Farshid Guilak
@farsh-g.bsky.social
@ShrinersStLouis @wustlortho @washubme @washudevbio @wustlCRM @theNAMedicine @theNAEng @AcadofInventors @cytexortho @MyAOCConnect #racquetball
Pinned
Farshid Guilak
@farsh-g.bsky.social
· Jun 23
Congrats to Amanda Cimino and team on her latest paper in @JCRnEDITORS - she developed new synthetic chronogenetic gene circuits that allow controlled drug delivery at precise times day using various elements of the circadian clock! doi.org/10.1016/j.jc...
Reposted by Farshid Guilak
Exciting new study on the role of PIEZOs in Chondrocytes! Relevance to arthritis and pain. From: @farsh-g.bsky.social & @kelseyhcollins.bsky.social
arthritis-research.biomedcentral.com/articles/10....
arthritis-research.biomedcentral.com/articles/10....
Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice - Arthritis Research & Therapy
Background Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degeneration, synovial inflammation, and bone remodeling, with limited therapeutic options targeting the under...
arthritis-research.biomedcentral.com
July 21, 2025 at 8:15 PM
Exciting new study on the role of PIEZOs in Chondrocytes! Relevance to arthritis and pain. From: @farsh-g.bsky.social & @kelseyhcollins.bsky.social
arthritis-research.biomedcentral.com/articles/10....
arthritis-research.biomedcentral.com/articles/10....
Congrats to Amanda Cimino and team on her latest paper in @JCRnEDITORS - she developed new synthetic chronogenetic gene circuits that allow controlled drug delivery at precise times day using various elements of the circadian clock! doi.org/10.1016/j.jc...
June 23, 2025 at 12:00 PM
Congrats to Amanda Cimino and team on her latest paper in @JCRnEDITORS - she developed new synthetic chronogenetic gene circuits that allow controlled drug delivery at precise times day using various elements of the circadian clock! doi.org/10.1016/j.jc...
Huge congrats to Dr. Amanda Cimino for an outstanding presentation and defense - her committee said it was time for a "PhD+" degree. Amazing work!
June 11, 2025 at 8:02 PM
Huge congrats to Dr. Amanda Cimino for an outstanding presentation and defense - her committee said it was time for a "PhD+" degree. Amazing work!
Chronotherapy in Rheumatoid Arthritis Treatment: Tantalizing but Understudied
www.medscape.com/viewarticle/...
www.medscape.com/viewarticle/...
Chronotherapy in RA Treatment: Tantalizing but Understudied
Research is evaluating chronotherapy to target drugs to reduce morning stiffness and flares in rheumatoid arthritis, but it has a long way to go before it reaches the clinic.
www.medscape.com
June 3, 2025 at 5:05 PM
Chronotherapy in Rheumatoid Arthritis Treatment: Tantalizing but Understudied
www.medscape.com/viewarticle/...
www.medscape.com/viewarticle/...
Reposted by Farshid Guilak
We don’t always know what questions will change the world.
But public science has a way of answering them anyway.
Federal science funding isn’t just lines in a budget. It’s a vote for progress, for possibility.
www.nytimes.com/2025/05/16/s...
But public science has a way of answering them anyway.
Federal science funding isn’t just lines in a budget. It’s a vote for progress, for possibility.
www.nytimes.com/2025/05/16/s...
9 Federally Funded Scientific Breakthroughs That Changed Everything
www.nytimes.com
May 22, 2025 at 1:49 PM
We don’t always know what questions will change the world.
But public science has a way of answering them anyway.
Federal science funding isn’t just lines in a budget. It’s a vote for progress, for possibility.
www.nytimes.com/2025/05/16/s...
But public science has a way of answering them anyway.
Federal science funding isn’t just lines in a budget. It’s a vote for progress, for possibility.
www.nytimes.com/2025/05/16/s...
Most studies of cartilage mechanobiology study the upregulation of chondrocyte gene expression and biosynthesis with mechanical loading. Check out our recent paper where Daniel Palmer studied the down-regulated "mechanome" with Piezo1 or TRPV4 activation. www.tandfonline.com/doi/full/10....
May 22, 2025 at 3:16 PM
Most studies of cartilage mechanobiology study the upregulation of chondrocyte gene expression and biosynthesis with mechanical loading. Check out our recent paper where Daniel Palmer studied the down-regulated "mechanome" with Piezo1 or TRPV4 activation. www.tandfonline.com/doi/full/10....
