Kelsey H. Collins
@kelseyhcollins.bsky.social
#fatchat and novel therapies for OA/RA structure and pain, musculoskeletal interorgan crosstalk, aging, obesity
Assistant Professor, UCSF
collinslab.ucsf.edu
Assistant Professor, UCSF
collinslab.ucsf.edu
Sporting mine in Sydney, Australia! Learn more about the #whitesneaker campaign and resources for #worldosteoporosisday below 👇🏻
October 20, 2025 at 8:50 PM
Sporting mine in Sydney, Australia! Learn more about the #whitesneaker campaign and resources for #worldosteoporosisday below 👇🏻
Thrilled to be speaking at the McCaig International Research Conference on #Osteoarthritis, March 11–13, 2026 in Kananaskis, Alberta 🇨🇦
Trainee abstract submissions are open until Oct 31, 2025!
Learn more: mccaig.ucalgary.ca/event/intern...
#McCaig2026 #BoneAndJointHealth
Trainee abstract submissions are open until Oct 31, 2025!
Learn more: mccaig.ucalgary.ca/event/intern...
#McCaig2026 #BoneAndJointHealth
September 12, 2025 at 10:36 PM
Thrilled to be speaking at the McCaig International Research Conference on #Osteoarthritis, March 11–13, 2026 in Kananaskis, Alberta 🇨🇦
Trainee abstract submissions are open until Oct 31, 2025!
Learn more: mccaig.ucalgary.ca/event/intern...
#McCaig2026 #BoneAndJointHealth
Trainee abstract submissions are open until Oct 31, 2025!
Learn more: mccaig.ucalgary.ca/event/intern...
#McCaig2026 #BoneAndJointHealth
Reposted by Kelsey H. Collins
Love seeing the #WhiteSneakers being packed for #ASBMR2025, keep them coming! Wear them at the meeting on Saturday 06 Sept to Take Steps to Improve Bone Health. Even if you can't join us in Seattle, post a pic with your favorite pair and join the MOVEment! @asbmr.bsky.social 🦴💪🚶♀️🚶
Can't wait to join #ASBMR2025 @asbmr.bsky.social in just a few days! The first thing that I packed in my luggage was, of course, #WhiteSneakers, for Saturday, September 6, to support bone health! See you soon in Seattle!
September 2, 2025 at 3:51 PM
Love seeing the #WhiteSneakers being packed for #ASBMR2025, keep them coming! Wear them at the meeting on Saturday 06 Sept to Take Steps to Improve Bone Health. Even if you can't join us in Seattle, post a pic with your favorite pair and join the MOVEment! @asbmr.bsky.social 🦴💪🚶♀️🚶
Reposted by Kelsey H. Collins
The @asbmr.bsky.social Annual Meeting is less than 2 weeks away, and we're all lacing up our #whitesneakers to get ready! Wanna join the MOVEment and Take Steps to Improve Bone Health? Be sure to pack your white sneakers for #ASBMR2025 in Seattle, wear them on 06 Sept, and stay tuned for more!
August 25, 2025 at 2:43 PM
The @asbmr.bsky.social Annual Meeting is less than 2 weeks away, and we're all lacing up our #whitesneakers to get ready! Wanna join the MOVEment and Take Steps to Improve Bone Health? Be sure to pack your white sneakers for #ASBMR2025 in Seattle, wear them on 06 Sept, and stay tuned for more!
We are inviting original research studies that probe the interaction between Obesity and Osteoarthritis for
@oacjournal.bsky.social by May 1, 2026. Details below & happy to discuss!
@jointsintheworld.bsky.social
@profdavidhunter.bsky.social
@larhumato.bsky.social
Shannon Mihalko
Henning Bliddal
@oacjournal.bsky.social by May 1, 2026. Details below & happy to discuss!
@jointsintheworld.bsky.social
@profdavidhunter.bsky.social
@larhumato.bsky.social
Shannon Mihalko
Henning Bliddal
🔊 CALL FOR PAPERS!
Special Edition: Obesity and Osteoarthritis
www.sciencedirect.com/special-issu...
Deadline: 01 May 2026
Special Edition: Obesity and Osteoarthritis
www.sciencedirect.com/special-issu...
Deadline: 01 May 2026
July 22, 2025 at 2:46 PM
We are inviting original research studies that probe the interaction between Obesity and Osteoarthritis for
@oacjournal.bsky.social by May 1, 2026. Details below & happy to discuss!
