Osteoarthritis and Cartilage Journal
@oacjournal.bsky.social
Osteoarthritis and Cartilage, and Osteoarthritis and Cartilage Open - official journals of OARSI. Impact factor 9.
http://www.oarsijournal.com
http://www.oarsijournal.com
Ziemian et al. demonstrates repetitive loading induced protective effects in the joint & attenuated OA progression over time relative to a single bout of loading even when applied at hyperphysiological load magnitudes known to initiate cartilage damage.
Read more🔗
pubmed.ncbi.nlm.nih.gov/40020990/
Read more🔗
pubmed.ncbi.nlm.nih.gov/40020990/
January 20, 2026 at 2:17 PM
Ziemian et al. demonstrates repetitive loading induced protective effects in the joint & attenuated OA progression over time relative to a single bout of loading even when applied at hyperphysiological load magnitudes known to initiate cartilage damage.
Read more🔗
pubmed.ncbi.nlm.nih.gov/40020990/
Read more🔗
pubmed.ncbi.nlm.nih.gov/40020990/
The January #EditorsChoice #Basic #Science in #OAC is this review by Wallace et al. Learn about the decreased risk of OA in non-industrialized societies.
Read more: www.sciencedirect.com/science/arti...
Read more: www.sciencedirect.com/science/arti...
January 12, 2026 at 2:27 PM
The January #EditorsChoice #Basic #Science in #OAC is this review by Wallace et al. Learn about the decreased risk of OA in non-industrialized societies.
Read more: www.sciencedirect.com/science/arti...
Read more: www.sciencedirect.com/science/arti...
As we usher in the new year, we also wanted to celebrate the achievements of a giant in the hashtag#osteoarthritis community.
Read more about Frank's legacy and the Frank Beier Graduate Opportunity Scholarship in this month's issue here: www.oarsijournal.com/article/S106...
Read more about Frank's legacy and the Frank Beier Graduate Opportunity Scholarship in this month's issue here: www.oarsijournal.com/article/S106...
January 12, 2026 at 1:19 AM
As we usher in the new year, we also wanted to celebrate the achievements of a giant in the hashtag#osteoarthritis community.
Read more about Frank's legacy and the Frank Beier Graduate Opportunity Scholarship in this month's issue here: www.oarsijournal.com/article/S106...
Read more about Frank's legacy and the Frank Beier Graduate Opportunity Scholarship in this month's issue here: www.oarsijournal.com/article/S106...
🔥 New year new issue!
2026's first editors choice is this large (n>500,000) cohort study on the effects of air pollution on osteoarthritis risk
Read more from Chen et al here: oarsijournal.com/article/S106...
#carbonmonoxide #nitrogendioxide #pm10
2026's first editors choice is this large (n>500,000) cohort study on the effects of air pollution on osteoarthritis risk
Read more from Chen et al here: oarsijournal.com/article/S106...
#carbonmonoxide #nitrogendioxide #pm10
January 7, 2026 at 1:41 PM
🔥 New year new issue!
2026's first editors choice is this large (n>500,000) cohort study on the effects of air pollution on osteoarthritis risk
Read more from Chen et al here: oarsijournal.com/article/S106...
#carbonmonoxide #nitrogendioxide #pm10
2026's first editors choice is this large (n>500,000) cohort study on the effects of air pollution on osteoarthritis risk
Read more from Chen et al here: oarsijournal.com/article/S106...
#carbonmonoxide #nitrogendioxide #pm10
#New in #OAC Work from Chen et al. found that treadmill #exercise offers protective effects when initiated early after OA onset but may worsen outcomes if delayed.🏃🏃♂️🏃♀️
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oarsijournal.com/article/S106...
🔗
oarsijournal.com/article/S106...
December 29, 2025 at 9:09 PM
#New in #OAC Work from Chen et al. found that treadmill #exercise offers protective effects when initiated early after OA onset but may worsen outcomes if delayed.🏃🏃♂️🏃♀️
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oarsijournal.com/article/S106...
🔗
oarsijournal.com/article/S106...
How does Estrogen receptor-α loss accelerate cartilage degradation? 🧐
#New in #OAC this month!
Read more:
www.oarsijournal.com/article/S106...
#New in #OAC this month!
Read more:
www.oarsijournal.com/article/S106...
December 29, 2025 at 1:06 AM
How does Estrogen receptor-α loss accelerate cartilage degradation? 🧐
#New in #OAC this month!
Read more:
www.oarsijournal.com/article/S106...
#New in #OAC this month!
Read more:
www.oarsijournal.com/article/S106...
#OAC #Dec TMJ condylar cartilage exhibits a distinct hyaline microstructure compared to knee cartilage, characterized by higher cell density, smaller cells, and enlarged cell lacunae filled with GAGs, contributing to a load-responsive mechanical behavior.