Reposted by Farshid Guilak
Your research on Ion Channel Regulation might be the next watershed discovery! Join FASEB for the latest findings at #ICRSRC with keynote speaker @farsh-g.bsky.social
and organizers @roseedixon.bsky.social and Jonathan Silva. Submit your abstract by June 8 and save your space now! buff.ly/A3wmAbp
and organizers @roseedixon.bsky.social and Jonathan Silva. Submit your abstract by June 8 and save your space now! buff.ly/A3wmAbp
May 22, 2025 at 1:03 PM
Your research on Ion Channel Regulation might be the next watershed discovery! Join FASEB for the latest findings at #ICRSRC with keynote speaker @farsh-g.bsky.social
and organizers @roseedixon.bsky.social and Jonathan Silva. Submit your abstract by June 8 and save your space now! buff.ly/A3wmAbp
and organizers @roseedixon.bsky.social and Jonathan Silva. Submit your abstract by June 8 and save your space now! buff.ly/A3wmAbp
Congrats to Amanda Cimino for her latest paper creating a chronogenetic gene circuit that automatically delivers anti-inflammatory biologic drugs in response to inflammation or circadian signal! jbioleng.biomedcentral.com/articles/10....
May 20, 2025 at 11:50 AM
Congrats to Amanda Cimino for her latest paper creating a chronogenetic gene circuit that automatically delivers anti-inflammatory biologic drugs in response to inflammation or circadian signal! jbioleng.biomedcentral.com/articles/10....
Lots of celebrations this month in the Guilak Lab! Congrats to Xinyi Melissa Li and Katelyn Lipa for passing their qualifying exams with flying colors!
May 13, 2025 at 7:19 PM
Lots of celebrations this month in the Guilak Lab! Congrats to Xinyi Melissa Li and Katelyn Lipa for passing their qualifying exams with flying colors!
Reposted by Farshid Guilak
🚨 Big updates!
✅ Successfully defended my PhD thesis:
“Multiscale Modeling of Chondrocyte Mechanobiology: Insights into Degeneration and Regeneration”
✅ Joined the lab of @farsh-g.bsky.social at WashU St Louis as a Rita Levi-Montalcini Postdoc Fellow in regenerative medicine!
Grateful & excited !
✅ Successfully defended my PhD thesis:
“Multiscale Modeling of Chondrocyte Mechanobiology: Insights into Degeneration and Regeneration”
✅ Joined the lab of @farsh-g.bsky.social at WashU St Louis as a Rita Levi-Montalcini Postdoc Fellow in regenerative medicine!
Grateful & excited !
May 8, 2025 at 8:22 PM
🚨 Big updates!
✅ Successfully defended my PhD thesis:
“Multiscale Modeling of Chondrocyte Mechanobiology: Insights into Degeneration and Regeneration”
✅ Joined the lab of @farsh-g.bsky.social at WashU St Louis as a Rita Levi-Montalcini Postdoc Fellow in regenerative medicine!
Grateful & excited !
✅ Successfully defended my PhD thesis:
“Multiscale Modeling of Chondrocyte Mechanobiology: Insights into Degeneration and Regeneration”
✅ Joined the lab of @farsh-g.bsky.social at WashU St Louis as a Rita Levi-Montalcini Postdoc Fellow in regenerative medicine!
Grateful & excited !
Reposted by Farshid Guilak
Please widely share these 3 new advocacy letter templates with your colleagues.
@lolauic.bsky.social @orssociety.bsky.social @bmes-cmbe.bsky.social @aapmhq.bsky.social @acadrad.bsky.social @ceschmidt2024.bsky.social @settonlab.bsky.social @tejaladesai.bsky.social @farsh-g.bsky.social
@lolauic.bsky.social @orssociety.bsky.social @bmes-cmbe.bsky.social @aapmhq.bsky.social @acadrad.bsky.social @ceschmidt2024.bsky.social @settonlab.bsky.social @tejaladesai.bsky.social @farsh-g.bsky.social
May 5, 2025 at 6:40 PM
Please widely share these 3 new advocacy letter templates with your colleagues.