@jointsintheworld.bsky.social
@profdavidhunter.bsky.social
@larhumato.bsky.social
Shannon Mihalko
Henning Bliddal
@oacjournal.bsky.social by May 1, 2026. Details below & happy to discuss!
@jointsintheworld.bsky.social
@profdavidhunter.bsky.social
@larhumato.bsky.social
Shannon Mihalko
Henning Bliddal
Reposted by Kelsey H. Collins
Exciting new study on the role of PIEZOs in Chondrocytes! Relevance to arthritis and pain. From: @farsh-g.bsky.social & @kelseyhcollins.bsky.social
arthritis-research.biomedcentral.com/articles/10....
arthritis-research.biomedcentral.com/articles/10....
Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice - Arthritis Research & Therapy
Background Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degeneration, synovial inflammation, and bone remodeling, with limited therapeutic options targeting the under...
arthritis-research.biomedcentral.com
July 21, 2025 at 8:15 PM
Exciting new study on the role of PIEZOs in Chondrocytes! Relevance to arthritis and pain. From: @farsh-g.bsky.social & @kelseyhcollins.bsky.social
arthritis-research.biomedcentral.com/articles/10....
arthritis-research.biomedcentral.com/articles/10....
Reposted by Kelsey H. Collins
Most studies of cartilage mechanobiology study the upregulation of chondrocyte gene expression and biosynthesis with mechanical loading. Check out our recent paper where Daniel Palmer studied the down-regulated "mechanome" with Piezo1 or TRPV4 activation. www.tandfonline.com/doi/full/10....
May 22, 2025 at 3:16 PM
Most studies of cartilage mechanobiology study the upregulation of chondrocyte gene expression and biosynthesis with mechanical loading. Check out our recent paper where Daniel Palmer studied the down-regulated "mechanome" with Piezo1 or TRPV4 activation. www.tandfonline.com/doi/full/10....
Reposted by Kelsey H. Collins
1) Despite the chaos, I am very pleased to present the terrific research conducted by my post-doc @clarissacoveney.bsky.social. acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Complex regulatory interactions at GDF5 shape joint morphology and osteoarthritis disease risk
Objectives To reveal causal level osteoarthritis (OA) disease biology by targeting regulatory interactions at GDF5. Methods By investigating different GDF5 regulatory regions (R2, R3-5, R7-R9, R18...
acrjournals.onlinelibrary.wiley.com
May 21, 2025 at 2:11 PM
1) Despite the chaos, I am very pleased to present the terrific research conducted by my post-doc @clarissacoveney.bsky.social. acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
It is a joy to congratulate @jessicagwagner.bsky.social, Movement Science PhD Student in UCSF PT, on a fantastic qualifying exam this morning - first one in the lab! Way to go, Jess 👏
Here is a link to Jess' recently published paper: onlinelibrary.wiley.com/doi/full/10....
Here is a link to Jess' recently published paper: onlinelibrary.wiley.com/doi/full/10....
May 15, 2025 at 4:27 PM
It is a joy to congratulate @jessicagwagner.bsky.social, Movement Science PhD Student in UCSF PT, on a fantastic qualifying exam this morning - first one in the lab! Way to go, Jess 👏
Here is a link to Jess' recently published paper: onlinelibrary.wiley.com/doi/full/10....
Here is a link to Jess' recently published paper: onlinelibrary.wiley.com/doi/full/10....
Starting in 15 min! Thanks @jointsintheworld.bsky.social and CCOMP for the opportunity to share our work @farsh-g.bsky.social
Join us for our quarterly C-COMP journal club, featuring this exciting new paper by the team of @kelseyhcollins.bsky.social and @farsh-g.bsky.social Monday May 12th 10 am CST- ask us how to register!
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain
Osteoarthritis and knee joint pain are driven by systemic leptin and complement factor D secreted by adipose tissue.
www.science.org
May 12, 2025 at 2:43 PM
Starting in 15 min! Thanks @jointsintheworld.bsky.social and CCOMP for the opportunity to share our work @farsh-g.bsky.social
Reposted by Kelsey H. Collins
New to ORS? Join our New Member Orientation on May 21 at 12 PM CST via Zoom! Learn about member benefits, networking, and hear how ORS has impacted careers. Bring your questions!
🔗 Register now: bit.ly/3XzipIA
🔗 Register now: bit.ly/3XzipIA
May 5, 2025 at 7:26 PM
New to ORS? Join our New Member Orientation on May 21 at 12 PM CST via Zoom! Learn about member benefits, networking, and hear how ORS has impacted careers. Bring your questions!
