Fabian Ackle
@fabianackle.ch
PhD student studying protein trafficking in the early secretory pathway. Big fan of LC-MS/MS, nanopore sequencing, structural biology & #nanobodies 👀
https://fabianackle.ch/
https://fabianackle.ch/
Reposted by Fabian Ackle
Interested in viewing a talk from a previous Mutational Scanning Symposium?
Visit our youtube channel.
📺 🍿 www.youtube.com/@cmap_cegs84...
@isabellease.bsky.social 's wonderful #VariantEffect25 illustrations can be found here. 🎨 isabellezane.bio
Visit our youtube channel.
📺 🍿 www.youtube.com/@cmap_cegs84...
@isabellease.bsky.social 's wonderful #VariantEffect25 illustrations can be found here. 🎨 isabellezane.bio
August 29, 2025 at 2:24 PM
Interested in viewing a talk from a previous Mutational Scanning Symposium?
Visit our youtube channel.
📺 🍿 www.youtube.com/@cmap_cegs84...
@isabellease.bsky.social 's wonderful #VariantEffect25 illustrations can be found here. 🎨 isabellezane.bio
Visit our youtube channel.
📺 🍿 www.youtube.com/@cmap_cegs84...
@isabellease.bsky.social 's wonderful #VariantEffect25 illustrations can be found here. 🎨 isabellezane.bio
Reposted by Fabian Ackle
Preprint by the Jinek and Martinez labs with 1st author Moritz Pfleiderer "
Structural framework for the assembly of the human tRNA
ligase complex" @biorxivpreprint.bsky.social buff.ly/9rwwEP4
@martinjinek.bsky.social
@maxperutzlabs.bsky.social
Structural framework for the assembly of the human tRNA
ligase complex" @biorxivpreprint.bsky.social buff.ly/9rwwEP4
@martinjinek.bsky.social
@maxperutzlabs.bsky.social
August 20, 2025 at 7:00 AM
Preprint by the Jinek and Martinez labs with 1st author Moritz Pfleiderer "
Structural framework for the assembly of the human tRNA
ligase complex" @biorxivpreprint.bsky.social buff.ly/9rwwEP4
@martinjinek.bsky.social
@maxperutzlabs.bsky.social
Structural framework for the assembly of the human tRNA
ligase complex" @biorxivpreprint.bsky.social buff.ly/9rwwEP4
@martinjinek.bsky.social
@maxperutzlabs.bsky.social
Reposted by Fabian Ackle
Exciting times ahead!
Today marks the first day of the Loeff Lab at Leiden University Medical Center in the Netherlands 🇳🇱. I’m thrilled to begin this new adventure and continue exploring microbial defense mechanisms and their applications through an integrative structural biology approach.
Today marks the first day of the Loeff Lab at Leiden University Medical Center in the Netherlands 🇳🇱. I’m thrilled to begin this new adventure and continue exploring microbial defense mechanisms and their applications through an integrative structural biology approach.
August 18, 2025 at 2:54 PM
Exciting times ahead!
Today marks the first day of the Loeff Lab at Leiden University Medical Center in the Netherlands 🇳🇱. I’m thrilled to begin this new adventure and continue exploring microbial defense mechanisms and their applications through an integrative structural biology approach.
Today marks the first day of the Loeff Lab at Leiden University Medical Center in the Netherlands 🇳🇱. I’m thrilled to begin this new adventure and continue exploring microbial defense mechanisms and their applications through an integrative structural biology approach.
Reposted by Fabian Ackle
I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
July 25, 2025 at 7:48 AM
I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
Reposted by Fabian Ackle
We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design!
github.com/martinpacesa...
github.com/martinpacesa...
June 30, 2025 at 7:45 PM
We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design!
github.com/martinpacesa...
github.com/martinpacesa...
Reposted by Fabian Ackle
New blog post!
In it, I benchmark the new version of Dorado from @nanoporetech.com, which comes with new DNA basecalling models. Short version: big accuracy gains for hac, small improvements for sup.
Check it out for the full results:
rrwick.github.io/2025/05/27/d...
In it, I benchmark the new version of Dorado from @nanoporetech.com, which comes with new DNA basecalling models. Short version: big accuracy gains for hac, small improvements for sup.
Check it out for the full results:
rrwick.github.io/2025/05/27/d...
Dorado v1.0.0 and the v5.2.0 basecalling models
a blog for miscellaneous bioinformatics stuff
rrwick.github.io
May 27, 2025 at 7:02 AM
New blog post!
In it, I benchmark the new version of Dorado from @nanoporetech.com, which comes with new DNA basecalling models. Short version: big accuracy gains for hac, small improvements for sup.
Check it out for the full results:
rrwick.github.io/2025/05/27/d...
In it, I benchmark the new version of Dorado from @nanoporetech.com, which comes with new DNA basecalling models. Short version: big accuracy gains for hac, small improvements for sup.
Check it out for the full results:
rrwick.github.io/2025/05/27/d...
Reposted by Fabian Ackle
A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it.
www.science.org/content/blog...
www.science.org/content/blog...
What's Happening Inside the NIH and NSF
www.science.org
February 4, 2025 at 4:40 PM
A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it.
www.science.org/content/blog...
www.science.org/content/blog...
Reposted by Fabian Ackle
Well the award for most cowardly, boot-lickingest academic society has squarely gone to the American Society of Microbiology, who has taken down features of various non-white scientists. Absolutely pathetic behavior. Those articles are now coming up as “under review”. Truly sickening cowardice here.
February 3, 2025 at 4:39 AM
Well the award for most cowardly, boot-lickingest academic society has squarely gone to the American Society of Microbiology, who has taken down features of various non-white scientists. Absolutely pathetic behavior. Those articles are now coming up as “under review”. Truly sickening cowardice here.
Reposted by Fabian Ackle
Happy Birthday PDB, announced #OTD in 1971 In Nature New Biology.
Today we celebrate the 53rd anniversary of the Protein Data Bank and the PDB depositor community, and congratulate the 2024 Nobel Prize in Chemistry Awardees
www.rcsb.org/news/fe...
Today we celebrate the 53rd anniversary of the Protein Data Bank and the PDB depositor community, and congratulate the 2024 Nobel Prize in Chemistry Awardees
www.rcsb.org/news/fe...
The Nobel Prize in Chemistry 2024
Congratulations to David Baker, who was recognized for computational protein design, and to Demis Hassabis and John M. Jumper, who were recognized for protein structure prediction. These achievements also celebrate the work of the PDB depositor community and the PDB archive that underpinned development of their prediction methods.
www.rcsb.org
October 20, 2024 at 3:30 PM
Happy Birthday PDB, announced #OTD in 1971 In Nature New Biology.
Today we celebrate the 53rd anniversary of the Protein Data Bank and the PDB depositor community, and congratulate the 2024 Nobel Prize in Chemistry Awardees
www.rcsb.org/news/fe...
Today we celebrate the 53rd anniversary of the Protein Data Bank and the PDB depositor community, and congratulate the 2024 Nobel Prize in Chemistry Awardees
www.rcsb.org/news/fe...