@lolauic.bsky.social @orssociety.bsky.social @bmes-cmbe.bsky.social @aapmhq.bsky.social @acadrad.bsky.social @ceschmidt2024.bsky.social @settonlab.bsky.social @tejaladesai.bsky.social @farsh-g.bsky.social
@lolauic.bsky.social @orssociety.bsky.social @bmes-cmbe.bsky.social @aapmhq.bsky.social @acadrad.bsky.social @ceschmidt2024.bsky.social @settonlab.bsky.social @tejaladesai.bsky.social @farsh-g.bsky.social
Reposted by Farshid Guilak
Join us for our quarterly C-COMP journal club, featuring this exciting new paper by the team of @kelseyhcollins.bsky.social and @farsh-g.bsky.social Monday May 12th 10 am CST- ask us how to register!
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain
Osteoarthritis and knee joint pain are driven by systemic leptin and complement factor D secreted by adipose tissue.
www.science.org
May 2, 2025 at 7:08 PM
Join us for our quarterly C-COMP journal club, featuring this exciting new paper by the team of @kelseyhcollins.bsky.social and @farsh-g.bsky.social Monday May 12th 10 am CST- ask us how to register!
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Congrats to Sophie Paradi on a fantastic Master's thesis and defense! Amazing work and collaboration with Erica Ely and many others in the Guilak Lab
May 1, 2025 at 12:18 PM
Congrats to Sophie Paradi on a fantastic Master's thesis and defense! Amazing work and collaboration with Erica Ely and many others in the Guilak Lab
Reposted by Farshid Guilak
Ion channel research can have major consequences for cancer and cardiovascular disease treatments. Join FASEB at #ICRSRC for the latest findings with keynote speaker @farsh-g.bsky.social and organizer @roseedixon.bsky.social. Check out the full program and save your space: buff.ly/d213NE1
April 28, 2025 at 5:09 PM
Ion channel research can have major consequences for cancer and cardiovascular disease treatments. Join FASEB at #ICRSRC for the latest findings with keynote speaker @farsh-g.bsky.social and organizer @roseedixon.bsky.social. Check out the full program and save your space: buff.ly/d213NE1
Congrats @kelseyhcollins.bsky.social on another tour de force, shedding further light into the relationship between obesity and OA! The more we learn, the more complex it gets... Fantastic collaboration with the June lab and WashU Rheumatology!
Excited to share the latest chapter of our work on fat-joint interorgan crosstalk in knee OA, featuring the role of complement factor D secreted by fat in knee pain. Link here: bit.ly/42Og5hJ
Thanks to @farsh-g.bsky.social for all of your support - @thehopefulscie1.bsky.social and all coauthors!
Thanks to @farsh-g.bsky.social for all of your support - @thehopefulscie1.bsky.social and all coauthors!
April 25, 2025 at 7:24 PM
Congrats @kelseyhcollins.bsky.social on another tour de force, shedding further light into the relationship between obesity and OA! The more we learn, the more complex it gets... Fantastic collaboration with the June lab and WashU Rheumatology!
put me in, coach...
April 24, 2025 at 9:53 PM
put me in, coach...
Join us today for our AOC Thought Leaders Webinar: Managing the Research Enterprise — for anyone navigating the evolving landscape of academic orthopaedics.
April 24 | 4:00 PM ET
Register Here: lnkd.in/eTrzEem6
Joint the AOC at myaocconnect.com!
April 24 | 4:00 PM ET
Register Here: lnkd.in/eTrzEem6
Joint the AOC at myaocconnect.com!
April 24, 2025 at 12:13 PM
Join us today for our AOC Thought Leaders Webinar: Managing the Research Enterprise — for anyone navigating the evolving landscape of academic orthopaedics.
April 24 | 4:00 PM ET
Register Here: lnkd.in/eTrzEem6
Joint the AOC at myaocconnect.com!
April 24 | 4:00 PM ET
Register Here: lnkd.in/eTrzEem6
Joint the AOC at myaocconnect.com!
Congrats Dr. Jackie Garcia on an amazing dissertation on defense "Characterizing PIEZO1 Mechanotransduction in Articular Chondrocytes"!
April 10, 2025 at 8:55 PM
Congrats Dr. Jackie Garcia on an amazing dissertation on defense "Characterizing PIEZO1 Mechanotransduction in Articular Chondrocytes"!
Excited for our most recent publication mapping macrophage populations in the synovium with knee injury and obesity! Great work by @nharasymowicz.bsky.social and team!