🔗 Register now: bit.ly/3XzipIA
🔗 Register now: bit.ly/3XzipIA
Reposted by Kelsey H. Collins
Join us for our quarterly C-COMP journal club, featuring this exciting new paper by the team of @kelseyhcollins.bsky.social and @farsh-g.bsky.social Monday May 12th 10 am CST- ask us how to register!
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain
Osteoarthritis and knee joint pain are driven by systemic leptin and complement factor D secreted by adipose tissue.
www.science.org
May 2, 2025 at 7:08 PM
Join us for our quarterly C-COMP journal club, featuring this exciting new paper by the team of @kelseyhcollins.bsky.social and @farsh-g.bsky.social Monday May 12th 10 am CST- ask us how to register!
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by Kelsey H. Collins
@kelseyhcollins.bsky.social and I are kicking off the USASP Annual Scientific Meeting with a trip to the iconic Bean! Excited to be in Chicago, present my work this afternoon at poster B28, and join the Pain & Aging SIG tonight! 🎉
@usasp.bsky.social
@usasp.bsky.social
April 30, 2025 at 1:57 PM
@kelseyhcollins.bsky.social and I are kicking off the USASP Annual Scientific Meeting with a trip to the iconic Bean! Excited to be in Chicago, present my work this afternoon at poster B28, and join the Pain & Aging SIG tonight! 🎉
@usasp.bsky.social
@usasp.bsky.social
Excited to share the latest chapter of our work on fat-joint interorgan crosstalk in knee OA, featuring the role of complement factor D secreted by fat in knee pain. Link here: bit.ly/42Og5hJ
Thanks to @farsh-g.bsky.social for all of your support - @thehopefulscie1.bsky.social and all coauthors!
Thanks to @farsh-g.bsky.social for all of your support - @thehopefulscie1.bsky.social and all coauthors!
April 25, 2025 at 6:13 PM
Excited to share the latest chapter of our work on fat-joint interorgan crosstalk in knee OA, featuring the role of complement factor D secreted by fat in knee pain. Link here: bit.ly/42Og5hJ
Thanks to @farsh-g.bsky.social for all of your support - @thehopefulscie1.bsky.social and all coauthors!
Thanks to @farsh-g.bsky.social for all of your support - @thehopefulscie1.bsky.social and all coauthors!
Reposted by Kelsey H. Collins
Yet another study showing beneficial effects of metformin for pain - this time in OA pain. Effects on pain are modest, but better than placebo. Effects on WOMAC scores are more impressive. Also no sex differences observed. jamanetwork.com/journals/jam...
Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity
This randomized clinical trial assesses the effect of metformin on knee pain among patients with symptomatic knee osteoarthritis and overweight or obesity.
jamanetwork.com
April 25, 2025 at 1:50 PM
Yet another study showing beneficial effects of metformin for pain - this time in OA pain. Effects on pain are modest, but better than placebo. Effects on WOMAC scores are more impressive. Also no sex differences observed. jamanetwork.com/journals/jam...
Congratulations to @grainofscience.bsky.social on the 2025 OARSI Rising Star Award! Well deserved 👏
Excited to be in South Korea for #OARSI2025 I’ve landed a few days early and I’m making the most of it!
April 21, 2025 at 8:14 PM
Congratulations to @grainofscience.bsky.social on the 2025 OARSI Rising Star Award! Well deserved 👏
Reposted by Kelsey H. Collins
If you're around Palo Alto tomorrow, come hear how we gave menisci discarded from the food industry a second life to repair tracheas and eardrums @bioe-stanford.bsky.social @pennmedicine.bsky.social @pennengineering.bsky.social @upenn.edu #ENT
April 18, 2025 at 2:39 AM
If you're around Palo Alto tomorrow, come hear how we gave menisci discarded from the food industry a second life to repair tracheas and eardrums @bioe-stanford.bsky.social @pennmedicine.bsky.social @pennengineering.bsky.social @upenn.edu #ENT
Reposted by Kelsey H. Collins
Obesity has a distinct impact on the progression of OA. We showed significant loss of protective synovial lining macrophages in the synovium 3 days after joint injury, with a significant restoration in normal-weight but not in obese mice @farsh-g.bsky.social
ard.eular.org/article/S000...
ard.eular.org/article/S000...