🔗 www.sciencedirect.com/science/arti...
🔗 www.sciencedirect.com/science/arti...
December 10, 2025 at 2:37 PM
#OAC #Dec TMJ condylar cartilage exhibits a distinct hyaline microstructure compared to knee cartilage, characterized by higher cell density, smaller cells, and enlarged cell lacunae filled with GAGs, contributing to a load-responsive mechanical behavior.
🔗 www.sciencedirect.com/science/arti...
🔗 www.sciencedirect.com/science/arti...
Where does OA pain really come from? 🤔
December's Editor's Choice (Clinical) suggests it's NOT just the cartilage
Targeting entheses might be next frontier for symptom relief
Read more from Ziegeler et al: www.oarsijournal.com/article/S106...
December's Editor's Choice (Clinical) suggests it's NOT just the cartilage
Targeting entheses might be next frontier for symptom relief
Read more from Ziegeler et al: www.oarsijournal.com/article/S106...
December 3, 2025 at 12:59 PM
Where does OA pain really come from? 🤔
December's Editor's Choice (Clinical) suggests it's NOT just the cartilage
Targeting entheses might be next frontier for symptom relief
Read more from Ziegeler et al: www.oarsijournal.com/article/S106...
December's Editor's Choice (Clinical) suggests it's NOT just the cartilage
Targeting entheses might be next frontier for symptom relief
Read more from Ziegeler et al: www.oarsijournal.com/article/S106...
#New in #OAC Xiao et al. investigates the role of CX3CR1⁺ macrophages and microglia in local inflammation and pain using transgenic mouse models and surgically induced disc herniation model.
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sciencedirect.com/science/arti...
🔗
sciencedirect.com/science/arti...
November 29, 2025 at 4:22 PM
#New in #OAC Xiao et al. investigates the role of CX3CR1⁺ macrophages and microglia in local inflammation and pain using transgenic mouse models and surgically induced disc herniation model.
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sciencedirect.com/science/arti...
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sciencedirect.com/science/arti...
New in #OAC Alimy et al. identified subchondral bone endotypes with distinct clinical and cellular characteristics as a basis for developing novel OA therapies.
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www.oarsijournal.com/article/S106...
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www.oarsijournal.com/article/S106...
Multidimensional characterization and clinical profiling of subchondral bone endotypes in hip osteoarthritis
Treatment of osteoarthritis (OA) remains limited to symptom management and surgery
without addressing pathophysiological or individual patient-specific factors. Here,
we aimed to decipher whether indi...
www.oarsijournal.com
November 28, 2025 at 2:54 PM
New in #OAC Alimy et al. identified subchondral bone endotypes with distinct clinical and cellular characteristics as a basis for developing novel OA therapies.
🔗
www.oarsijournal.com/article/S106...
🔗
www.oarsijournal.com/article/S106...
This collaborative work from Farhat et al. seeks to learn about the brain-joint connection and reveals a CB1 dependent hypothalamic connection to the lateral meniscus that prevents its mineralization and subsequent articular cartilage damage.
🔗 www.oarsijournal.com/article/S106...
🔗 www.oarsijournal.com/article/S106...
November 24, 2025 at 4:41 PM
This collaborative work from Farhat et al. seeks to learn about the brain-joint connection and reveals a CB1 dependent hypothalamic connection to the lateral meniscus that prevents its mineralization and subsequent articular cartilage damage.
🔗 www.oarsijournal.com/article/S106...
🔗 www.oarsijournal.com/article/S106...
🆕 Editor's Choice!
This month's featured paper is on plasma #lipoprotein and #osteoarthritis risk
Lipoprotein subclasses play diverse roles in health and disease there is so much more to learn about its impact on knee #osteoarthritis
Read more from Li et al - www.oarsijournal.com/article/S106...
This month's featured paper is on plasma #lipoprotein and #osteoarthritis risk
Lipoprotein subclasses play diverse roles in health and disease there is so much more to learn about its impact on knee #osteoarthritis
Read more from Li et al - www.oarsijournal.com/article/S106...
November 14, 2025 at 3:19 PM
🆕 Editor's Choice!
This month's featured paper is on plasma #lipoprotein and #osteoarthritis risk
Lipoprotein subclasses play diverse roles in health and disease there is so much more to learn about its impact on knee #osteoarthritis
Read more from Li et al - www.oarsijournal.com/article/S106...
This month's featured paper is on plasma #lipoprotein and #osteoarthritis risk
Lipoprotein subclasses play diverse roles in health and disease there is so much more to learn about its impact on knee #osteoarthritis
Read more from Li et al - www.oarsijournal.com/article/S106...