Obesity has a distinct impact on the progression of OA. We showed significant loss of protective synovial lining macrophages in the synovium 3 days after joint injury, with a significant restoration in normal-weight but not in obese mice @farsh-g.bsky.social
ard.eular.org/article/S000...
ard.eular.org/article/S000...
April 7, 2025 at 9:55 PM
Excited for our most recent publication mapping macrophage populations in the synovium with knee injury and obesity! Great work by @nharasymowicz.bsky.social and team!
Reposted by Farshid Guilak
The 3/14 deadline to finalize the FY2025 budget is fast approaching! ⌛
AIMBE has developed a new advocacy letter (<1 min to send) for the scientific community to urge Congress to support our federal science agencies, including NIH, NSF, FDA, ARPA-H, CDMRP, and more 👇
takeaction.io/aimbe/suppor...
AIMBE has developed a new advocacy letter (<1 min to send) for the scientific community to urge Congress to support our federal science agencies, including NIH, NSF, FDA, ARPA-H, CDMRP, and more 👇
takeaction.io/aimbe/suppor...
Support Strong FY25 Funding for Biomedical Research by March 14
Use AIMBE's letter template below, edit as needed, or create your own message to your Members of Congress on issues that matter. Enter your contact information on the left, and your letter will be rou...
takeaction.io
March 11, 2025 at 2:29 PM
The 3/14 deadline to finalize the FY2025 budget is fast approaching! ⌛
AIMBE has developed a new advocacy letter (<1 min to send) for the scientific community to urge Congress to support our federal science agencies, including NIH, NSF, FDA, ARPA-H, CDMRP, and more 👇
takeaction.io/aimbe/suppor...
AIMBE has developed a new advocacy letter (<1 min to send) for the scientific community to urge Congress to support our federal science agencies, including NIH, NSF, FDA, ARPA-H, CDMRP, and more 👇
takeaction.io/aimbe/suppor...
Engineered stem cells automatically deliver arthritis drugs at prescribed times of day
apnews.com/press-releas...
www.nature.com/articles/s41...
apnews.com/press-releas...
www.nature.com/articles/s41...
Engineered stem cells automatically deliver arthritis drugs at prescribed times of day
“This technology has the potential to change a lot of lives.
apnews.com
March 7, 2025 at 1:45 PM
Engineered stem cells automatically deliver arthritis drugs at prescribed times of day
apnews.com/press-releas...
www.nature.com/articles/s41...
apnews.com/press-releas...
www.nature.com/articles/s41...
We’ve created a new field called “chronogenetics”: controlling gene expression with the cell’s internal clock! Lara Pferdehirt & Anna Damato made living implants that sync to the body & automatically deliver biological drugs on a 24 hr cycle. www.nature.com/articles/s41...
March 5, 2025 at 1:00 PM
We’ve created a new field called “chronogenetics”: controlling gene expression with the cell’s internal clock! Lara Pferdehirt & Anna Damato made living implants that sync to the body & automatically deliver biological drugs on a 24 hr cycle. www.nature.com/articles/s41...
On #RareDiseaseDay, we are excited to publish Zainab Harissa's paper showing that rare, dysplasia-causing mutations in the ion channel TRPV4 alter the response of chondrocytes to mechanical loading. journals.physiology.org/doi/abs/10.1...
February 28, 2025 at 10:21 PM
On #RareDiseaseDay, we are excited to publish Zainab Harissa's paper showing that rare, dysplasia-causing mutations in the ion channel TRPV4 alter the response of chondrocytes to mechanical loading. journals.physiology.org/doi/abs/10.1...
Check out the latest insights on what controls pericellular matrix properties (measured by atomic force microscopy) as it is degraded in OA. fantastic collaboration with Marina Danalache. Congrats to Jule Nieuwstraten for leading this study!
⚠️New #OAC #BasicScience How does MMP-2, -3, and -7 effect the structural integrity and biomechanical attributes of the pericellular matrix (PCM)?
@farsh-g.bsky.social
Read more📑 : https://buff.ly/3X62SyV
@farsh-g.bsky.social
Read more📑 : https://buff.ly/3X62SyV
February 20, 2025 at 11:40 AM
Check out the latest insights on what controls pericellular matrix properties (measured by atomic force microscopy) as it is degraded in OA. fantastic collaboration with Marina Danalache. Congrats to Jule Nieuwstraten for leading this study!