April 7, 2025 at 8:11 PM
Obesity has a distinct impact on the progression of OA. We showed significant loss of protective synovial lining macrophages in the synovium 3 days after joint injury, with a significant restoration in normal-weight but not in obese mice @farsh-g.bsky.social
ard.eular.org/article/S000...
ard.eular.org/article/S000...
Reposted by Kelsey H. Collins
Fascinating new article from the Basbaum Lab! Elora Midavaine et al. show that regulatory T cells can curb pain via endogenous opioid signaling - but only in female mice. #PainResearch #Neuroimmunology #Tregs #SexDifferences #Enkephalin www.science.org/doi/10.1126/...
Meningeal regulatory T cells inhibit nociception in female mice
T cells have emerged as orchestrators of pain amplification, but the mechanism by which T cells control pain processing is unresolved. We found that regulatory T cells (Treg cells) could inhibit nocic...
www.science.org
April 7, 2025 at 6:09 PM
Fascinating new article from the Basbaum Lab! Elora Midavaine et al. show that regulatory T cells can curb pain via endogenous opioid signaling - but only in female mice. #PainResearch #Neuroimmunology #Tregs #SexDifferences #Enkephalin www.science.org/doi/10.1126/...
Reposted by Kelsey H. Collins
Our Editorial is now online! Here, we discuss recent advancements and pertinent challenges in applying modern 'omics technologies to MSK tissues. This introduces our @oacjournal.bsky.social special edition. Still ~4 weeks left if you have a paper in the works! www.sciencedirect.com/science/arti...
A timely assessment of the state of transcriptomic and epigenomic profiling in OA: Opportunities for advancements
www.sciencedirect.com
April 5, 2025 at 11:50 AM
Our Editorial is now online! Here, we discuss recent advancements and pertinent challenges in applying modern 'omics technologies to MSK tissues. This introduces our @oacjournal.bsky.social special edition. Still ~4 weeks left if you have a paper in the works! www.sciencedirect.com/science/arti...
Reposted by Kelsey H. Collins
Want to do a #postdoc? Did you know more faculty jobs go to people who postdoc in slightly different subject area? doi.org/10.1073/pnas... Are you an expert in #microbiome OR #osteoarthritis? How'd you like to join me and @kelseyhcollins.bsky.social as we figure out how the two are connected?
March 26, 2025 at 9:54 PM
Want to do a #postdoc? Did you know more faculty jobs go to people who postdoc in slightly different subject area? doi.org/10.1073/pnas... Are you an expert in #microbiome OR #osteoarthritis? How'd you like to join me and @kelseyhcollins.bsky.social as we figure out how the two are connected?
Reposted by Kelsey H. Collins
I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reversible histone deacetylase activity catalyzes lysine acylation - Nature Chemical Biology
Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...
www.nature.com
March 26, 2025 at 2:02 PM
I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Hey #CartilageGRS2025 trainees! Defending soon, looking for a postdoc, and/or want to live in beautiful San Francisco, CA? We're looking for motivated folks to solve complex puzzles involving systemic factors, fat, aging, the gut microbiome and MSK health. DMs open! @thehopefulscie1.bsky.social
March 24, 2025 at 7:37 PM
Hey #CartilageGRS2025 trainees! Defending soon, looking for a postdoc, and/or want to live in beautiful San Francisco, CA? We're looking for motivated folks to solve complex puzzles involving systemic factors, fat, aging, the gut microbiome and MSK health. DMs open! @thehopefulscie1.bsky.social
Reposted by Kelsey H. Collins
Stop 4: Solvang (forgot to take any photos- sign of a good time)
Stop 5: In N Out (aka when in Cali) #CartilageGRC
Stop 5: In N Out (aka when in Cali) #CartilageGRC
March 24, 2025 at 7:20 PM
Stop 4: Solvang (forgot to take any photos- sign of a good time)
Stop 5: In N Out (aka when in Cali) #CartilageGRC
Stop 5: In N Out (aka when in Cali) #CartilageGRC
Having lots of fun at #CartilageGRC2025 - Congrats to @thehopefulscie1.bsky.social on her election as the 2027 Cartilage GRS Co-Chair and her GRS Podium Award! Her work on aging and sex differences is awesome and so we are proud to share this work at the GRC meeting. Way to go, Hope! 🥂
March 24, 2025 at 7:03 PM
Having lots of fun at #CartilageGRC2025 - Congrats to @thehopefulscie1.bsky.social on her election as the 2027 Cartilage GRS Co-Chair and her GRS Podium Award! Her work on aging and sex differences is awesome and so we are proud to share this work at the GRC meeting. Way to go, Hope! 🥂