LAST DAY TO SUBMIT!☺️
One week left to submit your #Cover #Art for the #OAC cover art competition. We look forward to seeing all of the creative designs. 🤩
Are you a creative scientist?🧐
#OAC is looking for a new cover design! Submit your Osteoarthritis and Cartilage based cover designs by November 10th, 2025🤩
forms.gle/5qVWiHrHk2G9...
#OAC is looking for a new cover design! Submit your Osteoarthritis and Cartilage based cover designs by November 10th, 2025🤩
forms.gle/5qVWiHrHk2G9...
November 10, 2025 at 12:49 PM
LAST DAY TO SUBMIT!☺️
How did Zhou et al. monitor the temporal profiling of lipid mediators in the synovium and tibial plateau during joint inflammation🧐? Learn out this work in this month's #EditorsChoice paper for #Basic #Science.
🔗
www.sciencedirect.com/science/arti...
🔗
www.sciencedirect.com/science/arti...
November 10, 2025 at 12:39 PM
How did Zhou et al. monitor the temporal profiling of lipid mediators in the synovium and tibial plateau during joint inflammation🧐? Learn out this work in this month's #EditorsChoice paper for #Basic #Science.
🔗
www.sciencedirect.com/science/arti...
🔗
www.sciencedirect.com/science/arti...
One week left to submit your #Cover #Art for the #OAC cover art competition. We look forward to seeing all of the creative designs. 🤩
Are you a creative scientist?🧐
#OAC is looking for a new cover design! Submit your Osteoarthritis and Cartilage based cover designs by November 10th, 2025🤩
forms.gle/5qVWiHrHk2G9...
#OAC is looking for a new cover design! Submit your Osteoarthritis and Cartilage based cover designs by November 10th, 2025🤩
forms.gle/5qVWiHrHk2G9...
November 3, 2025 at 1:56 PM
👋 Are you a young researcher interested in editorial roles?
If that is you, OAC is currently seeking Editorial Fellows for 2026!
Fellows will be mentored by our Editors-in-chief David Hunter @jointsintheworld.bsky.social and our team of Deputy Editors.
form.jotform.com/242315596999...
If that is you, OAC is currently seeking Editorial Fellows for 2026!
Fellows will be mentored by our Editors-in-chief David Hunter @jointsintheworld.bsky.social and our team of Deputy Editors.
form.jotform.com/242315596999...
October 31, 2025 at 11:31 PM
👋 Are you a young researcher interested in editorial roles?
If that is you, OAC is currently seeking Editorial Fellows for 2026!
Fellows will be mentored by our Editors-in-chief David Hunter @jointsintheworld.bsky.social and our team of Deputy Editors.
form.jotform.com/242315596999...
If that is you, OAC is currently seeking Editorial Fellows for 2026!
Fellows will be mentored by our Editors-in-chief David Hunter @jointsintheworld.bsky.social and our team of Deputy Editors.
form.jotform.com/242315596999...
#New research highlights the key role of the NGF/TrkA pathway in chronic #OA pain. Through gene expression analysis, specific genes and pathways linked to OA progression were found, offering insights for targeted therapies against OA pain. #PainResearch
📖:
www.sciencedirect.com/science/arti...
📖:
www.sciencedirect.com/science/arti...
October 28, 2025 at 1:19 PM
#New research highlights the key role of the NGF/TrkA pathway in chronic #OA pain. Through gene expression analysis, specific genes and pathways linked to OA progression were found, offering insights for targeted therapies against OA pain. #PainResearch
📖:
www.sciencedirect.com/science/arti...
📖:
www.sciencedirect.com/science/arti...
Think of transplanting stem cells like sending an athlete onto the field—without
training, they'll struggle. Ai et al. created a "warm-up" system that mechanically pre-trains
MSCs for the tough environment of the knee!
🔗https://www.sciencedirect.com/science/article/pii/S1063458425010659?via%3Dihub
training, they'll struggle. Ai et al. created a "warm-up" system that mechanically pre-trains
MSCs for the tough environment of the knee!
🔗https://www.sciencedirect.com/science/article/pii/S1063458425010659?via%3Dihub
October 22, 2025 at 3:37 PM
Think of transplanting stem cells like sending an athlete onto the field—without
training, they'll struggle. Ai et al. created a "warm-up" system that mechanically pre-trains
MSCs for the tough environment of the knee!
🔗https://www.sciencedirect.com/science/article/pii/S1063458425010659?via%3Dihub
training, they'll struggle. Ai et al. created a "warm-up" system that mechanically pre-trains
MSCs for the tough environment of the knee!
🔗https://www.sciencedirect.com/science/article/pii/S1063458425010659?via%3Dihub
Reposted by Osteoarthritis and Cartilage Journal
Great summary of our latest work - a real Team Science effort! 👥 🐭
#New in #OAC ! The sphingolipid sphingomyelin 34:1 is upregulated in the synovial fluid of those with OA. Work from @phar.cam.ac.uk shows that SM34:1 causes inflammatory pain in mice, inducing neuronal hyperexcitability.
