Luke Pattison
@interlukein.bsky.social
Research scientist interested in inflammatory pain 🔬 👨🔬 ✌️
Reposted by Luke Pattison
New pre-print from @phar.cam.ac.uk & Bellefroid lab at ULB! Led by @mayadannawi.bsky.social w support from @interlukein.bsky.social & more! We investigate impact of overexpressing the zinc finger transcriptional regulator Prdm12 on sensory neuron function / joint pain. #neuroskyence #PainResearch
AAV-mediated overexpression of Prdm12 in knee-innervating afferents reduces inflammatory joint pain and neuronal hyperexcitability in mice
Inflammatory joint pain features in numerous musculoskeletal disorders that affect millions globally. The Prdm12 gene encodes a conserved zinc finger transcriptional regulator expressed selectively in...
www.biorxiv.org
October 16, 2025 at 6:29 AM
New pre-print from @phar.cam.ac.uk & Bellefroid lab at ULB! Led by @mayadannawi.bsky.social w support from @interlukein.bsky.social & more! We investigate impact of overexpressing the zinc finger transcriptional regulator Prdm12 on sensory neuron function / joint pain. #neuroskyence #PainResearch
Great summary of our latest work - a real Team Science effort! 👥 🐭
#New in #OAC ! The sphingolipid sphingomyelin 34:1 is upregulated in the synovial fluid of those with OA. Work from @phar.cam.ac.uk shows that SM34:1 causes inflammatory pain in mice, inducing neuronal hyperexcitability.
@psalmotoxin.bsky.social
@interlukein.bsky.social
@mayadannawi.bsky.social
@psalmotoxin.bsky.social
@interlukein.bsky.social
@mayadannawi.bsky.social
October 2, 2025 at 7:11 PM
Great summary of our latest work - a real Team Science effort! 👥 🐭
I am currently curating a Special Issue for MDPI Cells
on “Molecular Mechanisms Underlying Inflammatory Pain.”
If you are working on, or planning a suitable manuscript, I would be delighted if you would consider submitting it to our issue.
mdpi.com/journal/cell...
on “Molecular Mechanisms Underlying Inflammatory Pain.”
If you are working on, or planning a suitable manuscript, I would be delighted if you would consider submitting it to our issue.
mdpi.com/journal/cell...
September 26, 2025 at 9:56 AM
I am currently curating a Special Issue for MDPI Cells
on “Molecular Mechanisms Underlying Inflammatory Pain.”
If you are working on, or planning a suitable manuscript, I would be delighted if you would consider submitting it to our issue.
mdpi.com/journal/cell...
on “Molecular Mechanisms Underlying Inflammatory Pain.”
If you are working on, or planning a suitable manuscript, I would be delighted if you would consider submitting it to our issue.
mdpi.com/journal/cell...
A new academic year! 🍏
Proud to watch my Pegasus Scholars students presenting on targeted cancer therapies today, after a week exploring the formation, functions, faults and fixing of proteins! 🔬
Glad to support Robinson College’s excellent widening participation initiation for another year! 👨🏫
Proud to watch my Pegasus Scholars students presenting on targeted cancer therapies today, after a week exploring the formation, functions, faults and fixing of proteins! 🔬
Glad to support Robinson College’s excellent widening participation initiation for another year! 👨🏫
September 25, 2025 at 1:07 PM
A new academic year! 🍏
Proud to watch my Pegasus Scholars students presenting on targeted cancer therapies today, after a week exploring the formation, functions, faults and fixing of proteins! 🔬
Glad to support Robinson College’s excellent widening participation initiation for another year! 👨🏫
Proud to watch my Pegasus Scholars students presenting on targeted cancer therapies today, after a week exploring the formation, functions, faults and fixing of proteins! 🔬
Glad to support Robinson College’s excellent widening participation initiation for another year! 👨🏫
If you have #osteoarthritis, please see below 👇 - I’m running a 2 minute survey and would love your input 😇
👋I’m developing a proposal to investigate how pain changes with progression of osteoarthritis (OA). 🦴⚡️
If you have OA, I’d love to hear how your experience with pain has changed over time - please consider answering this quick 10-question survey! 🙏
forms.office.com/e/pYwbTrD3Qv
If you have OA, I’d love to hear how your experience with pain has changed over time - please consider answering this quick 10-question survey! 🙏
forms.office.com/e/pYwbTrD3Qv
Microsoft Forms
forms.office.com
May 5, 2025 at 2:45 PM
If you have #osteoarthritis, please see below 👇 - I’m running a 2 minute survey and would love your input 😇
👋I’m developing a proposal to investigate how pain changes with progression of osteoarthritis (OA). 🦴⚡️
If you have OA, I’d love to hear how your experience with pain has changed over time - please consider answering this quick 10-question survey! 🙏
forms.office.com/e/pYwbTrD3Qv
If you have OA, I’d love to hear how your experience with pain has changed over time - please consider answering this quick 10-question survey! 🙏
forms.office.com/e/pYwbTrD3Qv
Microsoft Forms
forms.office.com
April 22, 2025 at 11:18 AM
👋I’m developing a proposal to investigate how pain changes with progression of osteoarthritis (OA). 🦴⚡️
If you have OA, I’d love to hear how your experience with pain has changed over time - please consider answering this quick 10-question survey! 🙏
forms.office.com/e/pYwbTrD3Qv
If you have OA, I’d love to hear how your experience with pain has changed over time - please consider answering this quick 10-question survey! 🙏
forms.office.com/e/pYwbTrD3Qv
Still got it! ⚡️
February 13, 2025 at 3:45 PM
Still got it! ⚡️
🤩 geeking out at Geneva light festival last weekend - double helix 🧬 & neuron 🧠 #genevalux
February 10, 2025 at 5:13 PM
🤩 geeking out at Geneva light festival last weekend - double helix 🧬 & neuron 🧠 #genevalux
Reposted by Luke Pattison
📣 Calling fellow ECRs studying the contributions of GPCRs to pain and/or analgesia!
