with Aysha in @febsj.bsky.social. We discuss how dysregulated type-I interferon signalling affects brain function, with a focus on the IFN-responsive state of microglia. Experimental work coming soon, stay tuned! febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
Recent insights reveal that type I interferon (IFN-I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN-I activity is increasingly linked to neurologica...
febs.onlinelibrary.wiley.com
April 30, 2025 at 10:34 PM
Reposted by The FEBS Journal
reviewcommons.org
Now published @febsj.bsky.social @febspress.bsky.social

--> doi.org/10.1111/febs...
FEBS Press
Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted proteases, including ADAMTS family members. Rainero and colleagues found t...
doi.org
April 30, 2025 at 10:46 AM
febsj.bsky.social
🧬 @febspress.bsky.social is hiring!

Join The FEBS Journal as a full-time Editor 📚

🌍 Fully remote, UK-based, permanent role
📅 Deadline: 31 May 2025
📩 Send your CV, cover letter, and a 200-word research highlight to: ruffell@febs.org

Learn more ➡️ febs.org/news/jobs-po...
April 28, 2025 at 10:29 AM
Reposted by The FEBS Journal
crismunozp.bsky.social
A reviewer asked: but why is IRE1 activated when glucose is low?
A committee member for Mabel Cruz's PhD asked: why is the UPR activated upon glucose deprivation?
So we wrote a review about it.
Here it is!
@ericchevet.bsky.social @febsj.bsky.social
febs.onlinelibrary.wiley.com/doi/10.1111/...
FEBS Press
The unfolded protein response (UPR) is engaged by perturbations of protein folding in the endoplasmic reticulum (ER). Here, we compile evidence that the UPR is activated by physiological and patholog...
febs.onlinelibrary.wiley.com
April 24, 2025 at 6:20 PM