@psalmotoxin.bsky.social
@interlukein.bsky.social
@mayadannawi.bsky.social
@psalmotoxin.bsky.social
@interlukein.bsky.social
@mayadannawi.bsky.social
October 2, 2025 at 7:11 PM
Great summary of our latest work - a real Team Science effort! 👥 🐭
Reposted by Osteoarthritis and Cartilage Journal
October's #EditorsChoice is on #guthealth
📈 Higher relative abundance of hashtag#alistipessenegalensis and alterations in tryptophan metabolites like indoleacrylic acid are associated with hand hashtag#osteoarthritis
✋ Access full-text and all their awesome figures here: lnkd.in/gPU3RNv7
📈 Higher relative abundance of hashtag#alistipessenegalensis and alterations in tryptophan metabolites like indoleacrylic acid are associated with hand hashtag#osteoarthritis
✋ Access full-text and all their awesome figures here: lnkd.in/gPU3RNv7
October 8, 2025 at 9:15 PM
October's #EditorsChoice is on #guthealth
📈 Higher relative abundance of hashtag#alistipessenegalensis and alterations in tryptophan metabolites like indoleacrylic acid are associated with hand hashtag#osteoarthritis
✋ Access full-text and all their awesome figures here: lnkd.in/gPU3RNv7
📈 Higher relative abundance of hashtag#alistipessenegalensis and alterations in tryptophan metabolites like indoleacrylic acid are associated with hand hashtag#osteoarthritis
✋ Access full-text and all their awesome figures here: lnkd.in/gPU3RNv7
#New in #OAC ! The sphingolipid sphingomyelin 34:1 is upregulated in the synovial fluid of those with OA. Work from @phar.cam.ac.uk shows that SM34:1 causes inflammatory pain in mice, inducing neuronal hyperexcitability.
@psalmotoxin.bsky.social
@interlukein.bsky.social
@mayadannawi.bsky.social
@psalmotoxin.bsky.social
@interlukein.bsky.social
@mayadannawi.bsky.social
October 2, 2025 at 6:03 PM
#New in #OAC ! The sphingolipid sphingomyelin 34:1 is upregulated in the synovial fluid of those with OA. Work from @phar.cam.ac.uk shows that SM34:1 causes inflammatory pain in mice, inducing neuronal hyperexcitability.
@psalmotoxin.bsky.social
@interlukein.bsky.social
@mayadannawi.bsky.social
@psalmotoxin.bsky.social
@interlukein.bsky.social
@mayadannawi.bsky.social
Are you a creative scientist?🧐
#OAC is looking for a new cover design! Submit your Osteoarthritis and Cartilage based cover designs by November 10th, 2025🤩
forms.gle/5qVWiHrHk2G9...
#OAC is looking for a new cover design! Submit your Osteoarthritis and Cartilage based cover designs by November 10th, 2025🤩
forms.gle/5qVWiHrHk2G9...
October 1, 2025 at 4:41 PM
Are you a creative scientist?🧐
#OAC is looking for a new cover design! Submit your Osteoarthritis and Cartilage based cover designs by November 10th, 2025🤩
forms.gle/5qVWiHrHk2G9...
#OAC is looking for a new cover design! Submit your Osteoarthritis and Cartilage based cover designs by November 10th, 2025🤩
forms.gle/5qVWiHrHk2G9...
#New this month in #OAC . Translocator protein 18 kDa (TSPO) plays an important role in #OA occurrence and development. Emapunil targeting TSPO improves OA by modulating #macrophage polarization and #inflammation through the CD14/TLR4/LY96 pathway.
🔗
www.sciencedirect.com/science/arti...
🔗
www.sciencedirect.com/science/arti...
September 29, 2025 at 3:03 PM
#New this month in #OAC . Translocator protein 18 kDa (TSPO) plays an important role in #OA occurrence and development. Emapunil targeting TSPO improves OA by modulating #macrophage polarization and #inflammation through the CD14/TLR4/LY96 pathway.
🔗
www.sciencedirect.com/science/arti...
🔗
www.sciencedirect.com/science/arti...
#New in #OAC This study by Xiao et al. demonstrates that YAP plays a critical role in subchondral bone remodeling and targeting the YAP-Hhip axis through regulation of Hh-Gli1 signaling in Gli1+ osteogenic progenitors could inhibit OA progression! 🐭
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 25, 2025 at 2:55 PM
#New in #OAC This study by Xiao et al. demonstrates that YAP plays a critical role in subchondral bone remodeling and targeting the YAP-Hhip axis through regulation of Hh-Gli1 signaling in Gli1+ osteogenic progenitors could inhibit OA progression! 🐭
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...