🧠 Interested in presenting at #SfN25 in San Diego in November?
🙏 Please drop me a message - looking for last few speakers for a mini symposium proposal!
#PainResearch #neuroskyance
🧠 Interested in presenting at #SfN25 in San Diego in November?
🙏 Please drop me a message - looking for last few speakers for a mini symposium proposal!
#PainResearch #neuroskyance
January 2, 2025 at 7:32 PM
📣 Calling fellow ECRs studying the contributions of GPCRs to pain and/or analgesia!
🧠 Interested in presenting at #SfN25 in San Diego in November?
🙏 Please drop me a message - looking for last few speakers for a mini symposium proposal!
#PainResearch #neuroskyance
🧠 Interested in presenting at #SfN25 in San Diego in November?
🙏 Please drop me a message - looking for last few speakers for a mini symposium proposal!
#PainResearch #neuroskyance
📣 Calling fellow ECRs studying the contributions of GPCRs to pain and/or analgesia!
🧠 Interested in presenting at #SfN25 in San Diego in November?
🙏 Please drop me a message - looking for last few speakers for a mini symposium proposal!
#PainResearch #neuroskyance
🧠 Interested in presenting at #SfN25 in San Diego in November?
🙏 Please drop me a message - looking for last few speakers for a mini symposium proposal!
#PainResearch #neuroskyance
January 2, 2025 at 7:32 PM
📣 Calling fellow ECRs studying the contributions of GPCRs to pain and/or analgesia!
🧠 Interested in presenting at #SfN25 in San Diego in November?
🙏 Please drop me a message - looking for last few speakers for a mini symposium proposal!
#PainResearch #neuroskyance
🧠 Interested in presenting at #SfN25 in San Diego in November?
🙏 Please drop me a message - looking for last few speakers for a mini symposium proposal!
#PainResearch #neuroskyance
Riding the year out on a high ✨ - latest paper out now in @pnas.org! ☺️ 🙏
Here we describe a role for the proton-sensing GPCR, GPR65 in mediating joint pain from fibroblast-like synoviocytes!
www.pnas.org/doi/10.1073/...
#PainResearch #Neuroskyence
More on this work below 👇 🧵 [1/10]
Here we describe a role for the proton-sensing GPCR, GPR65 in mediating joint pain from fibroblast-like synoviocytes!
www.pnas.org/doi/10.1073/...
#PainResearch #Neuroskyence
More on this work below 👇 🧵 [1/10]
Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain | PNAS
Inflammation is associated with localized acidosis, however, attributing physiological
and pathological roles to proton-sensitive receptors is chal...
www.pnas.org
December 11, 2024 at 3:58 PM
Riding the year out on a high ✨ - latest paper out now in @pnas.org! ☺️ 🙏
Here we describe a role for the proton-sensing GPCR, GPR65 in mediating joint pain from fibroblast-like synoviocytes!
www.pnas.org/doi/10.1073/...
#PainResearch #Neuroskyence
More on this work below 👇 🧵 [1/10]
Here we describe a role for the proton-sensing GPCR, GPR65 in mediating joint pain from fibroblast-like synoviocytes!
www.pnas.org/doi/10.1073/...
#PainResearch #Neuroskyence
More on this work below 👇 🧵 [1/10]
Interesting work! 👏
Gabapentin's Effect on Human Dorsal Root Ganglia: Donor-Specific Electrophysiological and Transcriptomic Profiles https://www.biorxiv.org/content/10.1101/2024.12.05.627067v1
December 10, 2024 at 3:22 PM
Interesting work! 👏
Excellent walk-through of our latest work, looking at lipids and inflammatory joint pain 👇
Pain = main driver of clinical decision making in osteoarthritis (OA). Our lab studies OA pain mechanisms.
During OA, multiple cell-cell interactions occur, many mediators being released that alter the contents of the synovial fluid.
#PainResearch #Neuroskyence
journals.lww.com/pain/Fulltex...
During OA, multiple cell-cell interactions occur, many mediators being released that alter the contents of the synovial fluid.
#PainResearch #Neuroskyence
journals.lww.com/pain/Fulltex...
November 21, 2024 at 10:12 AM
Excellent walk-through of our latest work, looking at lipids and inflammatory joint pain 👇
👋 Hello, I'm new here...
...followed the herd to a greener field! 🐏 🦋
I'm a postdoc interested in the mechanisms driving inflammatory pain, with the aim of identifying new points of intervention, for the development of better medicines! #PainResearch #FirstPost
...followed the herd to a greener field! 🐏 🦋
I'm a postdoc interested in the mechanisms driving inflammatory pain, with the aim of identifying new points of intervention, for the development of better medicines! #PainResearch #FirstPost
November 21, 2024 at 10:08 AM
👋 Hello, I'm new here...
...followed the herd to a greener field! 🐏 🦋
I'm a postdoc interested in the mechanisms driving inflammatory pain, with the aim of identifying new points of intervention, for the development of better medicines! #PainResearch #FirstPost
...followed the herd to a greener field! 🐏 🦋
I'm a postdoc interested in the mechanisms driving inflammatory pain, with the aim of identifying new points of intervention, for the development of better medicines! #PainResearch #FirstPost